TY  - JOUR
AU  - Ilić, Slavica B.
AU  - Konstantinović, Sandra S.
AU  - Gojgić-Cvijović, Gordana
AU  - Veljković, Vlada B.
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3247
AB  - Influence of a modified media on Hexaene H-85 and Azalomycine B production by Streptomyces hygroscopicus CH-7 was investigated. The amino acid L-tryptophan, as a nitrogen source, was replaced with isatin-3-thiosemicarbazone and its complexes with some divalent metal ions. Isatin-3-thiosemicarbazone was synthesized in crude glycerol obtained as a byproduct in biodiesel production from sunflower oil. The complexes were charac-terized by elemental microanalysis and magnetic susceptibility, as well as, by Atomic absorption(AA), Fourier-transform infrared (FTIR) and Ultraviolet–visible (UV/VIS) spectro-scopic methods. The spectral studies indicated an octahedral geometry for the Mn(II), Fe(II) and Ni(II) complexes and a tetrahedral one for the Zn(II) complex. Comparing to the basal medium, isatin-3-thiosemicarbazone (ITC) and its metal complexes in the concentration of 0.5 g dm-3 showed better results in the antibiotics production. Use of medium supple-mented with the Fe(II) complex resulted in the maximum Hexaene H-85 and Azalomycine B concentrations of 306 μg cm-3 and 127 μg cm-3, respectively. Addition of ITC and its complexes changed the morphology of S. hygroscopicus CH-7 from filaments to pellets as a dominant shape in media resulting in higher antibiotic production.
AB  - У раду је испитиван утицај модификованих хранљивих подлога на производњу антибиотика Hexaene H-85 и Azalomycine B помоћу Streptomyces hygroscopicus CH-7. Аминокиселина L-триптофан, као извор азота, замењена је изатин-3-тиосемикарбазоном (синтетисаним у сировом глицеролу који се добија као нуспродукт у производњи биодизела из сунцокретовог уља) и његовим комплексима са неким двоалентним металним јонима. Комплекси су карактерисани елементарном микроанализом, магнетном сусцептибилнош-ћу, атомском аспорпцијом (A), инфрацрвеним (IR) и ултравиолетним (UV/VIS) спектроскопским методама. Спектралне анализе показале су октахедралну геометрију комплекса Мn(II), Fе(II) и Ni(II) и тетраедарску за комплекс Zn(II). Изатин-3-тиосемикарбазон и његови комплекси са металима (0,5 g dm-3) утичу на повећање продукције антибиотика у поређењу са основном подлогом. Највеће концентрације антибиотика Hexaene H-85 и Azalomycine B су остварене у хранљивој подлози са Fe(II) комплексом (306 и 127 μg cm-3, редом). Комплекси ИТС и изатин 3-тиосемикарбазон утичу и на морфологију тестираног соја. Streptomyces hygroscopicus CH-7 растe у облику филамената и пелета, у подлогама у којима је остварена највећа продукција антибиотика.
PB  - Association of the Chemical Engineers of Serbia
T2  - Hemijska industrija
T1  - Antibiotic production by Streptomyces hygroscopicus CH-7 in medium containing Schiff base complexes
T1  - Продукција антибиотика помоћу Streptomyces hygroscopicus CH-7 у хранљивим подлогама са комплексима шифових базa
VL  - 73
IS  - 2
SP  - 93
EP  - 101
DO  - 10.2298/HEMIND181016008I
ER  - 

@article{
author = "Ilić, Slavica B. and Konstantinović, Sandra S. and Gojgić-Cvijović, Gordana and Veljković, Vlada B.",
year = "2019",
abstract = "Influence of a modified media on Hexaene H-85 and Azalomycine B production by Streptomyces hygroscopicus CH-7 was investigated. The amino acid L-tryptophan, as a nitrogen source, was replaced with isatin-3-thiosemicarbazone and its complexes with some divalent metal ions. Isatin-3-thiosemicarbazone was synthesized in crude glycerol obtained as a byproduct in biodiesel production from sunflower oil. The complexes were charac-terized by elemental microanalysis and magnetic susceptibility, as well as, by Atomic absorption(AA), Fourier-transform infrared (FTIR) and Ultraviolet–visible (UV/VIS) spectro-scopic methods. The spectral studies indicated an octahedral geometry for the Mn(II), Fe(II) and Ni(II) complexes and a tetrahedral one for the Zn(II) complex. Comparing to the basal medium, isatin-3-thiosemicarbazone (ITC) and its metal complexes in the concentration of 0.5 g dm-3 showed better results in the antibiotics production. Use of medium supple-mented with the Fe(II) complex resulted in the maximum Hexaene H-85 and Azalomycine B concentrations of 306 μg cm-3 and 127 μg cm-3, respectively. Addition of ITC and its complexes changed the morphology of S. hygroscopicus CH-7 from filaments to pellets as a dominant shape in media resulting in higher antibiotic production., У раду је испитиван утицај модификованих хранљивих подлога на производњу антибиотика Hexaene H-85 и Azalomycine B помоћу Streptomyces hygroscopicus CH-7. Аминокиселина L-триптофан, као извор азота, замењена је изатин-3-тиосемикарбазоном (синтетисаним у сировом глицеролу који се добија као нуспродукт у производњи биодизела из сунцокретовог уља) и његовим комплексима са неким двоалентним металним јонима. Комплекси су карактерисани елементарном микроанализом, магнетном сусцептибилнош-ћу, атомском аспорпцијом (A), инфрацрвеним (IR) и ултравиолетним (UV/VIS) спектроскопским методама. Спектралне анализе показале су октахедралну геометрију комплекса Мn(II), Fе(II) и Ni(II) и тетраедарску за комплекс Zn(II). Изатин-3-тиосемикарбазон и његови комплекси са металима (0,5 g dm-3) утичу на повећање продукције антибиотика у поређењу са основном подлогом. Највеће концентрације антибиотика Hexaene H-85 и Azalomycine B су остварене у хранљивој подлози са Fe(II) комплексом (306 и 127 μg cm-3, редом). Комплекси ИТС и изатин 3-тиосемикарбазон утичу и на морфологију тестираног соја. Streptomyces hygroscopicus CH-7 растe у облику филамената и пелета, у подлогама у којима је остварена највећа продукција антибиотика.",
publisher = "Association of the Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "Antibiotic production by Streptomyces hygroscopicus CH-7 in medium containing Schiff base complexes, Продукција антибиотика помоћу Streptomyces hygroscopicus CH-7 у хранљивим подлогама са комплексима шифових базa",
volume = "73",
number = "2",
pages = "93-101",
doi = "10.2298/HEMIND181016008I"
}

Ilić, S. B., Konstantinović, S. S., Gojgić-Cvijović, G.,& Veljković, V. B.. (2019). Antibiotic production by Streptomyces hygroscopicus CH-7 in medium containing Schiff base complexes. in Hemijska industrija
Association of the Chemical Engineers of Serbia., 73(2), 93-101.
https://doi.org/10.2298/HEMIND181016008I

Ilić SB, Konstantinović SS, Gojgić-Cvijović G, Veljković VB. Antibiotic production by Streptomyces hygroscopicus CH-7 in medium containing Schiff base complexes. in Hemijska industrija. 2019;73(2):93-101.
doi:10.2298/HEMIND181016008I .

Ilić, Slavica B., Konstantinović, Sandra S., Gojgić-Cvijović, Gordana, Veljković, Vlada B., "Antibiotic production by Streptomyces hygroscopicus CH-7 in medium containing Schiff base complexes" in Hemijska industrija, 73, no. 2 (2019):93-101,
https://doi.org/10.2298/HEMIND181016008I . .

TY  - JOUR
AU  - Konstantinović, Sandra S.
AU  - Zlatkovic, Milica Z.
AU  - Ciric, Jovan T.
AU  - Ilić, Slavica B.
AU  - Gojgić-Cvijović, Gordana
AU  - Veljković, Vlada B.
PY  - 2017
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2102
AB  - In the present work, four derivatives of salicylaldehyde (salicylaldehyde-hydrazone, phenylhydrazone, semicarbazone and thiosemicarbazone) were synthesized using both conventional (95% ethanol) and green (crude glycerol from biodiesel production) solvents. The obtained compounds were identified by elemental microanalysis, as well as FTIR, UV/Vis and H-1-NMR spectroscopic methods. Yields of 93-98% of the compounds in crude glycerol were achieved within 10-25 min. The derivatives of salicylaldehyde and crude glycerol were used as a nitrogen and carbon source, respectively, in the medium for antibiotic (hexaene H-85 and azalomycine B) production by Streptomyces hygroscopicus CH-7. The highest concentrations of hexaene H-85 and azalomycine B were achieved in the medium containing salicylaldehyde-thiosemicarbazone (198 and 69 mu g/cm(3), respectively). Derivatives of salicylaldehyde also impacted the strain morphology. In the media with salicylaldehyde- phenylhydrazone and salicylaldehyde-thiosemicarbazone, S. hygroscopicus CH-7 grew like large dispersive pellets with long twisted filaments that produced the highest yield of the antibiotics.
PB  - Association of Chemical Engineers of Serbia
T2  - Hemijska industrija
T1  - The use of salicylaldehyde derivatives as a nitrogen source for antibiotic production by Streptomyces hygroscopicus CH-7
VL  - 71
IS  - 6
SP  - 487
EP  - 494
DO  - 10.2298/HEMIND170124011K
ER  - 

@article{
author = "Konstantinović, Sandra S. and Zlatkovic, Milica Z. and Ciric, Jovan T. and Ilić, Slavica B. and Gojgić-Cvijović, Gordana and Veljković, Vlada B.",
year = "2017",
abstract = "In the present work, four derivatives of salicylaldehyde (salicylaldehyde-hydrazone, phenylhydrazone, semicarbazone and thiosemicarbazone) were synthesized using both conventional (95% ethanol) and green (crude glycerol from biodiesel production) solvents. The obtained compounds were identified by elemental microanalysis, as well as FTIR, UV/Vis and H-1-NMR spectroscopic methods. Yields of 93-98% of the compounds in crude glycerol were achieved within 10-25 min. The derivatives of salicylaldehyde and crude glycerol were used as a nitrogen and carbon source, respectively, in the medium for antibiotic (hexaene H-85 and azalomycine B) production by Streptomyces hygroscopicus CH-7. The highest concentrations of hexaene H-85 and azalomycine B were achieved in the medium containing salicylaldehyde-thiosemicarbazone (198 and 69 mu g/cm(3), respectively). Derivatives of salicylaldehyde also impacted the strain morphology. In the media with salicylaldehyde- phenylhydrazone and salicylaldehyde-thiosemicarbazone, S. hygroscopicus CH-7 grew like large dispersive pellets with long twisted filaments that produced the highest yield of the antibiotics.",
publisher = "Association of Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "The use of salicylaldehyde derivatives as a nitrogen source for antibiotic production by Streptomyces hygroscopicus CH-7",
volume = "71",
number = "6",
pages = "487-494",
doi = "10.2298/HEMIND170124011K"
}

Konstantinović, S. S., Zlatkovic, M. Z., Ciric, J. T., Ilić, S. B., Gojgić-Cvijović, G.,& Veljković, V. B.. (2017). The use of salicylaldehyde derivatives as a nitrogen source for antibiotic production by Streptomyces hygroscopicus CH-7. in Hemijska industrija
Association of Chemical Engineers of Serbia., 71(6), 487-494.
https://doi.org/10.2298/HEMIND170124011K

Konstantinović SS, Zlatkovic MZ, Ciric JT, Ilić SB, Gojgić-Cvijović G, Veljković VB. The use of salicylaldehyde derivatives as a nitrogen source for antibiotic production by Streptomyces hygroscopicus CH-7. in Hemijska industrija. 2017;71(6):487-494.
doi:10.2298/HEMIND170124011K .

Konstantinović, Sandra S., Zlatkovic, Milica Z., Ciric, Jovan T., Ilić, Slavica B., Gojgić-Cvijović, Gordana, Veljković, Vlada B., "The use of salicylaldehyde derivatives as a nitrogen source for antibiotic production by Streptomyces hygroscopicus CH-7" in Hemijska industrija, 71, no. 6 (2017):487-494,
https://doi.org/10.2298/HEMIND170124011K . .

TY  - JOUR
AU  - Ilić, Slavica B.
AU  - Konstantinović, Sandra S.
AU  - Ćirić, Jovan
AU  - Savić, Dragiša
AU  - Gojgić-Cvijović, Gordana
AU  - Veljković, Vlada B.
PY  - 2016
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1994
AB  - The microorganisam Streptomyces hygroscopicus CH-7 produces antibiotics Hexaene, Nigericine and Elaiophyline. The yield of antibiotics can be increased by changing the fermentation conditions and the composition of the nutrient medium. Based on the previous research with this strain and the literature reviewed, the aim of this work was to study the possibility of using waste materials (whey with proteins in varying ammounts and crude glycerol from the biodiesel production) as a carbon and nitrogen source in order to increase the yeald of antibiotics produced by Streptomyces hygroscopicus CH-7. The maximum concentration of Hexaene (47,2 μg/ cm3) was achieved in the medium with whey containing 80% of protein and glycerol from sunflower oil, while the maximum concentration of Elaiophyline (24,3μg/cm3) was achived in the basal medium.
AB  - Mikroorganizam Streptomyces hygroscopicus CH-7 produkuje antibiotike Heksaen, Nigericin i Elaiofilin. Promenom uslova fermentacije i sastava hranljive podloge može se povećati produkcija antibiotika. Na osnovu dosadašnjih istraživanja sa ovim sojem i literaturnog pregleda, cilj ovog rada je bio da se ispita mogućnost primene otpadnih sirovina (surutke sa različitim procentom proteina i sirovog glicerola iz proizvodnje biodizela) kao izvora ugljenika i azota, kako bi se povećala produkcija antibiotika pomoću Streptomyces hygroscopicus CH-7. Maksimalna koncentracija Heksaena (47,2 μg/cm 3) postignuta je na podlozi sa surutkom (koja sadrži 80% proteina) i glicerolom iz suncokretovog ulja, dok je maksimalna koncentracija Elaiofilina (24,3μg/cm3) ostvarena na osnovnoj podlozi.
PB  - Tehnološki fakultet, Leskovac
T2  - Advanced Technologies
T1  - Crude glycerol and whey as carbon and nitrogen sources for the production of antibiotics
T1  - Sirovi glicerol i surutka kao izvori ugljenika i azota za produkciju antibiotika
VL  - 5
IS  - 1
SP  - 5
EP  - 9
DO  - 10.5937/savteh1601005I
ER  - 

@article{
author = "Ilić, Slavica B. and Konstantinović, Sandra S. and Ćirić, Jovan and Savić, Dragiša and Gojgić-Cvijović, Gordana and Veljković, Vlada B.",
year = "2016",
abstract = "The microorganisam Streptomyces hygroscopicus CH-7 produces antibiotics Hexaene, Nigericine and Elaiophyline. The yield of antibiotics can be increased by changing the fermentation conditions and the composition of the nutrient medium. Based on the previous research with this strain and the literature reviewed, the aim of this work was to study the possibility of using waste materials (whey with proteins in varying ammounts and crude glycerol from the biodiesel production) as a carbon and nitrogen source in order to increase the yeald of antibiotics produced by Streptomyces hygroscopicus CH-7. The maximum concentration of Hexaene (47,2 μg/ cm3) was achieved in the medium with whey containing 80% of protein and glycerol from sunflower oil, while the maximum concentration of Elaiophyline (24,3μg/cm3) was achived in the basal medium., Mikroorganizam Streptomyces hygroscopicus CH-7 produkuje antibiotike Heksaen, Nigericin i Elaiofilin. Promenom uslova fermentacije i sastava hranljive podloge može se povećati produkcija antibiotika. Na osnovu dosadašnjih istraživanja sa ovim sojem i literaturnog pregleda, cilj ovog rada je bio da se ispita mogućnost primene otpadnih sirovina (surutke sa različitim procentom proteina i sirovog glicerola iz proizvodnje biodizela) kao izvora ugljenika i azota, kako bi se povećala produkcija antibiotika pomoću Streptomyces hygroscopicus CH-7. Maksimalna koncentracija Heksaena (47,2 μg/cm 3) postignuta je na podlozi sa surutkom (koja sadrži 80% proteina) i glicerolom iz suncokretovog ulja, dok je maksimalna koncentracija Elaiofilina (24,3μg/cm3) ostvarena na osnovnoj podlozi.",
publisher = "Tehnološki fakultet, Leskovac",
journal = "Advanced Technologies",
title = "Crude glycerol and whey as carbon and nitrogen sources for the production of antibiotics, Sirovi glicerol i surutka kao izvori ugljenika i azota za produkciju antibiotika",
volume = "5",
number = "1",
pages = "5-9",
doi = "10.5937/savteh1601005I"
}

Ilić, S. B., Konstantinović, S. S., Ćirić, J., Savić, D., Gojgić-Cvijović, G.,& Veljković, V. B.. (2016). Crude glycerol and whey as carbon and nitrogen sources for the production of antibiotics. in Advanced Technologies
Tehnološki fakultet, Leskovac., 5(1), 5-9.
https://doi.org/10.5937/savteh1601005I

Ilić SB, Konstantinović SS, Ćirić J, Savić D, Gojgić-Cvijović G, Veljković VB. Crude glycerol and whey as carbon and nitrogen sources for the production of antibiotics. in Advanced Technologies. 2016;5(1):5-9.
doi:10.5937/savteh1601005I .

Ilić, Slavica B., Konstantinović, Sandra S., Ćirić, Jovan, Savić, Dragiša, Gojgić-Cvijović, Gordana, Veljković, Vlada B., "Crude glycerol and whey as carbon and nitrogen sources for the production of antibiotics" in Advanced Technologies, 5, no. 1 (2016):5-9,
https://doi.org/10.5937/savteh1601005I . .

TY  - JOUR
AU  - Ciric, Jovan T
AU  - Konstantinović, Sandra S.
AU  - Ilić, Slavica B.
AU  - Gojgić-Cvijović, Gordana
AU  - Savic, Dragisa S
AU  - Veljković, Vlada B.
PY  - 2016
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2020
AB  - The effect of isatin derivatives as a nitrogen source on antibiotic (hexaene H-85 and azalomycine B) production by Streptomyces hygroscopicus CH-7 was studied. Isatin-3-hydrazone, 5-chloroisatin-3-hydrazone, isatin-3-tosylhydrazone, 5-chloroisatin-3-tosylhydrazone, isatin-3-(4-hidroxy) benzoilhydrazone and 5-chloroisatin-3-(4'-hidroxy) benzoylhydrazone were synthesized in a crude glycerol, obtained during the biodiesel production from edible sunflower oil. The highest concentration of Hexaene H-85 is achieved with 5-chloroisatin-3-hydrazone (197 mu g/cm(3)) in medium, while isatin-3-hydrazone has the greatest impact on azalomycine B production (72 mu g/cm(3)).
PB  - Association of Chemical Engineers of Serbia
T2  - Hemijska industrija
T1  - The impact of isatin derivatives on antibiotic production by Streptomyces hygroscopicus CH-7
VL  - 70
IS  - 2
SP  - 123
EP  - 128
DO  - 10.2298/HEMIND141127019C
ER  - 

@article{
author = "Ciric, Jovan T and Konstantinović, Sandra S. and Ilić, Slavica B. and Gojgić-Cvijović, Gordana and Savic, Dragisa S and Veljković, Vlada B.",
year = "2016",
abstract = "The effect of isatin derivatives as a nitrogen source on antibiotic (hexaene H-85 and azalomycine B) production by Streptomyces hygroscopicus CH-7 was studied. Isatin-3-hydrazone, 5-chloroisatin-3-hydrazone, isatin-3-tosylhydrazone, 5-chloroisatin-3-tosylhydrazone, isatin-3-(4-hidroxy) benzoilhydrazone and 5-chloroisatin-3-(4'-hidroxy) benzoylhydrazone were synthesized in a crude glycerol, obtained during the biodiesel production from edible sunflower oil. The highest concentration of Hexaene H-85 is achieved with 5-chloroisatin-3-hydrazone (197 mu g/cm(3)) in medium, while isatin-3-hydrazone has the greatest impact on azalomycine B production (72 mu g/cm(3)).",
publisher = "Association of Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "The impact of isatin derivatives on antibiotic production by Streptomyces hygroscopicus CH-7",
volume = "70",
number = "2",
pages = "123-128",
doi = "10.2298/HEMIND141127019C"
}

Ciric, J. T., Konstantinović, S. S., Ilić, S. B., Gojgić-Cvijović, G., Savic, D. S.,& Veljković, V. B.. (2016). The impact of isatin derivatives on antibiotic production by Streptomyces hygroscopicus CH-7. in Hemijska industrija
Association of Chemical Engineers of Serbia., 70(2), 123-128.
https://doi.org/10.2298/HEMIND141127019C

Ciric JT, Konstantinović SS, Ilić SB, Gojgić-Cvijović G, Savic DS, Veljković VB. The impact of isatin derivatives on antibiotic production by Streptomyces hygroscopicus CH-7. in Hemijska industrija. 2016;70(2):123-128.
doi:10.2298/HEMIND141127019C .

Ciric, Jovan T, Konstantinović, Sandra S., Ilić, Slavica B., Gojgić-Cvijović, Gordana, Savic, Dragisa S, Veljković, Vlada B., "The impact of isatin derivatives on antibiotic production by Streptomyces hygroscopicus CH-7" in Hemijska industrija, 70, no. 2 (2016):123-128,
https://doi.org/10.2298/HEMIND141127019C . .

TY  - JOUR
AU  - Ilić, Slavica B.
AU  - Konstantinović, Sandra S.
AU  - Gojgić-Cvijović, Gordana
AU  - Savić, Dragiša S.
AU  - Veljković, Vlada B.
PY  - 2015
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1656
AB  - A media consisting of isatin-Schiff bases and its inclusion complexes with beta-cyclodextrine was developed to maximize the production of antibiotics Hexaene H-85 and azalomycine B by Streptomyces hygroscopicus CH-7. The media With (-cyclodextrine inclusion complex of isatin-3-thiosemicarbazone resulted in the maximum antibiotics concentration of 493 ìg/cm3 for Hexaene H-85 and 191 ìg/cm3 for azalomycine B. The production of hexaene H-85 and azalomycine is higher when (-cyclodextrine complex is added as a nitrogen source, comparing to pure isatin-Schiff base. The maximum concentration of hexaene H-85 in medium with inclusion complex of isatin-Schiff base is 1.4-2.3 times higher than the basal medium. The maximum production of azalomycine is 2.1-3.4 times higher in media with inclusion complex of Schiff base. During the fermentation process, the nutrient media with (-cyclodextrine inclusion complexes with isatin-Schiff bases affect the strain morphology, since it is in the form of compact pellets, which are formed from short and long, branched filaments.
AB  - Streptomyces hygroscopicus je soj poznat po produkciji različitih vrsta antibiotika i komercijalno važnih sekundarnih metabolita. Formiranje metabolita je rezultat mikrobioloških procesa u toku fermentacije i zavisi od nivoa biomase mikroorganizma, morfološkog profila kulture, kao i od ekoloških uslova. U cilju povećanja prinosa antibiotika, osnovna hranljiva podloga je redefinisana izmenom izvora azota, tako što su umesto sojinog brašna (10 g/dm3) dodati kompleksi Šifovih baza sa (-ciklodekstrinom (10 g/dm3). Dodatak kompleksa Šifovih baza sa bciklodekstrinom rezultirao je znatno povećanje koncentracije oba antibiotika. Maksimalna koncentracija heksaena H-85 je ostvarena na podlozi sa kompleksom izatin-3-tiosemikarbazona sa (-ciklodekstrinom i iznosila je 493 ìg/cm3, dok je za azalomicin B iznosila 191 ìg/cm3. Povećanje maksimalnih koncentracija antibiotika na podlogama sa kompleksima Schiff-ovih baza je iznosilo 1,4-2,3 puta za heksaen H-85, odnosno 2,1-3,4 puta za azalomicin B, u odnosu na osnovnu podlogu. U toku procesa fermentacije na hranljivim podlogama sa kompleksima Šifovih baza sa (-ciklodekstrinom, soj raste u obliku kompaktnih peleta, koji se formiraju od kratkih i dugih, razgranatih filamenata.
PB  - Association of Chemical Engineers of Serbia
T2  - Hemijska industrija
T1  - The influence of Schiff base inclusion complexes with beta-cyclodextrine on antibiotic production by Streptomyces hygroscopicus CH-7
T1  - Uticaj kompleksa Šifovih baza sa beta-ciklodekstrinom na produkciju antibiotika pomoću Streptomyces hygroscopicus CH-7
VL  - 69
IS  - 1
SP  - 9
EP  - 15
DO  - 10.2298/HEMIND131113012I
ER  - 

@article{
author = "Ilić, Slavica B. and Konstantinović, Sandra S. and Gojgić-Cvijović, Gordana and Savić, Dragiša S. and Veljković, Vlada B.",
year = "2015",
abstract = "A media consisting of isatin-Schiff bases and its inclusion complexes with beta-cyclodextrine was developed to maximize the production of antibiotics Hexaene H-85 and azalomycine B by Streptomyces hygroscopicus CH-7. The media With (-cyclodextrine inclusion complex of isatin-3-thiosemicarbazone resulted in the maximum antibiotics concentration of 493 ìg/cm3 for Hexaene H-85 and 191 ìg/cm3 for azalomycine B. The production of hexaene H-85 and azalomycine is higher when (-cyclodextrine complex is added as a nitrogen source, comparing to pure isatin-Schiff base. The maximum concentration of hexaene H-85 in medium with inclusion complex of isatin-Schiff base is 1.4-2.3 times higher than the basal medium. The maximum production of azalomycine is 2.1-3.4 times higher in media with inclusion complex of Schiff base. During the fermentation process, the nutrient media with (-cyclodextrine inclusion complexes with isatin-Schiff bases affect the strain morphology, since it is in the form of compact pellets, which are formed from short and long, branched filaments., Streptomyces hygroscopicus je soj poznat po produkciji različitih vrsta antibiotika i komercijalno važnih sekundarnih metabolita. Formiranje metabolita je rezultat mikrobioloških procesa u toku fermentacije i zavisi od nivoa biomase mikroorganizma, morfološkog profila kulture, kao i od ekoloških uslova. U cilju povećanja prinosa antibiotika, osnovna hranljiva podloga je redefinisana izmenom izvora azota, tako što su umesto sojinog brašna (10 g/dm3) dodati kompleksi Šifovih baza sa (-ciklodekstrinom (10 g/dm3). Dodatak kompleksa Šifovih baza sa bciklodekstrinom rezultirao je znatno povećanje koncentracije oba antibiotika. Maksimalna koncentracija heksaena H-85 je ostvarena na podlozi sa kompleksom izatin-3-tiosemikarbazona sa (-ciklodekstrinom i iznosila je 493 ìg/cm3, dok je za azalomicin B iznosila 191 ìg/cm3. Povećanje maksimalnih koncentracija antibiotika na podlogama sa kompleksima Schiff-ovih baza je iznosilo 1,4-2,3 puta za heksaen H-85, odnosno 2,1-3,4 puta za azalomicin B, u odnosu na osnovnu podlogu. U toku procesa fermentacije na hranljivim podlogama sa kompleksima Šifovih baza sa (-ciklodekstrinom, soj raste u obliku kompaktnih peleta, koji se formiraju od kratkih i dugih, razgranatih filamenata.",
publisher = "Association of Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "The influence of Schiff base inclusion complexes with beta-cyclodextrine on antibiotic production by Streptomyces hygroscopicus CH-7, Uticaj kompleksa Šifovih baza sa beta-ciklodekstrinom na produkciju antibiotika pomoću Streptomyces hygroscopicus CH-7",
volume = "69",
number = "1",
pages = "9-15",
doi = "10.2298/HEMIND131113012I"
}

Ilić, S. B., Konstantinović, S. S., Gojgić-Cvijović, G., Savić, D. S.,& Veljković, V. B.. (2015). The influence of Schiff base inclusion complexes with beta-cyclodextrine on antibiotic production by Streptomyces hygroscopicus CH-7. in Hemijska industrija
Association of Chemical Engineers of Serbia., 69(1), 9-15.
https://doi.org/10.2298/HEMIND131113012I

Ilić SB, Konstantinović SS, Gojgić-Cvijović G, Savić DS, Veljković VB. The influence of Schiff base inclusion complexes with beta-cyclodextrine on antibiotic production by Streptomyces hygroscopicus CH-7. in Hemijska industrija. 2015;69(1):9-15.
doi:10.2298/HEMIND131113012I .

Ilić, Slavica B., Konstantinović, Sandra S., Gojgić-Cvijović, Gordana, Savić, Dragiša S., Veljković, Vlada B., "The influence of Schiff base inclusion complexes with beta-cyclodextrine on antibiotic production by Streptomyces hygroscopicus CH-7" in Hemijska industrija, 69, no. 1 (2015):9-15,
https://doi.org/10.2298/HEMIND131113012I . .

TY  - JOUR
AU  - Ilić, Slavica B.
AU  - Konstantinović, Sandra S.
AU  - Gojgić-Cvijović, Gordana
AU  - Savic, Dragisa S.
AU  - Veljković, Vlada B.
PY  - 2013
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1314
AB  - The impact of different carbon sources on the antibiotic production by Streptomyces hygroscopicus CH-7 was studied with the main goal to increase the yield of antibiotics hexaene H-85 and elaiophylin. Glucose, as a basic carbon source in the nutrition medium, was replaced with glycerol, xylose, sorbose, melibiose, inulin, and mannitol (15 g/dm(3)). Insuring the maximum yields of hexaene and elaiophylin of 192 and 88 mu g/cm(3), respectively, glycerol was shown to be the best carbon source among the investigated ones.
PB  - Springer Birkhauser, New York
T2  - Medicinal Chemistry Research
T1  - The impact of glycerol and some carbohydrates on antibiotic production by Streptomyces hygroscopicus CH-7
VL  - 22
IS  - 2
SP  - 934
EP  - 937
DO  - 10.1007/s00044-012-0088-9
ER  - 

@article{
author = "Ilić, Slavica B. and Konstantinović, Sandra S. and Gojgić-Cvijović, Gordana and Savic, Dragisa S. and Veljković, Vlada B.",
year = "2013",
abstract = "The impact of different carbon sources on the antibiotic production by Streptomyces hygroscopicus CH-7 was studied with the main goal to increase the yield of antibiotics hexaene H-85 and elaiophylin. Glucose, as a basic carbon source in the nutrition medium, was replaced with glycerol, xylose, sorbose, melibiose, inulin, and mannitol (15 g/dm(3)). Insuring the maximum yields of hexaene and elaiophylin of 192 and 88 mu g/cm(3), respectively, glycerol was shown to be the best carbon source among the investigated ones.",
publisher = "Springer Birkhauser, New York",
journal = "Medicinal Chemistry Research",
title = "The impact of glycerol and some carbohydrates on antibiotic production by Streptomyces hygroscopicus CH-7",
volume = "22",
number = "2",
pages = "934-937",
doi = "10.1007/s00044-012-0088-9"
}

Ilić, S. B., Konstantinović, S. S., Gojgić-Cvijović, G., Savic, D. S.,& Veljković, V. B.. (2013). The impact of glycerol and some carbohydrates on antibiotic production by Streptomyces hygroscopicus CH-7. in Medicinal Chemistry Research
Springer Birkhauser, New York., 22(2), 934-937.
https://doi.org/10.1007/s00044-012-0088-9

Ilić SB, Konstantinović SS, Gojgić-Cvijović G, Savic DS, Veljković VB. The impact of glycerol and some carbohydrates on antibiotic production by Streptomyces hygroscopicus CH-7. in Medicinal Chemistry Research. 2013;22(2):934-937.
doi:10.1007/s00044-012-0088-9 .

Ilić, Slavica B., Konstantinović, Sandra S., Gojgić-Cvijović, Gordana, Savic, Dragisa S., Veljković, Vlada B., "The impact of glycerol and some carbohydrates on antibiotic production by Streptomyces hygroscopicus CH-7" in Medicinal Chemistry Research, 22, no. 2 (2013):934-937,
https://doi.org/10.1007/s00044-012-0088-9 . .

TY  - BOOK
AU  - Ilić, Slavica
AU  - Konstantinović, Sandra
AU  - Gojgić-Cvijović, Gordana
AU  - Veljković, Vlada
AU  - Savić, Dragiša
PY  - 2012
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5001
PB  - Leskovac : Tehnološki fakultet
T1  - Biosinteza antibiotika pomoću streptomiceta iz različitih izvora ugljenika i azota
UR  - https://hdl.handle.net/21.15107/rcub_cer_5001
ER  - 

@book{
author = "Ilić, Slavica and Konstantinović, Sandra and Gojgić-Cvijović, Gordana and Veljković, Vlada and Savić, Dragiša",
year = "2012",
publisher = "Leskovac : Tehnološki fakultet",
title = "Biosinteza antibiotika pomoću streptomiceta iz različitih izvora ugljenika i azota",
url = "https://hdl.handle.net/21.15107/rcub_cer_5001"
}

Ilić, S., Konstantinović, S., Gojgić-Cvijović, G., Veljković, V.,& Savić, D.. (2012). Biosinteza antibiotika pomoću streptomiceta iz različitih izvora ugljenika i azota. 
Leskovac : Tehnološki fakultet..
https://hdl.handle.net/21.15107/rcub_cer_5001

Ilić S, Konstantinović S, Gojgić-Cvijović G, Veljković V, Savić D. Biosinteza antibiotika pomoću streptomiceta iz različitih izvora ugljenika i azota. 2012;.
https://hdl.handle.net/21.15107/rcub_cer_5001 .

Ilić, Slavica, Konstantinović, Sandra, Gojgić-Cvijović, Gordana, Veljković, Vlada, Savić, Dragiša, "Biosinteza antibiotika pomoću streptomiceta iz različitih izvora ugljenika i azota" (2012),
https://hdl.handle.net/21.15107/rcub_cer_5001 .

TY  - JOUR
AU  - Ilić, Slavica B.
AU  - Konstantinović, Sandra S.
AU  - Savić, D.S.
AU  - Veljković, Vlada B.
AU  - Gojgić-Cvijović, Gordana
PY  - 2010
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/754
AB  - A media consisting of isatin-Schiff bases (isatin-3-thiosemicarbazone, isatin-3-semicarbazone, and isatin-3-phenylhydrazone) was developed to maximize the production of antibiotics Hexaene H-85 and Azalomycine B by Streptomyces hygroscopicus. The media isatin-3-thiosemicarbazone resulted in the maximum antibiotics concentration of 372 μg cm-3 for Hexaene H-85 and 118 μg cm-3 for Azalomycine B. The impact of modified media on soil morphology also was investigated.
T2  - Medicinal Chemistry Research
T1  - The impact of Schiff bases on antibiotic production by Streptomyces hygroscopicus
VL  - 19
IS  - 7
SP  - 690
EP  - 697
DO  - 10.1007/s00044-009-9223-7
ER  - 

@article{
author = "Ilić, Slavica B. and Konstantinović, Sandra S. and Savić, D.S. and Veljković, Vlada B. and Gojgić-Cvijović, Gordana",
year = "2010",
abstract = "A media consisting of isatin-Schiff bases (isatin-3-thiosemicarbazone, isatin-3-semicarbazone, and isatin-3-phenylhydrazone) was developed to maximize the production of antibiotics Hexaene H-85 and Azalomycine B by Streptomyces hygroscopicus. The media isatin-3-thiosemicarbazone resulted in the maximum antibiotics concentration of 372 μg cm-3 for Hexaene H-85 and 118 μg cm-3 for Azalomycine B. The impact of modified media on soil morphology also was investigated.",
journal = "Medicinal Chemistry Research",
title = "The impact of Schiff bases on antibiotic production by Streptomyces hygroscopicus",
volume = "19",
number = "7",
pages = "690-697",
doi = "10.1007/s00044-009-9223-7"
}

Ilić, S. B., Konstantinović, S. S., Savić, D.S., Veljković, V. B.,& Gojgić-Cvijović, G.. (2010). The impact of Schiff bases on antibiotic production by Streptomyces hygroscopicus. in Medicinal Chemistry Research, 19(7), 690-697.
https://doi.org/10.1007/s00044-009-9223-7

Ilić SB, Konstantinović SS, Savić D, Veljković VB, Gojgić-Cvijović G. The impact of Schiff bases on antibiotic production by Streptomyces hygroscopicus. in Medicinal Chemistry Research. 2010;19(7):690-697.
doi:10.1007/s00044-009-9223-7 .

Ilić, Slavica B., Konstantinović, Sandra S., Savić, D.S., Veljković, Vlada B., Gojgić-Cvijović, Gordana, "The impact of Schiff bases on antibiotic production by Streptomyces hygroscopicus" in Medicinal Chemistry Research, 19, no. 7 (2010):690-697,
https://doi.org/10.1007/s00044-009-9223-7 . .

TY  - JOUR
AU  - Ilić, Slavica B.
AU  - Konstantinović, Sandra S.
AU  - Veljković, Vlada B.
AU  - Savić, D.S.
AU  - Lazić, M. L.
AU  - Gojgić-Cvijović, Gordana
PY  - 2008
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/479
AB  - A chemically defined media consisting of carboxymethylcellulose (CMC) was developed to maximize the production of antibiotics, hexaene H-85 and azalomycine, by Streptomyces hygroscopicus CH-7. The production of antibiotics by filamentous organisms is often dependent on the morphology and size distribution of the pellet population within the culture. By adding the polymer to the fermentation medium, the growth was changed from a single large glob to small reproducible pellets, and wall growth was diminished to a minimum. Maximum concentrations of hexaene H-85 (146.7 mg/dm3) and azalomycine (188.6 mg/dm3) were reached at 3.0% and 1.0% (w/v) CMC, respectively.
T2  - Current Microbiology
T1  - Impact of carboxymethylcellulose on morphology and antibiotic production by Streptomyces hygroscopicus
VL  - 57
IS  - 1
SP  - 8
EP  - 11
DO  - 10.1007/s00284-008-9143-7
ER  - 

@article{
author = "Ilić, Slavica B. and Konstantinović, Sandra S. and Veljković, Vlada B. and Savić, D.S. and Lazić, M. L. and Gojgić-Cvijović, Gordana",
year = "2008",
abstract = "A chemically defined media consisting of carboxymethylcellulose (CMC) was developed to maximize the production of antibiotics, hexaene H-85 and azalomycine, by Streptomyces hygroscopicus CH-7. The production of antibiotics by filamentous organisms is often dependent on the morphology and size distribution of the pellet population within the culture. By adding the polymer to the fermentation medium, the growth was changed from a single large glob to small reproducible pellets, and wall growth was diminished to a minimum. Maximum concentrations of hexaene H-85 (146.7 mg/dm3) and azalomycine (188.6 mg/dm3) were reached at 3.0% and 1.0% (w/v) CMC, respectively.",
journal = "Current Microbiology",
title = "Impact of carboxymethylcellulose on morphology and antibiotic production by Streptomyces hygroscopicus",
volume = "57",
number = "1",
pages = "8-11",
doi = "10.1007/s00284-008-9143-7"
}

Ilić, S. B., Konstantinović, S. S., Veljković, V. B., Savić, D.S., Lazić, M. L.,& Gojgić-Cvijović, G.. (2008). Impact of carboxymethylcellulose on morphology and antibiotic production by Streptomyces hygroscopicus. in Current Microbiology, 57(1), 8-11.
https://doi.org/10.1007/s00284-008-9143-7

Ilić SB, Konstantinović SS, Veljković VB, Savić D, Lazić ML, Gojgić-Cvijović G. Impact of carboxymethylcellulose on morphology and antibiotic production by Streptomyces hygroscopicus. in Current Microbiology. 2008;57(1):8-11.
doi:10.1007/s00284-008-9143-7 .

Ilić, Slavica B., Konstantinović, Sandra S., Veljković, Vlada B., Savić, D.S., Lazić, M. L., Gojgić-Cvijović, Gordana, "Impact of carboxymethylcellulose on morphology and antibiotic production by Streptomyces hygroscopicus" in Current Microbiology, 57, no. 1 (2008):8-11,
https://doi.org/10.1007/s00284-008-9143-7 . .