@article{
author = "Babić Radić, Marija M. and Filipović, Vuk and Vukomanović, Marija and Nikodinović Runić, Jasmina and Tomić, Simonida",
year = "2022",
abstract = "The design and evaluation of novel 2-hydroxyethyl methacrylate/gelatin/alginate/
graphene oxide hydrogels as innovative scaffolding biomaterials, which concurrently are the suitable
drug delivery carrier, was proposed. The hydrogels were prepared by the adapted porogen leaching
method; this is also the first time this method has been used to incorporate nanocolloidal graphene
oxide through the hydrogel and simultaneously form porous structures. The effects of a material’s
composition on its chemical, morphological, mechanical, and swelling properties, as well as on
cell viability and in vitro degradation, were assessed using Fourier transform infrared spectroscopy
(FTIR), scanning electron microscopy (SEM), measurements of Young’s modulus, gravimetric method
and MTT test, respectively. The engineered hydrogels show good swelling capacity, fully hydrophilic
surfaces, tunable porosity (from 56 to 76%) and mechanical properties (from 1.69 to 4.78 MPa),
curcumin entrapment efficiency above 99% and excellent curcumin release performances. In vitro
cytotoxicity on healthy human fibroblast (MRC5 cells) by MTT test reveal that the materials are
nontoxic and biocompatible, proposing novel hydrogels for in vivo clinical evaluation to optimize
tissue regeneration treatments by coupling the hydrogels with cells and different active agents to
create material/biofactor hybrids with new levels of biofunctionality.",
publisher = "MDPI",
journal = "Gels",
title = "Degradable 2-Hydroxyethyl Methacrylate/Gelatin/Alginate Hydrogels Infused by Nanocolloidal Graphene Oxide as Promising Drug Delivery and Scaffolding Biomaterials",
volume = "8",
number = "22",
pages = "2-14",
doi = "10.3390/gels8010022"
}
