TY  - JOUR
AU  - Svirčev, Zorica
AU  - Drobac, Damjana
AU  - Tokodi, Nada
AU  - Vidović, Milka
AU  - Simeunovic, Jelica
AU  - Miladinov-Mikov, Marica
AU  - Baltic, Vladimir
PY  - 2013
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1197
AB  - Today, the occurrence of harmful cyanobacterial blooms is a common phenomenon and a potential global health problem. Cyanobacteria can produce metabolites highly toxic to humans. More than 80% of reservoirs used for water supply in Central Serbia have bloomed over the past 80years. A 10-year epidemiological study showed a significant increase in the incidence of primary liver cancer (PLC) in the regions where water from the blooming reservoirs was used for human consumption. At the same time, no correlation was found between the incidence of PLC and other risk factors, such as cirrhosis and hepatitis viruses. Given the strong association with PLC induction and various known possible mechanisms of carcinogenic action, it is highly possible that, cyanotoxinsacting as initiator and promotermay be the major risk factor that acts synergistically with other risk factors to cause increased incidence of PLC. However, at present, it is still not certain whether cyanotoxins alone were sufficient to induce PLC. Therefore, additional assessment of the health risks that may arise from human exposure to cyanotoxins is advisable.
PB  - Taylor & Francis Inc, Philadelphia
T2  - Journal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology
T1  - Epidemiology of Primary Liver Cancer in Serbia and Possible Connection With Cyanobacterial Blooms
VL  - 31
IS  - 3
SP  - 181
EP  - 200
DO  - 10.1080/10590501.2013.824187
ER  - 

@article{
author = "Svirčev, Zorica and Drobac, Damjana and Tokodi, Nada and Vidović, Milka and Simeunovic, Jelica and Miladinov-Mikov, Marica and Baltic, Vladimir",
year = "2013",
abstract = "Today, the occurrence of harmful cyanobacterial blooms is a common phenomenon and a potential global health problem. Cyanobacteria can produce metabolites highly toxic to humans. More than 80% of reservoirs used for water supply in Central Serbia have bloomed over the past 80years. A 10-year epidemiological study showed a significant increase in the incidence of primary liver cancer (PLC) in the regions where water from the blooming reservoirs was used for human consumption. At the same time, no correlation was found between the incidence of PLC and other risk factors, such as cirrhosis and hepatitis viruses. Given the strong association with PLC induction and various known possible mechanisms of carcinogenic action, it is highly possible that, cyanotoxinsacting as initiator and promotermay be the major risk factor that acts synergistically with other risk factors to cause increased incidence of PLC. However, at present, it is still not certain whether cyanotoxins alone were sufficient to induce PLC. Therefore, additional assessment of the health risks that may arise from human exposure to cyanotoxins is advisable.",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Journal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology",
title = "Epidemiology of Primary Liver Cancer in Serbia and Possible Connection With Cyanobacterial Blooms",
volume = "31",
number = "3",
pages = "181-200",
doi = "10.1080/10590501.2013.824187"
}

Svirčev, Z., Drobac, D., Tokodi, N., Vidović, M., Simeunovic, J., Miladinov-Mikov, M.,& Baltic, V.. (2013). Epidemiology of Primary Liver Cancer in Serbia and Possible Connection With Cyanobacterial Blooms. in Journal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology
Taylor & Francis Inc, Philadelphia., 31(3), 181-200.
https://doi.org/10.1080/10590501.2013.824187

Svirčev Z, Drobac D, Tokodi N, Vidović M, Simeunovic J, Miladinov-Mikov M, Baltic V. Epidemiology of Primary Liver Cancer in Serbia and Possible Connection With Cyanobacterial Blooms. in Journal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology. 2013;31(3):181-200.
doi:10.1080/10590501.2013.824187 .

Svirčev, Zorica, Drobac, Damjana, Tokodi, Nada, Vidović, Milka, Simeunovic, Jelica, Miladinov-Mikov, Marica, Baltic, Vladimir, "Epidemiology of Primary Liver Cancer in Serbia and Possible Connection With Cyanobacterial Blooms" in Journal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology, 31, no. 3 (2013):181-200,
https://doi.org/10.1080/10590501.2013.824187 . .

TY  - JOUR
AU  - Drobac, Damjana
AU  - Svirčev, Zorica
AU  - Tokodi, Nada
AU  - Vidović, Milka
AU  - Baltić, Vladimir
AU  - Božić-Krstić, Verica
AU  - Lazić, Dragana
AU  - Pavlica, Tatjana
PY  - 2011
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/874
AB  - The Primary Liver Carcinoma (PLC) is one of the most common malignant diseases in the world. In Central Serbia during the period from 2000 to 2006 the average incidence was 16.9/100 000 that complies to the European epidemiology. The main risk factors for PLC are considered to be cirrhosis of liver and viral chronic Hepatitis B and C. The goal of this research was to analyze epidemiological data of these diseases and to state the correlation between PLC, liver cirrhosis and Hepatitis B and C in Serbia. During the research period of 6 years the correlations between PLC and the corresponding risk factors were negative. For this reason it was necessary to examine other risk factors. The high incidence of PLC in Nišavski, Toplički and Šumadijski region correlate with emerging blooms of Cyanobacteria in water reservoirs supplying these areas with drinking water. Since we examined only 7 years span and have no completed cyanotoxin analysis, it is necessary to complete more research in this field. The identification of cyanotoxins as risk factors that contribute to the development of liver cancer will help in the prevention of this disease.
PB  - University of Novi Sad, Department of Geography, Tourism and Hotel Management
T2  - Geographica Pannonica
T1  - Microcystins: Potential risk factors in carcinogenesis of primary liver cancer in Serbia
VL  - 15
IS  - 3
SP  - 70
EP  - 80
DO  - 10.5937/GeoPan1103070D
ER  - 

@article{
author = "Drobac, Damjana and Svirčev, Zorica and Tokodi, Nada and Vidović, Milka and Baltić, Vladimir and Božić-Krstić, Verica and Lazić, Dragana and Pavlica, Tatjana",
year = "2011",
abstract = "The Primary Liver Carcinoma (PLC) is one of the most common malignant diseases in the world. In Central Serbia during the period from 2000 to 2006 the average incidence was 16.9/100 000 that complies to the European epidemiology. The main risk factors for PLC are considered to be cirrhosis of liver and viral chronic Hepatitis B and C. The goal of this research was to analyze epidemiological data of these diseases and to state the correlation between PLC, liver cirrhosis and Hepatitis B and C in Serbia. During the research period of 6 years the correlations between PLC and the corresponding risk factors were negative. For this reason it was necessary to examine other risk factors. The high incidence of PLC in Nišavski, Toplički and Šumadijski region correlate with emerging blooms of Cyanobacteria in water reservoirs supplying these areas with drinking water. Since we examined only 7 years span and have no completed cyanotoxin analysis, it is necessary to complete more research in this field. The identification of cyanotoxins as risk factors that contribute to the development of liver cancer will help in the prevention of this disease.",
publisher = "University of Novi Sad, Department of Geography, Tourism and Hotel Management",
journal = "Geographica Pannonica",
title = "Microcystins: Potential risk factors in carcinogenesis of primary liver cancer in Serbia",
volume = "15",
number = "3",
pages = "70-80",
doi = "10.5937/GeoPan1103070D"
}

Drobac, D., Svirčev, Z., Tokodi, N., Vidović, M., Baltić, V., Božić-Krstić, V., Lazić, D.,& Pavlica, T.. (2011). Microcystins: Potential risk factors in carcinogenesis of primary liver cancer in Serbia. in Geographica Pannonica
University of Novi Sad, Department of Geography, Tourism and Hotel Management., 15(3), 70-80.
https://doi.org/10.5937/GeoPan1103070D

Drobac D, Svirčev Z, Tokodi N, Vidović M, Baltić V, Božić-Krstić V, Lazić D, Pavlica T. Microcystins: Potential risk factors in carcinogenesis of primary liver cancer in Serbia. in Geographica Pannonica. 2011;15(3):70-80.
doi:10.5937/GeoPan1103070D .

Drobac, Damjana, Svirčev, Zorica, Tokodi, Nada, Vidović, Milka, Baltić, Vladimir, Božić-Krstić, Verica, Lazić, Dragana, Pavlica, Tatjana, "Microcystins: Potential risk factors in carcinogenesis of primary liver cancer in Serbia" in Geographica Pannonica, 15, no. 3 (2011):70-80,
https://doi.org/10.5937/GeoPan1103070D . .