TY  - JOUR
AU  - Anchang, Kenneth Yongabi
AU  - Novaković, Miroslav
AU  - Bukvicki, Danka
AU  - Asakawa, Yoshinori
PY  - 2016
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1925
AB  - Liverworts are rich sources of terpenoids and aromatic compounds among which bis-bibenzyls are well known for their wide spectrum of biological activities. This is the first report of chemical analysis of the African liverwort Marchantia debilis Goebel. From the methanol extract marchantinquinone-l'-methyl ether was newly isolated together with three known bis-bibenzyls, marchantin C, marchantinquinone and perrottetin E. The presence of bis-bibenzyls with a quinone moiety is noted for the first time in the Marchantia genus.
PB  - Natural Products Inc, Westerville
T2  - Natural Product Communications
T1  - Bis-bibenzyls from the Cameroon Liverwort Marchantia debilis
VL  - 11
IS  - 9
SP  - 1317
EP  - 1318
UR  - https://hdl.handle.net/21.15107/rcub_cer_1925
ER  - 

@article{
author = "Anchang, Kenneth Yongabi and Novaković, Miroslav and Bukvicki, Danka and Asakawa, Yoshinori",
year = "2016",
abstract = "Liverworts are rich sources of terpenoids and aromatic compounds among which bis-bibenzyls are well known for their wide spectrum of biological activities. This is the first report of chemical analysis of the African liverwort Marchantia debilis Goebel. From the methanol extract marchantinquinone-l'-methyl ether was newly isolated together with three known bis-bibenzyls, marchantin C, marchantinquinone and perrottetin E. The presence of bis-bibenzyls with a quinone moiety is noted for the first time in the Marchantia genus.",
publisher = "Natural Products Inc, Westerville",
journal = "Natural Product Communications",
title = "Bis-bibenzyls from the Cameroon Liverwort Marchantia debilis",
volume = "11",
number = "9",
pages = "1317-1318",
url = "https://hdl.handle.net/21.15107/rcub_cer_1925"
}

Anchang, K. Y., Novaković, M., Bukvicki, D.,& Asakawa, Y.. (2016). Bis-bibenzyls from the Cameroon Liverwort Marchantia debilis. in Natural Product Communications
Natural Products Inc, Westerville., 11(9), 1317-1318.
https://hdl.handle.net/21.15107/rcub_cer_1925

Anchang KY, Novaković M, Bukvicki D, Asakawa Y. Bis-bibenzyls from the Cameroon Liverwort Marchantia debilis. in Natural Product Communications. 2016;11(9):1317-1318.
https://hdl.handle.net/21.15107/rcub_cer_1925 .

Anchang, Kenneth Yongabi, Novaković, Miroslav, Bukvicki, Danka, Asakawa, Yoshinori, "Bis-bibenzyls from the Cameroon Liverwort Marchantia debilis" in Natural Product Communications, 11, no. 9 (2016):1317-1318,
https://hdl.handle.net/21.15107/rcub_cer_1925 .

TY  - JOUR
AU  - Yongabi, Kenneth Anchang
AU  - Novaković, Miroslav
AU  - Bukvicki, Danka
AU  - Reeb, Catherine
AU  - Asakawa, Yoshinori
PY  - 2016
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1926
AB  - Diabetic bacterial foot infections (DBFIs) are limb-threatening complications in patients with diabetes mellitus, accounting for 50% of diabetes related lower limb amputations in developing countries, representing approximately 20 percent of all diabetes-related hospital admissions with significant healthcare-related costs involved. The widespread problem of bacterial resistance to most commonly used antibiotics places a huge economic burden on the healthcare system, with both increased morbidity and mortality among diabetic patients with foot infections. In this study, the antibacterial activity of organic extracts of the fresh liverwort Marchantia debilis from the North West Region of Cameroon is reported. An exit pool system, where patients presenting with DBFIs consented to be involved in the use of phytomedicines, after long term treatment of ulcers with antibiotics and not yielding significant long term benefit, presented themselves at the Phytobiotechnology Research clinic (PRF). Continuous culture of swabs from foot and toe wounds from 30 infected patients on nutrient agar and MacConkey agars in triplicate as well as Gram stain microscopy, revealed the presence of Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis and Bacillus species. Light petroleum and methanol extracts of the whole bryophyte plants at 100% concentration were tested. In vitro inhibition of the tested bacterial isolates from the diabetic foot ulcers by M debilis was observed only with the light petroleum extract. No inhibition by the extracts was observed for the Pseudomonas aeruginosa isolate. The light petroleum extract of M debilis was formulated into a petroleum oil based cream named BryoCream (TM). This was administered to 20 of the patients with 90% cure rate in a three week time period. The main nonpolar components were determined by GCMS as lepidozene and beta-barbatene, and by NMR. as stigmasterol and beta-sitosterol. In conclusion, nonpolar extracts from bryophytes from Cameroon could, potentially, be used to treat diabetic bacterial foot infections.
PB  - Natural Products Inc, Westerville
T2  - Natural Product Communications
T1  - Management of Diabetic Bacterial Foot Infections with Organic Extracts of Liverwort Marchantia debilis from Cameroon
VL  - 11
IS  - 9
SP  - 1333
EP  - 1336
UR  - https://hdl.handle.net/21.15107/rcub_cer_1926
ER  - 

@article{
author = "Yongabi, Kenneth Anchang and Novaković, Miroslav and Bukvicki, Danka and Reeb, Catherine and Asakawa, Yoshinori",
year = "2016",
abstract = "Diabetic bacterial foot infections (DBFIs) are limb-threatening complications in patients with diabetes mellitus, accounting for 50% of diabetes related lower limb amputations in developing countries, representing approximately 20 percent of all diabetes-related hospital admissions with significant healthcare-related costs involved. The widespread problem of bacterial resistance to most commonly used antibiotics places a huge economic burden on the healthcare system, with both increased morbidity and mortality among diabetic patients with foot infections. In this study, the antibacterial activity of organic extracts of the fresh liverwort Marchantia debilis from the North West Region of Cameroon is reported. An exit pool system, where patients presenting with DBFIs consented to be involved in the use of phytomedicines, after long term treatment of ulcers with antibiotics and not yielding significant long term benefit, presented themselves at the Phytobiotechnology Research clinic (PRF). Continuous culture of swabs from foot and toe wounds from 30 infected patients on nutrient agar and MacConkey agars in triplicate as well as Gram stain microscopy, revealed the presence of Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis and Bacillus species. Light petroleum and methanol extracts of the whole bryophyte plants at 100% concentration were tested. In vitro inhibition of the tested bacterial isolates from the diabetic foot ulcers by M debilis was observed only with the light petroleum extract. No inhibition by the extracts was observed for the Pseudomonas aeruginosa isolate. The light petroleum extract of M debilis was formulated into a petroleum oil based cream named BryoCream (TM). This was administered to 20 of the patients with 90% cure rate in a three week time period. The main nonpolar components were determined by GCMS as lepidozene and beta-barbatene, and by NMR. as stigmasterol and beta-sitosterol. In conclusion, nonpolar extracts from bryophytes from Cameroon could, potentially, be used to treat diabetic bacterial foot infections.",
publisher = "Natural Products Inc, Westerville",
journal = "Natural Product Communications",
title = "Management of Diabetic Bacterial Foot Infections with Organic Extracts of Liverwort Marchantia debilis from Cameroon",
volume = "11",
number = "9",
pages = "1333-1336",
url = "https://hdl.handle.net/21.15107/rcub_cer_1926"
}

Yongabi, K. A., Novaković, M., Bukvicki, D., Reeb, C.,& Asakawa, Y.. (2016). Management of Diabetic Bacterial Foot Infections with Organic Extracts of Liverwort Marchantia debilis from Cameroon. in Natural Product Communications
Natural Products Inc, Westerville., 11(9), 1333-1336.
https://hdl.handle.net/21.15107/rcub_cer_1926

Yongabi KA, Novaković M, Bukvicki D, Reeb C, Asakawa Y. Management of Diabetic Bacterial Foot Infections with Organic Extracts of Liverwort Marchantia debilis from Cameroon. in Natural Product Communications. 2016;11(9):1333-1336.
https://hdl.handle.net/21.15107/rcub_cer_1926 .

Yongabi, Kenneth Anchang, Novaković, Miroslav, Bukvicki, Danka, Reeb, Catherine, Asakawa, Yoshinori, "Management of Diabetic Bacterial Foot Infections with Organic Extracts of Liverwort Marchantia debilis from Cameroon" in Natural Product Communications, 11, no. 9 (2016):1333-1336,
https://hdl.handle.net/21.15107/rcub_cer_1926 .