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dc.creatorSpasojević, Ivan
dc.creatorObradović, Budimir
dc.creatorSpasić, Snežana
dc.date.accessioned2019-01-30T17:31:18Z
dc.date.available2019-01-30T17:31:18Z
dc.date.issued2012
dc.identifier.issn1466-609X
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1047
dc.description.abstractThe present review is aimed at elucidating the neonatal 'sepsis redox cycle' - the cascade of inflammatory and redox events involved in the pathogenesis of sepsis in neonates. While adult and neonatal sepses share some common features, there are some substantial differences: higher mortality rates occur in adult sepsis and worse long-term effects are evident in neonatal sepsis survivors. Such epidemiological data may be explained by the lower ability of IL6 and IL8 to activate NF-kappa B-regulated transcription in neonatal sepsis in comparison to TNF-alpha, which is involved in the mechanisms of adult sepsis. The activation of NF-kappa B in neonatal sepsis is further promoted by hydrogen peroxide and results in mitochondrial dysfunction and energy failure as septic neonates experience decreased O-2 consumption as well as lower heat production and body temperature in comparison to healthy peers. In neonates, specific organs that are still under development are vulnerable to sepsis-provoked stress, which may lead to brain, lung, and heart injury, as well as vision and hearing impairments. In the light of the processes integrated here, it is clear that therapeutic approaches should also target specific steps in the neonatal 'sepsis redox cycle' in addition to the current therapeutic approach that is mainly focused on pathogen eradication.en
dc.publisherBiomed Central Ltd, London
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173014/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/43004/RS//
dc.rightsopenAccess
dc.sourceCritical Care
dc.titleBench-to-bedside review: Neonatal sepsis - redox processes in pathogenesisen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСпасић, Снежана; Спасојевиц, Иван; Обрадовић, Будимир;
dc.citation.volume16
dc.citation.issue3
dc.citation.other16(3):
dc.citation.rankM21
dc.identifier.pmid22574892
dc.identifier.doi10.1186/cc11183
dc.identifier.rcubConv_2908
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs//bitstream/id/7608/1045.pdf
dc.identifier.scopus2-s2.0-84860791562
dc.identifier.wos000313197500056
dc.type.versionpublishedVersion


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