Artemisinins and synthetic peroxides as highly efficient antimalarials
Abstract
Malaria is devastating disease and global public health problem, with nearly half world population exposed to risk. Illness is caused by five Plasmodium species, P falciparum, P ovale, P viva; P malaria and P knowlesi, from which P falciparum is the most serious one causing cerebral malaria and is the major reason for malaria mortality. Vaccine against malaria is not expected in the near future and chemotherapy remains as most feasible alternative for treatment of the disease. The development of widespread drug-resistance to chloroquine (CQ), the most successful antimalarial drug up to date, has resulted in severe health issues for countries in malaria endemic regions. Organic peroxides, like artemisinins, 1,2,4-trioxanes, 1,2,4-trioxolanes, 1,2,4,5-tetraoxanes and their chimeras, are the best choice for malaria treatment nowadays. These therapeutics are fast acting, non-toxic, low costing and without reported data of parasite resistance. Stability of peroxide bonds enables synthetic c...omfort and resulting in diversity of synthesized structures. The most important classes of peroxide antimalarials with promising representatives are reviewed and possible mechanisms of action were presented in details.
Keywords:
antimalarials / artemisinin / peroxides / trioxanes / trioxolanes / tetraoxanes / chimerasSource:
Macedonian Journal of Chemistry and Chemical Engineering, 2012, 31, 2, 137-182Publisher:
- Soc Chemists Technologists Madeconia, Skopje
Funding / projects:
- The synthesis of aminoquinoline-based antimalarials and botulinum neurotoxin A inhibitors (RS-MESTD-Basic Research (BR or ON)-172008)
- Serbian Academy of Sciences and Arts
Collections
Institution/Community
IHTMTY - JOUR AU - Opsenica, Dejan AU - Šolaja, Bogdan PY - 2012 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1088 AB - Malaria is devastating disease and global public health problem, with nearly half world population exposed to risk. Illness is caused by five Plasmodium species, P falciparum, P ovale, P viva; P malaria and P knowlesi, from which P falciparum is the most serious one causing cerebral malaria and is the major reason for malaria mortality. Vaccine against malaria is not expected in the near future and chemotherapy remains as most feasible alternative for treatment of the disease. The development of widespread drug-resistance to chloroquine (CQ), the most successful antimalarial drug up to date, has resulted in severe health issues for countries in malaria endemic regions. Organic peroxides, like artemisinins, 1,2,4-trioxanes, 1,2,4-trioxolanes, 1,2,4,5-tetraoxanes and their chimeras, are the best choice for malaria treatment nowadays. These therapeutics are fast acting, non-toxic, low costing and without reported data of parasite resistance. Stability of peroxide bonds enables synthetic comfort and resulting in diversity of synthesized structures. The most important classes of peroxide antimalarials with promising representatives are reviewed and possible mechanisms of action were presented in details. PB - Soc Chemists Technologists Madeconia, Skopje T2 - Macedonian Journal of Chemistry and Chemical Engineering T1 - Artemisinins and synthetic peroxides as highly efficient antimalarials VL - 31 IS - 2 SP - 137 EP - 182 UR - https://hdl.handle.net/21.15107/rcub_cherry_1579 ER -
@article{ author = "Opsenica, Dejan and Šolaja, Bogdan", year = "2012", abstract = "Malaria is devastating disease and global public health problem, with nearly half world population exposed to risk. Illness is caused by five Plasmodium species, P falciparum, P ovale, P viva; P malaria and P knowlesi, from which P falciparum is the most serious one causing cerebral malaria and is the major reason for malaria mortality. Vaccine against malaria is not expected in the near future and chemotherapy remains as most feasible alternative for treatment of the disease. The development of widespread drug-resistance to chloroquine (CQ), the most successful antimalarial drug up to date, has resulted in severe health issues for countries in malaria endemic regions. Organic peroxides, like artemisinins, 1,2,4-trioxanes, 1,2,4-trioxolanes, 1,2,4,5-tetraoxanes and their chimeras, are the best choice for malaria treatment nowadays. These therapeutics are fast acting, non-toxic, low costing and without reported data of parasite resistance. Stability of peroxide bonds enables synthetic comfort and resulting in diversity of synthesized structures. The most important classes of peroxide antimalarials with promising representatives are reviewed and possible mechanisms of action were presented in details.", publisher = "Soc Chemists Technologists Madeconia, Skopje", journal = "Macedonian Journal of Chemistry and Chemical Engineering", title = "Artemisinins and synthetic peroxides as highly efficient antimalarials", volume = "31", number = "2", pages = "137-182", url = "https://hdl.handle.net/21.15107/rcub_cherry_1579" }
Opsenica, D.,& Šolaja, B.. (2012). Artemisinins and synthetic peroxides as highly efficient antimalarials. in Macedonian Journal of Chemistry and Chemical Engineering Soc Chemists Technologists Madeconia, Skopje., 31(2), 137-182. https://hdl.handle.net/21.15107/rcub_cherry_1579
Opsenica D, Šolaja B. Artemisinins and synthetic peroxides as highly efficient antimalarials. in Macedonian Journal of Chemistry and Chemical Engineering. 2012;31(2):137-182. https://hdl.handle.net/21.15107/rcub_cherry_1579 .
Opsenica, Dejan, Šolaja, Bogdan, "Artemisinins and synthetic peroxides as highly efficient antimalarials" in Macedonian Journal of Chemistry and Chemical Engineering, 31, no. 2 (2012):137-182, https://hdl.handle.net/21.15107/rcub_cherry_1579 .