TY  - JOUR
AU  - Abulseoud, Osama A.
AU  - Ho, Man Choi
AU  - Choi, Doo-Sup
AU  - Stanojevic, Ana
AU  - Čupić, Željko
AU  - Kolar-Anić, Ljiljana
AU  - Vukojevic, Vladana
PY  - 2017
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2269
AB  - Changes in the hypothalamic-pituitary-adrenal (HPA) axis activity constitute a key component of bipolar mania, but the extent and nature of these alterations are not fully understood. We use here the lateral hypothalamic-kindled (LHK) rat model to deliberately induce an acute manic-like episode and measure serum corticosterone concentrations to assess changes in HPA axis activity. A mathematical model is developed to succinctly describe the entwined biochemical transformations that underlay the HPA axis and emulate by numerical simulations the considerable increase in serum corticosterone concentration induced by LHK. Synergistic combination of the LHK rat model and dynamical systems theory allows us to quantitatively characterize changes in HPA axis activity under controlled induction of acute manic-like states and provides a framework to study in silico how the dynamic integration of neurochemical transformations underlying the HPA axis is disrupted in these states.
PB  - Public Library of Science (PLoS)
T2  - Plos One
T1  - Corticosterone oscillations during mania induction in the lateral hypothalamic kindled rat-Experimental observations and mathematical modeling
VL  - 12
IS  - 5
DO  - 10.1371/journal.pone.0177551
ER  - 

@article{
author = "Abulseoud, Osama A. and Ho, Man Choi and Choi, Doo-Sup and Stanojevic, Ana and Čupić, Željko and Kolar-Anić, Ljiljana and Vukojevic, Vladana",
year = "2017",
abstract = "Changes in the hypothalamic-pituitary-adrenal (HPA) axis activity constitute a key component of bipolar mania, but the extent and nature of these alterations are not fully understood. We use here the lateral hypothalamic-kindled (LHK) rat model to deliberately induce an acute manic-like episode and measure serum corticosterone concentrations to assess changes in HPA axis activity. A mathematical model is developed to succinctly describe the entwined biochemical transformations that underlay the HPA axis and emulate by numerical simulations the considerable increase in serum corticosterone concentration induced by LHK. Synergistic combination of the LHK rat model and dynamical systems theory allows us to quantitatively characterize changes in HPA axis activity under controlled induction of acute manic-like states and provides a framework to study in silico how the dynamic integration of neurochemical transformations underlying the HPA axis is disrupted in these states.",
publisher = "Public Library of Science (PLoS)",
journal = "Plos One",
title = "Corticosterone oscillations during mania induction in the lateral hypothalamic kindled rat-Experimental observations and mathematical modeling",
volume = "12",
number = "5",
doi = "10.1371/journal.pone.0177551"
}

Abulseoud, O. A., Ho, M. C., Choi, D., Stanojevic, A., Čupić, Ž., Kolar-Anić, L.,& Vukojevic, V.. (2017). Corticosterone oscillations during mania induction in the lateral hypothalamic kindled rat-Experimental observations and mathematical modeling. in Plos One
Public Library of Science (PLoS)., 12(5).
https://doi.org/10.1371/journal.pone.0177551

Abulseoud OA, Ho MC, Choi D, Stanojevic A, Čupić Ž, Kolar-Anić L, Vukojevic V. Corticosterone oscillations during mania induction in the lateral hypothalamic kindled rat-Experimental observations and mathematical modeling. in Plos One. 2017;12(5).
doi:10.1371/journal.pone.0177551 .

Abulseoud, Osama A., Ho, Man Choi, Choi, Doo-Sup, Stanojevic, Ana, Čupić, Željko, Kolar-Anić, Ljiljana, Vukojevic, Vladana, "Corticosterone oscillations during mania induction in the lateral hypothalamic kindled rat-Experimental observations and mathematical modeling" in Plos One, 12, no. 5 (2017),
https://doi.org/10.1371/journal.pone.0177551 . .