TY  - CONF
AU  - Jokić, Ivana
AU  - Đurić, Zoran G.
AU  - Radulović, Katarina
AU  - Frantlović, Miloš
AU  - Krstajić, Predrag
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3256
AB  - Real-time in situ operation of bio/chemical sensors assumes detection of chemical substances or biological specimens in samples of complex composition. Since sensor selectivity cannot be ideal, adsorption of particles other than target particles inevitably occur on the sensing surface. That affects the sensor response and its intrinsic fluctuations which are caused by stochastic fluctuations of the numbers of adsorbed particles of all the adsorbing substances. In microfluidic sensors, such response fluctuations are a result of coupled adsorption, desorption and mass transfer (convection and diffusion) processes of analyte particles. Analysis of these fluctuations is important because they constitute the adsorption-desorption noise, which limits the sensing performance. In this work we perform the analysis of fluctuations by using a stochastic model of sensor response after the steady state is reached, in the case of two-analyte adsorption, considering mass transfer processes. The results enable estimation of the ultimate sensing performance of adsorption-based microfluidic bio/chemical sensors of different sensing areas, operating in bianalyte mixture environments.
PB  - Institute of Electrical and Electronics Engineers (IEEE)
C3  - 2019 IEEE 31st International Conference on Microelectronics, MIEL 2019 - Proceedings
T1  - Analysis of Intrinsic Stochastic Fluctuations of the Time Response of Adsorption-Based Microfluidic Bio/Chemical Sensors: the Case of Bianalyte Mixtures
SP  - 161
EP  - 164
DO  - 10.1109/MIEL.2019.8889579
ER  - 

@conference{
author = "Jokić, Ivana and Đurić, Zoran G. and Radulović, Katarina and Frantlović, Miloš and Krstajić, Predrag",
year = "2019",
abstract = "Real-time in situ operation of bio/chemical sensors assumes detection of chemical substances or biological specimens in samples of complex composition. Since sensor selectivity cannot be ideal, adsorption of particles other than target particles inevitably occur on the sensing surface. That affects the sensor response and its intrinsic fluctuations which are caused by stochastic fluctuations of the numbers of adsorbed particles of all the adsorbing substances. In microfluidic sensors, such response fluctuations are a result of coupled adsorption, desorption and mass transfer (convection and diffusion) processes of analyte particles. Analysis of these fluctuations is important because they constitute the adsorption-desorption noise, which limits the sensing performance. In this work we perform the analysis of fluctuations by using a stochastic model of sensor response after the steady state is reached, in the case of two-analyte adsorption, considering mass transfer processes. The results enable estimation of the ultimate sensing performance of adsorption-based microfluidic bio/chemical sensors of different sensing areas, operating in bianalyte mixture environments.",
publisher = "Institute of Electrical and Electronics Engineers (IEEE)",
journal = "2019 IEEE 31st International Conference on Microelectronics, MIEL 2019 - Proceedings",
title = "Analysis of Intrinsic Stochastic Fluctuations of the Time Response of Adsorption-Based Microfluidic Bio/Chemical Sensors: the Case of Bianalyte Mixtures",
pages = "161-164",
doi = "10.1109/MIEL.2019.8889579"
}

Jokić, I., Đurić, Z. G., Radulović, K., Frantlović, M.,& Krstajić, P.. (2019). Analysis of Intrinsic Stochastic Fluctuations of the Time Response of Adsorption-Based Microfluidic Bio/Chemical Sensors: the Case of Bianalyte Mixtures. in 2019 IEEE 31st International Conference on Microelectronics, MIEL 2019 - Proceedings
Institute of Electrical and Electronics Engineers (IEEE)., 161-164.
https://doi.org/10.1109/MIEL.2019.8889579

Jokić I, Đurić ZG, Radulović K, Frantlović M, Krstajić P. Analysis of Intrinsic Stochastic Fluctuations of the Time Response of Adsorption-Based Microfluidic Bio/Chemical Sensors: the Case of Bianalyte Mixtures. in 2019 IEEE 31st International Conference on Microelectronics, MIEL 2019 - Proceedings. 2019;:161-164.
doi:10.1109/MIEL.2019.8889579 .

Jokić, Ivana, Đurić, Zoran G., Radulović, Katarina, Frantlović, Miloš, Krstajić, Predrag, "Analysis of Intrinsic Stochastic Fluctuations of the Time Response of Adsorption-Based Microfluidic Bio/Chemical Sensors: the Case of Bianalyte Mixtures" in 2019 IEEE 31st International Conference on Microelectronics, MIEL 2019 - Proceedings (2019):161-164,
https://doi.org/10.1109/MIEL.2019.8889579 . .

TY  - CONF
AU  - Jokić, Ivana
AU  - Radulović, Katarina
AU  - Frantlović, Miloš
AU  - Đurić, Zoran G.
AU  - Cvetanović Zobenica, Katarina
AU  - Krstajić, Predrag
PY  - 2019
UR  - http://dais.sanu.ac.rs/123456789/6961
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3326
AB  - Detection limits in microfluidic chemical and biological sensors, which determine the range of analyte concentrations reliably detectable by the sensor, are important sensor parameters. The lower limit of detection, defined as the lowest concentration that can be distinguished from noise, has its minimum determined by the fundamental adsorption-desorption (AD) noise, inevitable in adsorption-based devices. In this work, we analyze this fundamental detection limit, particularly considering the influence of mass transfer processes in microfluidic devices. For that purpose, we derive the expression for the sensor’s signal-to-noise ratio (SNR), which takes into account the AD noise, and then the equation for the minimal analyte concentration at which the SNR has a sufficiently high value for reliable analyte detection. Subsequently, we analyze the mass transfer influence on the sensor’s maximal achievable signal-to-noise ratio and on the fundamental detection limit. The results of the analysis show a significant mass transfer influence on these important sensor performance metrics. They also provide guidelines for achieving the sensor’s best possible detection performance through the optimization of the sensor design and operating conditions.
PB  - Belgrade : ETRAN
PB  - Belgrade :Academic Mind
C3  - Proceedings of Papers – 6th International Conference on Electrical, Electronic and Computing Engineering, IcETRAN 2019, Silver Lake, Serbia, June 03 – 06, 2019 / Zbornik radova - 63. Konferencija za elektroniku, telekomunikacije, računarstvo, automatiku i nuklearnu tehniku, Srebrno jezero, 03 – 06. juna, 2019. godine
T1  - Analysis of the Fundamental Detection Limit in Microfluidic Chemical and Biological Sensors
SP  - 571
EP  - 574
UR  - https://hdl.handle.net/21.15107/rcub_dais_6961
ER  - 

@conference{
author = "Jokić, Ivana and Radulović, Katarina and Frantlović, Miloš and Đurić, Zoran G. and Cvetanović Zobenica, Katarina and Krstajić, Predrag",
year = "2019",
abstract = "Detection limits in microfluidic chemical and biological sensors, which determine the range of analyte concentrations reliably detectable by the sensor, are important sensor parameters. The lower limit of detection, defined as the lowest concentration that can be distinguished from noise, has its minimum determined by the fundamental adsorption-desorption (AD) noise, inevitable in adsorption-based devices. In this work, we analyze this fundamental detection limit, particularly considering the influence of mass transfer processes in microfluidic devices. For that purpose, we derive the expression for the sensor’s signal-to-noise ratio (SNR), which takes into account the AD noise, and then the equation for the minimal analyte concentration at which the SNR has a sufficiently high value for reliable analyte detection. Subsequently, we analyze the mass transfer influence on the sensor’s maximal achievable signal-to-noise ratio and on the fundamental detection limit. The results of the analysis show a significant mass transfer influence on these important sensor performance metrics. They also provide guidelines for achieving the sensor’s best possible detection performance through the optimization of the sensor design and operating conditions.",
publisher = "Belgrade : ETRAN, Belgrade :Academic Mind",
journal = "Proceedings of Papers – 6th International Conference on Electrical, Electronic and Computing Engineering, IcETRAN 2019, Silver Lake, Serbia, June 03 – 06, 2019 / Zbornik radova - 63. Konferencija za elektroniku, telekomunikacije, računarstvo, automatiku i nuklearnu tehniku, Srebrno jezero, 03 – 06. juna, 2019. godine",
title = "Analysis of the Fundamental Detection Limit in Microfluidic Chemical and Biological Sensors",
pages = "571-574",
url = "https://hdl.handle.net/21.15107/rcub_dais_6961"
}

Jokić, I., Radulović, K., Frantlović, M., Đurić, Z. G., Cvetanović Zobenica, K.,& Krstajić, P.. (2019). Analysis of the Fundamental Detection Limit in Microfluidic Chemical and Biological Sensors. in Proceedings of Papers – 6th International Conference on Electrical, Electronic and Computing Engineering, IcETRAN 2019, Silver Lake, Serbia, June 03 – 06, 2019 / Zbornik radova - 63. Konferencija za elektroniku, telekomunikacije, računarstvo, automatiku i nuklearnu tehniku, Srebrno jezero, 03 – 06. juna, 2019. godine
Belgrade : ETRAN., 571-574.
https://hdl.handle.net/21.15107/rcub_dais_6961

Jokić I, Radulović K, Frantlović M, Đurić ZG, Cvetanović Zobenica K, Krstajić P. Analysis of the Fundamental Detection Limit in Microfluidic Chemical and Biological Sensors. in Proceedings of Papers – 6th International Conference on Electrical, Electronic and Computing Engineering, IcETRAN 2019, Silver Lake, Serbia, June 03 – 06, 2019 / Zbornik radova - 63. Konferencija za elektroniku, telekomunikacije, računarstvo, automatiku i nuklearnu tehniku, Srebrno jezero, 03 – 06. juna, 2019. godine. 2019;:571-574.
https://hdl.handle.net/21.15107/rcub_dais_6961 .

Jokić, Ivana, Radulović, Katarina, Frantlović, Miloš, Đurić, Zoran G., Cvetanović Zobenica, Katarina, Krstajić, Predrag, "Analysis of the Fundamental Detection Limit in Microfluidic Chemical and Biological Sensors" in Proceedings of Papers – 6th International Conference on Electrical, Electronic and Computing Engineering, IcETRAN 2019, Silver Lake, Serbia, June 03 – 06, 2019 / Zbornik radova - 63. Konferencija za elektroniku, telekomunikacije, računarstvo, automatiku i nuklearnu tehniku, Srebrno jezero, 03 – 06. juna, 2019. godine (2019):571-574,
https://hdl.handle.net/21.15107/rcub_dais_6961 .

TY  - CONF
AU  - Jokić, Ivana
AU  - Đurić, Zoran G.
AU  - Radulović, Katarina
AU  - Frantlović, Miloš
PY  - 2018
UR  - https://www.mdpi.com/2504-3900/2/13/991
UR  - http://dais.sanu.ac.rs/123456789/4715
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2607
AB  - A model of stochastic time response of adsorption-based microfluidic biosensors is presented, that considers the competitive adsorption-desorption process coupled with mass transfer of two analytes. By using the model we analyze the expected value of the adsorbed particles number of each analyte, which determine the sensor response kinetics. The comparison with the case when only one analyte exists is used for investigation of the influence of competitive adsorption on the sensor response. The response kinetics analyzed by using the stochastic model is compared with the kinetics predicted by the deterministic response model. The results are useful for optimization of micro/nanosensors intended for detection of substances in ultra-low concentrations in complex samples.
PB  - MDPI
C3  - Proceedings, Volume 2, Eurosensors 2018
T1  - Analysis of Stochastic Time Response of Microfluidic Biosensors in the Case of Competitive Adsorption of Two Analytes
VL  - 2
IS  - 13
SP  - 991
DO  - 10.3390/proceedings2130991
ER  - 

@conference{
author = "Jokić, Ivana and Đurić, Zoran G. and Radulović, Katarina and Frantlović, Miloš",
year = "2018",
abstract = "A model of stochastic time response of adsorption-based microfluidic biosensors is presented, that considers the competitive adsorption-desorption process coupled with mass transfer of two analytes. By using the model we analyze the expected value of the adsorbed particles number of each analyte, which determine the sensor response kinetics. The comparison with the case when only one analyte exists is used for investigation of the influence of competitive adsorption on the sensor response. The response kinetics analyzed by using the stochastic model is compared with the kinetics predicted by the deterministic response model. The results are useful for optimization of micro/nanosensors intended for detection of substances in ultra-low concentrations in complex samples.",
publisher = "MDPI",
journal = "Proceedings, Volume 2, Eurosensors 2018",
title = "Analysis of Stochastic Time Response of Microfluidic Biosensors in the Case of Competitive Adsorption of Two Analytes",
volume = "2",
number = "13",
pages = "991",
doi = "10.3390/proceedings2130991"
}

Jokić, I., Đurić, Z. G., Radulović, K.,& Frantlović, M.. (2018). Analysis of Stochastic Time Response of Microfluidic Biosensors in the Case of Competitive Adsorption of Two Analytes. in Proceedings, Volume 2, Eurosensors 2018
MDPI., 2(13), 991.
https://doi.org/10.3390/proceedings2130991

Jokić I, Đurić ZG, Radulović K, Frantlović M. Analysis of Stochastic Time Response of Microfluidic Biosensors in the Case of Competitive Adsorption of Two Analytes. in Proceedings, Volume 2, Eurosensors 2018. 2018;2(13):991.
doi:10.3390/proceedings2130991 .

Jokić, Ivana, Đurić, Zoran G., Radulović, Katarina, Frantlović, Miloš, "Analysis of Stochastic Time Response of Microfluidic Biosensors in the Case of Competitive Adsorption of Two Analytes" in Proceedings, Volume 2, Eurosensors 2018, 2, no. 13 (2018):991,
https://doi.org/10.3390/proceedings2130991 . .

TY  - CONF
AU  - Jokić, Ivana
AU  - Đurić, Zoran G.
AU  - Radulović, Katarina
AU  - Frantlović, Miloš
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2419
AB  - We investigate the stochastic sensor response in equilibrium, taking into account competitive adsorption and mass transfer of analyte particles in a microfluidic biosensor chamber. After presentation of the stochastic model, we perform the analysis of the equilibrium response expected value as a function of the sensing area and the competitor molecules concentrations. By comparison with the deterministic value of the sensor response, the limits of applicability of the deterministic approach are investigated. The results of the presented analysis enable better interpretation of measurement results obtained by using sensors with micro/nanoscale sensing surface, as well as optimization of their design and operating conditions.
C3  - Materials Today-Proceedings
T1  - Deterministic versus Stochastic Analysis of Competitive Adsorption in Equilibrium in Microfluidic Biosensors
VL  - 5
IS  - 8
SP  - 16006
EP  - 16011
DO  - 10.1016/j.matpr.2018.05.045
ER  - 

@conference{
author = "Jokić, Ivana and Đurić, Zoran G. and Radulović, Katarina and Frantlović, Miloš",
year = "2018",
abstract = "We investigate the stochastic sensor response in equilibrium, taking into account competitive adsorption and mass transfer of analyte particles in a microfluidic biosensor chamber. After presentation of the stochastic model, we perform the analysis of the equilibrium response expected value as a function of the sensing area and the competitor molecules concentrations. By comparison with the deterministic value of the sensor response, the limits of applicability of the deterministic approach are investigated. The results of the presented analysis enable better interpretation of measurement results obtained by using sensors with micro/nanoscale sensing surface, as well as optimization of their design and operating conditions.",
journal = "Materials Today-Proceedings",
title = "Deterministic versus Stochastic Analysis of Competitive Adsorption in Equilibrium in Microfluidic Biosensors",
volume = "5",
number = "8",
pages = "16006-16011",
doi = "10.1016/j.matpr.2018.05.045"
}

Jokić, I., Đurić, Z. G., Radulović, K.,& Frantlović, M.. (2018). Deterministic versus Stochastic Analysis of Competitive Adsorption in Equilibrium in Microfluidic Biosensors. in Materials Today-Proceedings, 5(8), 16006-16011.
https://doi.org/10.1016/j.matpr.2018.05.045

Jokić I, Đurić ZG, Radulović K, Frantlović M. Deterministic versus Stochastic Analysis of Competitive Adsorption in Equilibrium in Microfluidic Biosensors. in Materials Today-Proceedings. 2018;5(8):16006-16011.
doi:10.1016/j.matpr.2018.05.045 .

Jokić, Ivana, Đurić, Zoran G., Radulović, Katarina, Frantlović, Miloš, "Deterministic versus Stochastic Analysis of Competitive Adsorption in Equilibrium in Microfluidic Biosensors" in Materials Today-Proceedings, 5, no. 8 (2018):16006-16011,
https://doi.org/10.1016/j.matpr.2018.05.045 . .

TY  - CONF
AU  - Jokić, Ivana
AU  - Đurić, Zoran G.
AU  - Radulović, Katarina
AU  - Frantlović, Miloš
PY  - 2017
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2101
AB  - An approximate model for efficient analysis of stochastic time response of microfluidic biosensors is presented, that considers a random AD process coupled with mass transfer (convection and diffusion) of target substance particles. The deterministic model of sensor response is also reviewed. We perform the analysis of the mass transfer influence on the kinetics and the steady-state value of the response calculated according to the two models (deterministic and stochastic). The results are presented for the sensors with different micro/nanoscale active surfaces. The comparison of the responses obtained by using the two models can be utilized to distinguish the cases in which the application of the deterministic model is justified from those in which the stochastic model is necessary. The presented findings enable more accurate interpretation of measurement results obtained by using micro/nanobiosensors.
PB  - Institute of Electrical and Electronics Engineers Inc.
C3  - Proceedings of the International Conference on Microelectronics, ICM
T1  - Stochastic Time Response of Adsorption-based Micro/Nanobiosensors with a Fluidic Reaction Chamber: the Influence of Mass Transfer
SP  - 127
EP  - 130
DO  - 10.1109/MIEL.2017.8190084
ER  - 

@conference{
author = "Jokić, Ivana and Đurić, Zoran G. and Radulović, Katarina and Frantlović, Miloš",
year = "2017",
abstract = "An approximate model for efficient analysis of stochastic time response of microfluidic biosensors is presented, that considers a random AD process coupled with mass transfer (convection and diffusion) of target substance particles. The deterministic model of sensor response is also reviewed. We perform the analysis of the mass transfer influence on the kinetics and the steady-state value of the response calculated according to the two models (deterministic and stochastic). The results are presented for the sensors with different micro/nanoscale active surfaces. The comparison of the responses obtained by using the two models can be utilized to distinguish the cases in which the application of the deterministic model is justified from those in which the stochastic model is necessary. The presented findings enable more accurate interpretation of measurement results obtained by using micro/nanobiosensors.",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
journal = "Proceedings of the International Conference on Microelectronics, ICM",
title = "Stochastic Time Response of Adsorption-based Micro/Nanobiosensors with a Fluidic Reaction Chamber: the Influence of Mass Transfer",
pages = "127-130",
doi = "10.1109/MIEL.2017.8190084"
}

Jokić, I., Đurić, Z. G., Radulović, K.,& Frantlović, M.. (2017). Stochastic Time Response of Adsorption-based Micro/Nanobiosensors with a Fluidic Reaction Chamber: the Influence of Mass Transfer. in Proceedings of the International Conference on Microelectronics, ICM
Institute of Electrical and Electronics Engineers Inc.., 127-130.
https://doi.org/10.1109/MIEL.2017.8190084

Jokić I, Đurić ZG, Radulović K, Frantlović M. Stochastic Time Response of Adsorption-based Micro/Nanobiosensors with a Fluidic Reaction Chamber: the Influence of Mass Transfer. in Proceedings of the International Conference on Microelectronics, ICM. 2017;:127-130.
doi:10.1109/MIEL.2017.8190084 .

Jokić, Ivana, Đurić, Zoran G., Radulović, Katarina, Frantlović, Miloš, "Stochastic Time Response of Adsorption-based Micro/Nanobiosensors with a Fluidic Reaction Chamber: the Influence of Mass Transfer" in Proceedings of the International Conference on Microelectronics, ICM (2017):127-130,
https://doi.org/10.1109/MIEL.2017.8190084 . .

TY  - JOUR
AU  - Jokić, Ivana
AU  - Frantlović, Miloš
AU  - Đurić, Zoran G.
AU  - Radulović, Katarina
AU  - Jokic, Zorana
PY  - 2015
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1615
AB  - We present a theoretical model of adsorption-desorption (AD) noise in microfluidic biosensors operating in multianalyte environments. This noise is caused by the stochastic nature of the processes that generate the sensor response: reversible adsorption of n analytes coupled with mass transfer (convection and diffusion) of analyte particles through the microfluidic channel to and from the surface binding sites. The parameters of the obtained analytical expression for the AD noise power spectral density, determining the shape of the noise spectrum, contain information on the concentrations of all the adsorbing species, their association and dissociation rate constants, mass transfer coefficients and molecular masses. The AD noise spectrum, therefore, offers additional data about multiple analytes, apart from those obtained by the commonly used time domain analysis of sensor response. Therefore the derived model of AD noise contributes to the theoretical basis necessary for the development of new methods for determination of target analyte parameters in complex samples or even for simultaneous detection of multiple analytes using a single sensor, based on the measured noise spectrum.
PB  - Elsevier
T2  - Microelectronic Engineering
T1  - Adsorption-desorption noise in microfluidic biosensors operating in multianalyte environments
VL  - 144
SP  - 32
EP  - 36
DO  - 10.1016/j.mee.2015.02.032
ER  - 

@article{
author = "Jokić, Ivana and Frantlović, Miloš and Đurić, Zoran G. and Radulović, Katarina and Jokic, Zorana",
year = "2015",
abstract = "We present a theoretical model of adsorption-desorption (AD) noise in microfluidic biosensors operating in multianalyte environments. This noise is caused by the stochastic nature of the processes that generate the sensor response: reversible adsorption of n analytes coupled with mass transfer (convection and diffusion) of analyte particles through the microfluidic channel to and from the surface binding sites. The parameters of the obtained analytical expression for the AD noise power spectral density, determining the shape of the noise spectrum, contain information on the concentrations of all the adsorbing species, their association and dissociation rate constants, mass transfer coefficients and molecular masses. The AD noise spectrum, therefore, offers additional data about multiple analytes, apart from those obtained by the commonly used time domain analysis of sensor response. Therefore the derived model of AD noise contributes to the theoretical basis necessary for the development of new methods for determination of target analyte parameters in complex samples or even for simultaneous detection of multiple analytes using a single sensor, based on the measured noise spectrum.",
publisher = "Elsevier",
journal = "Microelectronic Engineering",
title = "Adsorption-desorption noise in microfluidic biosensors operating in multianalyte environments",
volume = "144",
pages = "32-36",
doi = "10.1016/j.mee.2015.02.032"
}

Jokić, I., Frantlović, M., Đurić, Z. G., Radulović, K.,& Jokic, Z.. (2015). Adsorption-desorption noise in microfluidic biosensors operating in multianalyte environments. in Microelectronic Engineering
Elsevier., 144, 32-36.
https://doi.org/10.1016/j.mee.2015.02.032

Jokić I, Frantlović M, Đurić ZG, Radulović K, Jokic Z. Adsorption-desorption noise in microfluidic biosensors operating in multianalyte environments. in Microelectronic Engineering. 2015;144:32-36.
doi:10.1016/j.mee.2015.02.032 .

Jokić, Ivana, Frantlović, Miloš, Đurić, Zoran G., Radulović, Katarina, Jokic, Zorana, "Adsorption-desorption noise in microfluidic biosensors operating in multianalyte environments" in Microelectronic Engineering, 144 (2015):32-36,
https://doi.org/10.1016/j.mee.2015.02.032 . .

TY  - JOUR
AU  - Đurić, Zoran G.
AU  - Jokić, Ivana
AU  - Peleš, Adriana
PY  - 2014
UR  - http://dais.sanu.ac.rs/123456789/4727
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2604
AB  - In this study we have developed, for the first time, the comprehensive theoretical model of the fluctuations of the number of adsorbed molecules in MEMS chemical and biological sensors, taking into account the processes of mass transfer, adsorption and desorption, and surface diffusion of adsorbed molecules. It is observed that the shape of the fluctuations spectrum contains information about various parameters of the adsorbed analyte and that even the analytes with the same affinity for the same binding sites have different spectra. The numerical calculations performed using the derived theory show that the influence of surface diffusion on the fluctuations spectrum can be significant. The practical value of this work stems from the fact that the fluctuations of the number of adsorbed molecules can be a dominant noise component in affinity-based bio/chemical sensors. Therefore, the derived theory is useful for development of the methods for the detection of analytes based on frequency domain analysis of the measured fluctuations. The recognition of an adsorbed analyte using sensors with non-functionalized sensing surface will also be considered using the presented theory.
PB  - Elsevier
T2  - Microelectronic Engineering
T1  - Fluctuations of the number of adsorbed molecules due to adsorption–desorption processes coupled with mass transfer and surface diffusion in bio/chemical MEMS sensors
VL  - 124
SP  - 81
EP  - 85
DO  - 10.1016/j.mee.2014.06.001
ER  - 

@article{
author = "Đurić, Zoran G. and Jokić, Ivana and Peleš, Adriana",
year = "2014",
abstract = "In this study we have developed, for the first time, the comprehensive theoretical model of the fluctuations of the number of adsorbed molecules in MEMS chemical and biological sensors, taking into account the processes of mass transfer, adsorption and desorption, and surface diffusion of adsorbed molecules. It is observed that the shape of the fluctuations spectrum contains information about various parameters of the adsorbed analyte and that even the analytes with the same affinity for the same binding sites have different spectra. The numerical calculations performed using the derived theory show that the influence of surface diffusion on the fluctuations spectrum can be significant. The practical value of this work stems from the fact that the fluctuations of the number of adsorbed molecules can be a dominant noise component in affinity-based bio/chemical sensors. Therefore, the derived theory is useful for development of the methods for the detection of analytes based on frequency domain analysis of the measured fluctuations. The recognition of an adsorbed analyte using sensors with non-functionalized sensing surface will also be considered using the presented theory.",
publisher = "Elsevier",
journal = "Microelectronic Engineering",
title = "Fluctuations of the number of adsorbed molecules due to adsorption–desorption processes coupled with mass transfer and surface diffusion in bio/chemical MEMS sensors",
volume = "124",
pages = "81-85",
doi = "10.1016/j.mee.2014.06.001"
}

Đurić, Z. G., Jokić, I.,& Peleš, A.. (2014). Fluctuations of the number of adsorbed molecules due to adsorption–desorption processes coupled with mass transfer and surface diffusion in bio/chemical MEMS sensors. in Microelectronic Engineering
Elsevier., 124, 81-85.
https://doi.org/10.1016/j.mee.2014.06.001

Đurić ZG, Jokić I, Peleš A. Fluctuations of the number of adsorbed molecules due to adsorption–desorption processes coupled with mass transfer and surface diffusion in bio/chemical MEMS sensors. in Microelectronic Engineering. 2014;124:81-85.
doi:10.1016/j.mee.2014.06.001 .

Đurić, Zoran G., Jokić, Ivana, Peleš, Adriana, "Fluctuations of the number of adsorbed molecules due to adsorption–desorption processes coupled with mass transfer and surface diffusion in bio/chemical MEMS sensors" in Microelectronic Engineering, 124 (2014):81-85,
https://doi.org/10.1016/j.mee.2014.06.001 . .

TY  - JOUR
AU  - Đurić, Zoran G.
AU  - Jokić, Ivana
AU  - Peleš, Adriana
PY  - 2014
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1410
AB  - In this study we have developed, for the first time, the comprehensive theoretical model of the fluctuations of the number of adsorbed molecules in MEMS chemical and biological sensors, taking into account the processes of mass transfer, adsorption and desorption, and surface diffusion of adsorbed molecules. It is observed that the shape of the fluctuations spectrum contains information about various parameters of the adsorbed analyte and that even the analytes with the same affinity for the same binding sites have different spectra. The numerical calculations performed using the derived theory show that the influence of surface diffusion on the fluctuations spectrum can be significant. The practical value of this work stems from the fact that the fluctuations of the number of adsorbed molecules can be a dominant noise component in affinity-based bio/chemical sensors. Therefore, the derived theory is useful for development of the methods for the detection of analytes based on frequency domain analysis of the measured fluctuations. The recognition of an adsorbed analyte using sensors with non-functionalized sensing surface will also be considered using the presented theory.
PB  - Elsevier
T2  - Microelectronic Engineering
T1  - Fluctuations of the number of adsorbed molecules due to adsorption-desorption processes coupled with mass transfer and surface diffusion in bio/chemical MEMS sensors
VL  - 124
SP  - 81
EP  - 85
DO  - 10.1016/j.mee.2014.06.001
ER  - 

@article{
author = "Đurić, Zoran G. and Jokić, Ivana and Peleš, Adriana",
year = "2014",
abstract = "In this study we have developed, for the first time, the comprehensive theoretical model of the fluctuations of the number of adsorbed molecules in MEMS chemical and biological sensors, taking into account the processes of mass transfer, adsorption and desorption, and surface diffusion of adsorbed molecules. It is observed that the shape of the fluctuations spectrum contains information about various parameters of the adsorbed analyte and that even the analytes with the same affinity for the same binding sites have different spectra. The numerical calculations performed using the derived theory show that the influence of surface diffusion on the fluctuations spectrum can be significant. The practical value of this work stems from the fact that the fluctuations of the number of adsorbed molecules can be a dominant noise component in affinity-based bio/chemical sensors. Therefore, the derived theory is useful for development of the methods for the detection of analytes based on frequency domain analysis of the measured fluctuations. The recognition of an adsorbed analyte using sensors with non-functionalized sensing surface will also be considered using the presented theory.",
publisher = "Elsevier",
journal = "Microelectronic Engineering",
title = "Fluctuations of the number of adsorbed molecules due to adsorption-desorption processes coupled with mass transfer and surface diffusion in bio/chemical MEMS sensors",
volume = "124",
pages = "81-85",
doi = "10.1016/j.mee.2014.06.001"
}

Đurić, Z. G., Jokić, I.,& Peleš, A.. (2014). Fluctuations of the number of adsorbed molecules due to adsorption-desorption processes coupled with mass transfer and surface diffusion in bio/chemical MEMS sensors. in Microelectronic Engineering
Elsevier., 124, 81-85.
https://doi.org/10.1016/j.mee.2014.06.001

Đurić ZG, Jokić I, Peleš A. Fluctuations of the number of adsorbed molecules due to adsorption-desorption processes coupled with mass transfer and surface diffusion in bio/chemical MEMS sensors. in Microelectronic Engineering. 2014;124:81-85.
doi:10.1016/j.mee.2014.06.001 .

Đurić, Zoran G., Jokić, Ivana, Peleš, Adriana, "Fluctuations of the number of adsorbed molecules due to adsorption-desorption processes coupled with mass transfer and surface diffusion in bio/chemical MEMS sensors" in Microelectronic Engineering, 124 (2014):81-85,
https://doi.org/10.1016/j.mee.2014.06.001 . .

TY  - JOUR
AU  - Frantlović, Miloš
AU  - Jokić, Ivana
AU  - Đurić, Zoran G.
AU  - Radulović, Katarina
PY  - 2013
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1255
AB  - We analyze the fluctuations of the equilibrium adsorbed mass in affinity-based biosensors, considering adsorption-desorption and mass transfer processes of two molecular species which compete for binding to the same probe molecules immobilized on the sensing surface. The analytical expression for the fluctuations spectral density is derived. The calculations show the significant influence of both the competitive adsorption and the mass transfer on the fluctuations spectrum, and also of their combined effect. The dependences of the fluctuations on association and dissociation rate constants of both adsorbing species, their concentrations, molecular masses and mass transfer coefficients and also on the density of capturing probes can be examined by using the presented model. The model is applicable for biosensors in which the spatial distribution of adsorbates concentrations in the reaction chamber can be approximated using the two-compartment model. The theory provides a more realistic estimation of the biosensors' limiting performance, and is useful for their improvement.
PB  - Elsevier
T2  - Sensors and Actuators, B: Chemical
T1  - Analysis of the competitive adsorption and mass transfer influence on equilibrium mass fluctuations in affinity-based biosensors
VL  - 189
SP  - 71
EP  - 79
DO  - 10.1016/j.snb.2012.12.080
ER  - 

@article{
author = "Frantlović, Miloš and Jokić, Ivana and Đurić, Zoran G. and Radulović, Katarina",
year = "2013",
abstract = "We analyze the fluctuations of the equilibrium adsorbed mass in affinity-based biosensors, considering adsorption-desorption and mass transfer processes of two molecular species which compete for binding to the same probe molecules immobilized on the sensing surface. The analytical expression for the fluctuations spectral density is derived. The calculations show the significant influence of both the competitive adsorption and the mass transfer on the fluctuations spectrum, and also of their combined effect. The dependences of the fluctuations on association and dissociation rate constants of both adsorbing species, their concentrations, molecular masses and mass transfer coefficients and also on the density of capturing probes can be examined by using the presented model. The model is applicable for biosensors in which the spatial distribution of adsorbates concentrations in the reaction chamber can be approximated using the two-compartment model. The theory provides a more realistic estimation of the biosensors' limiting performance, and is useful for their improvement.",
publisher = "Elsevier",
journal = "Sensors and Actuators, B: Chemical",
title = "Analysis of the competitive adsorption and mass transfer influence on equilibrium mass fluctuations in affinity-based biosensors",
volume = "189",
pages = "71-79",
doi = "10.1016/j.snb.2012.12.080"
}

Frantlović, M., Jokić, I., Đurić, Z. G.,& Radulović, K.. (2013). Analysis of the competitive adsorption and mass transfer influence on equilibrium mass fluctuations in affinity-based biosensors. in Sensors and Actuators, B: Chemical
Elsevier., 189, 71-79.
https://doi.org/10.1016/j.snb.2012.12.080

Frantlović M, Jokić I, Đurić ZG, Radulović K. Analysis of the competitive adsorption and mass transfer influence on equilibrium mass fluctuations in affinity-based biosensors. in Sensors and Actuators, B: Chemical. 2013;189:71-79.
doi:10.1016/j.snb.2012.12.080 .

Frantlović, Miloš, Jokić, Ivana, Đurić, Zoran G., Radulović, Katarina, "Analysis of the competitive adsorption and mass transfer influence on equilibrium mass fluctuations in affinity-based biosensors" in Sensors and Actuators, B: Chemical, 189 (2013):71-79,
https://doi.org/10.1016/j.snb.2012.12.080 . .