Van Deun, Rik

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  • Van Deun, Rik (5)
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Novel cerium and praseodymium doped phosphate tungsten bronzes: Synthesis, characterization, the behavior in the Briggs-Rauscher reaction and photoluminescence properties

Maksimović, Tijana; Tančić, Pavle; Maksimović, Jelena; Mara, Dimitrije; Ilić, Marija; Van Deun, Rik; Joksović, Ljubinka; Pagnacco, Maja

(Elsevier B.V., 2023)

TY  - JOUR
AU  - Maksimović, Tijana
AU  - Tančić, Pavle
AU  - Maksimović, Jelena
AU  - Mara, Dimitrije
AU  - Ilić, Marija
AU  - Van Deun, Rik
AU  - Joksović, Ljubinka
AU  - Pagnacco, Maja
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6461
AB  - Due to the interesting and potentially useful properties, phosphate tungsten bronzes are constantly being studied and attract a lot of attention. In the present work, two different metallic elements, belonging to the group of rare-earth metals, cerium and praseodymium, were used as a dopants for phosphate tungsten bronzes. Novel cerium and praseodymium doped phosphate tungsten bronzes were successfully synthesized and further characterized by thermal analyses, Fourier-transform infrared spectroscopy, X-ray powder diffraction, scanning electron microscopy
with energy-dispersive X-ray spectrometer and photoluminescence spectroscopy. The behavior of
cerium and praseodymium doped phosphate tungsten bronzes were examined in the Briggs-Rauscher oscillatory reaction. The changes in the oscillatory dynamics, caused by the addition of cerium doped and praseodymium doped phosphate tungsten bronzes, are used for distinction of these bronzes and also as a method for testing the catalytic features of the bronzes. Beside the nonlinear behavior, the bronzes have shown photoluminescence in the visible region (blue region).
PB  - Elsevier B.V.
T2  - Optical Materials
T1  - Novel cerium and praseodymium doped phosphate tungsten bronzes: Synthesis, characterization, the behavior in the Briggs-Rauscher reaction and photoluminescence properties
VL  - 143
SP  - 114125
DO  - 10.1016/j.optmat.2023.114125
ER  - 
@article{
author = "Maksimović, Tijana and Tančić, Pavle and Maksimović, Jelena and Mara, Dimitrije and Ilić, Marija and Van Deun, Rik and Joksović, Ljubinka and Pagnacco, Maja",
year = "2023",
abstract = "Due to the interesting and potentially useful properties, phosphate tungsten bronzes are constantly being studied and attract a lot of attention. In the present work, two different metallic elements, belonging to the group of rare-earth metals, cerium and praseodymium, were used as a dopants for phosphate tungsten bronzes. Novel cerium and praseodymium doped phosphate tungsten bronzes were successfully synthesized and further characterized by thermal analyses, Fourier-transform infrared spectroscopy, X-ray powder diffraction, scanning electron microscopy
with energy-dispersive X-ray spectrometer and photoluminescence spectroscopy. The behavior of
cerium and praseodymium doped phosphate tungsten bronzes were examined in the Briggs-Rauscher oscillatory reaction. The changes in the oscillatory dynamics, caused by the addition of cerium doped and praseodymium doped phosphate tungsten bronzes, are used for distinction of these bronzes and also as a method for testing the catalytic features of the bronzes. Beside the nonlinear behavior, the bronzes have shown photoluminescence in the visible region (blue region).",
publisher = "Elsevier B.V.",
journal = "Optical Materials",
title = "Novel cerium and praseodymium doped phosphate tungsten bronzes: Synthesis, characterization, the behavior in the Briggs-Rauscher reaction and photoluminescence properties",
volume = "143",
pages = "114125",
doi = "10.1016/j.optmat.2023.114125"
}
Maksimović, T., Tančić, P., Maksimović, J., Mara, D., Ilić, M., Van Deun, R., Joksović, L.,& Pagnacco, M.. (2023). Novel cerium and praseodymium doped phosphate tungsten bronzes: Synthesis, characterization, the behavior in the Briggs-Rauscher reaction and photoluminescence properties. in Optical Materials
Elsevier B.V.., 143, 114125.
https://doi.org/10.1016/j.optmat.2023.114125
Maksimović T, Tančić P, Maksimović J, Mara D, Ilić M, Van Deun R, Joksović L, Pagnacco M. Novel cerium and praseodymium doped phosphate tungsten bronzes: Synthesis, characterization, the behavior in the Briggs-Rauscher reaction and photoluminescence properties. in Optical Materials. 2023;143:114125.
doi:10.1016/j.optmat.2023.114125 .
Maksimović, Tijana, Tančić, Pavle, Maksimović, Jelena, Mara, Dimitrije, Ilić, Marija, Van Deun, Rik, Joksović, Ljubinka, Pagnacco, Maja, "Novel cerium and praseodymium doped phosphate tungsten bronzes: Synthesis, characterization, the behavior in the Briggs-Rauscher reaction and photoluminescence properties" in Optical Materials, 143 (2023):114125,
https://doi.org/10.1016/j.optmat.2023.114125 . .
2
1

Supplementary Materials for: "Novel cerium and praseodymium doped phosphate tungsten bronzes: Synthesis, characterization, photoluminescent properties and behavior in Briggs-Rauscher reaction"

Maksimović, Tijana; Tančić, Pavle; Maksimović, Jelena; Mara, Dimitrije; Ilić, Marija; Van Deun, Rik; Joksović, Ljubinka; Pagnacco, Maja

(Elsevier B.V., 2023)

TY  - DATA
AU  - Maksimović, Tijana
AU  - Tančić, Pavle
AU  - Maksimović, Jelena
AU  - Mara, Dimitrije
AU  - Ilić, Marija
AU  - Van Deun, Rik
AU  - Joksović, Ljubinka
AU  - Pagnacco, Maja
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6980
AB  - Fig. S1 FTIR spectrum of 6-PWA; Table S1 Observed inter-planar spacings (dobs, in Å) and intensities (Iobs, in %) of Ce-PWA and Pr-PWA, in comparison with 6-PWA and Ca-PWA; Table S2 Observed inter-planar spacings (dobs, in Å) and intensities (Iobs, in %) of Ce-PWB and Pr-PWB, in comparison with PWB, Ca-PWB, and Li-PWB; Table S3 Calculated inter-planar spacings (dcalc, in Å) of Ce-PWB, Pr-PWB, Ca-PWB, and Li-PWB in comparison with PWB; Figure S2 Linear (column I, left) and polynomial (column II, right; C1) variations of ionic radiuses (in Å) for Ce-PWB, Pr-PWB, Ca-PWB and Li-PWB bronzes by: a) axis a0 (in Å); b) axis b0 (in Å); c) axis c0 (in Å); d) angle β0 (in o); and e) volume V0 (in Å3); Figure S3 Linear (column I, left) and polynomial (column II, right; C2) variations of ionic radiuses (in Å) for Ce-PWB, Pr-PWB, Ca-PWB and Li-PWB bronzes by: a) axis a0 (in Å); b) axis b0 (in Å); c) axis c0 (in Å); d) angle β0 (in o); and e) volume V0 (in Å3); Figure S4 Linear (column I, left) and polynomial (column II, right; C3) variations of ionic radiuses (in Å) for Ce-PWB, Pr-PWB, Ca-PWB and Li-PWB bronzes by: a) axis a0 (in Å); b) axis b0 (in Å); c) axis c0 (in Å); d) angle β0 (in o); and e) volume V0 (in Å3); Figure S5 Linear (column I, left) and polynomial (column II, right; C4) variations of ionic radiuses (in Å) for Ce-PWB, Pr-PWB, Ca-PWB and Li-PWB bronzes by: a) axis a0 (in Å); b) axis b0 (in Å); c) axis c0 (in Å); d) angle β0 (in o); and e) volume V0 (in Å3); Table S4 The results of lifetime measurements of pure matrixes and doped samples; Fig. S6 Emission spectra of: a PWA and b Ce-PWA excited at 320 nm; c Ce-PWA and d Pr-PWA under excitation at 376 nm at room temperature; Fig. S7 Excitation spectra of: a PWA; b Ce-PWA; c Pr-PWA emission observed at peak maxima ~ 430 nm at room temperature; Fig. S8 Decay profiles of: a PWB; b Ce-PWB; c Pr-PWB excited at 376 nm and measured at room temperature; Fig. S9 Decay profiles of: a PWA and b Ce-PWA excited at 320 nm; c Ce-PWA and d Pr-PWA excited at 376 nm, measured at room temperature; Fig. S10  The CIE chromaticity diagram of: a PWA (x = 0.167, y = 0.127) and b Ce-PWA (x= 1.175, y = 0.158) excited at 320 nm; c Ce-PWA(x = 0.165, y = 0.125) and d Pr-PWA (x = 0.158, y = 0.099) excited at 376 nm.
PB  - Elsevier B.V.
T2  - Optical Materials
T1  - Supplementary Materials for: "Novel cerium and praseodymium doped phosphate tungsten bronzes: Synthesis, characterization, photoluminescent properties and behavior in Briggs-Rauscher reaction"
UR  - https://hdl.handle.net/21.15107/rcub_cer_6980
ER  - 
@misc{
author = "Maksimović, Tijana and Tančić, Pavle and Maksimović, Jelena and Mara, Dimitrije and Ilić, Marija and Van Deun, Rik and Joksović, Ljubinka and Pagnacco, Maja",
year = "2023",
abstract = "Fig. S1 FTIR spectrum of 6-PWA; Table S1 Observed inter-planar spacings (dobs, in Å) and intensities (Iobs, in %) of Ce-PWA and Pr-PWA, in comparison with 6-PWA and Ca-PWA; Table S2 Observed inter-planar spacings (dobs, in Å) and intensities (Iobs, in %) of Ce-PWB and Pr-PWB, in comparison with PWB, Ca-PWB, and Li-PWB; Table S3 Calculated inter-planar spacings (dcalc, in Å) of Ce-PWB, Pr-PWB, Ca-PWB, and Li-PWB in comparison with PWB; Figure S2 Linear (column I, left) and polynomial (column II, right; C1) variations of ionic radiuses (in Å) for Ce-PWB, Pr-PWB, Ca-PWB and Li-PWB bronzes by: a) axis a0 (in Å); b) axis b0 (in Å); c) axis c0 (in Å); d) angle β0 (in o); and e) volume V0 (in Å3); Figure S3 Linear (column I, left) and polynomial (column II, right; C2) variations of ionic radiuses (in Å) for Ce-PWB, Pr-PWB, Ca-PWB and Li-PWB bronzes by: a) axis a0 (in Å); b) axis b0 (in Å); c) axis c0 (in Å); d) angle β0 (in o); and e) volume V0 (in Å3); Figure S4 Linear (column I, left) and polynomial (column II, right; C3) variations of ionic radiuses (in Å) for Ce-PWB, Pr-PWB, Ca-PWB and Li-PWB bronzes by: a) axis a0 (in Å); b) axis b0 (in Å); c) axis c0 (in Å); d) angle β0 (in o); and e) volume V0 (in Å3); Figure S5 Linear (column I, left) and polynomial (column II, right; C4) variations of ionic radiuses (in Å) for Ce-PWB, Pr-PWB, Ca-PWB and Li-PWB bronzes by: a) axis a0 (in Å); b) axis b0 (in Å); c) axis c0 (in Å); d) angle β0 (in o); and e) volume V0 (in Å3); Table S4 The results of lifetime measurements of pure matrixes and doped samples; Fig. S6 Emission spectra of: a PWA and b Ce-PWA excited at 320 nm; c Ce-PWA and d Pr-PWA under excitation at 376 nm at room temperature; Fig. S7 Excitation spectra of: a PWA; b Ce-PWA; c Pr-PWA emission observed at peak maxima ~ 430 nm at room temperature; Fig. S8 Decay profiles of: a PWB; b Ce-PWB; c Pr-PWB excited at 376 nm and measured at room temperature; Fig. S9 Decay profiles of: a PWA and b Ce-PWA excited at 320 nm; c Ce-PWA and d Pr-PWA excited at 376 nm, measured at room temperature; Fig. S10  The CIE chromaticity diagram of: a PWA (x = 0.167, y = 0.127) and b Ce-PWA (x= 1.175, y = 0.158) excited at 320 nm; c Ce-PWA(x = 0.165, y = 0.125) and d Pr-PWA (x = 0.158, y = 0.099) excited at 376 nm.",
publisher = "Elsevier B.V.",
journal = "Optical Materials",
title = "Supplementary Materials for: "Novel cerium and praseodymium doped phosphate tungsten bronzes: Synthesis, characterization, photoluminescent properties and behavior in Briggs-Rauscher reaction"",
url = "https://hdl.handle.net/21.15107/rcub_cer_6980"
}
Maksimović, T., Tančić, P., Maksimović, J., Mara, D., Ilić, M., Van Deun, R., Joksović, L.,& Pagnacco, M.. (2023). Supplementary Materials for: "Novel cerium and praseodymium doped phosphate tungsten bronzes: Synthesis, characterization, photoluminescent properties and behavior in Briggs-Rauscher reaction". in Optical Materials
Elsevier B.V...
https://hdl.handle.net/21.15107/rcub_cer_6980
Maksimović T, Tančić P, Maksimović J, Mara D, Ilić M, Van Deun R, Joksović L, Pagnacco M. Supplementary Materials for: "Novel cerium and praseodymium doped phosphate tungsten bronzes: Synthesis, characterization, photoluminescent properties and behavior in Briggs-Rauscher reaction". in Optical Materials. 2023;.
https://hdl.handle.net/21.15107/rcub_cer_6980 .
Maksimović, Tijana, Tančić, Pavle, Maksimović, Jelena, Mara, Dimitrije, Ilić, Marija, Van Deun, Rik, Joksović, Ljubinka, Pagnacco, Maja, "Supplementary Materials for: "Novel cerium and praseodymium doped phosphate tungsten bronzes: Synthesis, characterization, photoluminescent properties and behavior in Briggs-Rauscher reaction"" in Optical Materials (2023),
https://hdl.handle.net/21.15107/rcub_cer_6980 .

Comparison of the luminescence properties of phosphate-tungsten bronze and cerium doped phosphate-tungsten bronze

Maksimović, Tijana; Joksović, Ljubinka; Mara, Dimitrije; Van Deun, Rik; Nedić, Zoran; Simović-Pavlović, Marina; Pagnacco, Maja

(Kragujevac, Serbia : Institute for Information Technologies, University of Kragujevac, 2023)

TY  - CONF
AU  - Maksimović, Tijana
AU  - Joksović, Ljubinka
AU  - Mara, Dimitrije
AU  - Van Deun, Rik
AU  - Nedić, Zoran
AU  - Simović-Pavlović, Marina
AU  - Pagnacco, Maja
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/7343
AB  - Phosphate-tungsten bronzes (PWBs) constantly attract a lot of attention owing to their interesting chemical, mechanical, and optical properties. Furthermore, tungsten bronzes as inert inorganic solids, exhibit interesting and useful electronic properties when rare-earth ions are incorporated into their structure. Cerium doped phosphate-tungsten bronze (Ce-PWB) is obtained in the process of phase transformations of CePW12O40×6H2O (Ce-PWA) salt. The brown crystals of Ce-PWB are formed after heating of Ce-PWA in a furnace, in a temperature range from room temperature to 650 °C. In the present paper the luminescence properties of undoped PWB and Ce-PWB are analyzed and compared. Regarding the characterized luminescence properties of PWB and Ce-PWB, only PWB matrix showed luminescence, while dopant Ce3+ had no significant influence on the change of the emission spectra with characteristic spectra for this ion. The obtained CIE chromaticity diagrams showed that both samples emit in the deep blue region, suggesting their possible use as a blue emitting source for white light-emitting diodes (LEDs).
PB  - Kragujevac, Serbia : Institute for Information Technologies, University of Kragujevac
C3  - 2nd International Conference on Chemo and  Bioinformatics - Book of proceedings,  September 28-29, 2023. Kragujevac, Serbia
T1  - Comparison of the luminescence properties of phosphate-tungsten bronze and cerium doped phosphate-tungsten bronze
SP  - 160
EP  - 163
DO  - 10.46793/ICCBI23.160M
ER  - 
@conference{
author = "Maksimović, Tijana and Joksović, Ljubinka and Mara, Dimitrije and Van Deun, Rik and Nedić, Zoran and Simović-Pavlović, Marina and Pagnacco, Maja",
year = "2023",
abstract = "Phosphate-tungsten bronzes (PWBs) constantly attract a lot of attention owing to their interesting chemical, mechanical, and optical properties. Furthermore, tungsten bronzes as inert inorganic solids, exhibit interesting and useful electronic properties when rare-earth ions are incorporated into their structure. Cerium doped phosphate-tungsten bronze (Ce-PWB) is obtained in the process of phase transformations of CePW12O40×6H2O (Ce-PWA) salt. The brown crystals of Ce-PWB are formed after heating of Ce-PWA in a furnace, in a temperature range from room temperature to 650 °C. In the present paper the luminescence properties of undoped PWB and Ce-PWB are analyzed and compared. Regarding the characterized luminescence properties of PWB and Ce-PWB, only PWB matrix showed luminescence, while dopant Ce3+ had no significant influence on the change of the emission spectra with characteristic spectra for this ion. The obtained CIE chromaticity diagrams showed that both samples emit in the deep blue region, suggesting their possible use as a blue emitting source for white light-emitting diodes (LEDs).",
publisher = "Kragujevac, Serbia : Institute for Information Technologies, University of Kragujevac",
journal = "2nd International Conference on Chemo and  Bioinformatics - Book of proceedings,  September 28-29, 2023. Kragujevac, Serbia",
title = "Comparison of the luminescence properties of phosphate-tungsten bronze and cerium doped phosphate-tungsten bronze",
pages = "160-163",
doi = "10.46793/ICCBI23.160M"
}
Maksimović, T., Joksović, L., Mara, D., Van Deun, R., Nedić, Z., Simović-Pavlović, M.,& Pagnacco, M.. (2023). Comparison of the luminescence properties of phosphate-tungsten bronze and cerium doped phosphate-tungsten bronze. in 2nd International Conference on Chemo and  Bioinformatics - Book of proceedings,  September 28-29, 2023. Kragujevac, Serbia
Kragujevac, Serbia : Institute for Information Technologies, University of Kragujevac., 160-163.
https://doi.org/10.46793/ICCBI23.160M
Maksimović T, Joksović L, Mara D, Van Deun R, Nedić Z, Simović-Pavlović M, Pagnacco M. Comparison of the luminescence properties of phosphate-tungsten bronze and cerium doped phosphate-tungsten bronze. in 2nd International Conference on Chemo and  Bioinformatics - Book of proceedings,  September 28-29, 2023. Kragujevac, Serbia. 2023;:160-163.
doi:10.46793/ICCBI23.160M .
Maksimović, Tijana, Joksović, Ljubinka, Mara, Dimitrije, Van Deun, Rik, Nedić, Zoran, Simović-Pavlović, Marina, Pagnacco, Maja, "Comparison of the luminescence properties of phosphate-tungsten bronze and cerium doped phosphate-tungsten bronze" in 2nd International Conference on Chemo and  Bioinformatics - Book of proceedings,  September 28-29, 2023. Kragujevac, Serbia (2023):160-163,
https://doi.org/10.46793/ICCBI23.160M . .

Luminescent properties of praseodymium doped phosphate tungsten bronze

Joksović, Ljubinka; Maksimović, Tijana; Van Deun, Rik; Mara, Dimitrije; Pagnacco, Maja

(Faculty of Management Herceg Novi, 2023)

TY  - CONF
AU  - Joksović, Ljubinka
AU  - Maksimović, Tijana
AU  - Van Deun, Rik
AU  - Mara, Dimitrije
AU  - Pagnacco, Maja
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/7354
AB  - Nowadays phosphate tungsten bronzes (PWBs) attract a lot of attention due to their interesting chemical, mechanical, and optical features. Moreover, tungsten bronzes as inert inorganic solids, with incorporated rare-earth ions in their structure, show interesting and useful electronic properties. Praseodymium doped phosphate tungsten bronze (Pr-PWB) is obtained in the process of phase transformations of PrPW12O40∙6H2O (Pr-PWA) salt. The green crystals of Pr-PWB are formed after the heating of Pr-PWA in a furnace, in a temperature range from room temperature to 650 °C. In the present paper the fluorescent properties are analyzed of Pr-PWB, its precursor – 12-tungstophosphoric heteropoly acid, H3PW12O40∙29H2O (PWA) with Keggin's anion structure, as well as the intermediate – Pr-PWA salt. The luminescent properties where characterized and the 
obtained results showed that both samples emit in the deep blue region, indicating their potential use as a blue emitting source for white light LED's.
PB  - Faculty of Management Herceg Novi
C3  - Second International Conference on Advances in Science and Technology - COAST, Proceedings, 31 May - 03 June, Herzeg Novi, Montenegro
T1  - Luminescent properties of praseodymium doped phosphate tungsten bronze
SP  - 353
EP  - 358
UR  - https://hdl.handle.net/21.15107/rcub_cer_7354
ER  - 
@conference{
author = "Joksović, Ljubinka and Maksimović, Tijana and Van Deun, Rik and Mara, Dimitrije and Pagnacco, Maja",
year = "2023",
abstract = "Nowadays phosphate tungsten bronzes (PWBs) attract a lot of attention due to their interesting chemical, mechanical, and optical features. Moreover, tungsten bronzes as inert inorganic solids, with incorporated rare-earth ions in their structure, show interesting and useful electronic properties. Praseodymium doped phosphate tungsten bronze (Pr-PWB) is obtained in the process of phase transformations of PrPW12O40∙6H2O (Pr-PWA) salt. The green crystals of Pr-PWB are formed after the heating of Pr-PWA in a furnace, in a temperature range from room temperature to 650 °C. In the present paper the fluorescent properties are analyzed of Pr-PWB, its precursor – 12-tungstophosphoric heteropoly acid, H3PW12O40∙29H2O (PWA) with Keggin's anion structure, as well as the intermediate – Pr-PWA salt. The luminescent properties where characterized and the 
obtained results showed that both samples emit in the deep blue region, indicating their potential use as a blue emitting source for white light LED's.",
publisher = "Faculty of Management Herceg Novi",
journal = "Second International Conference on Advances in Science and Technology - COAST, Proceedings, 31 May - 03 June, Herzeg Novi, Montenegro",
title = "Luminescent properties of praseodymium doped phosphate tungsten bronze",
pages = "353-358",
url = "https://hdl.handle.net/21.15107/rcub_cer_7354"
}
Joksović, L., Maksimović, T., Van Deun, R., Mara, D.,& Pagnacco, M.. (2023). Luminescent properties of praseodymium doped phosphate tungsten bronze. in Second International Conference on Advances in Science and Technology - COAST, Proceedings, 31 May - 03 June, Herzeg Novi, Montenegro
Faculty of Management Herceg Novi., 353-358.
https://hdl.handle.net/21.15107/rcub_cer_7354
Joksović L, Maksimović T, Van Deun R, Mara D, Pagnacco M. Luminescent properties of praseodymium doped phosphate tungsten bronze. in Second International Conference on Advances in Science and Technology - COAST, Proceedings, 31 May - 03 June, Herzeg Novi, Montenegro. 2023;:353-358.
https://hdl.handle.net/21.15107/rcub_cer_7354 .
Joksović, Ljubinka, Maksimović, Tijana, Van Deun, Rik, Mara, Dimitrije, Pagnacco, Maja, "Luminescent properties of praseodymium doped phosphate tungsten bronze" in Second International Conference on Advances in Science and Technology - COAST, Proceedings, 31 May - 03 June, Herzeg Novi, Montenegro (2023):353-358,
https://hdl.handle.net/21.15107/rcub_cer_7354 .

Antitumor activity of organoruthenium complexes with chelate aromatic ligands, derived from 1,10-phenantroline: Synthesis and biological activity

Savić, Aleksandar; Gligorijević, Nevenka; Aranđelović, Sandra; Dojčinović, Biljana; Kaczmarek, Anna M.; Radulović, Siniša; Van Deun, Rik; Van Hecke, Kristof

(Elsevier, 2020)

TY  - JOUR
AU  - Savić, Aleksandar
AU  - Gligorijević, Nevenka
AU  - Aranđelović, Sandra
AU  - Dojčinović, Biljana
AU  - Kaczmarek, Anna M.
AU  - Radulović, Siniša
AU  - Van Deun, Rik
AU  - Van Hecke, Kristof
PY  - 2020
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3352
AB  - The monocationic chloro complexes containing chelating N∩N ligands: [(η6-p-cymene)Ru(L1–4)Cl]+ (1–4), where L1 = 4-methyl-1,10-phenantroline, L2 = dipyrido[3,2-a:2′,3′-c]phenazine, L3 = 11-chloro-dipyrido[3,2-a:2′,3′-c]phenazine, L4 = 11-nitro-dipyrido[3,2-a:2′,3′-c]phenazine; p-cymene = 1-methyl-4-isopropylbenzene) have been prepared and characterized as the hexafluorophosphate salts. The biological activity of 1–4 has been investigated in selected 2D monolayer cell cultures (A549, PANC-1, MDA-MB-231, MRC-5). All investigated ruthenium complexes showed similar or even better cytotoxicity to cisplatin. However, there was no significant reduction in growth of PANC-1 cells in a 3D cell culture of multicellular tumor spheroids (MCTS) after treatment with 2–4, while the cisplatin treatment induced retardation in MCTS growth. Flow cytometry analysis of the cell cycle of PANC-1 cells shows that 3 caused changes of cell cycle phase distribution characterized by slight accumulation of cells in the G2-M phase. Absence of the Sub-G1 phase in the cell cycle of the treated cells indicated that there was no fragmentation of DNA for the analyzed time intervals (48 and 72 h treatment). Fluorescent microscopy, after acridine orange/ethidium bromide staining, revealed that the investigated ruthenium complexes induced some characteristics of apoptotic morphology (shrinking and condensation of chromatin) with notably preserved integrity of the plasma membrane. Investigation of cellular uptake and DNA - fraction accumulation performed by inductively coupled plasma mass spectrometry in PANC-1 cells with equimolar concentrations (5 μM) of 2–4 and cisplatin showed more efficient cellular uptake and DNA - fraction accumulation of complex 3 compared to complexes 2 and 4.
PB  - Elsevier
T2  - Journal of Inorganic Biochemistry
T1  - Antitumor activity of organoruthenium complexes with chelate aromatic ligands, derived from 1,10-phenantroline: Synthesis and biological activity
VL  - 202
SP  - 110869
SP  - 110869
DO  - 10.1016/j.jinorgbio.2019.110869
ER  - 
@article{
author = "Savić, Aleksandar and Gligorijević, Nevenka and Aranđelović, Sandra and Dojčinović, Biljana and Kaczmarek, Anna M. and Radulović, Siniša and Van Deun, Rik and Van Hecke, Kristof",
year = "2020",
abstract = "The monocationic chloro complexes containing chelating N∩N ligands: [(η6-p-cymene)Ru(L1–4)Cl]+ (1–4), where L1 = 4-methyl-1,10-phenantroline, L2 = dipyrido[3,2-a:2′,3′-c]phenazine, L3 = 11-chloro-dipyrido[3,2-a:2′,3′-c]phenazine, L4 = 11-nitro-dipyrido[3,2-a:2′,3′-c]phenazine; p-cymene = 1-methyl-4-isopropylbenzene) have been prepared and characterized as the hexafluorophosphate salts. The biological activity of 1–4 has been investigated in selected 2D monolayer cell cultures (A549, PANC-1, MDA-MB-231, MRC-5). All investigated ruthenium complexes showed similar or even better cytotoxicity to cisplatin. However, there was no significant reduction in growth of PANC-1 cells in a 3D cell culture of multicellular tumor spheroids (MCTS) after treatment with 2–4, while the cisplatin treatment induced retardation in MCTS growth. Flow cytometry analysis of the cell cycle of PANC-1 cells shows that 3 caused changes of cell cycle phase distribution characterized by slight accumulation of cells in the G2-M phase. Absence of the Sub-G1 phase in the cell cycle of the treated cells indicated that there was no fragmentation of DNA for the analyzed time intervals (48 and 72 h treatment). Fluorescent microscopy, after acridine orange/ethidium bromide staining, revealed that the investigated ruthenium complexes induced some characteristics of apoptotic morphology (shrinking and condensation of chromatin) with notably preserved integrity of the plasma membrane. Investigation of cellular uptake and DNA - fraction accumulation performed by inductively coupled plasma mass spectrometry in PANC-1 cells with equimolar concentrations (5 μM) of 2–4 and cisplatin showed more efficient cellular uptake and DNA - fraction accumulation of complex 3 compared to complexes 2 and 4.",
publisher = "Elsevier",
journal = "Journal of Inorganic Biochemistry",
title = "Antitumor activity of organoruthenium complexes with chelate aromatic ligands, derived from 1,10-phenantroline: Synthesis and biological activity",
volume = "202",
pages = "110869-110869",
doi = "10.1016/j.jinorgbio.2019.110869"
}
Savić, A., Gligorijević, N., Aranđelović, S., Dojčinović, B., Kaczmarek, A. M., Radulović, S., Van Deun, R.,& Van Hecke, K.. (2020). Antitumor activity of organoruthenium complexes with chelate aromatic ligands, derived from 1,10-phenantroline: Synthesis and biological activity. in Journal of Inorganic Biochemistry
Elsevier., 202, 110869.
https://doi.org/10.1016/j.jinorgbio.2019.110869
Savić A, Gligorijević N, Aranđelović S, Dojčinović B, Kaczmarek AM, Radulović S, Van Deun R, Van Hecke K. Antitumor activity of organoruthenium complexes with chelate aromatic ligands, derived from 1,10-phenantroline: Synthesis and biological activity. in Journal of Inorganic Biochemistry. 2020;202:110869.
doi:10.1016/j.jinorgbio.2019.110869 .
Savić, Aleksandar, Gligorijević, Nevenka, Aranđelović, Sandra, Dojčinović, Biljana, Kaczmarek, Anna M., Radulović, Siniša, Van Deun, Rik, Van Hecke, Kristof, "Antitumor activity of organoruthenium complexes with chelate aromatic ligands, derived from 1,10-phenantroline: Synthesis and biological activity" in Journal of Inorganic Biochemistry, 202 (2020):110869,
https://doi.org/10.1016/j.jinorgbio.2019.110869 . .
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