TY  - JOUR
AU  - Nikolić-Kokić, Aleksandra
AU  - Stević, Zorica
AU  - Stojanović, Srđan
AU  - Blagojević, Duško
AU  - Jones, David
AU  - Pavlović, Sanja
AU  - Nikrtić, Vesna
AU  - Apostolski, Slobodan
AU  - Spasić, Mihajlo
PY  - 2005
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3868
AB  - Recent findings indicate that nitric oxide (NO•) over-production might be an important factor in thepathogenesis  of  sporadic  amyotrophic  lateral  sclerosis  (SALS).  We  measured  significantly  higherconcentrations   of   uric   acid   and   thiol   group-containing   molecules   (R–SH   groups)   in   thecerebrospinal  fluid  (CSF)  from  SALS  patients  compared  to  controls.  The  above  factors,  togetherwith a slightly increased free iron concentration found in the CSF, favour conditions necessary forthe  formation  of  the  dinitrosyl  iron  complex,  capable  of  NO•bio-transformation.  Thus,  weperformed ex vivosaturation of CSF (from both SALS patients and controls) with NO•. A decreasein the level of R–SH was found. This was more pronounced in the CSF from SALS patients. In theCSF from SALS patients the production of nitrite and hydroxylamine was greater than that observedin the CSF from controls. Moreover, we also found increased Cu,Zn-SOD activity in the CSF fromSALS  patients  (when  compared  to  control  subjects)  but  no  activity  corresponding  to  Mn-SOD  inany CSF samples. As Cu,Zn-SOD can react with nitroxyl forming NO•, the conditions for a closed,but continuous, loop of NO•biotransformation are present in the CSF of ALS patients.
PB  - Maney Publishing
T2  - Redox Report
T1  - Biotransformation of nitric oxide in the cerebrospinal fluid of amyotrophic lateral sclerosis patients
VL  - 10
IS  - 5
SP  - 265
EP  - 270
DO  - 10.1179/135100005X70242
ER  - 

@article{
author = "Nikolić-Kokić, Aleksandra and Stević, Zorica and Stojanović, Srđan and Blagojević, Duško and Jones, David and Pavlović, Sanja and Nikrtić, Vesna and Apostolski, Slobodan and Spasić, Mihajlo",
year = "2005",
abstract = "Recent findings indicate that nitric oxide (NO•) over-production might be an important factor in thepathogenesis  of  sporadic  amyotrophic  lateral  sclerosis  (SALS).  We  measured  significantly  higherconcentrations   of   uric   acid   and   thiol   group-containing   molecules   (R–SH   groups)   in   thecerebrospinal  fluid  (CSF)  from  SALS  patients  compared  to  controls.  The  above  factors,  togetherwith a slightly increased free iron concentration found in the CSF, favour conditions necessary forthe  formation  of  the  dinitrosyl  iron  complex,  capable  of  NO•bio-transformation.  Thus,  weperformed ex vivosaturation of CSF (from both SALS patients and controls) with NO•. A decreasein the level of R–SH was found. This was more pronounced in the CSF from SALS patients. In theCSF from SALS patients the production of nitrite and hydroxylamine was greater than that observedin the CSF from controls. Moreover, we also found increased Cu,Zn-SOD activity in the CSF fromSALS  patients  (when  compared  to  control  subjects)  but  no  activity  corresponding  to  Mn-SOD  inany CSF samples. As Cu,Zn-SOD can react with nitroxyl forming NO•, the conditions for a closed,but continuous, loop of NO•biotransformation are present in the CSF of ALS patients.",
publisher = "Maney Publishing",
journal = "Redox Report",
title = "Biotransformation of nitric oxide in the cerebrospinal fluid of amyotrophic lateral sclerosis patients",
volume = "10",
number = "5",
pages = "265-270",
doi = "10.1179/135100005X70242"
}

Nikolić-Kokić, A., Stević, Z., Stojanović, S., Blagojević, D., Jones, D., Pavlović, S., Nikrtić, V., Apostolski, S.,& Spasić, M.. (2005). Biotransformation of nitric oxide in the cerebrospinal fluid of amyotrophic lateral sclerosis patients. in Redox Report
Maney Publishing., 10(5), 265-270.
https://doi.org/10.1179/135100005X70242

Nikolić-Kokić A, Stević Z, Stojanović S, Blagojević D, Jones D, Pavlović S, Nikrtić V, Apostolski S, Spasić M. Biotransformation of nitric oxide in the cerebrospinal fluid of amyotrophic lateral sclerosis patients. in Redox Report. 2005;10(5):265-270.
doi:10.1179/135100005X70242 .

Nikolić-Kokić, Aleksandra, Stević, Zorica, Stojanović, Srđan, Blagojević, Duško, Jones, David, Pavlović, Sanja, Nikrtić, Vesna, Apostolski, Slobodan, Spasić, Mihajlo, "Biotransformation of nitric oxide in the cerebrospinal fluid of amyotrophic lateral sclerosis patients" in Redox Report, 10, no. 5 (2005):265-270,
https://doi.org/10.1179/135100005X70242 . .