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Bench-to-bedside review: Neonatal sepsis - redox processes in pathogenesis

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2012
1045.pdf (315.1Kb)
Authors
Spasojević, Ivan
Obradović, Budimir
Spasić, Snežana
Article (Published version)
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Abstract
The present review is aimed at elucidating the neonatal 'sepsis redox cycle' - the cascade of inflammatory and redox events involved in the pathogenesis of sepsis in neonates. While adult and neonatal sepses share some common features, there are some substantial differences: higher mortality rates occur in adult sepsis and worse long-term effects are evident in neonatal sepsis survivors. Such epidemiological data may be explained by the lower ability of IL6 and IL8 to activate NF-kappa B-regulated transcription in neonatal sepsis in comparison to TNF-alpha, which is involved in the mechanisms of adult sepsis. The activation of NF-kappa B in neonatal sepsis is further promoted by hydrogen peroxide and results in mitochondrial dysfunction and energy failure as septic neonates experience decreased O-2 consumption as well as lower heat production and body temperature in comparison to healthy peers. In neonates, specific organs that are still under development are vulnerable to sepsis-provo...ked stress, which may lead to brain, lung, and heart injury, as well as vision and hearing impairments. In the light of the processes integrated here, it is clear that therapeutic approaches should also target specific steps in the neonatal 'sepsis redox cycle' in addition to the current therapeutic approach that is mainly focused on pathogen eradication.

Source:
Critical Care, 2012, 16, 3
Publisher:
  • Biomed Central Ltd, London
Projects:
  • Molecular mechanisms of redox signalling in homeostasis: adaptation and pathology (RS-173014)
  • Simultaneous Bioremediation and Soilification of Degraded Areas to Preserve Natural Resources of Biologically Active Substances, and Development and Production of Biomaterials and Dietetic Products (RS-43004)

DOI: 10.1186/cc11183

ISSN: 1466-609X

PubMed: 22574892

WoS: 000313197500056

Scopus: 2-s2.0-84860791562
[ Google Scholar ]
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URI
http://cer.ihtm.bg.ac.rs/handle/123456789/1047
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IHTM

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