TY  - JOUR
AU  - Stanojević, A
AU  - Marković, V M
AU  - Maćešić, Stevan
AU  - Kolar-Anić, Ljiljana
AU  - Vukojević, V
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2920
AB  - The sex hormone testosterone (TTS) and the hypothalamic–pituitary–adrenal (HPA) axis mutually control one another’s activity, wherein TTS suppresses corticotrophin releasing hormone (CRH) stimulated HPA axis activity, whereas the activation of HPA axis has an inhibitory effect on TTS secretion. With an intention to explain these phenomena, a network reaction model is developed from the previously postulated stoichiometric models for HPA activity where main dynamic behaviors are controlled by two catalytic steps (one autocatalytic and one autoinhibitory) with respect to cortisol, both found experimentally. The capacity of the model to emulate TTS effects on HPA axis dynamics and its response to acute CRH-induced stress is examined using numerical simulations. Model predictions are compared with empirically obtained results reported in the literature. Thus, the reaction kinetic examinations of nonlinear biochemical transformations that constitute the HPA axis, including the negative feedback effect of TTS on HPA axis activity, recapitulates the well-established fact that TTS dampens HPA axis basal activity, decreasing both cortisol level and the amplitude of ultradian cortisol oscillations. The model also replicates TTS inhibitory action on the HPA axis response to acute environmental challenges, particularly CRH-induced stress. In addition, kinetic modelling revealed that TTS induced reduction in ultradian cortisol amplitude arises because the system moves towards a supercritical Hopf bifurcation as TTS is being increased. © 2017, The Author(s).
PB  - Springer Netherlands
T2  - Reaction Kinetics, Mechanisms and Catalysis
T1  - Kinetic modelling of testosterone-related differences in the hypothalamic–pituitary–adrenal axis response to stress
VL  - 123
IS  - 1
SP  - 17
EP  - 30
DO  - 10.1007/s11144-017-1315-7
ER  - 

@article{
author = "Stanojević, A and Marković, V M and Maćešić, Stevan and Kolar-Anić, Ljiljana and Vukojević, V",
year = "2018",
abstract = "The sex hormone testosterone (TTS) and the hypothalamic–pituitary–adrenal (HPA) axis mutually control one another’s activity, wherein TTS suppresses corticotrophin releasing hormone (CRH) stimulated HPA axis activity, whereas the activation of HPA axis has an inhibitory effect on TTS secretion. With an intention to explain these phenomena, a network reaction model is developed from the previously postulated stoichiometric models for HPA activity where main dynamic behaviors are controlled by two catalytic steps (one autocatalytic and one autoinhibitory) with respect to cortisol, both found experimentally. The capacity of the model to emulate TTS effects on HPA axis dynamics and its response to acute CRH-induced stress is examined using numerical simulations. Model predictions are compared with empirically obtained results reported in the literature. Thus, the reaction kinetic examinations of nonlinear biochemical transformations that constitute the HPA axis, including the negative feedback effect of TTS on HPA axis activity, recapitulates the well-established fact that TTS dampens HPA axis basal activity, decreasing both cortisol level and the amplitude of ultradian cortisol oscillations. The model also replicates TTS inhibitory action on the HPA axis response to acute environmental challenges, particularly CRH-induced stress. In addition, kinetic modelling revealed that TTS induced reduction in ultradian cortisol amplitude arises because the system moves towards a supercritical Hopf bifurcation as TTS is being increased. © 2017, The Author(s).",
publisher = "Springer Netherlands",
journal = "Reaction Kinetics, Mechanisms and Catalysis",
title = "Kinetic modelling of testosterone-related differences in the hypothalamic–pituitary–adrenal axis response to stress",
volume = "123",
number = "1",
pages = "17-30",
doi = "10.1007/s11144-017-1315-7"
}

Stanojević, A., Marković, V. M., Maćešić, S., Kolar-Anić, L.,& Vukojević, V.. (2018). Kinetic modelling of testosterone-related differences in the hypothalamic–pituitary–adrenal axis response to stress. in Reaction Kinetics, Mechanisms and Catalysis
Springer Netherlands., 123(1), 17-30.
https://doi.org/10.1007/s11144-017-1315-7

Stanojević A, Marković VM, Maćešić S, Kolar-Anić L, Vukojević V. Kinetic modelling of testosterone-related differences in the hypothalamic–pituitary–adrenal axis response to stress. in Reaction Kinetics, Mechanisms and Catalysis. 2018;123(1):17-30.
doi:10.1007/s11144-017-1315-7 .

Stanojević, A, Marković, V M, Maćešić, Stevan, Kolar-Anić, Ljiljana, Vukojević, V, "Kinetic modelling of testosterone-related differences in the hypothalamic–pituitary–adrenal axis response to stress" in Reaction Kinetics, Mechanisms and Catalysis, 123, no. 1 (2018):17-30,
https://doi.org/10.1007/s11144-017-1315-7 . .

TY  - JOUR
AU  - Dolic, Maja B.
AU  - Rajakovic-Ognjanovic, Vladana N.
AU  - Štrbac, Svetlana
AU  - Dimitrijević, Suzana I.
AU  - Mitrić, Miodrag
AU  - Onjia, Antonije E.
AU  - Rajaković, Ljubinka V.
PY  - 2017
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3030
AB  - The objective of this study was to investigate the modification of materials used in wastewater treatment for possible antimicrobial application(s). Granulated activated carbon (GAC) and natural clinoptilolite (CLI) were activated using Cu2+-and Zn2+-ions and the disinfection ability of the resulting materials was tested. Studies of the sorption and desorption kinetics were performed in order to determine and clarify the antimicrobial activity of the metal-activated sorbents. The exact sorption capacities of the selected sorbents, GAC and CLI, activated through use of Cu2+-ions, were 15.90 and 3.60 mg/g, respectively, while for the materials activated by Zn2+-ions, the corresponding capacities were 14.00 and 4.72 mg/g,. The desorption rates were 2 and 3 orders of magnitude lower than their sorption efficacy for the Cu2+-, and Zn2+-activated sorbents, respectively. The intermediate sorption capacity and low desorption rate indicated that the overall antimicrobial activity of the metal-modified sorbents was a result of metal ions immobilized onto surface sites. The effect of antimicrobial activity of free ions desorbed from the metal-activated surface may thus be disregarded. The antimicrobial activities of Cu/GAC, Zn/GAC, Cu/CLI and Zn/ CLI were also tested against Escherichia coli, Staphylococcus aureus, and Candida albicans. After 15 min exposure, the highest levels of cell inactivation were obtained through the Cu/CLI and the Cu/GAC against E. coli, 100.0 and 98.24%, respectively. However, for S. aureus and yeast cell inactivation, all Cu2+-and Zn2+-activated sorbents proved to be unsatisfactory. A characterization of the sorbents was performed by Xray diffraction (XRD), X-ray photo electron spectroscopy (XPS), and field emission scanning electron microscopy (FE-SEM). A concentration of the adsorbed and released ions was determined by inductively coupled plasma-optical emission spectroscopy (ICP-OES) and mass spectrometry (ICP-MS). The results showed that the antimicrobial performance of the activated sorbents depended on the surface characteristics of the material, which itself designates the distribution and the bioavailability of the activating agent.
PB  - Elsevier
T2  - New Biotechnology
T1  - Natural sorbents modified by divalent Cu2+- and Zn2+- ions and their corresponding antimicrobial activity
VL  - 39
SP  - 150
EP  - 159
DO  - 10.1016/j.nbt.2017.03.001
ER  - 

@article{
author = "Dolic, Maja B. and Rajakovic-Ognjanovic, Vladana N. and Štrbac, Svetlana and Dimitrijević, Suzana I. and Mitrić, Miodrag and Onjia, Antonije E. and Rajaković, Ljubinka V.",
year = "2017",
abstract = "The objective of this study was to investigate the modification of materials used in wastewater treatment for possible antimicrobial application(s). Granulated activated carbon (GAC) and natural clinoptilolite (CLI) were activated using Cu2+-and Zn2+-ions and the disinfection ability of the resulting materials was tested. Studies of the sorption and desorption kinetics were performed in order to determine and clarify the antimicrobial activity of the metal-activated sorbents. The exact sorption capacities of the selected sorbents, GAC and CLI, activated through use of Cu2+-ions, were 15.90 and 3.60 mg/g, respectively, while for the materials activated by Zn2+-ions, the corresponding capacities were 14.00 and 4.72 mg/g,. The desorption rates were 2 and 3 orders of magnitude lower than their sorption efficacy for the Cu2+-, and Zn2+-activated sorbents, respectively. The intermediate sorption capacity and low desorption rate indicated that the overall antimicrobial activity of the metal-modified sorbents was a result of metal ions immobilized onto surface sites. The effect of antimicrobial activity of free ions desorbed from the metal-activated surface may thus be disregarded. The antimicrobial activities of Cu/GAC, Zn/GAC, Cu/CLI and Zn/ CLI were also tested against Escherichia coli, Staphylococcus aureus, and Candida albicans. After 15 min exposure, the highest levels of cell inactivation were obtained through the Cu/CLI and the Cu/GAC against E. coli, 100.0 and 98.24%, respectively. However, for S. aureus and yeast cell inactivation, all Cu2+-and Zn2+-activated sorbents proved to be unsatisfactory. A characterization of the sorbents was performed by Xray diffraction (XRD), X-ray photo electron spectroscopy (XPS), and field emission scanning electron microscopy (FE-SEM). A concentration of the adsorbed and released ions was determined by inductively coupled plasma-optical emission spectroscopy (ICP-OES) and mass spectrometry (ICP-MS). The results showed that the antimicrobial performance of the activated sorbents depended on the surface characteristics of the material, which itself designates the distribution and the bioavailability of the activating agent.",
publisher = "Elsevier",
journal = "New Biotechnology",
title = "Natural sorbents modified by divalent Cu2+- and Zn2+- ions and their corresponding antimicrobial activity",
volume = "39",
pages = "150-159",
doi = "10.1016/j.nbt.2017.03.001"
}

Dolic, M. B., Rajakovic-Ognjanovic, V. N., Štrbac, S., Dimitrijević, S. I., Mitrić, M., Onjia, A. E.,& Rajaković, L. V.. (2017). Natural sorbents modified by divalent Cu2+- and Zn2+- ions and their corresponding antimicrobial activity. in New Biotechnology
Elsevier., 39, 150-159.
https://doi.org/10.1016/j.nbt.2017.03.001

Dolic MB, Rajakovic-Ognjanovic VN, Štrbac S, Dimitrijević SI, Mitrić M, Onjia AE, Rajaković LV. Natural sorbents modified by divalent Cu2+- and Zn2+- ions and their corresponding antimicrobial activity. in New Biotechnology. 2017;39:150-159.
doi:10.1016/j.nbt.2017.03.001 .

Dolic, Maja B., Rajakovic-Ognjanovic, Vladana N., Štrbac, Svetlana, Dimitrijević, Suzana I., Mitrić, Miodrag, Onjia, Antonije E., Rajaković, Ljubinka V., "Natural sorbents modified by divalent Cu2+- and Zn2+- ions and their corresponding antimicrobial activity" in New Biotechnology, 39 (2017):150-159,
https://doi.org/10.1016/j.nbt.2017.03.001 . .