The facile preparation of a racemic hydrazine bridged diphosphonium compound possessing a ring system analogous to bicyclo[3.3.2]decane is reported. Although the reaction yield is low, the structure of the compound, which possesses an eight-membered ring, two phosphonium cationic centers, a biimino bridge, molecular chirality and two fused aromatic rings locked into roughly perpendicular planes is unusual. The compound displays substantial biological activity in the brine shrimp test and cleaves plasmid DNA.
Keywords:
hydrazine bridged diphosphonium compound / DNA cleavage / brine shrimp test / X-ray
TY - JOUR
AU - Milenković, Milica R.
AU - Warzajtis, Beata
AU - Rychlewska, Urszula
AU - Radanović, Dušanka
AU - Anđelković, Katarina
AU - Božić, Tatjana T.
AU - Vujčić, Miroslava
AU - Sladić, Dušan
PY - 2012
UR - http://cer.ihtm.bg.ac.rs/handle/123456789/1025
AB - The facile preparation of a racemic hydrazine bridged diphosphonium compound possessing a ring system analogous to bicyclo[3.3.2]decane is reported. Although the reaction yield is low, the structure of the compound, which possesses an eight-membered ring, two phosphonium cationic centers, a biimino bridge, molecular chirality and two fused aromatic rings locked into roughly perpendicular planes is unusual. The compound displays substantial biological activity in the brine shrimp test and cleaves plasmid DNA.
PB - MDPI AG
T2 - Molecules
T1 - Synthesis, Spectral and Solid State Characterization of a New Bioactive Hydrazine Bridged Cyclic Diphosphonium Compound
VL - 17
IS - 3
SP - 2567
EP - 2578
DO - 10.3390/molecules17032567
ER -
@article{
author = "Milenković, Milica R. and Warzajtis, Beata and Rychlewska, Urszula and Radanović, Dušanka and Anđelković, Katarina and Božić, Tatjana T. and Vujčić, Miroslava and Sladić, Dušan",
year = "2012",
url = "http://cer.ihtm.bg.ac.rs/handle/123456789/1025",
abstract = "The facile preparation of a racemic hydrazine bridged diphosphonium compound possessing a ring system analogous to bicyclo[3.3.2]decane is reported. Although the reaction yield is low, the structure of the compound, which possesses an eight-membered ring, two phosphonium cationic centers, a biimino bridge, molecular chirality and two fused aromatic rings locked into roughly perpendicular planes is unusual. The compound displays substantial biological activity in the brine shrimp test and cleaves plasmid DNA.",
publisher = "MDPI AG",
journal = "Molecules",
title = "Synthesis, Spectral and Solid State Characterization of a New Bioactive Hydrazine Bridged Cyclic Diphosphonium Compound",
volume = "17",
number = "3",
pages = "2567-2578",
doi = "10.3390/molecules17032567"
}
Milenković, M. R., Warzajtis, B., Rychlewska, U., Radanović, D., Anđelković, K., Božić, T. T., Vujčić, M.,& Sladić, D. (2012). Synthesis, Spectral and Solid State Characterization of a New Bioactive Hydrazine Bridged Cyclic Diphosphonium Compound.
Molecules
MDPI AG., 17(3), 2567-2578.
https://doi.org/10.3390/molecules17032567
Milenković MR, Warzajtis B, Rychlewska U, Radanović D, Anđelković K, Božić TT, Vujčić M, Sladić D. Synthesis, Spectral and Solid State Characterization of a New Bioactive Hydrazine Bridged Cyclic Diphosphonium Compound. Molecules. 2012;17(3):2567-2578
Milenković Milica R., Warzajtis Beata, Rychlewska Urszula, Radanović Dušanka, Anđelković Katarina, Božić Tatjana T., Vujčić Miroslava, Sladić Dušan, "Synthesis, Spectral and Solid State Characterization of a New Bioactive Hydrazine Bridged Cyclic Diphosphonium Compound" Molecules, 17, no. 3 (2012):2567-2578,
https://doi.org/10.3390/molecules17032567 .
