TY  - JOUR
AU  - Husinec, Suren
AU  - Jadranin, Milka
AU  - Marković, Rade
AU  - Petkovic, Milos
AU  - Savić, Vladimir
AU  - Todorović, Nina
PY  - 2010
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/643
AB  - Allyl acetates were synthesised from allenes utilising methodology based on the general reactivity of pi-allyl palladium intermediates which participate efficiently in transformations involving nucleophiles. Reactions of allenes and aryl iodides in the presence of AcONa and Pd(OAc)(2)/PPh(3) as the catalytic system afforded allyl acetates in moderate to good yields. Monosubstituted allenes, depending on their structure, produced either a separable mixture of two regioisomeric products or a single regioisomer. As allylic acetates can be easily hydrolysed, the methodology is applicable for the synthesis of allyl alcohols as well.
PB  - Oxford : Pergamon-Elsevier Science Ltd
T2  - Tetrahedron Letters
T1  - Palladium-catalysed synthesis of allyl acetates from allenes
VL  - 51
IS  - 31
SP  - 4066
EP  - 4068
DO  - 10.1016/j.tetlet.2010.05.136
ER  - 

@article{
author = "Husinec, Suren and Jadranin, Milka and Marković, Rade and Petkovic, Milos and Savić, Vladimir and Todorović, Nina",
year = "2010",
abstract = "Allyl acetates were synthesised from allenes utilising methodology based on the general reactivity of pi-allyl palladium intermediates which participate efficiently in transformations involving nucleophiles. Reactions of allenes and aryl iodides in the presence of AcONa and Pd(OAc)(2)/PPh(3) as the catalytic system afforded allyl acetates in moderate to good yields. Monosubstituted allenes, depending on their structure, produced either a separable mixture of two regioisomeric products or a single regioisomer. As allylic acetates can be easily hydrolysed, the methodology is applicable for the synthesis of allyl alcohols as well.",
publisher = "Oxford : Pergamon-Elsevier Science Ltd",
journal = "Tetrahedron Letters",
title = "Palladium-catalysed synthesis of allyl acetates from allenes",
volume = "51",
number = "31",
pages = "4066-4068",
doi = "10.1016/j.tetlet.2010.05.136"
}

Husinec, S., Jadranin, M., Marković, R., Petkovic, M., Savić, V.,& Todorović, N.. (2010). Palladium-catalysed synthesis of allyl acetates from allenes. in Tetrahedron Letters
Oxford : Pergamon-Elsevier Science Ltd., 51(31), 4066-4068.
https://doi.org/10.1016/j.tetlet.2010.05.136

Husinec S, Jadranin M, Marković R, Petkovic M, Savić V, Todorović N. Palladium-catalysed synthesis of allyl acetates from allenes. in Tetrahedron Letters. 2010;51(31):4066-4068.
doi:10.1016/j.tetlet.2010.05.136 .

Husinec, Suren, Jadranin, Milka, Marković, Rade, Petkovic, Milos, Savić, Vladimir, Todorović, Nina, "Palladium-catalysed synthesis of allyl acetates from allenes" in Tetrahedron Letters, 51, no. 31 (2010):4066-4068,
https://doi.org/10.1016/j.tetlet.2010.05.136 . .

TY  - JOUR
AU  - Solomun, L
AU  - Ibrić, Svetlana
AU  - Vajs, Vlatka
AU  - Vuković, Ivan
AU  - Vujić, Z
PY  - 2010
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2778
AB  - In this work, the behavior of the active pharmaceutical substances methylprednisolone (in a form of methylprednisolone sodium succinate) in finished pharmaceutical dosage form, i.e., freeze-dried powder for injections, was examined. The goal was to evaluate the chemical stabilities of methylprednisolone sodium succinate packaged in a dual chamber vial, as a specific container closure system. The effect of different parameters: temperature, moisture and light were monitored. The method proposed by United States Pharmacopeia was used to determine concentrations of methylprednisolone, as the sum of the concentration of methylprednisolone esters (17-hydrogen succinate and 21-hydrogen succinate) and free methylprednisolone. The HPLC method was used for stability evaluation of the active substance and determination of related substances. Four main degradation products were registered. Temperature has a major impact on the degradation process with the appearance of 3 degradation products (impurities B, C and D), while the presence of light caused an increasing content of impurity A. Identification of impurity B, C and D has been realized using mass and NMR spectroscopy. All three substances are substances related to methylprednisolone. © 2010 (CC) SCS.
AB  - У овом раду испитиване су особине фармаколошки активне супстанце метилпреднизолона (у облику метилпреднизолон-натријум-сукцината) у готовом производу – лиофилизату за раствор за инјекције. Циљ рада је испитивање хемијске стабилности метилпреднизолон-натријум-сукцината у двокоморној бочици, као специфичном систему контактног паковања. Испитан је ефекат различитих параметара: температуре, влаге и светлости. За одређивање концентрације метилпреднизолона, као збирне концентрације метилпреднизолон естара (17-хидроген-сукцината и 21-хидроген-сукцината) и слободног метилпреднизолона, коришћена је метода описана у Америчкој фармакопеји. За испитивање сродних супстанци примењена је HPLC метода. Уочена су 4 деградациона производа. Доказано је да повећање температуре има највећи значај на процес деградације и утиче на повећање садржаја нечистоћа B, C и D, док присуство светлости доводи до повећања садржаја нечистоће А. Нечистоће B, C и D су идентификоване применом масене и NMR спектроскопије. Све три нечистоће су идентификоване као сродне супстанце метилпреднизолона.
T2  - Journal of the Serbian Chemical Society
T1  - Methylprednisolone and its related substances in freeze-dried powders for injections
T1  - Метилпреднизолон и његове сродне супстанце у лиофилизату за раствор за инјекције
VL  - 75
IS  - 10
SP  - 1441
EP  - 1452
DO  - 10.2298/JSC100115087S
ER  - 

@article{
author = "Solomun, L and Ibrić, Svetlana and Vajs, Vlatka and Vuković, Ivan and Vujić, Z",
year = "2010",
abstract = "In this work, the behavior of the active pharmaceutical substances methylprednisolone (in a form of methylprednisolone sodium succinate) in finished pharmaceutical dosage form, i.e., freeze-dried powder for injections, was examined. The goal was to evaluate the chemical stabilities of methylprednisolone sodium succinate packaged in a dual chamber vial, as a specific container closure system. The effect of different parameters: temperature, moisture and light were monitored. The method proposed by United States Pharmacopeia was used to determine concentrations of methylprednisolone, as the sum of the concentration of methylprednisolone esters (17-hydrogen succinate and 21-hydrogen succinate) and free methylprednisolone. The HPLC method was used for stability evaluation of the active substance and determination of related substances. Four main degradation products were registered. Temperature has a major impact on the degradation process with the appearance of 3 degradation products (impurities B, C and D), while the presence of light caused an increasing content of impurity A. Identification of impurity B, C and D has been realized using mass and NMR spectroscopy. All three substances are substances related to methylprednisolone. © 2010 (CC) SCS., У овом раду испитиване су особине фармаколошки активне супстанце метилпреднизолона (у облику метилпреднизолон-натријум-сукцината) у готовом производу – лиофилизату за раствор за инјекције. Циљ рада је испитивање хемијске стабилности метилпреднизолон-натријум-сукцината у двокоморној бочици, као специфичном систему контактног паковања. Испитан је ефекат различитих параметара: температуре, влаге и светлости. За одређивање концентрације метилпреднизолона, као збирне концентрације метилпреднизолон естара (17-хидроген-сукцината и 21-хидроген-сукцината) и слободног метилпреднизолона, коришћена је метода описана у Америчкој фармакопеји. За испитивање сродних супстанци примењена је HPLC метода. Уочена су 4 деградациона производа. Доказано је да повећање температуре има највећи значај на процес деградације и утиче на повећање садржаја нечистоћа B, C и D, док присуство светлости доводи до повећања садржаја нечистоће А. Нечистоће B, C и D су идентификоване применом масене и NMR спектроскопије. Све три нечистоће су идентификоване као сродне супстанце метилпреднизолона.",
journal = "Journal of the Serbian Chemical Society",
title = "Methylprednisolone and its related substances in freeze-dried powders for injections, Метилпреднизолон и његове сродне супстанце у лиофилизату за раствор за инјекције",
volume = "75",
number = "10",
pages = "1441-1452",
doi = "10.2298/JSC100115087S"
}

Solomun, L., Ibrić, S., Vajs, V., Vuković, I.,& Vujić, Z.. (2010). Methylprednisolone and its related substances in freeze-dried powders for injections. in Journal of the Serbian Chemical Society, 75(10), 1441-1452.
https://doi.org/10.2298/JSC100115087S

Solomun L, Ibrić S, Vajs V, Vuković I, Vujić Z. Methylprednisolone and its related substances in freeze-dried powders for injections. in Journal of the Serbian Chemical Society. 2010;75(10):1441-1452.
doi:10.2298/JSC100115087S .

Solomun, L, Ibrić, Svetlana, Vajs, Vlatka, Vuković, Ivan, Vujić, Z, "Methylprednisolone and its related substances in freeze-dried powders for injections" in Journal of the Serbian Chemical Society, 75, no. 10 (2010):1441-1452,
https://doi.org/10.2298/JSC100115087S . .

TY  - JOUR
AU  - Grigg, Ronald
AU  - Husinec, Suren
AU  - Savić, Vladimir
PY  - 2010
UR  - http://farfar.pharmacy.bg.ac.rs/handle/123456789/1417
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3507
AB  - Stereoselective cyclo-addition reactions of azomethine ylides promoted by in situ generated Ag(I)/bisphosphine complexes were studied. Under the optimized conditions, the pyrrolidine products were isolated in up to 84 % yield and with up to 71% e.e. The effects of various reaction variables on the stereoselectivity were also investigated.
AB  - Proučavane su stereoselektivne cikloadicione reakcije azometinskih ilida katalizovane kompleksima srebra i bisfosfinskog liganda generisanih in situ. Pirolidinski derivati izolovani su u dobrim prinosima i sa enantioselektivnošću do 71%. Proučavani su takođe i efekti reakcionih uslova na stereoselektivnost ovih reakcija.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Stereoselective cyclo-addition reactions of azomethine ylides catalysed by in situ generated Ag(I)/bisphosphine complexes
T1  - Stereoselektivne cikloadicione reakcije azometinskih ilida katalizovane in situ generisanim Ag(I)/bisfosfinskim kompleksima
VL  - 75
IS  - 1
SP  - 1
EP  - 9
DO  - 10.2298/JSC1001001G
ER  - 

@article{
author = "Grigg, Ronald and Husinec, Suren and Savić, Vladimir",
year = "2010",
abstract = "Stereoselective cyclo-addition reactions of azomethine ylides promoted by in situ generated Ag(I)/bisphosphine complexes were studied. Under the optimized conditions, the pyrrolidine products were isolated in up to 84 % yield and with up to 71% e.e. The effects of various reaction variables on the stereoselectivity were also investigated., Proučavane su stereoselektivne cikloadicione reakcije azometinskih ilida katalizovane kompleksima srebra i bisfosfinskog liganda generisanih in situ. Pirolidinski derivati izolovani su u dobrim prinosima i sa enantioselektivnošću do 71%. Proučavani su takođe i efekti reakcionih uslova na stereoselektivnost ovih reakcija.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Stereoselective cyclo-addition reactions of azomethine ylides catalysed by in situ generated Ag(I)/bisphosphine complexes, Stereoselektivne cikloadicione reakcije azometinskih ilida katalizovane in situ generisanim Ag(I)/bisfosfinskim kompleksima",
volume = "75",
number = "1",
pages = "1-9",
doi = "10.2298/JSC1001001G"
}

Grigg, R., Husinec, S.,& Savić, V.. (2010). Stereoselective cyclo-addition reactions of azomethine ylides catalysed by in situ generated Ag(I)/bisphosphine complexes. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 75(1), 1-9.
https://doi.org/10.2298/JSC1001001G

Grigg R, Husinec S, Savić V. Stereoselective cyclo-addition reactions of azomethine ylides catalysed by in situ generated Ag(I)/bisphosphine complexes. in Journal of the Serbian Chemical Society. 2010;75(1):1-9.
doi:10.2298/JSC1001001G .

Grigg, Ronald, Husinec, Suren, Savić, Vladimir, "Stereoselective cyclo-addition reactions of azomethine ylides catalysed by in situ generated Ag(I)/bisphosphine complexes" in Journal of the Serbian Chemical Society, 75, no. 1 (2010):1-9,
https://doi.org/10.2298/JSC1001001G . .