TY  - JOUR
AU  - Pržulj, Sanja
AU  - Radojičić, Ana
AU  - Kašanin-Grubin, Milica
AU  - Pešević, Dušica
AU  - Stojadinović, Sanja
AU  - Jovančićević, Branimir
AU  - Veselinović, Gorica
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5024
AB  - Heavy metals are naturally occurring elements, but they are regarded as significant environmental pollutants due to their high density and high toxicity even at low concentrations. The aim of this paper is the evaluation of the pollution level of heavy metals in the river and riverbank sediments, as well as the estimation of their origin and spatial differences along the course of the Vrbas River through Banja Luka. The concentrations of metals have been assessed using the Inductively coupled plasma – optical emission spectrometry and Advanced mercury analyzer for mercury determination. The anthropogenic impact on heavy metal concentration in sediments was estimated by the calculating of pollution indices: geoaccumulation index (Igeo ), contamination factor (Cf ), pollution load index (PLI) and potential ecological risk index (Er). Obtained results indicate that there is no statistically significant spatial difference in metal concentration, indicating that heavy metals in sediments have a constant source. The anthropogenic impact expressed by the values of pollution indices showed that sites are generally uncontaminated by Co, Cr and V and moderately contaminated by Zn, Cu and Ni. On the contrary, lead, mercury and cadmium pose the highest ecological risk. The anthropogenic source of Pb, Hg and Cd is industry, municipal waste and the combustion of fossil fuels. The obtained results demonstrate the high ecological risk and the need for environmental monitoring, with the aim to support an efficient strategy to reduce local pollution and contamination of the investigated system.
AB  - Тешки метали су елементи природног порекла, али се сматрају значајним полутантима животне средине због велике густине и токсичности, чак и при малим концентрацијама. Циљ овог рада је процена нивоа загађености речних и приобалних седимената тешким металима, као и процена њиховог порекла и просторне расподеле дуж тока реке Врбас кроз Бањалуку. Концентрације тешких метала одређиване су помоћу индуктивно спрегнуте плазме – оптичке емисионе спектрометрије и наменског живиног анализатора. Антропогени утицај на концентрацију тешких метала у седиментима процењен је израчунавањем различитих индекса загађења: индекса геоакумулације (Igeo),фактора контаминације (Cf), индекса оптерећења загађењем (PLI) и индекса потенцијалног еколошког ризика (Er). Добијени резултати указују да не постоје статистички значајне просторне разлике у концентрацији метала, што указује на то да тешки метали у испитиваним седиментима имају константан извор. Антропогени утицај изражен у вредностима индекса загађења показао је да су локације генерално незагађене кобалтом, хромом и ванадијумом, а умерено загађене цинком, бакром и никлом. С друге стране, кадмијум, жива и олово представљају највећи еколошки ризик. Антропогени извори ових метала су индустрија, комунални отпад и сагоревање фосилних горива. Добијени резултати показују висок еколошки ризик и потребу за мониторингом животне средине, подржавајући развој ефикасне стратегије за смањење локалног загађења и загађења испитиваног подручја.
PB  - Serbian Chemical Society
T2  - Journal of Serbian Chemical Society
T1  - Distribution and provenance of heavy metals in sediments of the Vrbas River, Bosnia and Herzegovina
T1  - Примена индекса загађења у одређивању просторних и временских разлика у концентрацији тешких метала у седиментима реке Врбас, (Бања Лука, Босна и Херцеговина)
VL  - 87
IS  - 4
SP  - 519
EP  - 530
DO  - 10.2298/JSC210608070P
ER  - 

@article{
author = "Pržulj, Sanja and Radojičić, Ana and Kašanin-Grubin, Milica and Pešević, Dušica and Stojadinović, Sanja and Jovančićević, Branimir and Veselinović, Gorica",
year = "2022",
abstract = "Heavy metals are naturally occurring elements, but they are regarded as significant environmental pollutants due to their high density and high toxicity even at low concentrations. The aim of this paper is the evaluation of the pollution level of heavy metals in the river and riverbank sediments, as well as the estimation of their origin and spatial differences along the course of the Vrbas River through Banja Luka. The concentrations of metals have been assessed using the Inductively coupled plasma – optical emission spectrometry and Advanced mercury analyzer for mercury determination. The anthropogenic impact on heavy metal concentration in sediments was estimated by the calculating of pollution indices: geoaccumulation index (Igeo ), contamination factor (Cf ), pollution load index (PLI) and potential ecological risk index (Er). Obtained results indicate that there is no statistically significant spatial difference in metal concentration, indicating that heavy metals in sediments have a constant source. The anthropogenic impact expressed by the values of pollution indices showed that sites are generally uncontaminated by Co, Cr and V and moderately contaminated by Zn, Cu and Ni. On the contrary, lead, mercury and cadmium pose the highest ecological risk. The anthropogenic source of Pb, Hg and Cd is industry, municipal waste and the combustion of fossil fuels. The obtained results demonstrate the high ecological risk and the need for environmental monitoring, with the aim to support an efficient strategy to reduce local pollution and contamination of the investigated system., Тешки метали су елементи природног порекла, али се сматрају значајним полутантима животне средине због велике густине и токсичности, чак и при малим концентрацијама. Циљ овог рада је процена нивоа загађености речних и приобалних седимената тешким металима, као и процена њиховог порекла и просторне расподеле дуж тока реке Врбас кроз Бањалуку. Концентрације тешких метала одређиване су помоћу индуктивно спрегнуте плазме – оптичке емисионе спектрометрије и наменског живиног анализатора. Антропогени утицај на концентрацију тешких метала у седиментима процењен је израчунавањем различитих индекса загађења: индекса геоакумулације (Igeo),фактора контаминације (Cf), индекса оптерећења загађењем (PLI) и индекса потенцијалног еколошког ризика (Er). Добијени резултати указују да не постоје статистички значајне просторне разлике у концентрацији метала, што указује на то да тешки метали у испитиваним седиментима имају константан извор. Антропогени утицај изражен у вредностима индекса загађења показао је да су локације генерално незагађене кобалтом, хромом и ванадијумом, а умерено загађене цинком, бакром и никлом. С друге стране, кадмијум, жива и олово представљају највећи еколошки ризик. Антропогени извори ових метала су индустрија, комунални отпад и сагоревање фосилних горива. Добијени резултати показују висок еколошки ризик и потребу за мониторингом животне средине, подржавајући развој ефикасне стратегије за смањење локалног загађења и загађења испитиваног подручја.",
publisher = "Serbian Chemical Society",
journal = "Journal of Serbian Chemical Society",
title = "Distribution and provenance of heavy metals in sediments of the Vrbas River, Bosnia and Herzegovina, Примена индекса загађења у одређивању просторних и временских разлика у концентрацији тешких метала у седиментима реке Врбас, (Бања Лука, Босна и Херцеговина)",
volume = "87",
number = "4",
pages = "519-530",
doi = "10.2298/JSC210608070P"
}

Pržulj, S., Radojičić, A., Kašanin-Grubin, M., Pešević, D., Stojadinović, S., Jovančićević, B.,& Veselinović, G.. (2022). Distribution and provenance of heavy metals in sediments of the Vrbas River, Bosnia and Herzegovina. in Journal of Serbian Chemical Society
Serbian Chemical Society., 87(4), 519-530.
https://doi.org/10.2298/JSC210608070P

Pržulj S, Radojičić A, Kašanin-Grubin M, Pešević D, Stojadinović S, Jovančićević B, Veselinović G. Distribution and provenance of heavy metals in sediments of the Vrbas River, Bosnia and Herzegovina. in Journal of Serbian Chemical Society. 2022;87(4):519-530.
doi:10.2298/JSC210608070P .

Pržulj, Sanja, Radojičić, Ana, Kašanin-Grubin, Milica, Pešević, Dušica, Stojadinović, Sanja, Jovančićević, Branimir, Veselinović, Gorica, "Distribution and provenance of heavy metals in sediments of the Vrbas River, Bosnia and Herzegovina" in Journal of Serbian Chemical Society, 87, no. 4 (2022):519-530,
https://doi.org/10.2298/JSC210608070P . .

TY  - JOUR
AU  - Veselinović, Gorica
AU  - Tripković, Boban
AU  - Antić, Nevena
AU  - Šajnović, Aleksandra
AU  - Kašanin-Grubin, Milica
AU  - Tosti, Tomislav
AU  - Penezić, Kristina
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4973
AB  - This study aims to determine the palaeoenvironmental characteristics and activity patterns of Obrovac-type archaeological sites in Western Serbia, dated to the Late Neolithic/Early Eneolithic period, ∼5th millennium BC. These mound-like sites, enclosed by a wide ditch, that are not known in other parts of the central Balkan area, have long intrigued archaeologists investigating their origin and function over the last few decades.

In this study, for the first time, organic-geochemical analysis of paleosol samples from the Obrovac-type sites was applied with the aim of palaeoenvironmental reconstruction. Additionally, organic carbon content and anion analysis of 58 subsoil samples from these settlements were performed to determine the use of space and activity zones.

The analysis of biomarkers from selected sites suggests significant plant biodiversity in the Mačva region during the Late Neolithic/Early Eneolithic. Distribution of n-alkanes with the maximum at n-C25 and predominance of C30 hop-22(29)-ene among hopanoids in samples from Obrovac type-sites indisputably indicates that macrophytes are a dominant source of organic matter, implying a marshy and floodplain depositional environment. On the other side, a strong signal of long-chain n-alkanes indicates the input of terrestrial plants into the precursor biomass, confirming that this environment was habitable for the first settlers in this region. Anion-based analysis delineates certain activity zones, demonstrating that Obrovac type-sites manifest rather complex spatial behavior despite their relatively small size and available space.
PB  - Elsevier
T2  - Quaternary International
T1  - Reconstruction of palaeoenvironment and ancient human activities at Obrovac-type settlements (Serbia) using a geochemical approach
VL  - 610
SP  - 122
EP  - 132
DO  - 10.1016/j.quaint.2021.09.001
ER  - 

@article{
author = "Veselinović, Gorica and Tripković, Boban and Antić, Nevena and Šajnović, Aleksandra and Kašanin-Grubin, Milica and Tosti, Tomislav and Penezić, Kristina",
year = "2022",
abstract = "This study aims to determine the palaeoenvironmental characteristics and activity patterns of Obrovac-type archaeological sites in Western Serbia, dated to the Late Neolithic/Early Eneolithic period, ∼5th millennium BC. These mound-like sites, enclosed by a wide ditch, that are not known in other parts of the central Balkan area, have long intrigued archaeologists investigating their origin and function over the last few decades.

In this study, for the first time, organic-geochemical analysis of paleosol samples from the Obrovac-type sites was applied with the aim of palaeoenvironmental reconstruction. Additionally, organic carbon content and anion analysis of 58 subsoil samples from these settlements were performed to determine the use of space and activity zones.

The analysis of biomarkers from selected sites suggests significant plant biodiversity in the Mačva region during the Late Neolithic/Early Eneolithic. Distribution of n-alkanes with the maximum at n-C25 and predominance of C30 hop-22(29)-ene among hopanoids in samples from Obrovac type-sites indisputably indicates that macrophytes are a dominant source of organic matter, implying a marshy and floodplain depositional environment. On the other side, a strong signal of long-chain n-alkanes indicates the input of terrestrial plants into the precursor biomass, confirming that this environment was habitable for the first settlers in this region. Anion-based analysis delineates certain activity zones, demonstrating that Obrovac type-sites manifest rather complex spatial behavior despite their relatively small size and available space.",
publisher = "Elsevier",
journal = "Quaternary International",
title = "Reconstruction of palaeoenvironment and ancient human activities at Obrovac-type settlements (Serbia) using a geochemical approach",
volume = "610",
pages = "122-132",
doi = "10.1016/j.quaint.2021.09.001"
}

Veselinović, G., Tripković, B., Antić, N., Šajnović, A., Kašanin-Grubin, M., Tosti, T.,& Penezić, K.. (2022). Reconstruction of palaeoenvironment and ancient human activities at Obrovac-type settlements (Serbia) using a geochemical approach. in Quaternary International
Elsevier., 610, 122-132.
https://doi.org/10.1016/j.quaint.2021.09.001

Veselinović G, Tripković B, Antić N, Šajnović A, Kašanin-Grubin M, Tosti T, Penezić K. Reconstruction of palaeoenvironment and ancient human activities at Obrovac-type settlements (Serbia) using a geochemical approach. in Quaternary International. 2022;610:122-132.
doi:10.1016/j.quaint.2021.09.001 .

Veselinović, Gorica, Tripković, Boban, Antić, Nevena, Šajnović, Aleksandra, Kašanin-Grubin, Milica, Tosti, Tomislav, Penezić, Kristina, "Reconstruction of palaeoenvironment and ancient human activities at Obrovac-type settlements (Serbia) using a geochemical approach" in Quaternary International, 610 (2022):122-132,
https://doi.org/10.1016/j.quaint.2021.09.001 . .

TY  - JOUR
AU  - Yan, Luo-bin
AU  - Petrović, Srđan
AU  - Huang, Cheng
AU  - Xie, Chun-xia
AU  - Zong, Hui-ming
AU  - Kašanin-Grubin, Milica
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5475
AB  - Quantifying rock weathering processes, especially in ways of nondisturbance and on-site investigation, is one of the most critical tasks in predicting rocks erosion rates and understanding the sediment transportation. We proposed a more reproducible approach to test how image analysis can quantify the changes in the size and shape of fragments during the weathering process. Four artificial models were designed to select suitable metrics among over 20 parameters. To validate the efficiency of image analysis, we analyzed rocks from badlands in Nanxiong Basin, Southeast China, under three different ranges of temperature differences (TD) during cyclic wetting and drying (WD). Our results show that TDs can accelerate the disintegration rate, and even if there is only a 20°C difference in the range of TDs, an apparent difference in fragment size was observed. Moreover, the shape of fragments became more round as the increasing number of cyclic treatments, and for samples that went through the same number of treatments, the larger the temperature difference, the more round the shape became. All that serves as another evidence for landscape evolution response to climatic warming.
PB  - Springer Nature
T2  - Journal of Mountain Science
T1  - Effect of temperature on mudstone disintegration process revealed with image analysis
VL  - 19
IS  - 7
SP  - 2126
EP  - 2135
DO  - 10.1007/s11629-021-7268-3
ER  - 

@article{
author = "Yan, Luo-bin and Petrović, Srđan and Huang, Cheng and Xie, Chun-xia and Zong, Hui-ming and Kašanin-Grubin, Milica",
year = "2022",
abstract = "Quantifying rock weathering processes, especially in ways of nondisturbance and on-site investigation, is one of the most critical tasks in predicting rocks erosion rates and understanding the sediment transportation. We proposed a more reproducible approach to test how image analysis can quantify the changes in the size and shape of fragments during the weathering process. Four artificial models were designed to select suitable metrics among over 20 parameters. To validate the efficiency of image analysis, we analyzed rocks from badlands in Nanxiong Basin, Southeast China, under three different ranges of temperature differences (TD) during cyclic wetting and drying (WD). Our results show that TDs can accelerate the disintegration rate, and even if there is only a 20°C difference in the range of TDs, an apparent difference in fragment size was observed. Moreover, the shape of fragments became more round as the increasing number of cyclic treatments, and for samples that went through the same number of treatments, the larger the temperature difference, the more round the shape became. All that serves as another evidence for landscape evolution response to climatic warming.",
publisher = "Springer Nature",
journal = "Journal of Mountain Science",
title = "Effect of temperature on mudstone disintegration process revealed with image analysis",
volume = "19",
number = "7",
pages = "2126-2135",
doi = "10.1007/s11629-021-7268-3"
}

Yan, L., Petrović, S., Huang, C., Xie, C., Zong, H.,& Kašanin-Grubin, M.. (2022). Effect of temperature on mudstone disintegration process revealed with image analysis. in Journal of Mountain Science
Springer Nature., 19(7), 2126-2135.
https://doi.org/10.1007/s11629-021-7268-3

Yan L, Petrović S, Huang C, Xie C, Zong H, Kašanin-Grubin M. Effect of temperature on mudstone disintegration process revealed with image analysis. in Journal of Mountain Science. 2022;19(7):2126-2135.
doi:10.1007/s11629-021-7268-3 .

Yan, Luo-bin, Petrović, Srđan, Huang, Cheng, Xie, Chun-xia, Zong, Hui-ming, Kašanin-Grubin, Milica, "Effect of temperature on mudstone disintegration process revealed with image analysis" in Journal of Mountain Science, 19, no. 7 (2022):2126-2135,
https://doi.org/10.1007/s11629-021-7268-3 . .

TY  - JOUR
AU  - Yan, Luo-bin
AU  - Petrović, Srdjan
AU  - Huang, Cheng
AU  - Xie, Chun-xia
AU  - Zong, Hui-ming
AU  - Kašanin-Grubin, Milica
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5589
AB  - Quantifying rock weathering processes, especially in ways of nondisturbance and on-site investigation, is one of the most critical tasks in predicting rocks erosion rates and understanding the sediment transportation. We proposed a more reproducible approach to test how image analysis can quantify the changes in the size and shape of fragments during the weathering process. Four artificial models were designed to select suitable metrics among over 20 parameters. To validate the efficiency of image analysis, we analyzed rocks from badlands in Nanxiong Basin, Southeast China, under three different ranges of temperature differences (TD) during cyclic wetting and drying (WD). Our results show that TDs can accelerate the disintegration rate, and even if there is only a 20°C difference in the range of TDs, an apparent difference in fragment size was observed. Moreover, the shape of fragments became more round as the increasing number of cyclic treatments, and for samples that went through the same number of treatments, the larger the temperature difference, the more round the shape became. All that serves as another evidence for landscape evolution response to climatic warming.
PB  - Springer
T2  - Journal of Mountain Science
T1  - Effect of temperature on mudstone disintegration process revealed with image analysis
VL  - 19
IS  - 7
SP  - 2126
EP  - 2135
DO  - 10.1007/s11629-021-7268-3
ER  - 

@article{
author = "Yan, Luo-bin and Petrović, Srdjan and Huang, Cheng and Xie, Chun-xia and Zong, Hui-ming and Kašanin-Grubin, Milica",
year = "2022",
abstract = "Quantifying rock weathering processes, especially in ways of nondisturbance and on-site investigation, is one of the most critical tasks in predicting rocks erosion rates and understanding the sediment transportation. We proposed a more reproducible approach to test how image analysis can quantify the changes in the size and shape of fragments during the weathering process. Four artificial models were designed to select suitable metrics among over 20 parameters. To validate the efficiency of image analysis, we analyzed rocks from badlands in Nanxiong Basin, Southeast China, under three different ranges of temperature differences (TD) during cyclic wetting and drying (WD). Our results show that TDs can accelerate the disintegration rate, and even if there is only a 20°C difference in the range of TDs, an apparent difference in fragment size was observed. Moreover, the shape of fragments became more round as the increasing number of cyclic treatments, and for samples that went through the same number of treatments, the larger the temperature difference, the more round the shape became. All that serves as another evidence for landscape evolution response to climatic warming.",
publisher = "Springer",
journal = "Journal of Mountain Science",
title = "Effect of temperature on mudstone disintegration process revealed with image analysis",
volume = "19",
number = "7",
pages = "2126-2135",
doi = "10.1007/s11629-021-7268-3"
}

Yan, L., Petrović, S., Huang, C., Xie, C., Zong, H.,& Kašanin-Grubin, M.. (2022). Effect of temperature on mudstone disintegration process revealed with image analysis. in Journal of Mountain Science
Springer., 19(7), 2126-2135.
https://doi.org/10.1007/s11629-021-7268-3

Yan L, Petrović S, Huang C, Xie C, Zong H, Kašanin-Grubin M. Effect of temperature on mudstone disintegration process revealed with image analysis. in Journal of Mountain Science. 2022;19(7):2126-2135.
doi:10.1007/s11629-021-7268-3 .

Yan, Luo-bin, Petrović, Srdjan, Huang, Cheng, Xie, Chun-xia, Zong, Hui-ming, Kašanin-Grubin, Milica, "Effect of temperature on mudstone disintegration process revealed with image analysis" in Journal of Mountain Science, 19, no. 7 (2022):2126-2135,
https://doi.org/10.1007/s11629-021-7268-3 . .

TY  - JOUR
AU  - Pergal, Marija
AU  - Brkljačić, Jelena
AU  - Tovilović-Kovačević, Gordana
AU  - Špírková, Milena
AU  - Kodranov, Igor
AU  - Manojlović, Dragan
AU  - Ostojić, Sanja
AU  - Knežević, Nikola Ž.
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4016
AB  - Novel polyurethane nanocomposite (PUN) materials containing different surface-functionalized mesoporous silica nanoparticles (MSNs) were prepared by in situ polymerization methodology. Polyurethane network was formed from poly(dimethylsiloxane)-based macrodiol (PDMS), 4,4′-methylenediphenyldiisocyanate (MDI), and hyperbranched polyester of the second pseudo-generation (BH-20; used as crosslinking agent). PU and PU/MSN nanocomposites contained equal ratios of soft PDMS and hard MDI-BH-20 segments. Non-functionalized and surface-functionalized (with 3-(trihydroxysilyl)propyl methylphosphonate (FOMSN) and 2-[methoxy(polyethyleneoxy)6−9propyl]trimethoxysilane (PEGMSN)) MSNs were used as the nanofillers at a concentration of 1 wt%. Prepared materials were characterized by Fourier transform infrared (FTIR) spectroscopy, atomic force microscopy (AFM), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), dynamic mechanical thermal analyses (DMTA), nanoindentation, equilibrium swelling and water absorption measurements. Characteristics of the prepared PUNs when in contact with a biological environment were assessed through testing their biocompatibility, protein adsorption and adhesion of endothelial cells. The favourable influence of MSNs on the physico-chemical and biological characteristics of these novel PUN materials was identified, which evidences their vast applicability potential as coatings for medical devices and implants.
PB  - Elsevier
T2  - Progress in Organic Coatings
T1  - Effect of mesoporous silica nanoparticles on the properties of polyurethane network composites
VL  - 151
SP  - 106049
DO  - 10.1016/j.porgcoat.2020.106049
ER  - 

@article{
author = "Pergal, Marija and Brkljačić, Jelena and Tovilović-Kovačević, Gordana and Špírková, Milena and Kodranov, Igor and Manojlović, Dragan and Ostojić, Sanja and Knežević, Nikola Ž.",
year = "2021",
abstract = "Novel polyurethane nanocomposite (PUN) materials containing different surface-functionalized mesoporous silica nanoparticles (MSNs) were prepared by in situ polymerization methodology. Polyurethane network was formed from poly(dimethylsiloxane)-based macrodiol (PDMS), 4,4′-methylenediphenyldiisocyanate (MDI), and hyperbranched polyester of the second pseudo-generation (BH-20; used as crosslinking agent). PU and PU/MSN nanocomposites contained equal ratios of soft PDMS and hard MDI-BH-20 segments. Non-functionalized and surface-functionalized (with 3-(trihydroxysilyl)propyl methylphosphonate (FOMSN) and 2-[methoxy(polyethyleneoxy)6−9propyl]trimethoxysilane (PEGMSN)) MSNs were used as the nanofillers at a concentration of 1 wt%. Prepared materials were characterized by Fourier transform infrared (FTIR) spectroscopy, atomic force microscopy (AFM), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), dynamic mechanical thermal analyses (DMTA), nanoindentation, equilibrium swelling and water absorption measurements. Characteristics of the prepared PUNs when in contact with a biological environment were assessed through testing their biocompatibility, protein adsorption and adhesion of endothelial cells. The favourable influence of MSNs on the physico-chemical and biological characteristics of these novel PUN materials was identified, which evidences their vast applicability potential as coatings for medical devices and implants.",
publisher = "Elsevier",
journal = "Progress in Organic Coatings",
title = "Effect of mesoporous silica nanoparticles on the properties of polyurethane network composites",
volume = "151",
pages = "106049",
doi = "10.1016/j.porgcoat.2020.106049"
}

Pergal, M., Brkljačić, J., Tovilović-Kovačević, G., Špírková, M., Kodranov, I., Manojlović, D., Ostojić, S.,& Knežević, N. Ž.. (2021). Effect of mesoporous silica nanoparticles on the properties of polyurethane network composites. in Progress in Organic Coatings
Elsevier., 151, 106049.
https://doi.org/10.1016/j.porgcoat.2020.106049

Pergal M, Brkljačić J, Tovilović-Kovačević G, Špírková M, Kodranov I, Manojlović D, Ostojić S, Knežević NŽ. Effect of mesoporous silica nanoparticles on the properties of polyurethane network composites. in Progress in Organic Coatings. 2021;151:106049.
doi:10.1016/j.porgcoat.2020.106049 .

Pergal, Marija, Brkljačić, Jelena, Tovilović-Kovačević, Gordana, Špírková, Milena, Kodranov, Igor, Manojlović, Dragan, Ostojić, Sanja, Knežević, Nikola Ž., "Effect of mesoporous silica nanoparticles on the properties of polyurethane network composites" in Progress in Organic Coatings, 151 (2021):106049,
https://doi.org/10.1016/j.porgcoat.2020.106049 . .

TY  - JOUR
AU  - Mladenović, Minja
AU  - Morgan, Ibrahim
AU  - Ilić, Nebojša
AU  - Saoud, Mohamad
AU  - Pergal, Marija
AU  - Kaluđerović, Goran N.
AU  - Knežević, Nikola Ž.
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4572
AB  - Ruthenium complexes are attracting interest in cancer treatment due to their potent cytotoxic activity. However, as their high toxicity may also affect healthy tissues, efficient and selective drug delivery systems to tumour tissues are needed. Our study focuses on the construction of such drug delivery systems for the delivery of cytotoxic Ru(II) complexes upon exposure to a weakly acidic environment of tumours. As nanocarriers, mesoporous silica nanoparticles (MSN) are utilized, whose surface is functionalized with two types of ligands, (2-thienylmethyl)hydrazine hydrochloride (H1) and (5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)hydrazine (H2), which were attached to MSN through a pH-responsive hydrazone linkage. Further coordination to ruthenium(II) center yielded two types of nanomaterials MSN-H1[Ru] and MSN-H2[Ru]. Spectrophotometric measurements of the drug release kinetics at different pH (5.0, 6.0 and 7.4) confirm the enhanced release of Ru(II) complexes at lower pH values, which is further supported by inductively coupled plasma optical emission spectrometry (ICP-OES) measurements. Furthermore, the cytotoxicity effect of the released metallotherapeutics is evaluated in vitro on metastatic B16F1 melanoma cells and enhanced cancer cell-killing efficacy is demonstrated upon exposure of the nanomaterials to weakly acidic conditions. The obtained results showcase the promising capabilities of the designed MSN nanocarriers for the pH-responsive delivery of metallotherapeutics and targeted treatment of cancer.
PB  - MDPI
T2  - Pharmaceutics
T1  - Ph-responsive release of ruthenium metallotherapeutics from mesoporous silica-based nanocarriers
VL  - 13
IS  - 4
SP  - 460
DO  - 10.3390/pharmaceutics13040460
ER  - 

@article{
author = "Mladenović, Minja and Morgan, Ibrahim and Ilić, Nebojša and Saoud, Mohamad and Pergal, Marija and Kaluđerović, Goran N. and Knežević, Nikola Ž.",
year = "2021",
abstract = "Ruthenium complexes are attracting interest in cancer treatment due to their potent cytotoxic activity. However, as their high toxicity may also affect healthy tissues, efficient and selective drug delivery systems to tumour tissues are needed. Our study focuses on the construction of such drug delivery systems for the delivery of cytotoxic Ru(II) complexes upon exposure to a weakly acidic environment of tumours. As nanocarriers, mesoporous silica nanoparticles (MSN) are utilized, whose surface is functionalized with two types of ligands, (2-thienylmethyl)hydrazine hydrochloride (H1) and (5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)hydrazine (H2), which were attached to MSN through a pH-responsive hydrazone linkage. Further coordination to ruthenium(II) center yielded two types of nanomaterials MSN-H1[Ru] and MSN-H2[Ru]. Spectrophotometric measurements of the drug release kinetics at different pH (5.0, 6.0 and 7.4) confirm the enhanced release of Ru(II) complexes at lower pH values, which is further supported by inductively coupled plasma optical emission spectrometry (ICP-OES) measurements. Furthermore, the cytotoxicity effect of the released metallotherapeutics is evaluated in vitro on metastatic B16F1 melanoma cells and enhanced cancer cell-killing efficacy is demonstrated upon exposure of the nanomaterials to weakly acidic conditions. The obtained results showcase the promising capabilities of the designed MSN nanocarriers for the pH-responsive delivery of metallotherapeutics and targeted treatment of cancer.",
publisher = "MDPI",
journal = "Pharmaceutics",
title = "Ph-responsive release of ruthenium metallotherapeutics from mesoporous silica-based nanocarriers",
volume = "13",
number = "4",
pages = "460",
doi = "10.3390/pharmaceutics13040460"
}

Mladenović, M., Morgan, I., Ilić, N., Saoud, M., Pergal, M., Kaluđerović, G. N.,& Knežević, N. Ž.. (2021). Ph-responsive release of ruthenium metallotherapeutics from mesoporous silica-based nanocarriers. in Pharmaceutics
MDPI., 13(4), 460.
https://doi.org/10.3390/pharmaceutics13040460

Mladenović M, Morgan I, Ilić N, Saoud M, Pergal M, Kaluđerović GN, Knežević NŽ. Ph-responsive release of ruthenium metallotherapeutics from mesoporous silica-based nanocarriers. in Pharmaceutics. 2021;13(4):460.
doi:10.3390/pharmaceutics13040460 .

Mladenović, Minja, Morgan, Ibrahim, Ilić, Nebojša, Saoud, Mohamad, Pergal, Marija, Kaluđerović, Goran N., Knežević, Nikola Ž., "Ph-responsive release of ruthenium metallotherapeutics from mesoporous silica-based nanocarriers" in Pharmaceutics, 13, no. 4 (2021):460,
https://doi.org/10.3390/pharmaceutics13040460 . .

TY  - DATA
AU  - Mladenović, Minja
AU  - Morgan, Ibrahim
AU  - Ilić, Nebojša
AU  - Saoud, Mohamad
AU  - Pergal, Marija
AU  - Kaluđerović, Goran N.
AU  - Knežević, Nikola Ž.
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4573
AB  - Figure S1. Full range FTIR spectra of the synthesized materials. Figure S2. Particle size distribution of Ru-modified nanoparticles in water (top) and culture medium (bottom). Figure S3. EDS chromatograms of (a) MSN-H1[Ru]; (b) MSN-H2[Ru] and (c) MSN[Ru] with insets representing Ru mapping. Figure S4. UV/VIS spectra of supernatants at different pH values after 48 h of stirring. Figure S5. Viability of the B16F1 cells determined with CV and MTT assays treated (48 h) with pristine MSN on pH 5.0 and 7.2.
PB  - MDPI
T2  - Pharmaceutics
T1  - Supplementary material to: "Ph-responsive release of ruthenium metallotherapeutics from mesoporous silica-based nanocarriers"
UR  - https://hdl.handle.net/21.15107/rcub_cer_4573
ER  - 

@misc{
author = "Mladenović, Minja and Morgan, Ibrahim and Ilić, Nebojša and Saoud, Mohamad and Pergal, Marija and Kaluđerović, Goran N. and Knežević, Nikola Ž.",
year = "2021",
abstract = "Figure S1. Full range FTIR spectra of the synthesized materials. Figure S2. Particle size distribution of Ru-modified nanoparticles in water (top) and culture medium (bottom). Figure S3. EDS chromatograms of (a) MSN-H1[Ru]; (b) MSN-H2[Ru] and (c) MSN[Ru] with insets representing Ru mapping. Figure S4. UV/VIS spectra of supernatants at different pH values after 48 h of stirring. Figure S5. Viability of the B16F1 cells determined with CV and MTT assays treated (48 h) with pristine MSN on pH 5.0 and 7.2.",
publisher = "MDPI",
journal = "Pharmaceutics",
title = "Supplementary material to: "Ph-responsive release of ruthenium metallotherapeutics from mesoporous silica-based nanocarriers"",
url = "https://hdl.handle.net/21.15107/rcub_cer_4573"
}

Mladenović, M., Morgan, I., Ilić, N., Saoud, M., Pergal, M., Kaluđerović, G. N.,& Knežević, N. Ž.. (2021). Supplementary material to: "Ph-responsive release of ruthenium metallotherapeutics from mesoporous silica-based nanocarriers". in Pharmaceutics
MDPI..
https://hdl.handle.net/21.15107/rcub_cer_4573

Mladenović M, Morgan I, Ilić N, Saoud M, Pergal M, Kaluđerović GN, Knežević NŽ. Supplementary material to: "Ph-responsive release of ruthenium metallotherapeutics from mesoporous silica-based nanocarriers". in Pharmaceutics. 2021;.
https://hdl.handle.net/21.15107/rcub_cer_4573 .

Mladenović, Minja, Morgan, Ibrahim, Ilić, Nebojša, Saoud, Mohamad, Pergal, Marija, Kaluđerović, Goran N., Knežević, Nikola Ž., "Supplementary material to: "Ph-responsive release of ruthenium metallotherapeutics from mesoporous silica-based nanocarriers"" in Pharmaceutics (2021),
https://hdl.handle.net/21.15107/rcub_cer_4573 .