TY  - JOUR
AU  - Menković, Nebojša
AU  - Gođevac, Dejan
AU  - Savikin, Katarina
AU  - Zdunić, Gordana
AU  - Milosavljević, Slobodan
AU  - Bojadzi, Andon
AU  - Avramoski, Oliver
PY  - 2013
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1333
AB  - Collection of Sideritis raeseri subsp. raeseri has a long tradition in local communities in the Ohrid-Prespa region. The aim of the present study was the analysis of bioactive compounds especially those with anti-inflammatory activity. Combination of the UV and MS data allowed the characterization of 17 compounds, which could be classified into flavonoid glycosides or hydroxycynnamic acid derivatives. Six of them were isolated using preparative HPLC: isoscutellarein 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside, 4'-O-methylhypolaetin 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside, hypolaetin 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-6 ''-O-acetyl-beta-D-glucopyranoside, 4'-O-methylisoscutellarein 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside, isoscutellarein 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-6 ''-O-acetyl-beta-D-glucopyranoside and 4'-O-methylhypolaetin 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-6 ''-O-acetyl-beta-D-glucopyranoside. The presence of phenylpropanoid glycoside martynoside was reported for the first time in the wild growing S. raeseri subsp. raeseri. Hypolaetin derivatives, known for their antiinflammatory activity, dominated and were more abundant in S. raeseri subsp. raeseri grown in NPG in comparison with S. scardica grown nearby the NPG. The type of solvent affected distribution and the amount of bioactive compounds and the advantage was given to less polar extracts which were richer in hypolaetin derivatives.
PB  - ACG Publications
T2  - Records of Natural Products
T1  - Bioactive Compounds of Endemic Species Sideritis raeseri subsp raeseri Grown in National Park Galicica
VL  - 7
IS  - 3
SP  - 161
EP  - 168
UR  - https://hdl.handle.net/21.15107/rcub_cer_1333
ER  - 

@article{
author = "Menković, Nebojša and Gođevac, Dejan and Savikin, Katarina and Zdunić, Gordana and Milosavljević, Slobodan and Bojadzi, Andon and Avramoski, Oliver",
year = "2013",
abstract = "Collection of Sideritis raeseri subsp. raeseri has a long tradition in local communities in the Ohrid-Prespa region. The aim of the present study was the analysis of bioactive compounds especially those with anti-inflammatory activity. Combination of the UV and MS data allowed the characterization of 17 compounds, which could be classified into flavonoid glycosides or hydroxycynnamic acid derivatives. Six of them were isolated using preparative HPLC: isoscutellarein 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside, 4'-O-methylhypolaetin 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside, hypolaetin 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-6 ''-O-acetyl-beta-D-glucopyranoside, 4'-O-methylisoscutellarein 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside, isoscutellarein 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-6 ''-O-acetyl-beta-D-glucopyranoside and 4'-O-methylhypolaetin 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-6 ''-O-acetyl-beta-D-glucopyranoside. The presence of phenylpropanoid glycoside martynoside was reported for the first time in the wild growing S. raeseri subsp. raeseri. Hypolaetin derivatives, known for their antiinflammatory activity, dominated and were more abundant in S. raeseri subsp. raeseri grown in NPG in comparison with S. scardica grown nearby the NPG. The type of solvent affected distribution and the amount of bioactive compounds and the advantage was given to less polar extracts which were richer in hypolaetin derivatives.",
publisher = "ACG Publications",
journal = "Records of Natural Products",
title = "Bioactive Compounds of Endemic Species Sideritis raeseri subsp raeseri Grown in National Park Galicica",
volume = "7",
number = "3",
pages = "161-168",
url = "https://hdl.handle.net/21.15107/rcub_cer_1333"
}

Menković, N., Gođevac, D., Savikin, K., Zdunić, G., Milosavljević, S., Bojadzi, A.,& Avramoski, O.. (2013). Bioactive Compounds of Endemic Species Sideritis raeseri subsp raeseri Grown in National Park Galicica. in Records of Natural Products
ACG Publications., 7(3), 161-168.
https://hdl.handle.net/21.15107/rcub_cer_1333

Menković N, Gođevac D, Savikin K, Zdunić G, Milosavljević S, Bojadzi A, Avramoski O. Bioactive Compounds of Endemic Species Sideritis raeseri subsp raeseri Grown in National Park Galicica. in Records of Natural Products. 2013;7(3):161-168.
https://hdl.handle.net/21.15107/rcub_cer_1333 .

Menković, Nebojša, Gođevac, Dejan, Savikin, Katarina, Zdunić, Gordana, Milosavljević, Slobodan, Bojadzi, Andon, Avramoski, Oliver, "Bioactive Compounds of Endemic Species Sideritis raeseri subsp raeseri Grown in National Park Galicica" in Records of Natural Products, 7, no. 3 (2013):161-168,
https://hdl.handle.net/21.15107/rcub_cer_1333 .