Arsenic in drinking water and acute coronary syndrome in Zrenjanin municipality, Serbia
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2012
Authors
Jovanović, Dragana D.
Paunović, Katarina

Manojlović, Dragan

Jakovljevic, Branko
Rasic-Milutinovic, Zorica
Dojčinović, Biljana

Article (Published version)

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Background: Arsenic is constantly present in drinking water supply systems of Zrenjanin municipality across decades. It presents a great public health problem in Serbia, but its relationship with acute coronary syndrome (ACS) has not been studied previously. Objectives: The aims of this study were to assess the incidence of ACS in two areas from Zrenjanin municipality consuming different levels of arsenic in drinking water, and to explore the association between arsenic exposure and the probability of fatal outcome of ACS. Methods: The research was a registry-based ecological study of two populations consuming water with different arsenic levels, based on current guidelines (10 mu g/L). Median arsenic in the area above national standard was 80 mu g/L; median arsenic in the other area was 1 mu g/L. Newly diagnosed cases of ACS were obtained from the National Registry for Acute Coronary Syndrome from 2006 to 2010. Results: The two populations were comparable by age, gender, and prevalenc...e of risk factors for ACS. Standardized incidence rates (SIR) of ACS were higher for people consuming arsenic above standard (average five-year SIR was 237.00 per 100.000: 95% CI=214.93-260.74), in comparison to people consuming arsenic within limits (average SIR=124.40 per 100.000; 95% CI=96.00-158.56). Exposure to arsenic above limits was insignificantly associated with fatal outcome of ACS for the whole population, men and women. Conclusions: Consumption of arsenic above national standards was associated with higher risk for the occurrence of acute coronary syndrome and with insignificantly higher probability of fatal outcome of ACS in Zrenjanin municipality.
Keywords:
Acute coronary syndrome / Arsenic / Water pollution / Drinking waterSource:
Environmental Research, 2012, 117, 75-82Publisher:
- Academic Press Inc Elsevier Science, San Diego
DOI: 10.1016/j.envres.2012.04.016
ISSN: 0013-9351
PubMed: 22626473
WoS: 000307912900010
Scopus: 2-s2.0-84864959777
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IHTMTY - JOUR AU - Jovanović, Dragana D. AU - Paunović, Katarina AU - Manojlović, Dragan AU - Jakovljevic, Branko AU - Rasic-Milutinovic, Zorica AU - Dojčinović, Biljana PY - 2012 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1111 AB - Background: Arsenic is constantly present in drinking water supply systems of Zrenjanin municipality across decades. It presents a great public health problem in Serbia, but its relationship with acute coronary syndrome (ACS) has not been studied previously. Objectives: The aims of this study were to assess the incidence of ACS in two areas from Zrenjanin municipality consuming different levels of arsenic in drinking water, and to explore the association between arsenic exposure and the probability of fatal outcome of ACS. Methods: The research was a registry-based ecological study of two populations consuming water with different arsenic levels, based on current guidelines (10 mu g/L). Median arsenic in the area above national standard was 80 mu g/L; median arsenic in the other area was 1 mu g/L. Newly diagnosed cases of ACS were obtained from the National Registry for Acute Coronary Syndrome from 2006 to 2010. Results: The two populations were comparable by age, gender, and prevalence of risk factors for ACS. Standardized incidence rates (SIR) of ACS were higher for people consuming arsenic above standard (average five-year SIR was 237.00 per 100.000: 95% CI=214.93-260.74), in comparison to people consuming arsenic within limits (average SIR=124.40 per 100.000; 95% CI=96.00-158.56). Exposure to arsenic above limits was insignificantly associated with fatal outcome of ACS for the whole population, men and women. Conclusions: Consumption of arsenic above national standards was associated with higher risk for the occurrence of acute coronary syndrome and with insignificantly higher probability of fatal outcome of ACS in Zrenjanin municipality. PB - Academic Press Inc Elsevier Science, San Diego T2 - Environmental Research T1 - Arsenic in drinking water and acute coronary syndrome in Zrenjanin municipality, Serbia VL - 117 SP - 75 EP - 82 DO - 10.1016/j.envres.2012.04.016 ER -
@article{ author = "Jovanović, Dragana D. and Paunović, Katarina and Manojlović, Dragan and Jakovljevic, Branko and Rasic-Milutinovic, Zorica and Dojčinović, Biljana", year = "2012", abstract = "Background: Arsenic is constantly present in drinking water supply systems of Zrenjanin municipality across decades. It presents a great public health problem in Serbia, but its relationship with acute coronary syndrome (ACS) has not been studied previously. Objectives: The aims of this study were to assess the incidence of ACS in two areas from Zrenjanin municipality consuming different levels of arsenic in drinking water, and to explore the association between arsenic exposure and the probability of fatal outcome of ACS. Methods: The research was a registry-based ecological study of two populations consuming water with different arsenic levels, based on current guidelines (10 mu g/L). Median arsenic in the area above national standard was 80 mu g/L; median arsenic in the other area was 1 mu g/L. Newly diagnosed cases of ACS were obtained from the National Registry for Acute Coronary Syndrome from 2006 to 2010. Results: The two populations were comparable by age, gender, and prevalence of risk factors for ACS. Standardized incidence rates (SIR) of ACS were higher for people consuming arsenic above standard (average five-year SIR was 237.00 per 100.000: 95% CI=214.93-260.74), in comparison to people consuming arsenic within limits (average SIR=124.40 per 100.000; 95% CI=96.00-158.56). Exposure to arsenic above limits was insignificantly associated with fatal outcome of ACS for the whole population, men and women. Conclusions: Consumption of arsenic above national standards was associated with higher risk for the occurrence of acute coronary syndrome and with insignificantly higher probability of fatal outcome of ACS in Zrenjanin municipality.", publisher = "Academic Press Inc Elsevier Science, San Diego", journal = "Environmental Research", title = "Arsenic in drinking water and acute coronary syndrome in Zrenjanin municipality, Serbia", volume = "117", pages = "75-82", doi = "10.1016/j.envres.2012.04.016" }
Jovanović, D. D., Paunović, K., Manojlović, D., Jakovljevic, B., Rasic-Milutinovic, Z.,& Dojčinović, B.. (2012). Arsenic in drinking water and acute coronary syndrome in Zrenjanin municipality, Serbia. in Environmental Research Academic Press Inc Elsevier Science, San Diego., 117, 75-82. https://doi.org/10.1016/j.envres.2012.04.016
Jovanović DD, Paunović K, Manojlović D, Jakovljevic B, Rasic-Milutinovic Z, Dojčinović B. Arsenic in drinking water and acute coronary syndrome in Zrenjanin municipality, Serbia. in Environmental Research. 2012;117:75-82. doi:10.1016/j.envres.2012.04.016 .
Jovanović, Dragana D., Paunović, Katarina, Manojlović, Dragan, Jakovljevic, Branko, Rasic-Milutinovic, Zorica, Dojčinović, Biljana, "Arsenic in drinking water and acute coronary syndrome in Zrenjanin municipality, Serbia" in Environmental Research, 117 (2012):75-82, https://doi.org/10.1016/j.envres.2012.04.016 . .