TY  - JOUR
AU  - Opsenica, Igor
AU  - Terzić-Jovanović, Nataša
AU  - Opsenica, Dejan
AU  - Milhous, Wilbur K.
AU  - Šolaja, Bogdan
PY  - 2004
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/140
AB  - Several C2 symmetrical mixed tetraoxanes were prepared starting from a gemdihydroperoxide and a ketone. The obtained tetraoxanes showed pronounced antimalarial activity against P. falciparum chloroquine resistant W2 and chloroquine susceptible D6 strains, with N-(2-dimethylamino)ethyl-7,8,15,16-tetraoxa-dispiro Š5.2.5.2Ćhexadecane-3-carboxamide being as active as artemisinin.
AB  - U ovom radu prikazana je sinteza serije C2 mešovitih tetraoksana polazeći od gem-dihidroperoksida cikloheksanona. Dobijenim derivatima ispitana je in vitro aktivnost prema W2 i D6 sojevima P. falciparum. Utvrđeno je da derivat N-(2-dimetilamino)etil 7,8,15,16-tetraoksa-dispiroŠ5.2.5.2Ćheksadekan-3-karboksamid pokazuje aktivnost vrlo blisku aktivnosti poznatog antimalarika artemizinina.
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - 7, 8, 15, 16-Tetraoxa-dispiro [5. 2. 5. 2]hexadecane-3-carboxylic acid derivatives and their antimalarial activity
T1  - Antimalarijska aktivnost derivata 7,8,15,16-tetraoksa-dispiro5.2.5.2heksadekan-3-karboksilne kiseline
VL  - 69
IS  - 11
SP  - 919
EP  - 922
DO  - 10.2298/JSC0411919O
ER  - 

@article{
author = "Opsenica, Igor and Terzić-Jovanović, Nataša and Opsenica, Dejan and Milhous, Wilbur K. and Šolaja, Bogdan",
year = "2004",
abstract = "Several C2 symmetrical mixed tetraoxanes were prepared starting from a gemdihydroperoxide and a ketone. The obtained tetraoxanes showed pronounced antimalarial activity against P. falciparum chloroquine resistant W2 and chloroquine susceptible D6 strains, with N-(2-dimethylamino)ethyl-7,8,15,16-tetraoxa-dispiro Š5.2.5.2Ćhexadecane-3-carboxamide being as active as artemisinin., U ovom radu prikazana je sinteza serije C2 mešovitih tetraoksana polazeći od gem-dihidroperoksida cikloheksanona. Dobijenim derivatima ispitana je in vitro aktivnost prema W2 i D6 sojevima P. falciparum. Utvrđeno je da derivat N-(2-dimetilamino)etil 7,8,15,16-tetraoksa-dispiroŠ5.2.5.2Ćheksadekan-3-karboksamid pokazuje aktivnost vrlo blisku aktivnosti poznatog antimalarika artemizinina.",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "7, 8, 15, 16-Tetraoxa-dispiro [5. 2. 5. 2]hexadecane-3-carboxylic acid derivatives and their antimalarial activity, Antimalarijska aktivnost derivata 7,8,15,16-tetraoksa-dispiro5.2.5.2heksadekan-3-karboksilne kiseline",
volume = "69",
number = "11",
pages = "919-922",
doi = "10.2298/JSC0411919O"
}

Opsenica, I., Terzić-Jovanović, N., Opsenica, D., Milhous, W. K.,& Šolaja, B.. (2004). 7, 8, 15, 16-Tetraoxa-dispiro [5. 2. 5. 2]hexadecane-3-carboxylic acid derivatives and their antimalarial activity. in Journal of the Serbian Chemical Society
Serbian Chemical Society., 69(11), 919-922.
https://doi.org/10.2298/JSC0411919O

Opsenica I, Terzić-Jovanović N, Opsenica D, Milhous WK, Šolaja B. 7, 8, 15, 16-Tetraoxa-dispiro [5. 2. 5. 2]hexadecane-3-carboxylic acid derivatives and their antimalarial activity. in Journal of the Serbian Chemical Society. 2004;69(11):919-922.
doi:10.2298/JSC0411919O .

Opsenica, Igor, Terzić-Jovanović, Nataša, Opsenica, Dejan, Milhous, Wilbur K., Šolaja, Bogdan, "7, 8, 15, 16-Tetraoxa-dispiro [5. 2. 5. 2]hexadecane-3-carboxylic acid derivatives and their antimalarial activity" in Journal of the Serbian Chemical Society, 69, no. 11 (2004):919-922,
https://doi.org/10.2298/JSC0411919O . .