TY  - JOUR
AU  - Baralić, Marko
AU  - Pažitná, Lucia
AU  - Brković, Voin
AU  - Laušević, Mirjana
AU  - Gligorijević, Nikola
AU  - Katrlík, Jaroslav
AU  - Nedić, Olgica
AU  - Robajac, Dragana
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5664
AB  - As we already reported, fibrinogen fucosylation emerged as a prognostic marker of peritoneal
membrane function in end-stage renal disease (ESRD) patients on peritoneal dialysis. After a
follow-up period of 18 months, we estimated the ability of employed lectins, as well as other biochemical
parameters, to serve as mortality predictors in these patients. Following a univariate Cox
regression analysis, ferritin, urea clearance, residual diuresis, hyperglycemia, and an increase in the
signal intensity obtained with Galanthus nivalis lectin (GNL) emerged as potential mortality predictors,
but additional multivariate Cox regression analysis pointed only to glucose concentration
and GNL as mortality predictors. Higher signal intensity obtained with GNL in patients that died
suggested the importance of paucimannosidic/highly mannosidic N-glycan structures on fibrinogen
as factors that are related to unwanted cardiovascular events and all-cause mortality and can possibly
be seen as a prediction tool. Altered glycan structures composed of mannose residues are expected
to affect the reactivity of mannosylated glycoproteins with mannose-binding lectin and possibly
the entire cascade of events linked to this lectin. Since patients with ESRD are prone to cardiovascular
complications and the formation of atherosclerotic plaques, one can hypothesize that fibrinogen
with increasingly exposed mannose residues may contribute to the unwanted events.
PB  - Switzerland : Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Cells
T1  - Prediction of Mortality in Patients on Peritoneal Dialysis Based on the Fibrinogen Mannosylation
VL  - 12
IS  - 351
DO  - 10.3390/cells12030351
ER  - 

@article{
author = "Baralić, Marko and Pažitná, Lucia and Brković, Voin and Laušević, Mirjana and Gligorijević, Nikola and Katrlík, Jaroslav and Nedić, Olgica and Robajac, Dragana",
year = "2023",
abstract = "As we already reported, fibrinogen fucosylation emerged as a prognostic marker of peritoneal
membrane function in end-stage renal disease (ESRD) patients on peritoneal dialysis. After a
follow-up period of 18 months, we estimated the ability of employed lectins, as well as other biochemical
parameters, to serve as mortality predictors in these patients. Following a univariate Cox
regression analysis, ferritin, urea clearance, residual diuresis, hyperglycemia, and an increase in the
signal intensity obtained with Galanthus nivalis lectin (GNL) emerged as potential mortality predictors,
but additional multivariate Cox regression analysis pointed only to glucose concentration
and GNL as mortality predictors. Higher signal intensity obtained with GNL in patients that died
suggested the importance of paucimannosidic/highly mannosidic N-glycan structures on fibrinogen
as factors that are related to unwanted cardiovascular events and all-cause mortality and can possibly
be seen as a prediction tool. Altered glycan structures composed of mannose residues are expected
to affect the reactivity of mannosylated glycoproteins with mannose-binding lectin and possibly
the entire cascade of events linked to this lectin. Since patients with ESRD are prone to cardiovascular
complications and the formation of atherosclerotic plaques, one can hypothesize that fibrinogen
with increasingly exposed mannose residues may contribute to the unwanted events.",
publisher = "Switzerland : Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Cells",
title = "Prediction of Mortality in Patients on Peritoneal Dialysis Based on the Fibrinogen Mannosylation",
volume = "12",
number = "351",
doi = "10.3390/cells12030351"
}

Baralić, M., Pažitná, L., Brković, V., Laušević, M., Gligorijević, N., Katrlík, J., Nedić, O.,& Robajac, D.. (2023). Prediction of Mortality in Patients on Peritoneal Dialysis Based on the Fibrinogen Mannosylation. in Cells
Switzerland : Multidisciplinary Digital Publishing Institute (MDPI)., 12(351).
https://doi.org/10.3390/cells12030351

Baralić M, Pažitná L, Brković V, Laušević M, Gligorijević N, Katrlík J, Nedić O, Robajac D. Prediction of Mortality in Patients on Peritoneal Dialysis Based on the Fibrinogen Mannosylation. in Cells. 2023;12(351).
doi:10.3390/cells12030351 .

Baralić, Marko, Pažitná, Lucia, Brković, Voin, Laušević, Mirjana, Gligorijević, Nikola, Katrlík, Jaroslav, Nedić, Olgica, Robajac, Dragana, "Prediction of Mortality in Patients on Peritoneal Dialysis Based on the Fibrinogen Mannosylation" in Cells, 12, no. 351 (2023),
https://doi.org/10.3390/cells12030351 . .