TY  - JOUR
AU  - Simovic, Lj
AU  - Skundric, P.
AU  - Baralic, A. Medovic
AU  - Pajic-Lijakovic, I.
AU  - Milutinović Nikolić, Aleksandra
PY  - 2012
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1053
AB  - In this study, a bioactive complex containing nonwoven textile material (polypropilene (PP)/viscose), chitosan hydrogel, and lidocaine hydrochloride, was designed. The purpose of such biomedical textile was in the treatment of painful sites. Mercury intrusion porosimetry was used in order to estimate the influence of medical impregnation on porous structure of nonwoven material. It was estimated that more than 97% of pores in untreated nonwoven sample were larger than 15 mu m. Anesthetic treatment of nonwoven reduced total pore volume of ultramacropores and macropores, while total pore volume of mesopores slightly increased. Lidocaine hydrochloride release from the anesthetic/chitosan hydrogel/nonwoven complex was measured in vitro by Franz diffusion cell technique. Mathematical model was developed to estimate the release of the lidocaine from obtained bioactive textile material. The diffusive transport of lidocaine hydrochloride through three connected layers, i.e., polymer hydrogel, membrane, and solution is modeled based on Fick's second law. Taking all the relevant conditions, regarding this experiment, into consideration, the coefficient of lidocaine diffusion through the polymer hydrogel, as well as the concentration ratio parameter were determined by the mathematical model.
PB  - Wiley-Blackwell, Malden
T2  - Journal of Biomedical Materials Research Part A
T1  - Characterization and behavior of anesthetic bioactive textile complex in vitro condition
IS  - 1
SP  - 1
EP  - 6
DO  - 10.1002/jbm.a.33234
ER  - 

@article{
author = "Simovic, Lj and Skundric, P. and Baralic, A. Medovic and Pajic-Lijakovic, I. and Milutinović Nikolić, Aleksandra",
year = "2012",
abstract = "In this study, a bioactive complex containing nonwoven textile material (polypropilene (PP)/viscose), chitosan hydrogel, and lidocaine hydrochloride, was designed. The purpose of such biomedical textile was in the treatment of painful sites. Mercury intrusion porosimetry was used in order to estimate the influence of medical impregnation on porous structure of nonwoven material. It was estimated that more than 97% of pores in untreated nonwoven sample were larger than 15 mu m. Anesthetic treatment of nonwoven reduced total pore volume of ultramacropores and macropores, while total pore volume of mesopores slightly increased. Lidocaine hydrochloride release from the anesthetic/chitosan hydrogel/nonwoven complex was measured in vitro by Franz diffusion cell technique. Mathematical model was developed to estimate the release of the lidocaine from obtained bioactive textile material. The diffusive transport of lidocaine hydrochloride through three connected layers, i.e., polymer hydrogel, membrane, and solution is modeled based on Fick's second law. Taking all the relevant conditions, regarding this experiment, into consideration, the coefficient of lidocaine diffusion through the polymer hydrogel, as well as the concentration ratio parameter were determined by the mathematical model.",
publisher = "Wiley-Blackwell, Malden",
journal = "Journal of Biomedical Materials Research Part A",
title = "Characterization and behavior of anesthetic bioactive textile complex in vitro condition",
number = "1",
pages = "1-6",
doi = "10.1002/jbm.a.33234"
}

Simovic, L., Skundric, P., Baralic, A. M., Pajic-Lijakovic, I.,& Milutinović Nikolić, A.. (2012). Characterization and behavior of anesthetic bioactive textile complex in vitro condition. in Journal of Biomedical Materials Research Part A
Wiley-Blackwell, Malden.(1), 1-6.
https://doi.org/10.1002/jbm.a.33234

Simovic L, Skundric P, Baralic AM, Pajic-Lijakovic I, Milutinović Nikolić A. Characterization and behavior of anesthetic bioactive textile complex in vitro condition. in Journal of Biomedical Materials Research Part A. 2012;(1):1-6.
doi:10.1002/jbm.a.33234 .

Simovic, Lj, Skundric, P., Baralic, A. Medovic, Pajic-Lijakovic, I., Milutinović Nikolić, Aleksandra, "Characterization and behavior of anesthetic bioactive textile complex in vitro condition" in Journal of Biomedical Materials Research Part A, no. 1 (2012):1-6,
https://doi.org/10.1002/jbm.a.33234 . .