TY  - JOUR
AU  - Miličević, Dejan
AU  - Trifunović, Saša
AU  - Mudrinić, Tihana
AU  - Leskovac, Andreja
AU  - Ignjatović, Nenad
AU  - Dojčilović, Jablan
AU  - Suljovrujić, Edin
PY  - 2010
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/7023
AB  - U ovom radu ispitivan je uticaj gama zračenja na molekulsku masu i staklasti prelaz poli-L-laktida (PLLA). S obzirom da je PLLA pri izlaganju visokoenergijskom zračenju sklon kidanju lanaca i velikoj degradaciji, promene u molekulskoj masi su određene primenom gel propusne hromatografije (GPC). Radijaciono-indukovane promene u staklastom prelazu su ispitane pomoću diferencijalno skenirajuće kalorimetrije (DSC). Prividna aktivaciona energija za staklasti prelaz, ΔH*, određena je na osnovu zavisnosti temperature staklastog prelaza, Tg, od brzine zagrevanja. Kidanje lanaca, uzrokovano zračenjem, glavni je razlog opadanja Tg i ΔH* sa apsorbovanom dozom. Izazvane promene u molekulskoj masi i temperaturi staklastog prelaza odigravaju se na predvidljiv i prilično precizan način. Stoga, gama zračenje može biti korišćeno nesamo za sterilizaciju nego i za dobijanje ovog biomaterijala poželjnih karakteristika.
AB  - The influence of gamma radiation on the structure and glass transition behaviour of poly-L-lactide (PLLA) has been studied. Since PLLA exposed to high-energy radiation in the presence of air is prone to chain scission reactions and large degradation, changes in molecular weight were obtained by the gel permeation chromatography (GPC). Alterations in the glass transition behaviour were investigated by differential scanning calorimetry (DSC). The apparent activation energy, ΔH*, for the glass transition was determined on the basis of the heating rate dependence of the glass transition temperature, Tg. Our findings support the fact that chain scission is the main reason for the decrease of Tg and ΔH* with the absorbed dose. At low doses, despite large changes in molecular weight, only small alterations are observed in the glass transition temperature and apparent activation energy. Further increase in the absorbed dose introduces not only significant changes in the molecular weight but also in the glass transition temperature and the activation energy. Such glass transition behavior is a manifestation of a well-known effect of molecular weight on Tg, postulated by the Fox–Flory equation. However, all the observed alterations are small and tolerable at absorbed doses required for sterilization (up to 25 kGy in most circumstances). Furthermore, this study reveals that the radiation-induced changes in the molecular weight and the glass transition temperature occur in a predictable and fairly accurate manner. Therefore, gamma radiation can be used not only for sterilization but also for tailoring desirable end-use properties of PLLA based implants.
PB  - Association of Chemical Engineers of Serbia
T2  - Hemijska industrija
T1  - Uticaj gama zračenja na molekulsku masu i staklasti prelaz PLLA
T1  - The Structure and Glass Transition Behaviour of PLLA under the Influence of Gamma Radiation
VL  - 64
IS  - 4
SP  - 275
EP  - 281
DO  - 10.2298/HEMIND100329020M
ER  - 

@article{
author = "Miličević, Dejan and Trifunović, Saša and Mudrinić, Tihana and Leskovac, Andreja and Ignjatović, Nenad and Dojčilović, Jablan and Suljovrujić, Edin",
year = "2010",
abstract = "U ovom radu ispitivan je uticaj gama zračenja na molekulsku masu i staklasti prelaz poli-L-laktida (PLLA). S obzirom da je PLLA pri izlaganju visokoenergijskom zračenju sklon kidanju lanaca i velikoj degradaciji, promene u molekulskoj masi su određene primenom gel propusne hromatografije (GPC). Radijaciono-indukovane promene u staklastom prelazu su ispitane pomoću diferencijalno skenirajuće kalorimetrije (DSC). Prividna aktivaciona energija za staklasti prelaz, ΔH*, određena je na osnovu zavisnosti temperature staklastog prelaza, Tg, od brzine zagrevanja. Kidanje lanaca, uzrokovano zračenjem, glavni je razlog opadanja Tg i ΔH* sa apsorbovanom dozom. Izazvane promene u molekulskoj masi i temperaturi staklastog prelaza odigravaju se na predvidljiv i prilično precizan način. Stoga, gama zračenje može biti korišćeno nesamo za sterilizaciju nego i za dobijanje ovog biomaterijala poželjnih karakteristika., The influence of gamma radiation on the structure and glass transition behaviour of poly-L-lactide (PLLA) has been studied. Since PLLA exposed to high-energy radiation in the presence of air is prone to chain scission reactions and large degradation, changes in molecular weight were obtained by the gel permeation chromatography (GPC). Alterations in the glass transition behaviour were investigated by differential scanning calorimetry (DSC). The apparent activation energy, ΔH*, for the glass transition was determined on the basis of the heating rate dependence of the glass transition temperature, Tg. Our findings support the fact that chain scission is the main reason for the decrease of Tg and ΔH* with the absorbed dose. At low doses, despite large changes in molecular weight, only small alterations are observed in the glass transition temperature and apparent activation energy. Further increase in the absorbed dose introduces not only significant changes in the molecular weight but also in the glass transition temperature and the activation energy. Such glass transition behavior is a manifestation of a well-known effect of molecular weight on Tg, postulated by the Fox–Flory equation. However, all the observed alterations are small and tolerable at absorbed doses required for sterilization (up to 25 kGy in most circumstances). Furthermore, this study reveals that the radiation-induced changes in the molecular weight and the glass transition temperature occur in a predictable and fairly accurate manner. Therefore, gamma radiation can be used not only for sterilization but also for tailoring desirable end-use properties of PLLA based implants.",
publisher = "Association of Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "Uticaj gama zračenja na molekulsku masu i staklasti prelaz PLLA, The Structure and Glass Transition Behaviour of PLLA under the Influence of Gamma Radiation",
volume = "64",
number = "4",
pages = "275-281",
doi = "10.2298/HEMIND100329020M"
}

Miličević, D., Trifunović, S., Mudrinić, T., Leskovac, A., Ignjatović, N., Dojčilović, J.,& Suljovrujić, E.. (2010). Uticaj gama zračenja na molekulsku masu i staklasti prelaz PLLA. in Hemijska industrija
Association of Chemical Engineers of Serbia., 64(4), 275-281.
https://doi.org/10.2298/HEMIND100329020M

Miličević D, Trifunović S, Mudrinić T, Leskovac A, Ignjatović N, Dojčilović J, Suljovrujić E. Uticaj gama zračenja na molekulsku masu i staklasti prelaz PLLA. in Hemijska industrija. 2010;64(4):275-281.
doi:10.2298/HEMIND100329020M .

Miličević, Dejan, Trifunović, Saša, Mudrinić, Tihana, Leskovac, Andreja, Ignjatović, Nenad, Dojčilović, Jablan, Suljovrujić, Edin, "Uticaj gama zračenja na molekulsku masu i staklasti prelaz PLLA" in Hemijska industrija, 64, no. 4 (2010):275-281,
https://doi.org/10.2298/HEMIND100329020M . .

TY  - CONF
AU  - Tomić, Simonida Lj.
AU  - Mićić, M.M.
AU  - Dłokić, D.
AU  - Vasiljević-Radović, Dana
AU  - Filipović, J.M.
AU  - Suljovrujić, E. H.
PY  - 2009
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/610
AB  - Silver(I) complexes based on itaconic acid hydrogel were prepared and characterized in order to examine the potential use of these materials. FTIR, AFM, in vitro fluid-uptake, metal sorption, and antibacterial activity assay measurements were used for the characterization. Silver(I) ion uptake by hydrogels based on 2-hydroxyethyl methacrylate (HEMA), ethylene glycol dimethacrylate (EGDMA), and different content of itaconic acid (2; 3.5; 5mol%) were determined by inductively coupled plasma mass spectrometry. The coordination sites for metal ions were identified, and the stability in in-vitro condition was determined. Incorporation of silver(I) ions into hydrogels and the influence of these ions on material diffusion properties were analyzed. It was found that the itaconic acid moiety is the determining factor which influences metal ion binding and, therefore, fluid uptake inside the polymer network. Furthermore, obtained hydrogels showed a satisfactory antibacterial activity.
C3  - Materials and Manufacturing Processes
T1  - Preparation of silver(I) complexes with itaconic acid-based hydrogels for biomedical application
VL  - 24
IS  - 10-11
SP  - 1197
EP  - 1201
DO  - 10.1080/10426910903022247
ER  - 

@conference{
author = "Tomić, Simonida Lj. and Mićić, M.M. and Dłokić, D. and Vasiljević-Radović, Dana and Filipović, J.M. and Suljovrujić, E. H.",
year = "2009",
abstract = "Silver(I) complexes based on itaconic acid hydrogel were prepared and characterized in order to examine the potential use of these materials. FTIR, AFM, in vitro fluid-uptake, metal sorption, and antibacterial activity assay measurements were used for the characterization. Silver(I) ion uptake by hydrogels based on 2-hydroxyethyl methacrylate (HEMA), ethylene glycol dimethacrylate (EGDMA), and different content of itaconic acid (2; 3.5; 5mol%) were determined by inductively coupled plasma mass spectrometry. The coordination sites for metal ions were identified, and the stability in in-vitro condition was determined. Incorporation of silver(I) ions into hydrogels and the influence of these ions on material diffusion properties were analyzed. It was found that the itaconic acid moiety is the determining factor which influences metal ion binding and, therefore, fluid uptake inside the polymer network. Furthermore, obtained hydrogels showed a satisfactory antibacterial activity.",
journal = "Materials and Manufacturing Processes",
title = "Preparation of silver(I) complexes with itaconic acid-based hydrogels for biomedical application",
volume = "24",
number = "10-11",
pages = "1197-1201",
doi = "10.1080/10426910903022247"
}

Tomić, S. Lj., Mićić, M.M., Dłokić, D., Vasiljević-Radović, D., Filipović, J.M.,& Suljovrujić, E. H.. (2009). Preparation of silver(I) complexes with itaconic acid-based hydrogels for biomedical application. in Materials and Manufacturing Processes, 24(10-11), 1197-1201.
https://doi.org/10.1080/10426910903022247

Tomić SL, Mićić M, Dłokić D, Vasiljević-Radović D, Filipović J, Suljovrujić EH. Preparation of silver(I) complexes with itaconic acid-based hydrogels for biomedical application. in Materials and Manufacturing Processes. 2009;24(10-11):1197-1201.
doi:10.1080/10426910903022247 .

Tomić, Simonida Lj., Mićić, M.M., Dłokić, D., Vasiljević-Radović, Dana, Filipović, J.M., Suljovrujić, E. H., "Preparation of silver(I) complexes with itaconic acid-based hydrogels for biomedical application" in Materials and Manufacturing Processes, 24, no. 10-11 (2009):1197-1201,
https://doi.org/10.1080/10426910903022247 . .