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Voltammetric and Square-Wave Anodic Stripping Determination of Amlodipine Besylate on Gold Electrode

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2012
7032288.pdf (664.2Kb)
Authors
Stoiljković, Zora
Avramov Ivić, Milka
Petrović, Slobodan D.
Mijin, Dušan
Stevanović, Sanja
Lačnjevac, Uroš
Marinković, Aleksandar D.
Article (Published version)
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Abstract
The oxidative behaviour of amlodipine besylate was studied. The gold electrode and Au/o-MWCNT (oxidized multi-wall carbon nanotubes) were used for determination of amlodipine besylate standard and as a content of Alopres tablet, in 0.05 M NaHCO3 and in phosphate buffer (pH=11) by cyclic voltammetry and square-wave anodic stripping voltammetry. Electrode surfaces were characterized by AFM in the presence of amlodipine and the concentrations of drugs in electrolytes were simultaneously followed by HPLC. The linear dependency of the anodic currents of amlodipine besylate as standard and in Alopres tablet vs. concentration was observed in both electrolytes, but in phosphate buffer for the higher concentrations. The peak currents obtained in all experiments are more than fifty-fold higher comparing to all previously published results concerning the glassy carbon electrode and the carbon paste electrode. The gold electrode is better catalyst for anodic oxidation of amlodipine besylate than g...lassy carbone. The results obtained with Au/o-MWCNT show lower anodic activity comparing to previously published GC/o-MWCNT. GC/o-MWCNT is better catalyst than Au/o-MWCNT under similar experimental conditions.

Keywords:
amlodipine / gold electrode / o-MWCNT / atomic force microscopy
Source:
International Journal of Electrochemical Science, 2012, 7, 3, 2288-2303
Publisher:
  • Esg, Belgrade
Projects:
  • Study of the Synthesis, Structure and Activity of Natural and Synthetic Organic Compounds (RS-172013)

ISSN: 1452-3981

WoS: 000302730300044

Scopus: 2-s2.0-84858256976
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URI
http://cer.ihtm.bg.ac.rs/handle/123456789/1019
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IHTM

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