Voltammetric and Square-Wave Anodic Stripping Determination of Amlodipine Besylate on Gold Electrode
Authors
Stoiljković, ZoraAvramov Ivić, Milka
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Petrović, Slobodan D.
Mijin, Dušan
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Stevanović, Sanja
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Lačnjevac, Uroš
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Marinković, Aleksandar D.
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Article (Published version)
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The oxidative behaviour of amlodipine besylate was studied. The gold electrode and Au/o-MWCNT (oxidized multi-wall carbon nanotubes) were used for determination of amlodipine besylate standard and as a content of Alopres tablet, in 0.05 M NaHCO3 and in phosphate buffer (pH=11) by cyclic voltammetry and square-wave anodic stripping voltammetry. Electrode surfaces were characterized by AFM in the presence of amlodipine and the concentrations of drugs in electrolytes were simultaneously followed by HPLC. The linear dependency of the anodic currents of amlodipine besylate as standard and in Alopres tablet vs. concentration was observed in both electrolytes, but in phosphate buffer for the higher concentrations. The peak currents obtained in all experiments are more than fifty-fold higher comparing to all previously published results concerning the glassy carbon electrode and the carbon paste electrode. The gold electrode is better catalyst for anodic oxidation of amlodipine besylate than g...lassy carbone. The results obtained with Au/o-MWCNT show lower anodic activity comparing to previously published GC/o-MWCNT. GC/o-MWCNT is better catalyst than Au/o-MWCNT under similar experimental conditions.
Keywords:
amlodipine / gold electrode / o-MWCNT / atomic force microscopySource:
International Journal of Electrochemical Science, 2012, 7, 3, 2288-2303Publisher:
- Esg, Belgrade
Funding / projects:
- Study of the Synthesis, Structure and Activity of Natural and Synthetic Organic Compounds (RS-MESTD-Basic Research (BR or ON)-172013)
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IHTMTY - JOUR AU - Stoiljković, Zora AU - Avramov Ivić, Milka AU - Petrović, Slobodan D. AU - Mijin, Dušan AU - Stevanović, Sanja AU - Lačnjevac, Uroš AU - Marinković, Aleksandar D. PY - 2012 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1019 AB - The oxidative behaviour of amlodipine besylate was studied. The gold electrode and Au/o-MWCNT (oxidized multi-wall carbon nanotubes) were used for determination of amlodipine besylate standard and as a content of Alopres tablet, in 0.05 M NaHCO3 and in phosphate buffer (pH=11) by cyclic voltammetry and square-wave anodic stripping voltammetry. Electrode surfaces were characterized by AFM in the presence of amlodipine and the concentrations of drugs in electrolytes were simultaneously followed by HPLC. The linear dependency of the anodic currents of amlodipine besylate as standard and in Alopres tablet vs. concentration was observed in both electrolytes, but in phosphate buffer for the higher concentrations. The peak currents obtained in all experiments are more than fifty-fold higher comparing to all previously published results concerning the glassy carbon electrode and the carbon paste electrode. The gold electrode is better catalyst for anodic oxidation of amlodipine besylate than glassy carbone. The results obtained with Au/o-MWCNT show lower anodic activity comparing to previously published GC/o-MWCNT. GC/o-MWCNT is better catalyst than Au/o-MWCNT under similar experimental conditions. PB - Esg, Belgrade T2 - International Journal of Electrochemical Science T1 - Voltammetric and Square-Wave Anodic Stripping Determination of Amlodipine Besylate on Gold Electrode VL - 7 IS - 3 SP - 2288 EP - 2303 UR - https://hdl.handle.net/21.15107/rcub_cer_1019 ER -
@article{ author = "Stoiljković, Zora and Avramov Ivić, Milka and Petrović, Slobodan D. and Mijin, Dušan and Stevanović, Sanja and Lačnjevac, Uroš and Marinković, Aleksandar D.", year = "2012", abstract = "The oxidative behaviour of amlodipine besylate was studied. The gold electrode and Au/o-MWCNT (oxidized multi-wall carbon nanotubes) were used for determination of amlodipine besylate standard and as a content of Alopres tablet, in 0.05 M NaHCO3 and in phosphate buffer (pH=11) by cyclic voltammetry and square-wave anodic stripping voltammetry. Electrode surfaces were characterized by AFM in the presence of amlodipine and the concentrations of drugs in electrolytes were simultaneously followed by HPLC. The linear dependency of the anodic currents of amlodipine besylate as standard and in Alopres tablet vs. concentration was observed in both electrolytes, but in phosphate buffer for the higher concentrations. The peak currents obtained in all experiments are more than fifty-fold higher comparing to all previously published results concerning the glassy carbon electrode and the carbon paste electrode. The gold electrode is better catalyst for anodic oxidation of amlodipine besylate than glassy carbone. The results obtained with Au/o-MWCNT show lower anodic activity comparing to previously published GC/o-MWCNT. GC/o-MWCNT is better catalyst than Au/o-MWCNT under similar experimental conditions.", publisher = "Esg, Belgrade", journal = "International Journal of Electrochemical Science", title = "Voltammetric and Square-Wave Anodic Stripping Determination of Amlodipine Besylate on Gold Electrode", volume = "7", number = "3", pages = "2288-2303", url = "https://hdl.handle.net/21.15107/rcub_cer_1019" }
Stoiljković, Z., Avramov Ivić, M., Petrović, S. D., Mijin, D., Stevanović, S., Lačnjevac, U.,& Marinković, A. D.. (2012). Voltammetric and Square-Wave Anodic Stripping Determination of Amlodipine Besylate on Gold Electrode. in International Journal of Electrochemical Science Esg, Belgrade., 7(3), 2288-2303. https://hdl.handle.net/21.15107/rcub_cer_1019
Stoiljković Z, Avramov Ivić M, Petrović SD, Mijin D, Stevanović S, Lačnjevac U, Marinković AD. Voltammetric and Square-Wave Anodic Stripping Determination of Amlodipine Besylate on Gold Electrode. in International Journal of Electrochemical Science. 2012;7(3):2288-2303. https://hdl.handle.net/21.15107/rcub_cer_1019 .
Stoiljković, Zora, Avramov Ivić, Milka, Petrović, Slobodan D., Mijin, Dušan, Stevanović, Sanja, Lačnjevac, Uroš, Marinković, Aleksandar D., "Voltammetric and Square-Wave Anodic Stripping Determination of Amlodipine Besylate on Gold Electrode" in International Journal of Electrochemical Science, 7, no. 3 (2012):2288-2303, https://hdl.handle.net/21.15107/rcub_cer_1019 .