Synthesis, Spectral and Solid State Characterization of a New Bioactive Hydrazine Bridged Cyclic Diphosphonium Compound

2012
Authors
Milenković, Milica R.
Warzajtis, Beata

Rychlewska, Urszula

Radanović, Dušanka

Anđelković, Katarina

Božić, Tatjana T.

Vujčić, Miroslava

Sladić, Dušan

Article (Published version)
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The facile preparation of a racemic hydrazine bridged diphosphonium compound possessing a ring system analogous to bicyclo[3.3.2]decane is reported. Although the reaction yield is low, the structure of the compound, which possesses an eight-membered ring, two phosphonium cationic centers, a biimino bridge, molecular chirality and two fused aromatic rings locked into roughly perpendicular planes is unusual. The compound displays substantial biological activity in the brine shrimp test and cleaves plasmid DNA.
Keywords:
hydrazine bridged diphosphonium compound / DNA cleavage / brine shrimp test / X-raySource:
Molecules, 2012, 17, 3, 2567-2578Publisher:
- MDPI
Funding / projects:
DOI: 10.3390/molecules17032567
ISSN: 1420-3049
PubMed: 22388967
WoS: 000302120600021
Scopus: 2-s2.0-84858966075
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IHTMTY - JOUR AU - Milenković, Milica R. AU - Warzajtis, Beata AU - Rychlewska, Urszula AU - Radanović, Dušanka AU - Anđelković, Katarina AU - Božić, Tatjana T. AU - Vujčić, Miroslava AU - Sladić, Dušan PY - 2012 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1025 AB - The facile preparation of a racemic hydrazine bridged diphosphonium compound possessing a ring system analogous to bicyclo[3.3.2]decane is reported. Although the reaction yield is low, the structure of the compound, which possesses an eight-membered ring, two phosphonium cationic centers, a biimino bridge, molecular chirality and two fused aromatic rings locked into roughly perpendicular planes is unusual. The compound displays substantial biological activity in the brine shrimp test and cleaves plasmid DNA. PB - MDPI T2 - Molecules T1 - Synthesis, Spectral and Solid State Characterization of a New Bioactive Hydrazine Bridged Cyclic Diphosphonium Compound VL - 17 IS - 3 SP - 2567 EP - 2578 DO - 10.3390/molecules17032567 ER -
@article{ author = "Milenković, Milica R. and Warzajtis, Beata and Rychlewska, Urszula and Radanović, Dušanka and Anđelković, Katarina and Božić, Tatjana T. and Vujčić, Miroslava and Sladić, Dušan", year = "2012", abstract = "The facile preparation of a racemic hydrazine bridged diphosphonium compound possessing a ring system analogous to bicyclo[3.3.2]decane is reported. Although the reaction yield is low, the structure of the compound, which possesses an eight-membered ring, two phosphonium cationic centers, a biimino bridge, molecular chirality and two fused aromatic rings locked into roughly perpendicular planes is unusual. The compound displays substantial biological activity in the brine shrimp test and cleaves plasmid DNA.", publisher = "MDPI", journal = "Molecules", title = "Synthesis, Spectral and Solid State Characterization of a New Bioactive Hydrazine Bridged Cyclic Diphosphonium Compound", volume = "17", number = "3", pages = "2567-2578", doi = "10.3390/molecules17032567" }
Milenković, M. R., Warzajtis, B., Rychlewska, U., Radanović, D., Anđelković, K., Božić, T. T., Vujčić, M.,& Sladić, D.. (2012). Synthesis, Spectral and Solid State Characterization of a New Bioactive Hydrazine Bridged Cyclic Diphosphonium Compound. in Molecules MDPI., 17(3), 2567-2578. https://doi.org/10.3390/molecules17032567
Milenković MR, Warzajtis B, Rychlewska U, Radanović D, Anđelković K, Božić TT, Vujčić M, Sladić D. Synthesis, Spectral and Solid State Characterization of a New Bioactive Hydrazine Bridged Cyclic Diphosphonium Compound. in Molecules. 2012;17(3):2567-2578. doi:10.3390/molecules17032567 .
Milenković, Milica R., Warzajtis, Beata, Rychlewska, Urszula, Radanović, Dušanka, Anđelković, Katarina, Božić, Tatjana T., Vujčić, Miroslava, Sladić, Dušan, "Synthesis, Spectral and Solid State Characterization of a New Bioactive Hydrazine Bridged Cyclic Diphosphonium Compound" in Molecules, 17, no. 3 (2012):2567-2578, https://doi.org/10.3390/molecules17032567 . .