TY  - JOUR
AU  - Ignjatović, Jelisaveta
AU  - Đuriš, Jelena
AU  - Đuriš, Mihal
AU  - Bočarski, Teodora
AU  - Vasiljević, Vanja
AU  - Aleksić, Ivana
AU  - Cvijić, Sandra
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4527
AB  - Hot-melt coating (HMC) is an alternative, solvent-free coating method generally used to modify substrate release rate and/or mask its unpleasant taste. The aim of this study was to assess two HMC methods (pan-coating and mortar-coating) by assaying functional properties of the coated material. The selected substrates included highly soluble sodium chloride (model substance) and caffeine (bitter drug), and the coating agent was glycerol distearate without/with the addition of liquid paraffin. Experiments with sodium chloride revealed that pan-coating yielded particles of more regular shape, while mortar-coating yielded samples of more uniform coating layer. The flowability of the coated material depended on the particle size. Sustained sodium chloride release was achieved for all mortar-coated and some pan-coated samples. The analysis of the results indicated mortar-coating as a preferable HMC method for caffeine coating. The resulting caffeine yield in the coated samples was high (99%), the material showed satisfactory mechanical properties and drug release from the coated particles was sustained. Overall, the obtained results suggest that both pan-and mortar-coating can be used to sustain the release of drugs with unpleasant taste, but mortar-coating can be considered as a more simple and practical method that can be potentially used in compounding pharmacies.
AB  - Oblaganje topljenjem je alternativna metoda oblaganja, bez upotrebe rastvarača i uglavnom
se koristi za modifikaciju brzine rastvaranja i/ili maskiranje neprijatnog ukusa supstrata. Cilj ovog
rada je da se procene dve metode za oblaganje topljenjem (oblaganje u bubnju i oblaganje u
pateni), ispitivanjem funkcionalnih karakteristika obloženog materijala. Izabrana su dva visoko
rastvorljiva supstrata: natrijum-hlorid (model supstanca) i kofein (lekovita supstanca gorkog
ukusa), a za oblaganje je korišćen glicerildistearat bez/sa dodatkom tečnog parafina.
Eksperimenti sa natrijum-hloridom su pokazali da su oblaganjem u bubnju dobijene čestice
pravilnijeg oblika, dok su oblaganjem u pateni dobijeni uzorci sa ujednačenijom oblogom.
Protočnost obloženog materijala je zavisila od veličine čestica. Usporeno rastvaranje natrijumhlorida
postignuto je kod svih uzoraka obloženih u pateni i kod nekih uzoraka obloženih u bubnju.
Analiza rezultata je izdvojila oblaganje u pateni kao pogodniju metodu za oblaganje kofeina.
Dobijeni prinos obloženih čestica kofeina je bio visok (99%), obloženi materijal je imao
zadovoljavajuće mehaničke osobine i postignuta je usporena brzina rastvaranja kofeina. Sumarno,
dobijeni rezultati su pokazali da se i oblaganje u bubnju i u pateni mogu koristiti za usporavanje
rastvaranja lekovitih supstanci neprijatnog ukusa, no oblaganje u pateni predstavlja jednostavniju
i praktičniju metodu koja se potencijalno može koristiti i u izradi magistralnih lekova.
PB  - Serbia : Pharmaceutical Association of Serbia
T2  - Arhiv za Farmaciju
T1  - Assessment of hot-melt coating methods for multiparticulate substrates: Mortar-coating vs. pan-coating
T1  - Procena metoda za oblaganje višečestičnih supstrata topljenjem: oblaganje u pateni vs. oblaganje u bubnju
VL  - 71
IS  - 1
SP  - 35
EP  - 54
DO  - 10.5937/arhfarm71-30266
ER  - 

@article{
author = "Ignjatović, Jelisaveta and Đuriš, Jelena and Đuriš, Mihal and Bočarski, Teodora and Vasiljević, Vanja and Aleksić, Ivana and Cvijić, Sandra",
year = "2021",
abstract = "Hot-melt coating (HMC) is an alternative, solvent-free coating method generally used to modify substrate release rate and/or mask its unpleasant taste. The aim of this study was to assess two HMC methods (pan-coating and mortar-coating) by assaying functional properties of the coated material. The selected substrates included highly soluble sodium chloride (model substance) and caffeine (bitter drug), and the coating agent was glycerol distearate without/with the addition of liquid paraffin. Experiments with sodium chloride revealed that pan-coating yielded particles of more regular shape, while mortar-coating yielded samples of more uniform coating layer. The flowability of the coated material depended on the particle size. Sustained sodium chloride release was achieved for all mortar-coated and some pan-coated samples. The analysis of the results indicated mortar-coating as a preferable HMC method for caffeine coating. The resulting caffeine yield in the coated samples was high (99%), the material showed satisfactory mechanical properties and drug release from the coated particles was sustained. Overall, the obtained results suggest that both pan-and mortar-coating can be used to sustain the release of drugs with unpleasant taste, but mortar-coating can be considered as a more simple and practical method that can be potentially used in compounding pharmacies., Oblaganje topljenjem je alternativna metoda oblaganja, bez upotrebe rastvarača i uglavnom
se koristi za modifikaciju brzine rastvaranja i/ili maskiranje neprijatnog ukusa supstrata. Cilj ovog
rada je da se procene dve metode za oblaganje topljenjem (oblaganje u bubnju i oblaganje u
pateni), ispitivanjem funkcionalnih karakteristika obloženog materijala. Izabrana su dva visoko
rastvorljiva supstrata: natrijum-hlorid (model supstanca) i kofein (lekovita supstanca gorkog
ukusa), a za oblaganje je korišćen glicerildistearat bez/sa dodatkom tečnog parafina.
Eksperimenti sa natrijum-hloridom su pokazali da su oblaganjem u bubnju dobijene čestice
pravilnijeg oblika, dok su oblaganjem u pateni dobijeni uzorci sa ujednačenijom oblogom.
Protočnost obloženog materijala je zavisila od veličine čestica. Usporeno rastvaranje natrijumhlorida
postignuto je kod svih uzoraka obloženih u pateni i kod nekih uzoraka obloženih u bubnju.
Analiza rezultata je izdvojila oblaganje u pateni kao pogodniju metodu za oblaganje kofeina.
Dobijeni prinos obloženih čestica kofeina je bio visok (99%), obloženi materijal je imao
zadovoljavajuće mehaničke osobine i postignuta je usporena brzina rastvaranja kofeina. Sumarno,
dobijeni rezultati su pokazali da se i oblaganje u bubnju i u pateni mogu koristiti za usporavanje
rastvaranja lekovitih supstanci neprijatnog ukusa, no oblaganje u pateni predstavlja jednostavniju
i praktičniju metodu koja se potencijalno može koristiti i u izradi magistralnih lekova.",
publisher = "Serbia : Pharmaceutical Association of Serbia",
journal = "Arhiv za Farmaciju",
title = "Assessment of hot-melt coating methods for multiparticulate substrates: Mortar-coating vs. pan-coating, Procena metoda za oblaganje višečestičnih supstrata topljenjem: oblaganje u pateni vs. oblaganje u bubnju",
volume = "71",
number = "1",
pages = "35-54",
doi = "10.5937/arhfarm71-30266"
}

Ignjatović, J., Đuriš, J., Đuriš, M., Bočarski, T., Vasiljević, V., Aleksić, I.,& Cvijić, S.. (2021). Assessment of hot-melt coating methods for multiparticulate substrates: Mortar-coating vs. pan-coating. in Arhiv za Farmaciju
Serbia : Pharmaceutical Association of Serbia., 71(1), 35-54.
https://doi.org/10.5937/arhfarm71-30266

Ignjatović J, Đuriš J, Đuriš M, Bočarski T, Vasiljević V, Aleksić I, Cvijić S. Assessment of hot-melt coating methods for multiparticulate substrates: Mortar-coating vs. pan-coating. in Arhiv za Farmaciju. 2021;71(1):35-54.
doi:10.5937/arhfarm71-30266 .

Ignjatović, Jelisaveta, Đuriš, Jelena, Đuriš, Mihal, Bočarski, Teodora, Vasiljević, Vanja, Aleksić, Ivana, Cvijić, Sandra, "Assessment of hot-melt coating methods for multiparticulate substrates: Mortar-coating vs. pan-coating" in Arhiv za Farmaciju, 71, no. 1 (2021):35-54,
https://doi.org/10.5937/arhfarm71-30266 . .

TY  - JOUR
AU  - Đuriš, Jelena
AU  - Cirin-Varađan, Slobodanka
AU  - Aleksić, Ivana
AU  - Đuriš, Mihal
AU  - Cvijić, Sandra
AU  - Ibrić, Svetlana
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4693
AB  - Co-processing (CP) provides superior properties to excipients and has become a reliable option to facilitated formulation and manufacturing of variety of solid dosage forms. Development of directly compressible formulations with high doses of poorly flowing/compressible active pharmaceutical ingredients, such as paracetamol, remains a great challenge for the pharmaceutical industry due to the lack of understanding of the interplay between the formulation properties, process of compaction, and stages of tablets’ detachment and ejection. The aim of this study was to analyze the influence of the compression load, excipients’ co-processing and the addition of paracetamol on the obtained tablets’ tensile strength and the specific parameters of the tableting process, such as (net) compression work, elastic recovery, detachment, and ejection work, as well as the ejection force. Two types of neural networks were used to analyze the data: classification (Kohonen network) and regression networks (multilayer perceptron and radial basis function), to build prediction models and identify the variables that are predominantly affecting the tableting process and the obtained tablets’ tensile strength. It has been demonstrated that sophisticated data-mining methods are necessary to interpret complex phenomena regarding the effect of co-processing on tableting properties of directly compressible excipients.
PB  - MDPI
T2  - Pharmaceutics
T1  - Application of machine-learning algorithms for better understanding of tableting properties of lactose co-processed with lipid excipients
VL  - 13
IS  - 5
SP  - 663
DO  - 10.3390/pharmaceutics13050663
ER  - 

@article{
author = "Đuriš, Jelena and Cirin-Varađan, Slobodanka and Aleksić, Ivana and Đuriš, Mihal and Cvijić, Sandra and Ibrić, Svetlana",
year = "2021",
abstract = "Co-processing (CP) provides superior properties to excipients and has become a reliable option to facilitated formulation and manufacturing of variety of solid dosage forms. Development of directly compressible formulations with high doses of poorly flowing/compressible active pharmaceutical ingredients, such as paracetamol, remains a great challenge for the pharmaceutical industry due to the lack of understanding of the interplay between the formulation properties, process of compaction, and stages of tablets’ detachment and ejection. The aim of this study was to analyze the influence of the compression load, excipients’ co-processing and the addition of paracetamol on the obtained tablets’ tensile strength and the specific parameters of the tableting process, such as (net) compression work, elastic recovery, detachment, and ejection work, as well as the ejection force. Two types of neural networks were used to analyze the data: classification (Kohonen network) and regression networks (multilayer perceptron and radial basis function), to build prediction models and identify the variables that are predominantly affecting the tableting process and the obtained tablets’ tensile strength. It has been demonstrated that sophisticated data-mining methods are necessary to interpret complex phenomena regarding the effect of co-processing on tableting properties of directly compressible excipients.",
publisher = "MDPI",
journal = "Pharmaceutics",
title = "Application of machine-learning algorithms for better understanding of tableting properties of lactose co-processed with lipid excipients",
volume = "13",
number = "5",
pages = "663",
doi = "10.3390/pharmaceutics13050663"
}

Đuriš, J., Cirin-Varađan, S., Aleksić, I., Đuriš, M., Cvijić, S.,& Ibrić, S.. (2021). Application of machine-learning algorithms for better understanding of tableting properties of lactose co-processed with lipid excipients. in Pharmaceutics
MDPI., 13(5), 663.
https://doi.org/10.3390/pharmaceutics13050663

Đuriš J, Cirin-Varađan S, Aleksić I, Đuriš M, Cvijić S, Ibrić S. Application of machine-learning algorithms for better understanding of tableting properties of lactose co-processed with lipid excipients. in Pharmaceutics. 2021;13(5):663.
doi:10.3390/pharmaceutics13050663 .

Đuriš, Jelena, Cirin-Varađan, Slobodanka, Aleksić, Ivana, Đuriš, Mihal, Cvijić, Sandra, Ibrić, Svetlana, "Application of machine-learning algorithms for better understanding of tableting properties of lactose co-processed with lipid excipients" in Pharmaceutics, 13, no. 5 (2021):663,
https://doi.org/10.3390/pharmaceutics13050663 . .