TY  - JOUR
AU  - Gavrilović, Branka R.
AU  - Prokić, Marko D.
AU  - Petrović, Tamara G.
AU  - Despotović, Svetlana G.
AU  - Radovanović, Tijana B.
AU  - Krizmanić, Imre I.
AU  - Ćirić, Miloš
AU  - Gavrić, Jelena P.
PY  - 2020
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3343
AB  - There is little information in scientific literature as to how conditions created by a microcystin (MC) producing cyanobacterial bloom affect the oxidant/antioxidant, biotransformation and neurotoxicity parameters in adult frogs in situ. We investigated biochemical parameters in the skin and muscle of Pelophylax kl. esculentus from Lake Ludaš (Serbia) by comparing frogs that live on the northern bloom side (BS) of the lake with those that inhabit the southern no-bloom side (NBS). A higher protein carbonylation level and lower antioxidant defense system capability in the skin of frogs living in conditions of the cyanobacterial bloom were observed. Inhibition of glutathione-dependent machinery was the major mechanism responsible for the induction of cyanobacterial bloom-mediated oxidative stress in frog skin. On the other hand, the detected higher ability of muscle to overcome bloom prooxidant toxicity was linked to a higher efficiency of the biotransformation system through glutathione-S-transferase activity and/or was the consequence of indirect exposure of the tissue to the bloom. Our results have also revealed that the cyanobacterial bloom conditions induced the cholinergic neurotransmitter system in both tissues. This study provides a better understanding of the ecotoxicological impact of the MC producing cyanobacterial bloom on frogs in situ. However, further investigations of the complex mechanism involved in cyanobacterial bloom toxicity in real environmental conditions are required.
PB  - Elsevier
T2  - Aquatic Toxicology
T1  - Biochemical parameters in skin and muscle of Pelophylax kl. esculentus frogs: Influence of a cyanobacterial bloom in situ
VL  - 220
SP  - 105399
DO  - 10.1016/j.aquatox.2019.105399
ER  - 

@article{
author = "Gavrilović, Branka R. and Prokić, Marko D. and Petrović, Tamara G. and Despotović, Svetlana G. and Radovanović, Tijana B. and Krizmanić, Imre I. and Ćirić, Miloš and Gavrić, Jelena P.",
year = "2020",
abstract = "There is little information in scientific literature as to how conditions created by a microcystin (MC) producing cyanobacterial bloom affect the oxidant/antioxidant, biotransformation and neurotoxicity parameters in adult frogs in situ. We investigated biochemical parameters in the skin and muscle of Pelophylax kl. esculentus from Lake Ludaš (Serbia) by comparing frogs that live on the northern bloom side (BS) of the lake with those that inhabit the southern no-bloom side (NBS). A higher protein carbonylation level and lower antioxidant defense system capability in the skin of frogs living in conditions of the cyanobacterial bloom were observed. Inhibition of glutathione-dependent machinery was the major mechanism responsible for the induction of cyanobacterial bloom-mediated oxidative stress in frog skin. On the other hand, the detected higher ability of muscle to overcome bloom prooxidant toxicity was linked to a higher efficiency of the biotransformation system through glutathione-S-transferase activity and/or was the consequence of indirect exposure of the tissue to the bloom. Our results have also revealed that the cyanobacterial bloom conditions induced the cholinergic neurotransmitter system in both tissues. This study provides a better understanding of the ecotoxicological impact of the MC producing cyanobacterial bloom on frogs in situ. However, further investigations of the complex mechanism involved in cyanobacterial bloom toxicity in real environmental conditions are required.",
publisher = "Elsevier",
journal = "Aquatic Toxicology",
title = "Biochemical parameters in skin and muscle of Pelophylax kl. esculentus frogs: Influence of a cyanobacterial bloom in situ",
volume = "220",
pages = "105399",
doi = "10.1016/j.aquatox.2019.105399"
}

Gavrilović, B. R., Prokić, M. D., Petrović, T. G., Despotović, S. G., Radovanović, T. B., Krizmanić, I. I., Ćirić, M.,& Gavrić, J. P.. (2020). Biochemical parameters in skin and muscle of Pelophylax kl. esculentus frogs: Influence of a cyanobacterial bloom in situ. in Aquatic Toxicology
Elsevier., 220, 105399.
https://doi.org/10.1016/j.aquatox.2019.105399

Gavrilović BR, Prokić MD, Petrović TG, Despotović SG, Radovanović TB, Krizmanić II, Ćirić M, Gavrić JP. Biochemical parameters in skin and muscle of Pelophylax kl. esculentus frogs: Influence of a cyanobacterial bloom in situ. in Aquatic Toxicology. 2020;220:105399.
doi:10.1016/j.aquatox.2019.105399 .

Gavrilović, Branka R., Prokić, Marko D., Petrović, Tamara G., Despotović, Svetlana G., Radovanović, Tijana B., Krizmanić, Imre I., Ćirić, Miloš, Gavrić, Jelena P., "Biochemical parameters in skin and muscle of Pelophylax kl. esculentus frogs: Influence of a cyanobacterial bloom in situ" in Aquatic Toxicology, 220 (2020):105399,
https://doi.org/10.1016/j.aquatox.2019.105399 . .