TY  - JOUR
AU  - Husinec, Suren
AU  - Jadranin, Milka
AU  - Marković, Rade
AU  - Petkovic, Milos
AU  - Savić, Vladimir
AU  - Todorović, Nina
PY  - 2010
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/643
AB  - Allyl acetates were synthesised from allenes utilising methodology based on the general reactivity of pi-allyl palladium intermediates which participate efficiently in transformations involving nucleophiles. Reactions of allenes and aryl iodides in the presence of AcONa and Pd(OAc)(2)/PPh(3) as the catalytic system afforded allyl acetates in moderate to good yields. Monosubstituted allenes, depending on their structure, produced either a separable mixture of two regioisomeric products or a single regioisomer. As allylic acetates can be easily hydrolysed, the methodology is applicable for the synthesis of allyl alcohols as well.
PB  - Oxford : Pergamon-Elsevier Science Ltd
T2  - Tetrahedron Letters
T1  - Palladium-catalysed synthesis of allyl acetates from allenes
VL  - 51
IS  - 31
SP  - 4066
EP  - 4068
DO  - 10.1016/j.tetlet.2010.05.136
ER  - 

@article{
author = "Husinec, Suren and Jadranin, Milka and Marković, Rade and Petkovic, Milos and Savić, Vladimir and Todorović, Nina",
year = "2010",
abstract = "Allyl acetates were synthesised from allenes utilising methodology based on the general reactivity of pi-allyl palladium intermediates which participate efficiently in transformations involving nucleophiles. Reactions of allenes and aryl iodides in the presence of AcONa and Pd(OAc)(2)/PPh(3) as the catalytic system afforded allyl acetates in moderate to good yields. Monosubstituted allenes, depending on their structure, produced either a separable mixture of two regioisomeric products or a single regioisomer. As allylic acetates can be easily hydrolysed, the methodology is applicable for the synthesis of allyl alcohols as well.",
publisher = "Oxford : Pergamon-Elsevier Science Ltd",
journal = "Tetrahedron Letters",
title = "Palladium-catalysed synthesis of allyl acetates from allenes",
volume = "51",
number = "31",
pages = "4066-4068",
doi = "10.1016/j.tetlet.2010.05.136"
}

Husinec, S., Jadranin, M., Marković, R., Petkovic, M., Savić, V.,& Todorović, N.. (2010). Palladium-catalysed synthesis of allyl acetates from allenes. in Tetrahedron Letters
Oxford : Pergamon-Elsevier Science Ltd., 51(31), 4066-4068.
https://doi.org/10.1016/j.tetlet.2010.05.136

Husinec S, Jadranin M, Marković R, Petkovic M, Savić V, Todorović N. Palladium-catalysed synthesis of allyl acetates from allenes. in Tetrahedron Letters. 2010;51(31):4066-4068.
doi:10.1016/j.tetlet.2010.05.136 .

Husinec, Suren, Jadranin, Milka, Marković, Rade, Petkovic, Milos, Savić, Vladimir, Todorović, Nina, "Palladium-catalysed synthesis of allyl acetates from allenes" in Tetrahedron Letters, 51, no. 31 (2010):4066-4068,
https://doi.org/10.1016/j.tetlet.2010.05.136 . .

TY  - JOUR
AU  - Grigg, Ronald
AU  - Husinec, Suren
AU  - Savić, Vladimir
PY  - 2010
UR  - http://farfar.pharmacy.bg.ac.rs/handle/123456789/1417
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3507
AB  - Stereoselective cyclo-addition reactions of azomethine ylides promoted by in situ generated Ag(I)/bisphosphine complexes were studied. Under the optimized conditions, the pyrrolidine products were isolated in up to 84 % yield and with up to 71% e.e. The effects of various reaction variables on the stereoselectivity were also investigated.
AB  - Proučavane su stereoselektivne cikloadicione reakcije azometinskih ilida katalizovane kompleksima srebra i bisfosfinskog liganda generisanih in situ. Pirolidinski derivati izolovani su u dobrim prinosima i sa enantioselektivnošću do 71%. Proučavani su takođe i efekti reakcionih uslova na stereoselektivnost ovih reakcija.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Stereoselective cyclo-addition reactions of azomethine ylides catalysed by in situ generated Ag(I)/bisphosphine complexes
T1  - Stereoselektivne cikloadicione reakcije azometinskih ilida katalizovane in situ generisanim Ag(I)/bisfosfinskim kompleksima
VL  - 75
IS  - 1
SP  - 1
EP  - 9
DO  - 10.2298/JSC1001001G
ER  - 

@article{
author = "Grigg, Ronald and Husinec, Suren and Savić, Vladimir",
year = "2010",
abstract = "Stereoselective cyclo-addition reactions of azomethine ylides promoted by in situ generated Ag(I)/bisphosphine complexes were studied. Under the optimized conditions, the pyrrolidine products were isolated in up to 84 % yield and with up to 71% e.e. The effects of various reaction variables on the stereoselectivity were also investigated., Proučavane su stereoselektivne cikloadicione reakcije azometinskih ilida katalizovane kompleksima srebra i bisfosfinskog liganda generisanih in situ. Pirolidinski derivati izolovani su u dobrim prinosima i sa enantioselektivnošću do 71%. Proučavani su takođe i efekti reakcionih uslova na stereoselektivnost ovih reakcija.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Stereoselective cyclo-addition reactions of azomethine ylides catalysed by in situ generated Ag(I)/bisphosphine complexes, Stereoselektivne cikloadicione reakcije azometinskih ilida katalizovane in situ generisanim Ag(I)/bisfosfinskim kompleksima",
volume = "75",
number = "1",
pages = "1-9",
doi = "10.2298/JSC1001001G"
}

Grigg, R., Husinec, S.,& Savić, V.. (2010). Stereoselective cyclo-addition reactions of azomethine ylides catalysed by in situ generated Ag(I)/bisphosphine complexes. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 75(1), 1-9.
https://doi.org/10.2298/JSC1001001G

Grigg R, Husinec S, Savić V. Stereoselective cyclo-addition reactions of azomethine ylides catalysed by in situ generated Ag(I)/bisphosphine complexes. in Journal of the Serbian Chemical Society. 2010;75(1):1-9.
doi:10.2298/JSC1001001G .

Grigg, Ronald, Husinec, Suren, Savić, Vladimir, "Stereoselective cyclo-addition reactions of azomethine ylides catalysed by in situ generated Ag(I)/bisphosphine complexes" in Journal of the Serbian Chemical Society, 75, no. 1 (2010):1-9,
https://doi.org/10.2298/JSC1001001G . .

TY  - JOUR
AU  - Jocić, B.
AU  - Zečević, M.
AU  - Živanović, L.
AU  - Protić, A.
AU  - Jadranin, Milka
AU  - Vajs, Vlatka
PY  - 2009
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/581
AB  - The objective of the present study was to report the stability profile of novel antimigrain drug Eletriptan hydrobromide based on the information obtained from forced degradation studies. The drug was subjected to acid (0.1-1 mol L-1 HCl), neutral and base (0.1-1 mol L-1 NaOH) hydrolysis and to oxidative decomposition (3-15% (v/v) H2O2). Photolysis and thermo degradation at 75 °C were carried out in methanol solution and in solid state with both Eletriptan hydrobromide bulk drug and the tablet formulation. The products formed under different stress conditions were investigated by LC and LC-MS. The experimental conditions for LC were chosen by employing experimental design and multicriteria decision making methodology. These powerful tools enabled the accomplishment of satisfactory resolution with the shortest possible analysis time. Analytes were separated on a C18 column (XTerra™, 150 mm × 3.9 mm, 5 μm) with the mobile phase composed of methanol-water solution of TEA (pH 6.52, 1%, v/v) (30:70, v/v) pumped at 1 mL min-1 flow rate. The column temperature was set at 50 °C and the detection at 225 nm using DAD detector. The LC method was suitably modified for LC-MS analysis which was further used to characterize the arisen degradation products. The possible degradation pathway was outlined based on the results. The drug appeared to be instable towards every stress condition but oxidation. The stability was not jeopardized even under more exaggerated conditions such as increased temperature of the solutions to 75 °C, increased strength of acid/alkali solutions and prolonged testing period. Validation of the LC-DAD method was carried out in accordance with ICH guideline. The method met all required criteria and was applied when testing the commercially available tablets.
PB  - Elsevier
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Study of forced degradation behavior of Eletriptan hydrobromide by LC and LC-MS and development of stability-indicating method
VL  - 50
IS  - 4
SP  - 622
EP  - 629
DO  - 10.1016/j.jpba.2009.01.034
ER  - 

@article{
author = "Jocić, B. and Zečević, M. and Živanović, L. and Protić, A. and Jadranin, Milka and Vajs, Vlatka",
year = "2009",
abstract = "The objective of the present study was to report the stability profile of novel antimigrain drug Eletriptan hydrobromide based on the information obtained from forced degradation studies. The drug was subjected to acid (0.1-1 mol L-1 HCl), neutral and base (0.1-1 mol L-1 NaOH) hydrolysis and to oxidative decomposition (3-15% (v/v) H2O2). Photolysis and thermo degradation at 75 °C were carried out in methanol solution and in solid state with both Eletriptan hydrobromide bulk drug and the tablet formulation. The products formed under different stress conditions were investigated by LC and LC-MS. The experimental conditions for LC were chosen by employing experimental design and multicriteria decision making methodology. These powerful tools enabled the accomplishment of satisfactory resolution with the shortest possible analysis time. Analytes were separated on a C18 column (XTerra™, 150 mm × 3.9 mm, 5 μm) with the mobile phase composed of methanol-water solution of TEA (pH 6.52, 1%, v/v) (30:70, v/v) pumped at 1 mL min-1 flow rate. The column temperature was set at 50 °C and the detection at 225 nm using DAD detector. The LC method was suitably modified for LC-MS analysis which was further used to characterize the arisen degradation products. The possible degradation pathway was outlined based on the results. The drug appeared to be instable towards every stress condition but oxidation. The stability was not jeopardized even under more exaggerated conditions such as increased temperature of the solutions to 75 °C, increased strength of acid/alkali solutions and prolonged testing period. Validation of the LC-DAD method was carried out in accordance with ICH guideline. The method met all required criteria and was applied when testing the commercially available tablets.",
publisher = "Elsevier",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Study of forced degradation behavior of Eletriptan hydrobromide by LC and LC-MS and development of stability-indicating method",
volume = "50",
number = "4",
pages = "622-629",
doi = "10.1016/j.jpba.2009.01.034"
}

Jocić, B., Zečević, M., Živanović, L., Protić, A., Jadranin, M.,& Vajs, V.. (2009). Study of forced degradation behavior of Eletriptan hydrobromide by LC and LC-MS and development of stability-indicating method. in Journal of Pharmaceutical and Biomedical Analysis
Elsevier., 50(4), 622-629.
https://doi.org/10.1016/j.jpba.2009.01.034

Jocić B, Zečević M, Živanović L, Protić A, Jadranin M, Vajs V. Study of forced degradation behavior of Eletriptan hydrobromide by LC and LC-MS and development of stability-indicating method. in Journal of Pharmaceutical and Biomedical Analysis. 2009;50(4):622-629.
doi:10.1016/j.jpba.2009.01.034 .

Jocić, B., Zečević, M., Živanović, L., Protić, A., Jadranin, Milka, Vajs, Vlatka, "Study of forced degradation behavior of Eletriptan hydrobromide by LC and LC-MS and development of stability-indicating method" in Journal of Pharmaceutical and Biomedical Analysis, 50, no. 4 (2009):622-629,
https://doi.org/10.1016/j.jpba.2009.01.034 . .