Show simple item record

dc.creatorNovaković, Irena
dc.creatorAnđelković, Uroš
dc.creatorZlatović, Mario
dc.creatorGašić, Miroslav J.
dc.creatorSladić, Dušan
dc.date.accessioned2019-01-30T17:30:26Z
dc.date.available2019-01-30T17:30:26Z
dc.date.issued2012
dc.identifier.issn1043-1802
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1005
dc.description.abstractA conjugate of lysozyme with avarone, a bioactive sesquiterpene quinone of marine origin, and its three derivatives were synthesized. MALDI TOF mass spectral analysis and tryptic digestion showed that the only residue in lysozyme that was modified by all derivatives was lysine 97. The identity of the residue was in full correlation with the prediction obtained by molecular modeling. All bioconjugates preserved most of the enzymatic activity of lysozyme. The melting point of the conjugates was slightly increased in comparison to lysozyme, indicating a slight stabilization of structure. The antibacterial activity of all the conjugates to both Gram positive and Gram negative bacteria was stronger than the activity of either lysozyme or the quinones, the MIC values being in low micromolar range for some conjugates.en
dc.publisherAmer Chemical Soc, Washington
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172055/RS//
dc.relationDeutscher Akademischer Austausch Dienst (DAAD)
dc.rightsembargoedAccess
dc.sourceBioconjugate Chemistry
dc.titleBioconjugate of Lysozyme and the Antibacterial Marine Sesquiterpene Quinone Avarone and Its Derivativesen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractГасиц, Мирослав Ј.; Aнђелковић, Урош; Новаковић, Ирена; Златовиц, Марио; Сладиц, Дусан;
dc.citation.volume23
dc.citation.issue1
dc.citation.spage57
dc.citation.epage65
dc.citation.other23(1): 57-65
dc.citation.rankM21
dc.description.otherThis is the peer-reviewed version of the article: Novaković, I., Anđelković, U., Zlatović, M., Gašić, M.J., Sladić, D., 2012. Bioconjugate of Lysozyme and the Antibacterial Marine Sesquiterpene Quinone Avarone and Its Derivatives. Bioconjugate Chem. 23, 57–65. [https://doi.org/10.1021/bc200330m]
dc.identifier.pmid22148500
dc.identifier.doi10.1021/bc200330m
dc.identifier.rcubConv_2731
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs/bitstream/id/7570/1003.pdf
dc.identifier.scopus2-s2.0-84855919661
dc.identifier.wos000299591000007
dc.type.versionacceptedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record