TY  - JOUR
AU  - Ponjavić, Marijana
AU  - Malagurski, Ivana
AU  - Lazić, Jelena
AU  - Jeremić, Sanja
AU  - Pavlović, Vladimir
AU  - Prlainović, Nevena
AU  - Maksimović, Vesna
AU  - Ćosović, Vladan
AU  - Atanase, Leonard Ionut
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5690
AB  - The quest for sustainable biomaterials with excellent biocompatibility and tailorable
properties has put polyhydroxyalkanoates (PHAs) into the research spotlight. However, high production
costs and the lack of bioactivity limit their market penetration. To address this, poly(3-
hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) was combined with a bacterial pigment with strong
anticancer activity, prodigiosin (PG), to obtain functionally enhanced PHBV-based biomaterials. The
samples were produced in the form of films 115.6–118.8  m in thickness using the solvent casting
method. The effects of PG incorporation on the physical properties (morphology, biopolymer crystallinity
and thermal stability) and functionality of the obtained biomaterials were investigated. PG
has acted as a nucleating agent, in turn affecting the degree of crystallinity, thermal stability and
morphology of the films. All samples with PG had a more organized internal structure and higher
melting and degradation temperatures. The calculated degree of crystallinity of the PHBV copolymer
was 53%, while the PG1, PG3 and PG3 films had values of 64.0%, 63.9% and 69.2%, respectively.
Cytotoxicity studies have shown the excellent anticancer activity of films against HCT116 (colon
cancer) cells, thus advancing PHBV biomedical application potential.
PB  - Switzerland : Multidisciplinary Digital Publishing Institute (MDPI)
T2  - International Journal of Molecular Sciences
T1  - Advancing PHBV Biomedical Potential with the Incorporation of Bacterial Biopigment Prodigiosin
VL  - 24
SP  - 1906
DO  - 10.3390/ijms24031906
ER  - 

@article{
author = "Ponjavić, Marijana and Malagurski, Ivana and Lazić, Jelena and Jeremić, Sanja and Pavlović, Vladimir and Prlainović, Nevena and Maksimović, Vesna and Ćosović, Vladan and Atanase, Leonard Ionut",
year = "2023",
abstract = "The quest for sustainable biomaterials with excellent biocompatibility and tailorable
properties has put polyhydroxyalkanoates (PHAs) into the research spotlight. However, high production
costs and the lack of bioactivity limit their market penetration. To address this, poly(3-
hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) was combined with a bacterial pigment with strong
anticancer activity, prodigiosin (PG), to obtain functionally enhanced PHBV-based biomaterials. The
samples were produced in the form of films 115.6–118.8  m in thickness using the solvent casting
method. The effects of PG incorporation on the physical properties (morphology, biopolymer crystallinity
and thermal stability) and functionality of the obtained biomaterials were investigated. PG
has acted as a nucleating agent, in turn affecting the degree of crystallinity, thermal stability and
morphology of the films. All samples with PG had a more organized internal structure and higher
melting and degradation temperatures. The calculated degree of crystallinity of the PHBV copolymer
was 53%, while the PG1, PG3 and PG3 films had values of 64.0%, 63.9% and 69.2%, respectively.
Cytotoxicity studies have shown the excellent anticancer activity of films against HCT116 (colon
cancer) cells, thus advancing PHBV biomedical application potential.",
publisher = "Switzerland : Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "International Journal of Molecular Sciences",
title = "Advancing PHBV Biomedical Potential with the Incorporation of Bacterial Biopigment Prodigiosin",
volume = "24",
pages = "1906",
doi = "10.3390/ijms24031906"
}

Ponjavić, M., Malagurski, I., Lazić, J., Jeremić, S., Pavlović, V., Prlainović, N., Maksimović, V., Ćosović, V.,& Atanase, L. I.. (2023). Advancing PHBV Biomedical Potential with the Incorporation of Bacterial Biopigment Prodigiosin. in International Journal of Molecular Sciences
Switzerland : Multidisciplinary Digital Publishing Institute (MDPI)., 24, 1906.
https://doi.org/10.3390/ijms24031906

Ponjavić M, Malagurski I, Lazić J, Jeremić S, Pavlović V, Prlainović N, Maksimović V, Ćosović V, Atanase LI. Advancing PHBV Biomedical Potential with the Incorporation of Bacterial Biopigment Prodigiosin. in International Journal of Molecular Sciences. 2023;24:1906.
doi:10.3390/ijms24031906 .

Ponjavić, Marijana, Malagurski, Ivana, Lazić, Jelena, Jeremić, Sanja, Pavlović, Vladimir, Prlainović, Nevena, Maksimović, Vesna, Ćosović, Vladan, Atanase, Leonard Ionut, "Advancing PHBV Biomedical Potential with the Incorporation of Bacterial Biopigment Prodigiosin" in International Journal of Molecular Sciences, 24 (2023):1906,
https://doi.org/10.3390/ijms24031906 . .