TY  - JOUR
AU  - Filipović, Nenad R.
AU  - Ristić, Predrag
AU  - Janjić, Goran
AU  - Klisurić, Olivera
AU  - Puerta, Adrián
AU  - Padrón, José M.
AU  - Donnard, Morgan
AU  - Gulea, Mihaela
AU  - Todorović, Tamara R.
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3315
AB  - The first complexes of 2-pyridylthiocyanate (L) and silver nitrate (1) and perchlorate (2) were prepared
and characterized by a single crystal X-ray analysis. The common structural motif of both 1 and 2 is coordination
of two L molecules via pyridine nitrogen atom to Ag(I). In order to properly describe the nature
of coordinative bonds in 1 and 2, as well as crystal packings in respective structures, a Quantum Theory of
Atoms in Molecule topological analysis was performed. Coordinated nitrate ion provides more electron
density to Ag(I) in comparison to perchlorate ion. Additional electron density in the case of 2 was provided
by the coordination of third L molecule via thiocyanate nitrogen atom resulting in a 1D polymeric
structure. Detailed computational analysis of intermolecular interactions, as well analysis of interactions
between pyridine ring and –SCN group was performed. Antiproliferative activity of monomeric compound
1 was found to be better than of cisplatin on three out of four studied human cancer cell lines.
Docking studies indicate intercalation as a major binding mode of 1 to DNA, while human serum albumin
was revealed as possible carrier for distribution of 1 in the blood stream.
PB  - England : Elsevier
T2  - Polyhedron
T1  - Silver-based monomer and coordination polymer with organic thiocyanate ligand: Structural, computational and antiproliferative activity study
VL  - 173
SP  - 114132
DO  - 10.1016/j.poly.2019.114132
ER  - 

@article{
author = "Filipović, Nenad R. and Ristić, Predrag and Janjić, Goran and Klisurić, Olivera and Puerta, Adrián and Padrón, José M. and Donnard, Morgan and Gulea, Mihaela and Todorović, Tamara R.",
year = "2019",
abstract = "The first complexes of 2-pyridylthiocyanate (L) and silver nitrate (1) and perchlorate (2) were prepared
and characterized by a single crystal X-ray analysis. The common structural motif of both 1 and 2 is coordination
of two L molecules via pyridine nitrogen atom to Ag(I). In order to properly describe the nature
of coordinative bonds in 1 and 2, as well as crystal packings in respective structures, a Quantum Theory of
Atoms in Molecule topological analysis was performed. Coordinated nitrate ion provides more electron
density to Ag(I) in comparison to perchlorate ion. Additional electron density in the case of 2 was provided
by the coordination of third L molecule via thiocyanate nitrogen atom resulting in a 1D polymeric
structure. Detailed computational analysis of intermolecular interactions, as well analysis of interactions
between pyridine ring and –SCN group was performed. Antiproliferative activity of monomeric compound
1 was found to be better than of cisplatin on three out of four studied human cancer cell lines.
Docking studies indicate intercalation as a major binding mode of 1 to DNA, while human serum albumin
was revealed as possible carrier for distribution of 1 in the blood stream.",
publisher = "England : Elsevier",
journal = "Polyhedron",
title = "Silver-based monomer and coordination polymer with organic thiocyanate ligand: Structural, computational and antiproliferative activity study",
volume = "173",
pages = "114132",
doi = "10.1016/j.poly.2019.114132"
}

Filipović, N. R., Ristić, P., Janjić, G., Klisurić, O., Puerta, A., Padrón, J. M., Donnard, M., Gulea, M.,& Todorović, T. R.. (2019). Silver-based monomer and coordination polymer with organic thiocyanate ligand: Structural, computational and antiproliferative activity study. in Polyhedron
England : Elsevier., 173, 114132.
https://doi.org/10.1016/j.poly.2019.114132

Filipović NR, Ristić P, Janjić G, Klisurić O, Puerta A, Padrón JM, Donnard M, Gulea M, Todorović TR. Silver-based monomer and coordination polymer with organic thiocyanate ligand: Structural, computational and antiproliferative activity study. in Polyhedron. 2019;173:114132.
doi:10.1016/j.poly.2019.114132 .

Filipović, Nenad R., Ristić, Predrag, Janjić, Goran, Klisurić, Olivera, Puerta, Adrián, Padrón, José M., Donnard, Morgan, Gulea, Mihaela, Todorović, Tamara R., "Silver-based monomer and coordination polymer with organic thiocyanate ligand: Structural, computational and antiproliferative activity study" in Polyhedron, 173 (2019):114132,
https://doi.org/10.1016/j.poly.2019.114132 . .

TY  - JOUR
AU  - Todorović, Tamara
AU  - Grubišić, Sonja
AU  - Pregelj, Matej
AU  - Jagodic, Marko
AU  - Misirlic-Dencic, Sonja
AU  - Dulovic, Marija
AU  - Markovic, Ivanka
AU  - Klisurić, Olivera
AU  - Malešević, Aleksandar S.
AU  - Mitić, Dragana
AU  - Anđelković, Katarina
AU  - Filipovic, Nenad
PY  - 2015
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1705
AB  - Copper(II) complexes with the condensation derivative of methyl hydrazinoacetate and 2-acetylpyridine were synthesized. The X-ray crystal structures for both complexes revealed that they are polymerized isomers. A common feature of both complexes is the bidentate coordination of the ligand by one hydrazone and one pyridine nitrogen atom. In the monomeric complex, the copper(II) center is tetracoordinate, whereas dimerization through chlorido bridges results in a pentacoordinate arrangement about the metal ions in the dimer. The electronic and magnetic properties of both complexes are discussed on the basis of their X-ray structures, electron paramagnetic resonance (EPR) spectroscopy studies, and superconducting quantum interference device (SQUID) magnetization measurements combined with DFT calculations. Magnetostructural comparisons with structurally similar copper(II) complexes are also provided, and a possible correlation has been established. The antitumor activities of the Cu-II complexes were investigated against six different cancer cell lines, and the results suggest that the antiglioma action of the dimeric species is based on oxidative-stress-mediated phosphatidylserine externalization and caspase activation, which indicate apoptosis.
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - European Journal of Inorganic Chemistry
T1  - Structural, Magnetic, DFT, and Biological Studies of Mononuclear and Dinuclear Cu-II Complexes with Bidentate N-Heteroaromatic Schiff Base Ligands
IS  - 23
SP  - 3921
EP  - 3931
DO  - 10.1002/ejic.201500349
ER  - 

@article{
author = "Todorović, Tamara and Grubišić, Sonja and Pregelj, Matej and Jagodic, Marko and Misirlic-Dencic, Sonja and Dulovic, Marija and Markovic, Ivanka and Klisurić, Olivera and Malešević, Aleksandar S. and Mitić, Dragana and Anđelković, Katarina and Filipovic, Nenad",
year = "2015",
abstract = "Copper(II) complexes with the condensation derivative of methyl hydrazinoacetate and 2-acetylpyridine were synthesized. The X-ray crystal structures for both complexes revealed that they are polymerized isomers. A common feature of both complexes is the bidentate coordination of the ligand by one hydrazone and one pyridine nitrogen atom. In the monomeric complex, the copper(II) center is tetracoordinate, whereas dimerization through chlorido bridges results in a pentacoordinate arrangement about the metal ions in the dimer. The electronic and magnetic properties of both complexes are discussed on the basis of their X-ray structures, electron paramagnetic resonance (EPR) spectroscopy studies, and superconducting quantum interference device (SQUID) magnetization measurements combined with DFT calculations. Magnetostructural comparisons with structurally similar copper(II) complexes are also provided, and a possible correlation has been established. The antitumor activities of the Cu-II complexes were investigated against six different cancer cell lines, and the results suggest that the antiglioma action of the dimeric species is based on oxidative-stress-mediated phosphatidylserine externalization and caspase activation, which indicate apoptosis.",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "European Journal of Inorganic Chemistry",
title = "Structural, Magnetic, DFT, and Biological Studies of Mononuclear and Dinuclear Cu-II Complexes with Bidentate N-Heteroaromatic Schiff Base Ligands",
number = "23",
pages = "3921-3931",
doi = "10.1002/ejic.201500349"
}

Todorović, T., Grubišić, S., Pregelj, M., Jagodic, M., Misirlic-Dencic, S., Dulovic, M., Markovic, I., Klisurić, O., Malešević, A. S., Mitić, D., Anđelković, K.,& Filipovic, N.. (2015). Structural, Magnetic, DFT, and Biological Studies of Mononuclear and Dinuclear Cu-II Complexes with Bidentate N-Heteroaromatic Schiff Base Ligands. in European Journal of Inorganic Chemistry
Wiley-V C H Verlag Gmbh, Weinheim.(23), 3921-3931.
https://doi.org/10.1002/ejic.201500349

Todorović T, Grubišić S, Pregelj M, Jagodic M, Misirlic-Dencic S, Dulovic M, Markovic I, Klisurić O, Malešević AS, Mitić D, Anđelković K, Filipovic N. Structural, Magnetic, DFT, and Biological Studies of Mononuclear and Dinuclear Cu-II Complexes with Bidentate N-Heteroaromatic Schiff Base Ligands. in European Journal of Inorganic Chemistry. 2015;(23):3921-3931.
doi:10.1002/ejic.201500349 .

Todorović, Tamara, Grubišić, Sonja, Pregelj, Matej, Jagodic, Marko, Misirlic-Dencic, Sonja, Dulovic, Marija, Markovic, Ivanka, Klisurić, Olivera, Malešević, Aleksandar S., Mitić, Dragana, Anđelković, Katarina, Filipovic, Nenad, "Structural, Magnetic, DFT, and Biological Studies of Mononuclear and Dinuclear Cu-II Complexes with Bidentate N-Heteroaromatic Schiff Base Ligands" in European Journal of Inorganic Chemistry, no. 23 (2015):3921-3931,
https://doi.org/10.1002/ejic.201500349 . .

TY  - JOUR
AU  - Filipovic, Nenad
AU  - Grubišić, Sonja
AU  - Jovanović, Maja
AU  - Dulovic, Marija
AU  - Markovic, Ivanka
AU  - Klisurić, Olivera
AU  - Marinković, Aleksandar D.
AU  - Mitić, Dragana
AU  - Anđelković, Katarina
AU  - Todorović, Tamara
PY  - 2014
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1498
AB  - Novel Pd(II) complex with N-heteroaromatic Schiff base ligand, derived from 8-quinolinecarboxaldehyde (q8a) and ethyl hydrazinoacetate (haOEt), was synthesized and characterized by analytical and spectroscopy methods. The structure of novel complex, as well as structures of its quinoline and pyridine analogues, was optimized by density functional theory calculations, and theoretical data show good agreement with experimental results. A cytotoxic action of the complexes was evaluated on cultures of human promyelocytic leukemia (HL-60), human glioma (U251), rat glioma (C6), and mouse fibrosarcoma (L929) cell lines. Among investigated compounds, only complexes with quinoline-based ligands reduce the cell numbers in a dose-dependent manner in investigated cell lines. The observed cytotoxic effect of two isomeric quinoline-based complexes is predominantly mediated through the induction of apoptotic cell death in HL-60 cell line. The cytotoxicity of most efficient novel Pd(II) complex is comparable to the activity of cisplatin, in all cell lines investigated.
PB  - Wiley-Blackwell, Hoboken
T2  - Chemical Biology & Drug Design
T1  - Palladium(II) Complexes with N-Heteroaromatic Bidentate Hydrazone Ligands: The Effect of the Chelate Ring Size and Lipophilicity on in vitro Cytotoxic Activity
VL  - 84
IS  - 3
SP  - 333
EP  - 341
DO  - 10.1111/cbdd.12322
ER  - 

@article{
author = "Filipovic, Nenad and Grubišić, Sonja and Jovanović, Maja and Dulovic, Marija and Markovic, Ivanka and Klisurić, Olivera and Marinković, Aleksandar D. and Mitić, Dragana and Anđelković, Katarina and Todorović, Tamara",
year = "2014",
abstract = "Novel Pd(II) complex with N-heteroaromatic Schiff base ligand, derived from 8-quinolinecarboxaldehyde (q8a) and ethyl hydrazinoacetate (haOEt), was synthesized and characterized by analytical and spectroscopy methods. The structure of novel complex, as well as structures of its quinoline and pyridine analogues, was optimized by density functional theory calculations, and theoretical data show good agreement with experimental results. A cytotoxic action of the complexes was evaluated on cultures of human promyelocytic leukemia (HL-60), human glioma (U251), rat glioma (C6), and mouse fibrosarcoma (L929) cell lines. Among investigated compounds, only complexes with quinoline-based ligands reduce the cell numbers in a dose-dependent manner in investigated cell lines. The observed cytotoxic effect of two isomeric quinoline-based complexes is predominantly mediated through the induction of apoptotic cell death in HL-60 cell line. The cytotoxicity of most efficient novel Pd(II) complex is comparable to the activity of cisplatin, in all cell lines investigated.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Chemical Biology & Drug Design",
title = "Palladium(II) Complexes with N-Heteroaromatic Bidentate Hydrazone Ligands: The Effect of the Chelate Ring Size and Lipophilicity on in vitro Cytotoxic Activity",
volume = "84",
number = "3",
pages = "333-341",
doi = "10.1111/cbdd.12322"
}

Filipovic, N., Grubišić, S., Jovanović, M., Dulovic, M., Markovic, I., Klisurić, O., Marinković, A. D., Mitić, D., Anđelković, K.,& Todorović, T.. (2014). Palladium(II) Complexes with N-Heteroaromatic Bidentate Hydrazone Ligands: The Effect of the Chelate Ring Size and Lipophilicity on in vitro Cytotoxic Activity. in Chemical Biology & Drug Design
Wiley-Blackwell, Hoboken., 84(3), 333-341.
https://doi.org/10.1111/cbdd.12322

Filipovic N, Grubišić S, Jovanović M, Dulovic M, Markovic I, Klisurić O, Marinković AD, Mitić D, Anđelković K, Todorović T. Palladium(II) Complexes with N-Heteroaromatic Bidentate Hydrazone Ligands: The Effect of the Chelate Ring Size and Lipophilicity on in vitro Cytotoxic Activity. in Chemical Biology & Drug Design. 2014;84(3):333-341.
doi:10.1111/cbdd.12322 .

Filipovic, Nenad, Grubišić, Sonja, Jovanović, Maja, Dulovic, Marija, Markovic, Ivanka, Klisurić, Olivera, Marinković, Aleksandar D., Mitić, Dragana, Anđelković, Katarina, Todorović, Tamara, "Palladium(II) Complexes with N-Heteroaromatic Bidentate Hydrazone Ligands: The Effect of the Chelate Ring Size and Lipophilicity on in vitro Cytotoxic Activity" in Chemical Biology & Drug Design, 84, no. 3 (2014):333-341,
https://doi.org/10.1111/cbdd.12322 . .