TY  - DATA
AU  - Novaković, Miroslav
AU  - Bukvicki, Danka
AU  - Vajs, Vlatka
AU  - Tešević, Vele
AU  - Milosavljević, Slobodan
AU  - Marin, Petar D.
AU  - Asakawa, Yoshinori
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4448
AB  - Text S1. General experimental procedures Table S1. Elution system for the silica gel column chromatography separation of biotransformed products Figure 1S. 1 H NMR spectrum of compound 5 Figure 2S. 13C NMR spectrum of compound 5 Figure 3S. 1 H NMR spectrum of compound 6 Figure 4S. 13C NMR spectrum of compound 6 Figure 5S. 1 H NMR spectrum of compound 7 Figure 6S. Aromatic part of the 1 H NMR spectrum of compound 7 Figure 7S. 13C NMR spectrum of compound 7
PB  - SAGE Publications
T2  - Natural Product Communications
T1  - Supplementary material for: "Microbial Transformation of Calamintha glandulosa Essential Oil by Aspergillus niger"
UR  - https://hdl.handle.net/21.15107/rcub_cer_4448
ER  - 

@misc{
author = "Novaković, Miroslav and Bukvicki, Danka and Vajs, Vlatka and Tešević, Vele and Milosavljević, Slobodan and Marin, Petar D. and Asakawa, Yoshinori",
year = "2018",
abstract = "Text S1. General experimental procedures Table S1. Elution system for the silica gel column chromatography separation of biotransformed products Figure 1S. 1 H NMR spectrum of compound 5 Figure 2S. 13C NMR spectrum of compound 5 Figure 3S. 1 H NMR spectrum of compound 6 Figure 4S. 13C NMR spectrum of compound 6 Figure 5S. 1 H NMR spectrum of compound 7 Figure 6S. Aromatic part of the 1 H NMR spectrum of compound 7 Figure 7S. 13C NMR spectrum of compound 7",
publisher = "SAGE Publications",
journal = "Natural Product Communications",
title = "Supplementary material for: "Microbial Transformation of Calamintha glandulosa Essential Oil by Aspergillus niger"",
url = "https://hdl.handle.net/21.15107/rcub_cer_4448"
}

Novaković, M., Bukvicki, D., Vajs, V., Tešević, V., Milosavljević, S., Marin, P. D.,& Asakawa, Y.. (2018). Supplementary material for: "Microbial Transformation of Calamintha glandulosa Essential Oil by Aspergillus niger". in Natural Product Communications
SAGE Publications..
https://hdl.handle.net/21.15107/rcub_cer_4448

Novaković M, Bukvicki D, Vajs V, Tešević V, Milosavljević S, Marin PD, Asakawa Y. Supplementary material for: "Microbial Transformation of Calamintha glandulosa Essential Oil by Aspergillus niger". in Natural Product Communications. 2018;.
https://hdl.handle.net/21.15107/rcub_cer_4448 .

Novaković, Miroslav, Bukvicki, Danka, Vajs, Vlatka, Tešević, Vele, Milosavljević, Slobodan, Marin, Petar D., Asakawa, Yoshinori, "Supplementary material for: "Microbial Transformation of Calamintha glandulosa Essential Oil by Aspergillus niger"" in Natural Product Communications (2018),
https://hdl.handle.net/21.15107/rcub_cer_4448 .

TY  - JOUR
AU  - Bukvicki, Danka
AU  - Novaković, Miroslav
AU  - Ab, Ghani Nurunajah
AU  - Marin, Petar D.
AU  - Asakawa, Yoshinori
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2438
AB  - This manuscript describes the first detailed chemical investigation of endemic species Iris adriatica, including isolation and structure elucidation. Chemical analyses of the rhizome CH2Cl2/MeOH (2:1) extract revealed fourteen secondary metabolites, mainly isoflavonoids. Among isoflavonoids, two groups have been found: nigricin-type and tectorigenin-type. Dominant group of the isolated compounds has been nigricin-type isoflavones: nigricin, nigricin-4'-(1-O-beta-D- glucopyranoside) and nigricin-4'-(1-O-beta-D-glucopyranosyl (1-6)-beta-D-glucopyranoside) with 2.5, 10 and 1% of the total extract, respectively. Irisxanthone - xanthone C-glucoside, beta-sitosterol, benzophenone and one of its derivatives have also been found. Nigricin-type isoflavonoids and irisxanthone can be considered as possible chemotaxonomic markers for I. adriatica. 5,3',5'-Trimethoxy-6,7-methylenedioxyisoflavone-4'-(1-O-beta-D-glucopyranoside) and benzophenone have been isolated from Iris species for the first time. Left-hand image of Iris adriatica (Adriatic potato) with redditsh purple flowers
PB  - Taylor and Francis Ltd.
T2  - Natural Product Research
T1  - Secondary metabolites from endemic species Iris adriatica Trinajstic ex Mitic (Iridaceae)
VL  - 32
IS  - 15
SP  - 1849
EP  - 1852
DO  - 10.1080/14786419.2017.1402309
ER  - 

@article{
author = "Bukvicki, Danka and Novaković, Miroslav and Ab, Ghani Nurunajah and Marin, Petar D. and Asakawa, Yoshinori",
year = "2018",
abstract = "This manuscript describes the first detailed chemical investigation of endemic species Iris adriatica, including isolation and structure elucidation. Chemical analyses of the rhizome CH2Cl2/MeOH (2:1) extract revealed fourteen secondary metabolites, mainly isoflavonoids. Among isoflavonoids, two groups have been found: nigricin-type and tectorigenin-type. Dominant group of the isolated compounds has been nigricin-type isoflavones: nigricin, nigricin-4'-(1-O-beta-D- glucopyranoside) and nigricin-4'-(1-O-beta-D-glucopyranosyl (1-6)-beta-D-glucopyranoside) with 2.5, 10 and 1% of the total extract, respectively. Irisxanthone - xanthone C-glucoside, beta-sitosterol, benzophenone and one of its derivatives have also been found. Nigricin-type isoflavonoids and irisxanthone can be considered as possible chemotaxonomic markers for I. adriatica. 5,3',5'-Trimethoxy-6,7-methylenedioxyisoflavone-4'-(1-O-beta-D-glucopyranoside) and benzophenone have been isolated from Iris species for the first time. Left-hand image of Iris adriatica (Adriatic potato) with redditsh purple flowers",
publisher = "Taylor and Francis Ltd.",
journal = "Natural Product Research",
title = "Secondary metabolites from endemic species Iris adriatica Trinajstic ex Mitic (Iridaceae)",
volume = "32",
number = "15",
pages = "1849-1852",
doi = "10.1080/14786419.2017.1402309"
}

Bukvicki, D., Novaković, M., Ab, G. N., Marin, P. D.,& Asakawa, Y.. (2018). Secondary metabolites from endemic species Iris adriatica Trinajstic ex Mitic (Iridaceae). in Natural Product Research
Taylor and Francis Ltd.., 32(15), 1849-1852.
https://doi.org/10.1080/14786419.2017.1402309

Bukvicki D, Novaković M, Ab GN, Marin PD, Asakawa Y. Secondary metabolites from endemic species Iris adriatica Trinajstic ex Mitic (Iridaceae). in Natural Product Research. 2018;32(15):1849-1852.
doi:10.1080/14786419.2017.1402309 .

Bukvicki, Danka, Novaković, Miroslav, Ab, Ghani Nurunajah, Marin, Petar D., Asakawa, Yoshinori, "Secondary metabolites from endemic species Iris adriatica Trinajstic ex Mitic (Iridaceae)" in Natural Product Research, 32, no. 15 (2018):1849-1852,
https://doi.org/10.1080/14786419.2017.1402309 . .

TY  - DATA
AU  - Bukvicki, Danka
AU  - Novaković, Miroslav
AU  - Ab, Ghani Nurunajah
AU  - Marin, Petar D.
AU  - Asakawa, Yoshinori
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4469
AB  - Experimental data: Plant material; Extract preparation; Extract separation; General. Table S1. Silica gel column separation program. Isolation. Figure S1. The main HMBC correlations in both types of Iris adriatica isofavonoids; A - nigricin-type, B - tectorigenin-type. 1H and 13C NMR spectra of all isolated compounds.
PB  - Taylor and Francis
T2  - Natural Product Research
T1  - Supplementary material for: "Secondary metabolites from endemic species Iris adriatica Trinajstic ex Mitic (Iridaceae)"
DO  - 10.6084/m9.figshare.5592772.v1
ER  - 

@misc{
author = "Bukvicki, Danka and Novaković, Miroslav and Ab, Ghani Nurunajah and Marin, Petar D. and Asakawa, Yoshinori",
year = "2018",
abstract = "Experimental data: Plant material; Extract preparation; Extract separation; General. Table S1. Silica gel column separation program. Isolation. Figure S1. The main HMBC correlations in both types of Iris adriatica isofavonoids; A - nigricin-type, B - tectorigenin-type. 1H and 13C NMR spectra of all isolated compounds.",
publisher = "Taylor and Francis",
journal = "Natural Product Research",
title = "Supplementary material for: "Secondary metabolites from endemic species Iris adriatica Trinajstic ex Mitic (Iridaceae)"",
doi = "10.6084/m9.figshare.5592772.v1"
}

Bukvicki, D., Novaković, M., Ab, G. N., Marin, P. D.,& Asakawa, Y.. (2018). Supplementary material for: "Secondary metabolites from endemic species Iris adriatica Trinajstic ex Mitic (Iridaceae)". in Natural Product Research
Taylor and Francis..
https://doi.org/10.6084/m9.figshare.5592772.v1

Bukvicki D, Novaković M, Ab GN, Marin PD, Asakawa Y. Supplementary material for: "Secondary metabolites from endemic species Iris adriatica Trinajstic ex Mitic (Iridaceae)". in Natural Product Research. 2018;.
doi:10.6084/m9.figshare.5592772.v1 .

Bukvicki, Danka, Novaković, Miroslav, Ab, Ghani Nurunajah, Marin, Petar D., Asakawa, Yoshinori, "Supplementary material for: "Secondary metabolites from endemic species Iris adriatica Trinajstic ex Mitic (Iridaceae)"" in Natural Product Research (2018),
https://doi.org/10.6084/m9.figshare.5592772.v1 . .

TY  - JOUR
AU  - Novaković, Miroslav
AU  - Bukvicki, Danka
AU  - Vajs, Vlatka
AU  - Tešević, Vele
AU  - Milosavljević, Slobodan
AU  - Marin, Petar D.
AU  - Asakawa, Yoshinori
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2294
AB  - A number of potentially useful compounds with various biological activities can be obtained from plant metabolites by microorganisms. In present research, essential oil of Calamintha glandulosa was subjected to the biotransformation process by mycromicete Aspergillus niger. GC/MS analyses of the original and biotransformed essential oil have revealed six(1-6) biotransformed compounds from one of the main component-limonene and one biotransformed product (7) originating from the less abundant component-thymol. Piperitone epoxide and piperitenone epoxide, the most abundant components of the original oil, were not biotransformed but gave three artefacts (A1, A2, B1) due to the acidic conditions formed in A. niger medium. Compounds 5, 6 as well as 7 have not been previously found as a biotransformation products of limonene (5 and 6) and thymol (7), respectively. New products (5, 6, and 7) together with the artefacts, were isolated by silica gel column chromatography followed by preparative silica gel thin layer chromatography, and their structures were established by a combination of 1D and 2D NMR spectra and GC/MS data. Biotransformation has one more confirmed as useful method, complementary to synthesis, for obtaining different type of molecules.
PB  - SAGE Publications
T2  - Natural Product Communications
T1  - Microbial Transformation of Calamintha glandulosa Essential Oil by Aspergillus niger
VL  - 13
IS  - 4
SP  - 479
EP  - 482
DO  - 10.1177/1934578x1801300425
ER  - 

@article{
author = "Novaković, Miroslav and Bukvicki, Danka and Vajs, Vlatka and Tešević, Vele and Milosavljević, Slobodan and Marin, Petar D. and Asakawa, Yoshinori",
year = "2018",
abstract = "A number of potentially useful compounds with various biological activities can be obtained from plant metabolites by microorganisms. In present research, essential oil of Calamintha glandulosa was subjected to the biotransformation process by mycromicete Aspergillus niger. GC/MS analyses of the original and biotransformed essential oil have revealed six(1-6) biotransformed compounds from one of the main component-limonene and one biotransformed product (7) originating from the less abundant component-thymol. Piperitone epoxide and piperitenone epoxide, the most abundant components of the original oil, were not biotransformed but gave three artefacts (A1, A2, B1) due to the acidic conditions formed in A. niger medium. Compounds 5, 6 as well as 7 have not been previously found as a biotransformation products of limonene (5 and 6) and thymol (7), respectively. New products (5, 6, and 7) together with the artefacts, were isolated by silica gel column chromatography followed by preparative silica gel thin layer chromatography, and their structures were established by a combination of 1D and 2D NMR spectra and GC/MS data. Biotransformation has one more confirmed as useful method, complementary to synthesis, for obtaining different type of molecules.",
publisher = "SAGE Publications",
journal = "Natural Product Communications",
title = "Microbial Transformation of Calamintha glandulosa Essential Oil by Aspergillus niger",
volume = "13",
number = "4",
pages = "479-482",
doi = "10.1177/1934578x1801300425"
}

Novaković, M., Bukvicki, D., Vajs, V., Tešević, V., Milosavljević, S., Marin, P. D.,& Asakawa, Y.. (2018). Microbial Transformation of Calamintha glandulosa Essential Oil by Aspergillus niger. in Natural Product Communications
SAGE Publications., 13(4), 479-482.
https://doi.org/10.1177/1934578x1801300425

Novaković M, Bukvicki D, Vajs V, Tešević V, Milosavljević S, Marin PD, Asakawa Y. Microbial Transformation of Calamintha glandulosa Essential Oil by Aspergillus niger. in Natural Product Communications. 2018;13(4):479-482.
doi:10.1177/1934578x1801300425 .

Novaković, Miroslav, Bukvicki, Danka, Vajs, Vlatka, Tešević, Vele, Milosavljević, Slobodan, Marin, Petar D., Asakawa, Yoshinori, "Microbial Transformation of Calamintha glandulosa Essential Oil by Aspergillus niger" in Natural Product Communications, 13, no. 4 (2018):479-482,
https://doi.org/10.1177/1934578x1801300425 . .

TY  - JOUR
AU  - Anchang, Kenneth Yongabi
AU  - Novaković, Miroslav
AU  - Bukvicki, Danka
AU  - Asakawa, Yoshinori
PY  - 2016
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1925
AB  - Liverworts are rich sources of terpenoids and aromatic compounds among which bis-bibenzyls are well known for their wide spectrum of biological activities. This is the first report of chemical analysis of the African liverwort Marchantia debilis Goebel. From the methanol extract marchantinquinone-l'-methyl ether was newly isolated together with three known bis-bibenzyls, marchantin C, marchantinquinone and perrottetin E. The presence of bis-bibenzyls with a quinone moiety is noted for the first time in the Marchantia genus.
PB  - Natural Products Inc, Westerville
T2  - Natural Product Communications
T1  - Bis-bibenzyls from the Cameroon Liverwort Marchantia debilis
VL  - 11
IS  - 9
SP  - 1317
EP  - 1318
UR  - https://hdl.handle.net/21.15107/rcub_cer_1925
ER  - 

@article{
author = "Anchang, Kenneth Yongabi and Novaković, Miroslav and Bukvicki, Danka and Asakawa, Yoshinori",
year = "2016",
abstract = "Liverworts are rich sources of terpenoids and aromatic compounds among which bis-bibenzyls are well known for their wide spectrum of biological activities. This is the first report of chemical analysis of the African liverwort Marchantia debilis Goebel. From the methanol extract marchantinquinone-l'-methyl ether was newly isolated together with three known bis-bibenzyls, marchantin C, marchantinquinone and perrottetin E. The presence of bis-bibenzyls with a quinone moiety is noted for the first time in the Marchantia genus.",
publisher = "Natural Products Inc, Westerville",
journal = "Natural Product Communications",
title = "Bis-bibenzyls from the Cameroon Liverwort Marchantia debilis",
volume = "11",
number = "9",
pages = "1317-1318",
url = "https://hdl.handle.net/21.15107/rcub_cer_1925"
}

Anchang, K. Y., Novaković, M., Bukvicki, D.,& Asakawa, Y.. (2016). Bis-bibenzyls from the Cameroon Liverwort Marchantia debilis. in Natural Product Communications
Natural Products Inc, Westerville., 11(9), 1317-1318.
https://hdl.handle.net/21.15107/rcub_cer_1925

Anchang KY, Novaković M, Bukvicki D, Asakawa Y. Bis-bibenzyls from the Cameroon Liverwort Marchantia debilis. in Natural Product Communications. 2016;11(9):1317-1318.
https://hdl.handle.net/21.15107/rcub_cer_1925 .

Anchang, Kenneth Yongabi, Novaković, Miroslav, Bukvicki, Danka, Asakawa, Yoshinori, "Bis-bibenzyls from the Cameroon Liverwort Marchantia debilis" in Natural Product Communications, 11, no. 9 (2016):1317-1318,
https://hdl.handle.net/21.15107/rcub_cer_1925 .

TY  - JOUR
AU  - Yongabi, Kenneth Anchang
AU  - Novaković, Miroslav
AU  - Bukvicki, Danka
AU  - Reeb, Catherine
AU  - Asakawa, Yoshinori
PY  - 2016
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1926
AB  - Diabetic bacterial foot infections (DBFIs) are limb-threatening complications in patients with diabetes mellitus, accounting for 50% of diabetes related lower limb amputations in developing countries, representing approximately 20 percent of all diabetes-related hospital admissions with significant healthcare-related costs involved. The widespread problem of bacterial resistance to most commonly used antibiotics places a huge economic burden on the healthcare system, with both increased morbidity and mortality among diabetic patients with foot infections. In this study, the antibacterial activity of organic extracts of the fresh liverwort Marchantia debilis from the North West Region of Cameroon is reported. An exit pool system, where patients presenting with DBFIs consented to be involved in the use of phytomedicines, after long term treatment of ulcers with antibiotics and not yielding significant long term benefit, presented themselves at the Phytobiotechnology Research clinic (PRF). Continuous culture of swabs from foot and toe wounds from 30 infected patients on nutrient agar and MacConkey agars in triplicate as well as Gram stain microscopy, revealed the presence of Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis and Bacillus species. Light petroleum and methanol extracts of the whole bryophyte plants at 100% concentration were tested. In vitro inhibition of the tested bacterial isolates from the diabetic foot ulcers by M debilis was observed only with the light petroleum extract. No inhibition by the extracts was observed for the Pseudomonas aeruginosa isolate. The light petroleum extract of M debilis was formulated into a petroleum oil based cream named BryoCream (TM). This was administered to 20 of the patients with 90% cure rate in a three week time period. The main nonpolar components were determined by GCMS as lepidozene and beta-barbatene, and by NMR. as stigmasterol and beta-sitosterol. In conclusion, nonpolar extracts from bryophytes from Cameroon could, potentially, be used to treat diabetic bacterial foot infections.
PB  - Natural Products Inc, Westerville
T2  - Natural Product Communications
T1  - Management of Diabetic Bacterial Foot Infections with Organic Extracts of Liverwort Marchantia debilis from Cameroon
VL  - 11
IS  - 9
SP  - 1333
EP  - 1336
UR  - https://hdl.handle.net/21.15107/rcub_cer_1926
ER  - 

@article{
author = "Yongabi, Kenneth Anchang and Novaković, Miroslav and Bukvicki, Danka and Reeb, Catherine and Asakawa, Yoshinori",
year = "2016",
abstract = "Diabetic bacterial foot infections (DBFIs) are limb-threatening complications in patients with diabetes mellitus, accounting for 50% of diabetes related lower limb amputations in developing countries, representing approximately 20 percent of all diabetes-related hospital admissions with significant healthcare-related costs involved. The widespread problem of bacterial resistance to most commonly used antibiotics places a huge economic burden on the healthcare system, with both increased morbidity and mortality among diabetic patients with foot infections. In this study, the antibacterial activity of organic extracts of the fresh liverwort Marchantia debilis from the North West Region of Cameroon is reported. An exit pool system, where patients presenting with DBFIs consented to be involved in the use of phytomedicines, after long term treatment of ulcers with antibiotics and not yielding significant long term benefit, presented themselves at the Phytobiotechnology Research clinic (PRF). Continuous culture of swabs from foot and toe wounds from 30 infected patients on nutrient agar and MacConkey agars in triplicate as well as Gram stain microscopy, revealed the presence of Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis and Bacillus species. Light petroleum and methanol extracts of the whole bryophyte plants at 100% concentration were tested. In vitro inhibition of the tested bacterial isolates from the diabetic foot ulcers by M debilis was observed only with the light petroleum extract. No inhibition by the extracts was observed for the Pseudomonas aeruginosa isolate. The light petroleum extract of M debilis was formulated into a petroleum oil based cream named BryoCream (TM). This was administered to 20 of the patients with 90% cure rate in a three week time period. The main nonpolar components were determined by GCMS as lepidozene and beta-barbatene, and by NMR. as stigmasterol and beta-sitosterol. In conclusion, nonpolar extracts from bryophytes from Cameroon could, potentially, be used to treat diabetic bacterial foot infections.",
publisher = "Natural Products Inc, Westerville",
journal = "Natural Product Communications",
title = "Management of Diabetic Bacterial Foot Infections with Organic Extracts of Liverwort Marchantia debilis from Cameroon",
volume = "11",
number = "9",
pages = "1333-1336",
url = "https://hdl.handle.net/21.15107/rcub_cer_1926"
}

Yongabi, K. A., Novaković, M., Bukvicki, D., Reeb, C.,& Asakawa, Y.. (2016). Management of Diabetic Bacterial Foot Infections with Organic Extracts of Liverwort Marchantia debilis from Cameroon. in Natural Product Communications
Natural Products Inc, Westerville., 11(9), 1333-1336.
https://hdl.handle.net/21.15107/rcub_cer_1926

Yongabi KA, Novaković M, Bukvicki D, Reeb C, Asakawa Y. Management of Diabetic Bacterial Foot Infections with Organic Extracts of Liverwort Marchantia debilis from Cameroon. in Natural Product Communications. 2016;11(9):1333-1336.
https://hdl.handle.net/21.15107/rcub_cer_1926 .

Yongabi, Kenneth Anchang, Novaković, Miroslav, Bukvicki, Danka, Reeb, Catherine, Asakawa, Yoshinori, "Management of Diabetic Bacterial Foot Infections with Organic Extracts of Liverwort Marchantia debilis from Cameroon" in Natural Product Communications, 11, no. 9 (2016):1333-1336,
https://hdl.handle.net/21.15107/rcub_cer_1926 .