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A novel C,D-spirolactone analogue of paclitaxel: autophagy instead of apoptosis as a previously unknown mechanism of cytotoxic action for taxoids
(Royal Soc Chemistry, Cambridge, 2012)
The design, synthesis and biological evaluation of a novel C, D-spirolactone analogue of paclitaxel is described. This is the first paclitaxel analogue without an oxetane D-ring that shows a significant cytotoxic effect ...
The role of spin states in the catalytic mechanism of the intra- and extradiol cleavage of catechols by O-2
(Royal Soc Chemistry, Cambridge, 2017)
Iron-dependent enzymes and biomimetic iron complexes can catalyze the ring cleavage of very inert, aromatic compounds. The mechanisms of these transformations and the factors that lead either to extradiol cleavage or ...
Dehydrogenative C(sp3)–H bond functionalization of tetrahydroisoquinolines mediated by organic oxidants under mild conditions
(Royal Society of Chemistry (RSC), 2019)
The organocatalyzed Mannich reaction of unsubstituted and N-aryl-substituted tetrahydroisoquinolines (THIQs) and the Strecker reaction of several N-aryl-substituted THIQs through dehydrogenative C(sp3)–H bond functionalization ...
Total synthesis and biological evaluation of (-)-atrop-abyssomicin C
(Royal Soc Chemistry, Cambridge, 2013)
Enantioselective synthesis of a marine antibiotic (-)-atrop-abyssomicin C was accomplished in 21 steps, in 1.8% overall yield (4%, based on the recovered starting material). The key steps of the synthesis are the formation ...
Theoretical investigation of tautomerism of 2- and 4-pyridones: origin, substituent and solvent effects
(Royal Society of Chemistry (RSC), 2023)
Computational investigation at the BHandHLYP/6-311+G(d,p) level of theory of the gas-phase tautomerism of 2- and 4-pyridones confirmed the slight prevalence of lactim in the case of the former, but its dominance in the ...
Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines
(Great Britain : Royal Society of Chemistry, 2023)
We present the green, highly atom-economical, solid-state silica gel-catalyzed synthesis of polysubstituted
1,4- and 1,2-dihydropyridines (DHPs) from commercially available materials, amines and ethyl propiolate.
The DHP ...
Synthesis of thiazolidine-fused heterocycles via exo-mode cyclizations of vinylogous N-acyliminium ions
(Royal Soc Chemistry, Cambridge, 2012)
Syntheses of thiazolidine-fused heterocycles via exo-mode cyclizations of vinylogous N-acyliminium ions incorporating heteroatom-based nucleophiles have been examined and discussed. The formation of (5,6)-membered systems ...
Total synthesis and biological evaluation of atrop-O-benzyl-desmethylabyssomicin C
(Royal Soc Chemistry, Cambridge, 2014)
The total synthesis of desmethylabyssomicin C analogue 1 was accomplished using diastereotopos-selective ring closing metathesis and Nozaki-Hiyama-Kishi cyclization as the key steps. The synthetic analogue retained its ...