Department of Chemistry, University of Houston, 112 Fleming Building, Houston TX 77204- 5003, USA

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Department of Chemistry, University of Houston, 112 Fleming Building, Houston TX 77204- 5003, USA

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Inhibition potency of disulphides and trisulphides on various tumor cell lines growth

Mandić, Boris; Simić, Katarina; Trifunović, Snežana; Vujisić, Ljubodrag; Novaković, Miroslav; Tešević, Vele; Miljanić, Ognjen Š.

(S.C. Virtual Company of Phisics S.R.L, 2021)

TY  - JOUR
AU  - Mandić, Boris
AU  - Simić, Katarina
AU  - Trifunović, Snežana
AU  - Vujisić, Ljubodrag
AU  - Novaković, Miroslav
AU  - Tešević, Vele
AU  - Miljanić, Ognjen Š.
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/7389
AB  - Tumor is one of the leading diseases of today. Chemotherapy and radiation therapy healing chances are limited, so some alternative methods are resorted to. Many papers indicated that garlic and organosulphur compounds diallyldisulphide (DADS) and diallyltrisulphide, which are main components of garlic decrease the cancer risk and inhibit the cell proliferation. In this paper inhibition potency of disulphides (DADS and its synthetic analogues) and trisulphides with different alkyl and phenyl substituents on growth of various tumor (Non-Small cell Lung Cancer, Colon cancer, CNS Cancer, Melanoma, Ovarian Cancer, Renal Cancer, Prostate Cancer, Breast Cancer, Leukemia) cell lines was investigated. Concentration of each compound (DADS, diethyl disulphide, dipropyl disulphide, diphenyl disulphide, tetraethylthiuram disulphide (TETUDS), dimetil trisulphide, dipropyl trisulphide and metilpropyl trisulphide (MPTS) was 10 µmol/L. It was found that DADS has an inhibitory effect on the growth of several cancer cell lines, but synthetic analogues TETUDS and MPTS exhibit stronger effect on certain cells lines. MPTS inhibits the growth of even 12 cell lines for more than 10%, especially leukemia cell line SR and NCI-H522 cell line of Non-Small cell Lung Cancer (reduction of growth for 24% and 47%, resp.). Trisulphide analogues exhibit little higher inhibitory effects in comparison to disulphide ones.
PB  - S.C. Virtual Company of Phisics S.R.L
T2  - Digest Journal of Nanomaterials and Biostructures
T1  - Inhibition potency of disulphides and trisulphides on various tumor cell lines growth
VL  - 16
IS  - 2
SP  - 585
EP  - 592
DO  - 10.15251/DJNB.2021.162.585
ER  - 
@article{
author = "Mandić, Boris and Simić, Katarina and Trifunović, Snežana and Vujisić, Ljubodrag and Novaković, Miroslav and Tešević, Vele and Miljanić, Ognjen Š.",
year = "2021",
abstract = "Tumor is one of the leading diseases of today. Chemotherapy and radiation therapy healing chances are limited, so some alternative methods are resorted to. Many papers indicated that garlic and organosulphur compounds diallyldisulphide (DADS) and diallyltrisulphide, which are main components of garlic decrease the cancer risk and inhibit the cell proliferation. In this paper inhibition potency of disulphides (DADS and its synthetic analogues) and trisulphides with different alkyl and phenyl substituents on growth of various tumor (Non-Small cell Lung Cancer, Colon cancer, CNS Cancer, Melanoma, Ovarian Cancer, Renal Cancer, Prostate Cancer, Breast Cancer, Leukemia) cell lines was investigated. Concentration of each compound (DADS, diethyl disulphide, dipropyl disulphide, diphenyl disulphide, tetraethylthiuram disulphide (TETUDS), dimetil trisulphide, dipropyl trisulphide and metilpropyl trisulphide (MPTS) was 10 µmol/L. It was found that DADS has an inhibitory effect on the growth of several cancer cell lines, but synthetic analogues TETUDS and MPTS exhibit stronger effect on certain cells lines. MPTS inhibits the growth of even 12 cell lines for more than 10%, especially leukemia cell line SR and NCI-H522 cell line of Non-Small cell Lung Cancer (reduction of growth for 24% and 47%, resp.). Trisulphide analogues exhibit little higher inhibitory effects in comparison to disulphide ones.",
publisher = "S.C. Virtual Company of Phisics S.R.L",
journal = "Digest Journal of Nanomaterials and Biostructures",
title = "Inhibition potency of disulphides and trisulphides on various tumor cell lines growth",
volume = "16",
number = "2",
pages = "585-592",
doi = "10.15251/DJNB.2021.162.585"
}
Mandić, B., Simić, K., Trifunović, S., Vujisić, L., Novaković, M., Tešević, V.,& Miljanić, O. Š.. (2021). Inhibition potency of disulphides and trisulphides on various tumor cell lines growth. in Digest Journal of Nanomaterials and Biostructures
S.C. Virtual Company of Phisics S.R.L., 16(2), 585-592.
https://doi.org/10.15251/DJNB.2021.162.585
Mandić B, Simić K, Trifunović S, Vujisić L, Novaković M, Tešević V, Miljanić OŠ. Inhibition potency of disulphides and trisulphides on various tumor cell lines growth. in Digest Journal of Nanomaterials and Biostructures. 2021;16(2):585-592.
doi:10.15251/DJNB.2021.162.585 .
Mandić, Boris, Simić, Katarina, Trifunović, Snežana, Vujisić, Ljubodrag, Novaković, Miroslav, Tešević, Vele, Miljanić, Ognjen Š., "Inhibition potency of disulphides and trisulphides on various tumor cell lines growth" in Digest Journal of Nanomaterials and Biostructures, 16, no. 2 (2021):585-592,
https://doi.org/10.15251/DJNB.2021.162.585 . .