TY  - JOUR
AU  - Stanković, Mia
AU  - Kljun, Jakob
AU  - Stevanović, Nevena Lj.
AU  - Lazić, Jelena
AU  - Skaro Bogojevic, Sanja
AU  - Vojnović, Sandra
AU  - Zlatar, Matija
AU  - Nikodinović-Runić, Jasmina
AU  - Turel, Iztok
AU  - Đuran, Miloš
AU  - Glišić, Biljana
PY  - 2024
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/7296
AB  - Inspired by the emergence of resistance to currently available antifungal therapy and by the great potential of metal complexes for the treatment of various diseases, we synthesized three new silver(I) complexes containing clinically used antifungal azoles as ligands, [Ag(ecz)2]SbF6 (1, ecz is econazole), {[Ag(vcz)2]SbF6}n (2, vcz is voriconazole), and [Ag(ctz)2]SbF6 (3, ctz is clotrimazole), and investigated their antimicrobial properties. The synthesized complexes were characterized by mass spectrometry, IR, UV-vis and 1H NMR spectroscopy, cyclic voltammetry, and single-crystal X-ray diffraction analysis. In the mononuclear complexes 1 and 3 with ecz and ctz, respectively, the silver(I) ion has the expected linear geometry, in which the azoles are monodentately coordinated to this metal center through the N3 imidazole nitrogen atom. In contrast, the vcz-containing complex 2 has a polymeric structure in the solid state in which the silver(I) ions are coordinated by four nitrogen atoms in a distorted tetrahedral geometry. DFT calculations were done to predict the most favorable structures of the studied complexes in DMSO solution. All the studied silver(I) complexes have shown excellent antifungal and good to moderate antibacterial activities with minimal inhibitory concentration (MIC) values in the ranges of 0.01–27.1 and 2.61–47.9 μM on the selected panel of fungi and bacteria, respectively. Importantly, the complexes 1–3 have exhibited a significantly improved antifungal activity compared to the free azoles, with the most pronounced effect observed in the case of complex 2 compared to the parent vcz against Candida glabrata with an increase of activity by five orders of magnitude. Moreover, the silver(I)-azole complexes 2 and 3 significantly inhibited the formation of C. albicans hyphae and biofilms at the subinhibitory concentration of 50% MIC. To investigate the impact of the complex 3 more thoroughly on Candida pathogenesis, its effect on the adherence of C. albicans to A549 cells (human adenocarcinoma alveolar basal epithelial cells), as an initial step of the invasion of host cells, was studied.
PB  - Royal Society of Chemistry (RSC)
T2  - Dalton Transactions
T1  - Silver(I) complexes containing antifungal azoles: significant improvement of the anti-Candida potential of the azole drug after its coordination to the silver(I) ion
VL  - 53
SP  - 2218
EP  - 2230
DO  - 10.1039/D3DT03010E
ER  - 

@article{
author = "Stanković, Mia and Kljun, Jakob and Stevanović, Nevena Lj. and Lazić, Jelena and Skaro Bogojevic, Sanja and Vojnović, Sandra and Zlatar, Matija and Nikodinović-Runić, Jasmina and Turel, Iztok and Đuran, Miloš and Glišić, Biljana",
year = "2024",
abstract = "Inspired by the emergence of resistance to currently available antifungal therapy and by the great potential of metal complexes for the treatment of various diseases, we synthesized three new silver(I) complexes containing clinically used antifungal azoles as ligands, [Ag(ecz)2]SbF6 (1, ecz is econazole), {[Ag(vcz)2]SbF6}n (2, vcz is voriconazole), and [Ag(ctz)2]SbF6 (3, ctz is clotrimazole), and investigated their antimicrobial properties. The synthesized complexes were characterized by mass spectrometry, IR, UV-vis and 1H NMR spectroscopy, cyclic voltammetry, and single-crystal X-ray diffraction analysis. In the mononuclear complexes 1 and 3 with ecz and ctz, respectively, the silver(I) ion has the expected linear geometry, in which the azoles are monodentately coordinated to this metal center through the N3 imidazole nitrogen atom. In contrast, the vcz-containing complex 2 has a polymeric structure in the solid state in which the silver(I) ions are coordinated by four nitrogen atoms in a distorted tetrahedral geometry. DFT calculations were done to predict the most favorable structures of the studied complexes in DMSO solution. All the studied silver(I) complexes have shown excellent antifungal and good to moderate antibacterial activities with minimal inhibitory concentration (MIC) values in the ranges of 0.01–27.1 and 2.61–47.9 μM on the selected panel of fungi and bacteria, respectively. Importantly, the complexes 1–3 have exhibited a significantly improved antifungal activity compared to the free azoles, with the most pronounced effect observed in the case of complex 2 compared to the parent vcz against Candida glabrata with an increase of activity by five orders of magnitude. Moreover, the silver(I)-azole complexes 2 and 3 significantly inhibited the formation of C. albicans hyphae and biofilms at the subinhibitory concentration of 50% MIC. To investigate the impact of the complex 3 more thoroughly on Candida pathogenesis, its effect on the adherence of C. albicans to A549 cells (human adenocarcinoma alveolar basal epithelial cells), as an initial step of the invasion of host cells, was studied.",
publisher = "Royal Society of Chemistry (RSC)",
journal = "Dalton Transactions",
title = "Silver(I) complexes containing antifungal azoles: significant improvement of the anti-Candida potential of the azole drug after its coordination to the silver(I) ion",
volume = "53",
pages = "2218-2230",
doi = "10.1039/D3DT03010E"
}

Stanković, M., Kljun, J., Stevanović, N. Lj., Lazić, J., Skaro Bogojevic, S., Vojnović, S., Zlatar, M., Nikodinović-Runić, J., Turel, I., Đuran, M.,& Glišić, B.. (2024). Silver(I) complexes containing antifungal azoles: significant improvement of the anti-Candida potential of the azole drug after its coordination to the silver(I) ion. in Dalton Transactions
Royal Society of Chemistry (RSC)., 53, 2218-2230.
https://doi.org/10.1039/D3DT03010E

Stanković M, Kljun J, Stevanović NL, Lazić J, Skaro Bogojevic S, Vojnović S, Zlatar M, Nikodinović-Runić J, Turel I, Đuran M, Glišić B. Silver(I) complexes containing antifungal azoles: significant improvement of the anti-Candida potential of the azole drug after its coordination to the silver(I) ion. in Dalton Transactions. 2024;53:2218-2230.
doi:10.1039/D3DT03010E .

Stanković, Mia, Kljun, Jakob, Stevanović, Nevena Lj., Lazić, Jelena, Skaro Bogojevic, Sanja, Vojnović, Sandra, Zlatar, Matija, Nikodinović-Runić, Jasmina, Turel, Iztok, Đuran, Miloš, Glišić, Biljana, "Silver(I) complexes containing antifungal azoles: significant improvement of the anti-Candida potential of the azole drug after its coordination to the silver(I) ion" in Dalton Transactions, 53 (2024):2218-2230,
https://doi.org/10.1039/D3DT03010E . .

TY  - JOUR
AU  - Pantelić, Brana
AU  - Skaro Bogojević, Sanja
AU  - Milivojević, Dušan
AU  - Ilić-Tomić, Tatjana
AU  - Lončarević, Branka
AU  - Beškoski, Vladimir
AU  - Maslak, Veselin
AU  - Guzik, Maciej
AU  - Makryniotis, Konstantinos
AU  - Taxeidis, George
AU  - Siaperas, Romanos
AU  - Topakas, Evangelos
AU  - Nikodinović-Runić, Jasmina
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5789
AB  - Polyurethanes (PUs) are an exceedingly heterogeneous group of plastic polymers, widely used in a variety of industries from construction to medical implants. In the past decades, we have witnessed the accumulation of PU waste and its detrimental environmental impacts. PUs have been identified as one of the most toxic polymers leaching hazardous compounds derived both from the polymer itself and the additives used in production. Further environmental impact assessment, identification and characterization of substances derived from PU materials and establishing efficient degradation strategies are crucial. Thus, a selection of eight synthetic model compounds which represent partial PU hydrolysis products were synthesized and characterized both in terms of toxicity and suitability to be used as substrates for the identification of novel biocatalysts for PU biodegradation. Overall, the compounds exhibited low in vitro cytotoxicity against a healthy human fibroblast cell line and virtually no toxic effect on the nematode Caenorhabditis elegans up to 500 µg mL−1, and two of the substrates showed moderate aquatic ecotoxicity with EC50 values 53 µg mL−1 and 45 µg mL−1, respectively, on Aliivibrio fischeri. The compounds were successfully applied to study the mechanism of ester and urethane bond cleaving preference of known plastic-degrading enzymes and were used to single out a novel PU-degrading biocatalyst, Amycolatopsis mediterranei ISP5501, among 220 microbial strains. A. mediterranei ISP5501 can also degrade commercially available polyether and polyester PU materials, reducing the average molecular number of the polymer up to 13.5%. This study uncovered a biocatalyst capable of degrading different types of PUs and identified potential enzymes responsible as a key step in developing biotechnological process for PU waste treatment options.
PB  - Switzerland : Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Catalysts
T1  - Set of Small Molecule Polyurethane (PU) Model Substrates: Ecotoxicity Evaluation and Identification of PU Degrading Biocatalysts
VL  - 13
IS  - 2
SP  - 278
DO  - 10.3390/catal13020278
ER  - 

@article{
author = "Pantelić, Brana and Skaro Bogojević, Sanja and Milivojević, Dušan and Ilić-Tomić, Tatjana and Lončarević, Branka and Beškoski, Vladimir and Maslak, Veselin and Guzik, Maciej and Makryniotis, Konstantinos and Taxeidis, George and Siaperas, Romanos and Topakas, Evangelos and Nikodinović-Runić, Jasmina",
year = "2023",
abstract = "Polyurethanes (PUs) are an exceedingly heterogeneous group of plastic polymers, widely used in a variety of industries from construction to medical implants. In the past decades, we have witnessed the accumulation of PU waste and its detrimental environmental impacts. PUs have been identified as one of the most toxic polymers leaching hazardous compounds derived both from the polymer itself and the additives used in production. Further environmental impact assessment, identification and characterization of substances derived from PU materials and establishing efficient degradation strategies are crucial. Thus, a selection of eight synthetic model compounds which represent partial PU hydrolysis products were synthesized and characterized both in terms of toxicity and suitability to be used as substrates for the identification of novel biocatalysts for PU biodegradation. Overall, the compounds exhibited low in vitro cytotoxicity against a healthy human fibroblast cell line and virtually no toxic effect on the nematode Caenorhabditis elegans up to 500 µg mL−1, and two of the substrates showed moderate aquatic ecotoxicity with EC50 values 53 µg mL−1 and 45 µg mL−1, respectively, on Aliivibrio fischeri. The compounds were successfully applied to study the mechanism of ester and urethane bond cleaving preference of known plastic-degrading enzymes and were used to single out a novel PU-degrading biocatalyst, Amycolatopsis mediterranei ISP5501, among 220 microbial strains. A. mediterranei ISP5501 can also degrade commercially available polyether and polyester PU materials, reducing the average molecular number of the polymer up to 13.5%. This study uncovered a biocatalyst capable of degrading different types of PUs and identified potential enzymes responsible as a key step in developing biotechnological process for PU waste treatment options.",
publisher = "Switzerland : Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Catalysts",
title = "Set of Small Molecule Polyurethane (PU) Model Substrates: Ecotoxicity Evaluation and Identification of PU Degrading Biocatalysts",
volume = "13",
number = "2",
pages = "278",
doi = "10.3390/catal13020278"
}

Pantelić, B., Skaro Bogojević, S., Milivojević, D., Ilić-Tomić, T., Lončarević, B., Beškoski, V., Maslak, V., Guzik, M., Makryniotis, K., Taxeidis, G., Siaperas, R., Topakas, E.,& Nikodinović-Runić, J.. (2023). Set of Small Molecule Polyurethane (PU) Model Substrates: Ecotoxicity Evaluation and Identification of PU Degrading Biocatalysts. in Catalysts
Switzerland : Multidisciplinary Digital Publishing Institute (MDPI)., 13(2), 278.
https://doi.org/10.3390/catal13020278

Pantelić B, Skaro Bogojević S, Milivojević D, Ilić-Tomić T, Lončarević B, Beškoski V, Maslak V, Guzik M, Makryniotis K, Taxeidis G, Siaperas R, Topakas E, Nikodinović-Runić J. Set of Small Molecule Polyurethane (PU) Model Substrates: Ecotoxicity Evaluation and Identification of PU Degrading Biocatalysts. in Catalysts. 2023;13(2):278.
doi:10.3390/catal13020278 .

Pantelić, Brana, Skaro Bogojević, Sanja, Milivojević, Dušan, Ilić-Tomić, Tatjana, Lončarević, Branka, Beškoski, Vladimir, Maslak, Veselin, Guzik, Maciej, Makryniotis, Konstantinos, Taxeidis, George, Siaperas, Romanos, Topakas, Evangelos, Nikodinović-Runić, Jasmina, "Set of Small Molecule Polyurethane (PU) Model Substrates: Ecotoxicity Evaluation and Identification of PU Degrading Biocatalysts" in Catalysts, 13, no. 2 (2023):278,
https://doi.org/10.3390/catal13020278 . .

TY  - CONF
AU  - Lješević, Marija
AU  - Lončarević, Branka
AU  - Joksimović, Kristina
AU  - Žerađanin, Aleksandra
AU  - Pantelić, Brana
AU  - Gojgić-Cvijović, Gordana
AU  - Beškoski, Vladimir
AU  - Nikodinović-Runić, Jasmina
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6423
AB  - U poslednje vreme, bis-(2-hidroksietil)-tereftalat (BHET) se često koristi kao model jedinjenje za identifikovanje novih biokatalizatora za degradaciju polietilen-tereftalat (PET).  Stoga, u radu je predstavljeno ispitivanje mehanizma degradacije BHET-a pomoću mikroorganizama.
PB  - Srpsko hemijsko društvo
C3  - Knjiga uzvoda - 9. Simpozijum Hemija i Zaštita Životne Sredine - EnviroChem2023, 4-7. jun 2023, Kladovo / Book of abstracts - 9 th Symposium Chemistry and Environmental Protection - EnviroChem2023
T1  - Mikrobiološka degradacija bis (2-hidroksietil)-tereftalata.
T1  - Microbial degradation of bis (2-hydroxyethyl) terephthalate
SP  - 43
EP  - 44
UR  - https://hdl.handle.net/21.15107/rcub_cer_6423
ER  - 

@conference{
author = "Lješević, Marija and Lončarević, Branka and Joksimović, Kristina and Žerađanin, Aleksandra and Pantelić, Brana and Gojgić-Cvijović, Gordana and Beškoski, Vladimir and Nikodinović-Runić, Jasmina",
year = "2023",
abstract = "U poslednje vreme, bis-(2-hidroksietil)-tereftalat (BHET) se često koristi kao model jedinjenje za identifikovanje novih biokatalizatora za degradaciju polietilen-tereftalat (PET).  Stoga, u radu je predstavljeno ispitivanje mehanizma degradacije BHET-a pomoću mikroorganizama.",
publisher = "Srpsko hemijsko društvo",
journal = "Knjiga uzvoda - 9. Simpozijum Hemija i Zaštita Životne Sredine - EnviroChem2023, 4-7. jun 2023, Kladovo / Book of abstracts - 9 th Symposium Chemistry and Environmental Protection - EnviroChem2023",
title = "Mikrobiološka degradacija bis (2-hidroksietil)-tereftalata., Microbial degradation of bis (2-hydroxyethyl) terephthalate",
pages = "43-44",
url = "https://hdl.handle.net/21.15107/rcub_cer_6423"
}

Lješević, M., Lončarević, B., Joksimović, K., Žerađanin, A., Pantelić, B., Gojgić-Cvijović, G., Beškoski, V.,& Nikodinović-Runić, J.. (2023). Mikrobiološka degradacija bis (2-hidroksietil)-tereftalata.. in Knjiga uzvoda - 9. Simpozijum Hemija i Zaštita Životne Sredine - EnviroChem2023, 4-7. jun 2023, Kladovo / Book of abstracts - 9 th Symposium Chemistry and Environmental Protection - EnviroChem2023
Srpsko hemijsko društvo., 43-44.
https://hdl.handle.net/21.15107/rcub_cer_6423

Lješević M, Lončarević B, Joksimović K, Žerađanin A, Pantelić B, Gojgić-Cvijović G, Beškoski V, Nikodinović-Runić J. Mikrobiološka degradacija bis (2-hidroksietil)-tereftalata.. in Knjiga uzvoda - 9. Simpozijum Hemija i Zaštita Životne Sredine - EnviroChem2023, 4-7. jun 2023, Kladovo / Book of abstracts - 9 th Symposium Chemistry and Environmental Protection - EnviroChem2023. 2023;:43-44.
https://hdl.handle.net/21.15107/rcub_cer_6423 .

Lješević, Marija, Lončarević, Branka, Joksimović, Kristina, Žerađanin, Aleksandra, Pantelić, Brana, Gojgić-Cvijović, Gordana, Beškoski, Vladimir, Nikodinović-Runić, Jasmina, "Mikrobiološka degradacija bis (2-hidroksietil)-tereftalata." in Knjiga uzvoda - 9. Simpozijum Hemija i Zaštita Životne Sredine - EnviroChem2023, 4-7. jun 2023, Kladovo / Book of abstracts - 9 th Symposium Chemistry and Environmental Protection - EnviroChem2023 (2023):43-44,
https://hdl.handle.net/21.15107/rcub_cer_6423 .

TY  - CONF
AU  - Lončarević, Branka
AU  - Lješević, Marija
AU  - Joksimović, Kristina
AU  - Žerađanin, Aleksandra
AU  - Gojgić-Cvijović, Gordana
AU  - Beškoski, Vladimir
AU  - Nikodinović-Runić, Jasmina
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6424
AB  - Cilj ovog rada bio je selektovati mikroorganizme koji mogu da razgrade Bis-(2-hidroksietil)-tereftalat (BHET) kao model jedinjenje za ispitivanje degradacije plastičnog otpada na bazi polietilen tereftalata (PET) i sa visokim prinosom produkuju egzopolisaharide.
PB  - Srpsko hemijsko društvo
C3  - Knjiga uzvoda - 9. Simpozijum Hemija i Zaštita Životne Sredine - EnviroChem2023, 4-7. jun 2023, Kladovo / Book of abstracts - 9 th Symposium Chemistry and Environmental Protection - EnviroChem2023, 4-7 th June 2023, Kladovo, Serbia, 2023
T1  - Egzopolisaharidi mikroorganizama koji mogu da degraduju BHET: Optimizacija produkcije
T1  - Exopolysaccharides from microorganisms which degrade BHET: Optimization of production
SP  - 45
EP  - 46
UR  - https://hdl.handle.net/21.15107/rcub_cer_6424
ER  - 

@conference{
author = "Lončarević, Branka and Lješević, Marija and Joksimović, Kristina and Žerađanin, Aleksandra and Gojgić-Cvijović, Gordana and Beškoski, Vladimir and Nikodinović-Runić, Jasmina",
year = "2023",
abstract = "Cilj ovog rada bio je selektovati mikroorganizme koji mogu da razgrade Bis-(2-hidroksietil)-tereftalat (BHET) kao model jedinjenje za ispitivanje degradacije plastičnog otpada na bazi polietilen tereftalata (PET) i sa visokim prinosom produkuju egzopolisaharide.",
publisher = "Srpsko hemijsko društvo",
journal = "Knjiga uzvoda - 9. Simpozijum Hemija i Zaštita Životne Sredine - EnviroChem2023, 4-7. jun 2023, Kladovo / Book of abstracts - 9 th Symposium Chemistry and Environmental Protection - EnviroChem2023, 4-7 th June 2023, Kladovo, Serbia, 2023",
title = "Egzopolisaharidi mikroorganizama koji mogu da degraduju BHET: Optimizacija produkcije, Exopolysaccharides from microorganisms which degrade BHET: Optimization of production",
pages = "45-46",
url = "https://hdl.handle.net/21.15107/rcub_cer_6424"
}

Lončarević, B., Lješević, M., Joksimović, K., Žerađanin, A., Gojgić-Cvijović, G., Beškoski, V.,& Nikodinović-Runić, J.. (2023). Egzopolisaharidi mikroorganizama koji mogu da degraduju BHET: Optimizacija produkcije. in Knjiga uzvoda - 9. Simpozijum Hemija i Zaštita Životne Sredine - EnviroChem2023, 4-7. jun 2023, Kladovo / Book of abstracts - 9 th Symposium Chemistry and Environmental Protection - EnviroChem2023, 4-7 th June 2023, Kladovo, Serbia, 2023
Srpsko hemijsko društvo., 45-46.
https://hdl.handle.net/21.15107/rcub_cer_6424

Lončarević B, Lješević M, Joksimović K, Žerađanin A, Gojgić-Cvijović G, Beškoski V, Nikodinović-Runić J. Egzopolisaharidi mikroorganizama koji mogu da degraduju BHET: Optimizacija produkcije. in Knjiga uzvoda - 9. Simpozijum Hemija i Zaštita Životne Sredine - EnviroChem2023, 4-7. jun 2023, Kladovo / Book of abstracts - 9 th Symposium Chemistry and Environmental Protection - EnviroChem2023, 4-7 th June 2023, Kladovo, Serbia, 2023. 2023;:45-46.
https://hdl.handle.net/21.15107/rcub_cer_6424 .

Lončarević, Branka, Lješević, Marija, Joksimović, Kristina, Žerađanin, Aleksandra, Gojgić-Cvijović, Gordana, Beškoski, Vladimir, Nikodinović-Runić, Jasmina, "Egzopolisaharidi mikroorganizama koji mogu da degraduju BHET: Optimizacija produkcije" in Knjiga uzvoda - 9. Simpozijum Hemija i Zaštita Životne Sredine - EnviroChem2023, 4-7. jun 2023, Kladovo / Book of abstracts - 9 th Symposium Chemistry and Environmental Protection - EnviroChem2023, 4-7 th June 2023, Kladovo, Serbia, 2023 (2023):45-46,
https://hdl.handle.net/21.15107/rcub_cer_6424 .

TY  - CONF
AU  - Petronijević, Natalija
AU  - Lješević, Marija
AU  - Lončarević, Branka
AU  - Joksimović, Kristina
AU  - Žerađanin, Aleksandra
AU  - Gojgić-Cvijović, Gordana
AU  - Beškoski, Vladimir
AU  - Nikodinović-Runić, Jasmina
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6426
AB  - Plastika kao izvor zagađenja postaje sve veći globalni problem. Većina plastike je
dizajnirana za jednokratnu upotrebu, što dodatno povećava količinu plastičnog otpada. Usled preopterećenja zemlje i voda plastičnim otpadom neophodno je razviti procese koji će omogućiti efikasno uklanjanje plastike iz životne sredine. Kao povoljan metod degradacije PET plastike predlaže se enzimska hidroliza korišćenjem mikroorganizama koji kao izvor ugljenika mogu koristiti PET. Cilj ovog rada je bila identifikacija mikroorganizama koji potencijalno razgrađuju BHET, kao i primena čistih kultura za degradaciju istog.
PB  - Srpsko hemijsko društvo
C3  - Knjiga uzvoda - 9. Simpozijum Hemija i Zaštita Životne Sredine - EnviroChem2023, 4-7. jun 2023, Kladovo / Book of abstracts - 9 th Symposium Chemistry and Environmental Protection - EnviroChem2023, 4-7 th June 2023, Kladovo, Serbia, 2023
T1  - Molekularna karakterizacija mikroorganizama izolovanih iz kontaminirane životne sredine i njihova primena za degradaciju bis(2-hidroksietil) tereftalata
SP  - 133
EP  - 134
UR  - https://hdl.handle.net/21.15107/rcub_cer_6426
ER  - 

@conference{
author = "Petronijević, Natalija and Lješević, Marija and Lončarević, Branka and Joksimović, Kristina and Žerađanin, Aleksandra and Gojgić-Cvijović, Gordana and Beškoski, Vladimir and Nikodinović-Runić, Jasmina",
year = "2023",
abstract = "Plastika kao izvor zagađenja postaje sve veći globalni problem. Većina plastike je
dizajnirana za jednokratnu upotrebu, što dodatno povećava količinu plastičnog otpada. Usled preopterećenja zemlje i voda plastičnim otpadom neophodno je razviti procese koji će omogućiti efikasno uklanjanje plastike iz životne sredine. Kao povoljan metod degradacije PET plastike predlaže se enzimska hidroliza korišćenjem mikroorganizama koji kao izvor ugljenika mogu koristiti PET. Cilj ovog rada je bila identifikacija mikroorganizama koji potencijalno razgrađuju BHET, kao i primena čistih kultura za degradaciju istog.",
publisher = "Srpsko hemijsko društvo",
journal = "Knjiga uzvoda - 9. Simpozijum Hemija i Zaštita Životne Sredine - EnviroChem2023, 4-7. jun 2023, Kladovo / Book of abstracts - 9 th Symposium Chemistry and Environmental Protection - EnviroChem2023, 4-7 th June 2023, Kladovo, Serbia, 2023",
title = "Molekularna karakterizacija mikroorganizama izolovanih iz kontaminirane životne sredine i njihova primena za degradaciju bis(2-hidroksietil) tereftalata",
pages = "133-134",
url = "https://hdl.handle.net/21.15107/rcub_cer_6426"
}

Petronijević, N., Lješević, M., Lončarević, B., Joksimović, K., Žerađanin, A., Gojgić-Cvijović, G., Beškoski, V.,& Nikodinović-Runić, J.. (2023). Molekularna karakterizacija mikroorganizama izolovanih iz kontaminirane životne sredine i njihova primena za degradaciju bis(2-hidroksietil) tereftalata. in Knjiga uzvoda - 9. Simpozijum Hemija i Zaštita Životne Sredine - EnviroChem2023, 4-7. jun 2023, Kladovo / Book of abstracts - 9 th Symposium Chemistry and Environmental Protection - EnviroChem2023, 4-7 th June 2023, Kladovo, Serbia, 2023
Srpsko hemijsko društvo., 133-134.
https://hdl.handle.net/21.15107/rcub_cer_6426

Petronijević N, Lješević M, Lončarević B, Joksimović K, Žerađanin A, Gojgić-Cvijović G, Beškoski V, Nikodinović-Runić J. Molekularna karakterizacija mikroorganizama izolovanih iz kontaminirane životne sredine i njihova primena za degradaciju bis(2-hidroksietil) tereftalata. in Knjiga uzvoda - 9. Simpozijum Hemija i Zaštita Životne Sredine - EnviroChem2023, 4-7. jun 2023, Kladovo / Book of abstracts - 9 th Symposium Chemistry and Environmental Protection - EnviroChem2023, 4-7 th June 2023, Kladovo, Serbia, 2023. 2023;:133-134.
https://hdl.handle.net/21.15107/rcub_cer_6426 .

Petronijević, Natalija, Lješević, Marija, Lončarević, Branka, Joksimović, Kristina, Žerađanin, Aleksandra, Gojgić-Cvijović, Gordana, Beškoski, Vladimir, Nikodinović-Runić, Jasmina, "Molekularna karakterizacija mikroorganizama izolovanih iz kontaminirane životne sredine i njihova primena za degradaciju bis(2-hidroksietil) tereftalata" in Knjiga uzvoda - 9. Simpozijum Hemija i Zaštita Životne Sredine - EnviroChem2023, 4-7. jun 2023, Kladovo / Book of abstracts - 9 th Symposium Chemistry and Environmental Protection - EnviroChem2023, 4-7 th June 2023, Kladovo, Serbia, 2023 (2023):133-134,
https://hdl.handle.net/21.15107/rcub_cer_6426 .

TY  - CONF
AU  - Petronijević, Natalija
AU  - Lješević, Marija
AU  - Lončarević, Branka
AU  - Joksimović, Kristina
AU  - Gojgić-Cvijović, Gordana
AU  - Beškoski, Vladimir
AU  - Nikodinović-Runić, Jasmina
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/7118
AB  - Polyethylene terephthalate (PET) is a plastic material that poses a significant global concern
due to its durability and resistance to degradation. One effective method for minimizing PET
waste is through microbial degradation, resulting in the production of ethylene glycol and
terephthalic acid (TA). Terephthalic acid, as a PET monomer, holds promise as a model
compound for further exploration into PET plastic degradation and valorisation.
PB  - Institute of Technical Sciences of SASA
C3  - Programme and the Book of Abstracts - Twenty-first Young Researchers’ Conference Materials Science and Engineering, November 29 - December 1, 2023, Belgrad
T1  - Microbial degradation of terephtalic acid as a PET-derived compound
SP  - 28
EP  - 28
UR  - https://hdl.handle.net/21.15107/rcub_cer_7118
ER  - 

@conference{
author = "Petronijević, Natalija and Lješević, Marija and Lončarević, Branka and Joksimović, Kristina and Gojgić-Cvijović, Gordana and Beškoski, Vladimir and Nikodinović-Runić, Jasmina",
year = "2023",
abstract = "Polyethylene terephthalate (PET) is a plastic material that poses a significant global concern
due to its durability and resistance to degradation. One effective method for minimizing PET
waste is through microbial degradation, resulting in the production of ethylene glycol and
terephthalic acid (TA). Terephthalic acid, as a PET monomer, holds promise as a model
compound for further exploration into PET plastic degradation and valorisation.",
publisher = "Institute of Technical Sciences of SASA",
journal = "Programme and the Book of Abstracts - Twenty-first Young Researchers’ Conference Materials Science and Engineering, November 29 - December 1, 2023, Belgrad",
title = "Microbial degradation of terephtalic acid as a PET-derived compound",
pages = "28-28",
url = "https://hdl.handle.net/21.15107/rcub_cer_7118"
}

Petronijević, N., Lješević, M., Lončarević, B., Joksimović, K., Gojgić-Cvijović, G., Beškoski, V.,& Nikodinović-Runić, J.. (2023). Microbial degradation of terephtalic acid as a PET-derived compound. in Programme and the Book of Abstracts - Twenty-first Young Researchers’ Conference Materials Science and Engineering, November 29 - December 1, 2023, Belgrad
Institute of Technical Sciences of SASA., 28-28.
https://hdl.handle.net/21.15107/rcub_cer_7118

Petronijević N, Lješević M, Lončarević B, Joksimović K, Gojgić-Cvijović G, Beškoski V, Nikodinović-Runić J. Microbial degradation of terephtalic acid as a PET-derived compound. in Programme and the Book of Abstracts - Twenty-first Young Researchers’ Conference Materials Science and Engineering, November 29 - December 1, 2023, Belgrad. 2023;:28-28.
https://hdl.handle.net/21.15107/rcub_cer_7118 .

Petronijević, Natalija, Lješević, Marija, Lončarević, Branka, Joksimović, Kristina, Gojgić-Cvijović, Gordana, Beškoski, Vladimir, Nikodinović-Runić, Jasmina, "Microbial degradation of terephtalic acid as a PET-derived compound" in Programme and the Book of Abstracts - Twenty-first Young Researchers’ Conference Materials Science and Engineering, November 29 - December 1, 2023, Belgrad (2023):28-28,
https://hdl.handle.net/21.15107/rcub_cer_7118 .

TY  - JOUR
AU  - Solarz, Daria
AU  - Witko, Tomasz
AU  - Karcz, Robert
AU  - Malagurski, Ivana
AU  - Ponjavić, Marijana
AU  - Levic, Steva
AU  - Nešić, Aleksandra
AU  - Guzik, Maciej
AU  - Savić, Sanja
AU  - Nikodinović-Runić, Jasmina
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/7170
AB  - Polyhydroxyoctanoate, as a biocompatible and biodegradable biopolymer, represents an ideal candidate for biomedical applications. However, physical properties make it unsuitable for electrospinning, currently the most widely used technique for fabrication of fibrous scaffolds. To overcome this, it was blended with polylactic acid and polymer blend fibrous biomaterials were produced by electrospinning. The obtained PLA/PHO fibers were cylindrical, smaller in size, more hydrophilic and had a higher degree of biopolymer crystallinity and more favorable mechanical properties in comparison to the pure PLA sample. Cytotoxicity evaluation with human lung fibroblasts (MRC5 cells) combined with confocal microscopy were used to visualize mouse embryonic fibroblasts (MEF 3T3 cell line) migration and distribution showed that PLA/PHO samples support exceptional cell adhesion and viability, indicating excellent biocompatibility. The obtained results suggest that PLA/PHO fibrous biomaterials can be potentially used as biocompatible, biomimetic scaffolds for tissue engineering applications.
PB  - Royal Society of Chemistry (RSC)
T2  - RSC Advances
T1  - Biological and physiochemical studies of electrospun polylactid/polyhydroxyoctanoate PLA/ P(3HO) scaffolds for tissue engineering applications
VL  - 13
IS  - 34
SP  - 24112
EP  - 24128
DO  - 10.1039/D3RA03021K
ER  - 

@article{
author = "Solarz, Daria and Witko, Tomasz and Karcz, Robert and Malagurski, Ivana and Ponjavić, Marijana and Levic, Steva and Nešić, Aleksandra and Guzik, Maciej and Savić, Sanja and Nikodinović-Runić, Jasmina",
year = "2023",
abstract = "Polyhydroxyoctanoate, as a biocompatible and biodegradable biopolymer, represents an ideal candidate for biomedical applications. However, physical properties make it unsuitable for electrospinning, currently the most widely used technique for fabrication of fibrous scaffolds. To overcome this, it was blended with polylactic acid and polymer blend fibrous biomaterials were produced by electrospinning. The obtained PLA/PHO fibers were cylindrical, smaller in size, more hydrophilic and had a higher degree of biopolymer crystallinity and more favorable mechanical properties in comparison to the pure PLA sample. Cytotoxicity evaluation with human lung fibroblasts (MRC5 cells) combined with confocal microscopy were used to visualize mouse embryonic fibroblasts (MEF 3T3 cell line) migration and distribution showed that PLA/PHO samples support exceptional cell adhesion and viability, indicating excellent biocompatibility. The obtained results suggest that PLA/PHO fibrous biomaterials can be potentially used as biocompatible, biomimetic scaffolds for tissue engineering applications.",
publisher = "Royal Society of Chemistry (RSC)",
journal = "RSC Advances",
title = "Biological and physiochemical studies of electrospun polylactid/polyhydroxyoctanoate PLA/ P(3HO) scaffolds for tissue engineering applications",
volume = "13",
number = "34",
pages = "24112-24128",
doi = "10.1039/D3RA03021K"
}

Solarz, D., Witko, T., Karcz, R., Malagurski, I., Ponjavić, M., Levic, S., Nešić, A., Guzik, M., Savić, S.,& Nikodinović-Runić, J.. (2023). Biological and physiochemical studies of electrospun polylactid/polyhydroxyoctanoate PLA/ P(3HO) scaffolds for tissue engineering applications. in RSC Advances
Royal Society of Chemistry (RSC)., 13(34), 24112-24128.
https://doi.org/10.1039/D3RA03021K

Solarz D, Witko T, Karcz R, Malagurski I, Ponjavić M, Levic S, Nešić A, Guzik M, Savić S, Nikodinović-Runić J. Biological and physiochemical studies of electrospun polylactid/polyhydroxyoctanoate PLA/ P(3HO) scaffolds for tissue engineering applications. in RSC Advances. 2023;13(34):24112-24128.
doi:10.1039/D3RA03021K .

Solarz, Daria, Witko, Tomasz, Karcz, Robert, Malagurski, Ivana, Ponjavić, Marijana, Levic, Steva, Nešić, Aleksandra, Guzik, Maciej, Savić, Sanja, Nikodinović-Runić, Jasmina, "Biological and physiochemical studies of electrospun polylactid/polyhydroxyoctanoate PLA/ P(3HO) scaffolds for tissue engineering applications" in RSC Advances, 13, no. 34 (2023):24112-24128,
https://doi.org/10.1039/D3RA03021K . .

TY  - JOUR
AU  - Andrejević, Tina P.
AU  - Aleksić, Ivana
AU  - Kljun, Jakob
AU  - Počkaj, Marta
AU  - Zlatar, Matija
AU  - Vojnović, Sandra
AU  - Nikodinović-Runić, Jasmina
AU  - Turel, Iztok
AU  - Đuran, Miloš
AU  - Glišić, Biljana
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5654
AB  - Dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz) was used as a ligand for the synthesis of new copper(II) and silver(I) complexes, [CuCl2(py-2pz)]2 (1), [Cu(CF3SO3)(H2O)(py-2pz)2]CF3SO3·2H2O (2), [Ag(py-2pz)2]PF6 (3) and {[Ag(NO3)(py-2pz)]·0.5H2O}n (4). The complexes were characterized by spectroscopic and electrochemical methods, while their structures were determined by single crystal X-ray diffraction analysis. The X-ray analysis revealed the bidentate coordination mode of py-2pz to the corresponding metal ion via its pyridine and pyrazine nitrogen atoms in all complexes, while in polynuclear complex 4, the heterocyclic pyrazine ring of one py-2pz additionally behaves as a bridging ligand between two Ag(I) ions. DFT calculations were performed to elucidate the structures of the investigated complexes in solution. The antimicrobial potential of the complexes 1–4 was evaluated against two bacterial (Pseudomonas aeruginosa and Staphylococcus aureus) and two Candida (C. albicans and C. parapsilosis) species. Silver(I) complexes 3 and 4 have shown good antibacterial and antifungal properties with minimal inhibitory concentration (MIC) values ranging from 4.9 to 39.0 μM (3.9–31.2 μg mL−1). All complexes inhibited the filamentation of C. albicans and hyphae formation, while silver(I) complexes 3 and 4 had also the ability to inhibit the biofilm formation process of this fungus. The binding affinity of the complexes 1–4 with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) was studied by fluorescence emission spectroscopy to clarify the mode of their antimicrobial activity. Catechol oxidase biomimetic catalytic activity of copper(II) complexes 1 and 2 was additionally investigated by using 3,5-di-tert-butylcatechol (3,5-DTBC) and o-aminophenol (OAP) as substrates.
PB  - Royal Society of Chemistry (RSC)
T2  - RSC Advances
T1  - Copper(II) and silver(I) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex
VL  - 13
IS  - 7
SP  - 4376
EP  - 4393
DO  - 10.1039/D2RA07401J
ER  - 

@article{
author = "Andrejević, Tina P. and Aleksić, Ivana and Kljun, Jakob and Počkaj, Marta and Zlatar, Matija and Vojnović, Sandra and Nikodinović-Runić, Jasmina and Turel, Iztok and Đuran, Miloš and Glišić, Biljana",
year = "2023",
abstract = "Dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz) was used as a ligand for the synthesis of new copper(II) and silver(I) complexes, [CuCl2(py-2pz)]2 (1), [Cu(CF3SO3)(H2O)(py-2pz)2]CF3SO3·2H2O (2), [Ag(py-2pz)2]PF6 (3) and {[Ag(NO3)(py-2pz)]·0.5H2O}n (4). The complexes were characterized by spectroscopic and electrochemical methods, while their structures were determined by single crystal X-ray diffraction analysis. The X-ray analysis revealed the bidentate coordination mode of py-2pz to the corresponding metal ion via its pyridine and pyrazine nitrogen atoms in all complexes, while in polynuclear complex 4, the heterocyclic pyrazine ring of one py-2pz additionally behaves as a bridging ligand between two Ag(I) ions. DFT calculations were performed to elucidate the structures of the investigated complexes in solution. The antimicrobial potential of the complexes 1–4 was evaluated against two bacterial (Pseudomonas aeruginosa and Staphylococcus aureus) and two Candida (C. albicans and C. parapsilosis) species. Silver(I) complexes 3 and 4 have shown good antibacterial and antifungal properties with minimal inhibitory concentration (MIC) values ranging from 4.9 to 39.0 μM (3.9–31.2 μg mL−1). All complexes inhibited the filamentation of C. albicans and hyphae formation, while silver(I) complexes 3 and 4 had also the ability to inhibit the biofilm formation process of this fungus. The binding affinity of the complexes 1–4 with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) was studied by fluorescence emission spectroscopy to clarify the mode of their antimicrobial activity. Catechol oxidase biomimetic catalytic activity of copper(II) complexes 1 and 2 was additionally investigated by using 3,5-di-tert-butylcatechol (3,5-DTBC) and o-aminophenol (OAP) as substrates.",
publisher = "Royal Society of Chemistry (RSC)",
journal = "RSC Advances",
title = "Copper(II) and silver(I) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex",
volume = "13",
number = "7",
pages = "4376-4393",
doi = "10.1039/D2RA07401J"
}

Andrejević, T. P., Aleksić, I., Kljun, J., Počkaj, M., Zlatar, M., Vojnović, S., Nikodinović-Runić, J., Turel, I., Đuran, M.,& Glišić, B.. (2023). Copper(II) and silver(I) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex. in RSC Advances
Royal Society of Chemistry (RSC)., 13(7), 4376-4393.
https://doi.org/10.1039/D2RA07401J

Andrejević TP, Aleksić I, Kljun J, Počkaj M, Zlatar M, Vojnović S, Nikodinović-Runić J, Turel I, Đuran M, Glišić B. Copper(II) and silver(I) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex. in RSC Advances. 2023;13(7):4376-4393.
doi:10.1039/D2RA07401J .

Andrejević, Tina P., Aleksić, Ivana, Kljun, Jakob, Počkaj, Marta, Zlatar, Matija, Vojnović, Sandra, Nikodinović-Runić, Jasmina, Turel, Iztok, Đuran, Miloš, Glišić, Biljana, "Copper(II) and silver(I) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex" in RSC Advances, 13, no. 7 (2023):4376-4393,
https://doi.org/10.1039/D2RA07401J . .

TY  - DATA
AU  - Andrejević, Tina P.
AU  - Aleksić, Ivana
AU  - Kljun, Jakob
AU  - Počkaj, Marta
AU  - Zlatar, Matija
AU  - Vojnović, Sandra
AU  - Nikodinović-Runić, Jasmina
AU  - Turel, Iztok
AU  - Đuran, Miloš
AU  - Glišić, Biljana
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5669
AB  - TEZLOD : New Structure undergoing enhancement  Space Group: P 1 (2), Cell: a 7.7916(6)Å b 8.9848(6)Å c 11.9955(7)Å, α 104.394(6)° β 106.396(6)° γ 104.368(6)°
PB  - The Cambridge Crystallographic Data Centre (CCDC)
T1  - CCDC 2220146: Experimental Crystal Structure Determination. Crystallographic data for: "Copper(II) and silver(I) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex"
DO  - 10.5517/ccdc.csd.cc2dj7mt
ER  - 

@misc{
author = "Andrejević, Tina P. and Aleksić, Ivana and Kljun, Jakob and Počkaj, Marta and Zlatar, Matija and Vojnović, Sandra and Nikodinović-Runić, Jasmina and Turel, Iztok and Đuran, Miloš and Glišić, Biljana",
year = "2023",
abstract = "TEZLOD : New Structure undergoing enhancement  Space Group: P 1 (2), Cell: a 7.7916(6)Å b 8.9848(6)Å c 11.9955(7)Å, α 104.394(6)° β 106.396(6)° γ 104.368(6)°",
publisher = "The Cambridge Crystallographic Data Centre (CCDC)",
title = "CCDC 2220146: Experimental Crystal Structure Determination. Crystallographic data for: "Copper(II) and silver(I) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex"",
doi = "10.5517/ccdc.csd.cc2dj7mt"
}

Andrejević, T. P., Aleksić, I., Kljun, J., Počkaj, M., Zlatar, M., Vojnović, S., Nikodinović-Runić, J., Turel, I., Đuran, M.,& Glišić, B.. (2023). CCDC 2220146: Experimental Crystal Structure Determination. Crystallographic data for: "Copper(II) and silver(I) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex". 
The Cambridge Crystallographic Data Centre (CCDC)..
https://doi.org/10.5517/ccdc.csd.cc2dj7mt

Andrejević TP, Aleksić I, Kljun J, Počkaj M, Zlatar M, Vojnović S, Nikodinović-Runić J, Turel I, Đuran M, Glišić B. CCDC 2220146: Experimental Crystal Structure Determination. Crystallographic data for: "Copper(II) and silver(I) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex". 2023;.
doi:10.5517/ccdc.csd.cc2dj7mt .

Andrejević, Tina P., Aleksić, Ivana, Kljun, Jakob, Počkaj, Marta, Zlatar, Matija, Vojnović, Sandra, Nikodinović-Runić, Jasmina, Turel, Iztok, Đuran, Miloš, Glišić, Biljana, "CCDC 2220146: Experimental Crystal Structure Determination. Crystallographic data for: "Copper(II) and silver(I) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex"" (2023),
https://doi.org/10.5517/ccdc.csd.cc2dj7mt . .

TY  - DATA
AU  - Andrejević, Tina P.
AU  - Aleksić, Ivana
AU  - Kljun, Jakob
AU  - Počkaj, Marta
AU  - Zlatar, Matija
AU  - Vojnović, Sandra
AU  - Nikodinović-Runić, Jasmina
AU  - Turel, Iztok
AU  - Đuran, Miloš
AU  - Glišić, Biljana
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5669
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5670
AB  - TEZLUJ : New Structure undergoing enhancement  Space Group: P 1 (2), Cell: a 8.2856(3)Å b 12.1191(5)Å c 19.2393(6)Å, α 82.105(3)° β 86.220(3)° γ 77.071(3)°
PB  - The Cambridge Crystallographic Data Centre (CCDC)
T1  - CCDC 2220147: Experimental Crystal Structure Determination. Crystallographic data for: "Copper(II) and silver(I) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex"
DO  - 10.5517/ccdc.csd.cc2dj7nv
ER  - 

@misc{
author = "Andrejević, Tina P. and Aleksić, Ivana and Kljun, Jakob and Počkaj, Marta and Zlatar, Matija and Vojnović, Sandra and Nikodinović-Runić, Jasmina and Turel, Iztok and Đuran, Miloš and Glišić, Biljana",
year = "2023",
abstract = "TEZLUJ : New Structure undergoing enhancement  Space Group: P 1 (2), Cell: a 8.2856(3)Å b 12.1191(5)Å c 19.2393(6)Å, α 82.105(3)° β 86.220(3)° γ 77.071(3)°",
publisher = "The Cambridge Crystallographic Data Centre (CCDC)",
title = "CCDC 2220147: Experimental Crystal Structure Determination. Crystallographic data for: "Copper(II) and silver(I) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex"",
doi = "10.5517/ccdc.csd.cc2dj7nv"
}

Andrejević, T. P., Aleksić, I., Kljun, J., Počkaj, M., Zlatar, M., Vojnović, S., Nikodinović-Runić, J., Turel, I., Đuran, M.,& Glišić, B.. (2023). CCDC 2220147: Experimental Crystal Structure Determination. Crystallographic data for: "Copper(II) and silver(I) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex". 
The Cambridge Crystallographic Data Centre (CCDC)..
https://doi.org/10.5517/ccdc.csd.cc2dj7nv

Andrejević TP, Aleksić I, Kljun J, Počkaj M, Zlatar M, Vojnović S, Nikodinović-Runić J, Turel I, Đuran M, Glišić B. CCDC 2220147: Experimental Crystal Structure Determination. Crystallographic data for: "Copper(II) and silver(I) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex". 2023;.
doi:10.5517/ccdc.csd.cc2dj7nv .

Andrejević, Tina P., Aleksić, Ivana, Kljun, Jakob, Počkaj, Marta, Zlatar, Matija, Vojnović, Sandra, Nikodinović-Runić, Jasmina, Turel, Iztok, Đuran, Miloš, Glišić, Biljana, "CCDC 2220147: Experimental Crystal Structure Determination. Crystallographic data for: "Copper(II) and silver(I) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex"" (2023),
https://doi.org/10.5517/ccdc.csd.cc2dj7nv . .

TY  - DATA
AU  - Andrejević, Tina P.
AU  - Aleksić, Ivana
AU  - Kljun, Jakob
AU  - Počkaj, Marta
AU  - Zlatar, Matija
AU  - Vojnović, Sandra
AU  - Nikodinović-Runić, Jasmina
AU  - Turel, Iztok
AU  - Đuran, Miloš
AU  - Glišić, Biljana
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5671
AB  - TEZMAQ; Space Group: P 1 (2), Cell: a 8.2856(3)Å b 12.1191(5)Å c 19.2393(6)Å, α 82.105(3)° β 86.220(3)° γ 77.071(3)°
PB  - The Cambridge Crystallographic Data Centre (CCDC)
T1  - CCDC 2220148: Experimental Crystal Structure Determination. Crystallographic data for: "Copper(II) and silver(I) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex"
DO  - 10.5517/ccdc.csd.cc2dj7pw
ER  - 

@misc{
author = "Andrejević, Tina P. and Aleksić, Ivana and Kljun, Jakob and Počkaj, Marta and Zlatar, Matija and Vojnović, Sandra and Nikodinović-Runić, Jasmina and Turel, Iztok and Đuran, Miloš and Glišić, Biljana",
year = "2023",
abstract = "TEZMAQ; Space Group: P 1 (2), Cell: a 8.2856(3)Å b 12.1191(5)Å c 19.2393(6)Å, α 82.105(3)° β 86.220(3)° γ 77.071(3)°",
publisher = "The Cambridge Crystallographic Data Centre (CCDC)",
title = "CCDC 2220148: Experimental Crystal Structure Determination. Crystallographic data for: "Copper(II) and silver(I) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex"",
doi = "10.5517/ccdc.csd.cc2dj7pw"
}

Andrejević, T. P., Aleksić, I., Kljun, J., Počkaj, M., Zlatar, M., Vojnović, S., Nikodinović-Runić, J., Turel, I., Đuran, M.,& Glišić, B.. (2023). CCDC 2220148: Experimental Crystal Structure Determination. Crystallographic data for: "Copper(II) and silver(I) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex". 
The Cambridge Crystallographic Data Centre (CCDC)..
https://doi.org/10.5517/ccdc.csd.cc2dj7pw

Andrejević TP, Aleksić I, Kljun J, Počkaj M, Zlatar M, Vojnović S, Nikodinović-Runić J, Turel I, Đuran M, Glišić B. CCDC 2220148: Experimental Crystal Structure Determination. Crystallographic data for: "Copper(II) and silver(I) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex". 2023;.
doi:10.5517/ccdc.csd.cc2dj7pw .

Andrejević, Tina P., Aleksić, Ivana, Kljun, Jakob, Počkaj, Marta, Zlatar, Matija, Vojnović, Sandra, Nikodinović-Runić, Jasmina, Turel, Iztok, Đuran, Miloš, Glišić, Biljana, "CCDC 2220148: Experimental Crystal Structure Determination. Crystallographic data for: "Copper(II) and silver(I) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex"" (2023),
https://doi.org/10.5517/ccdc.csd.cc2dj7pw . .

TY  - DATA
AU  - Andrejević, Tina P.
AU  - Aleksić, Ivana
AU  - Kljun, Jakob
AU  - Počkaj, Marta
AU  - Zlatar, Matija
AU  - Vojnović, Sandra
AU  - Nikodinović-Runić, Jasmina
AU  - Turel, Iztok
AU  - Đuran, Miloš
AU  - Glišić, Biljana
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5672
AB  - TEZMEU: Space Group: P 1 (2), Cell: a 7.4731(4)Å b 11.7049(4)Å c 17.6092(8)Å, α 97.285(4)° β 96.617(4)° γ 102.781(4)°
PB  - The Cambridge Crystallographic Data Centre (CCDC)
T1  - CCDC 2220149: Experimental Crystal Structure Determination. Crystallographic data for: "Copper(II) and silver(I) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex"
DO  - 10.5517/ccdc.csd.cc2dj7qx
ER  - 

@misc{
author = "Andrejević, Tina P. and Aleksić, Ivana and Kljun, Jakob and Počkaj, Marta and Zlatar, Matija and Vojnović, Sandra and Nikodinović-Runić, Jasmina and Turel, Iztok and Đuran, Miloš and Glišić, Biljana",
year = "2023",
abstract = "TEZMEU: Space Group: P 1 (2), Cell: a 7.4731(4)Å b 11.7049(4)Å c 17.6092(8)Å, α 97.285(4)° β 96.617(4)° γ 102.781(4)°",
publisher = "The Cambridge Crystallographic Data Centre (CCDC)",
title = "CCDC 2220149: Experimental Crystal Structure Determination. Crystallographic data for: "Copper(II) and silver(I) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex"",
doi = "10.5517/ccdc.csd.cc2dj7qx"
}

Andrejević, T. P., Aleksić, I., Kljun, J., Počkaj, M., Zlatar, M., Vojnović, S., Nikodinović-Runić, J., Turel, I., Đuran, M.,& Glišić, B.. (2023). CCDC 2220149: Experimental Crystal Structure Determination. Crystallographic data for: "Copper(II) and silver(I) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex". 
The Cambridge Crystallographic Data Centre (CCDC)..
https://doi.org/10.5517/ccdc.csd.cc2dj7qx

Andrejević TP, Aleksić I, Kljun J, Počkaj M, Zlatar M, Vojnović S, Nikodinović-Runić J, Turel I, Đuran M, Glišić B. CCDC 2220149: Experimental Crystal Structure Determination. Crystallographic data for: "Copper(II) and silver(I) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex". 2023;.
doi:10.5517/ccdc.csd.cc2dj7qx .

Andrejević, Tina P., Aleksić, Ivana, Kljun, Jakob, Počkaj, Marta, Zlatar, Matija, Vojnović, Sandra, Nikodinović-Runić, Jasmina, Turel, Iztok, Đuran, Miloš, Glišić, Biljana, "CCDC 2220149: Experimental Crystal Structure Determination. Crystallographic data for: "Copper(II) and silver(I) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex"" (2023),
https://doi.org/10.5517/ccdc.csd.cc2dj7qx . .

TY  - DATA
AU  - Andrejević, Tina P.
AU  - Aleksić, Ivana
AU  - Kljun, Jakob
AU  - Počkaj, Marta
AU  - Zlatar, Matija
AU  - Vojnović, Sandra
AU  - Nikodinović-Runić, Jasmina
AU  - Turel, Iztok
AU  - Đuran, Miloš
AU  - Glišić, Biljana
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5673
AB  - TEZMIY: Space Group: P 21/n (14), Cell: a 11.0042(12)Å b 12.8657(8)Å c 12.5820(12)Å, α 90° β 115.436(13)° γ 90°
PB  - The Cambridge Crystallographic Data Centre (CCDC)
T1  - CCDC 2220150: Experimental Crystal Structure Determination. Crystallographic data for: "Copper(II) and silver(I) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex"
DO  - 10.5517/ccdc.csd.cc2dj7ry
ER  - 

@misc{
author = "Andrejević, Tina P. and Aleksić, Ivana and Kljun, Jakob and Počkaj, Marta and Zlatar, Matija and Vojnović, Sandra and Nikodinović-Runić, Jasmina and Turel, Iztok and Đuran, Miloš and Glišić, Biljana",
year = "2023",
abstract = "TEZMIY: Space Group: P 21/n (14), Cell: a 11.0042(12)Å b 12.8657(8)Å c 12.5820(12)Å, α 90° β 115.436(13)° γ 90°",
publisher = "The Cambridge Crystallographic Data Centre (CCDC)",
title = "CCDC 2220150: Experimental Crystal Structure Determination. Crystallographic data for: "Copper(II) and silver(I) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex"",
doi = "10.5517/ccdc.csd.cc2dj7ry"
}

Andrejević, T. P., Aleksić, I., Kljun, J., Počkaj, M., Zlatar, M., Vojnović, S., Nikodinović-Runić, J., Turel, I., Đuran, M.,& Glišić, B.. (2023). CCDC 2220150: Experimental Crystal Structure Determination. Crystallographic data for: "Copper(II) and silver(I) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex". 
The Cambridge Crystallographic Data Centre (CCDC)..
https://doi.org/10.5517/ccdc.csd.cc2dj7ry

Andrejević TP, Aleksić I, Kljun J, Počkaj M, Zlatar M, Vojnović S, Nikodinović-Runić J, Turel I, Đuran M, Glišić B. CCDC 2220150: Experimental Crystal Structure Determination. Crystallographic data for: "Copper(II) and silver(I) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex". 2023;.
doi:10.5517/ccdc.csd.cc2dj7ry .

Andrejević, Tina P., Aleksić, Ivana, Kljun, Jakob, Počkaj, Marta, Zlatar, Matija, Vojnović, Sandra, Nikodinović-Runić, Jasmina, Turel, Iztok, Đuran, Miloš, Glišić, Biljana, "CCDC 2220150: Experimental Crystal Structure Determination. Crystallographic data for: "Copper(II) and silver(I) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex"" (2023),
https://doi.org/10.5517/ccdc.csd.cc2dj7ry . .

TY  - DATA
AU  - Andrejević, Tina P.
AU  - Aleksić, Ivana
AU  - Kljun, Jakob
AU  - Počkaj, Marta
AU  - Zlatar, Matija
AU  - Vojnović, Sandra
AU  - Nikodinović-Runić, Jasmina
AU  - Turel, Iztok
AU  - Đuran, Miloš
AU  - Glišić, Biljana
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5674
AB  - Dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz) was used as a ligand for the synthesis of new copper(II) and silver(I) complexes, [CuCl2(py-2pz)]2 (1), [Cu(CF3SO3)(H2O)(py-2pz)2]CF3SO3·2H2O (2), [Ag(py-2pz)2]PF6 (3) and {[Ag(NO3)(py-2pz)]·0.5H2O}n (4). The complexes were characterized by spectroscopic and electrochemical methods, while their structures were determined by single crystal X-ray diffraction analysis. The X-ray analysis revealed the bidentate coordination mode of py-2pz to the corresponding metal ion via its pyridine and pyrazine nitrogen atoms in all complexes, while in polynuclear complex 4, the heterocyclic pyrazine ring of one py-2pz additionally behaves as a bridging ligand between two Ag(I) ions. DFT calculations were performed to elucidate the structures of the investigated complexes in solution. The antimicrobial potential of the complexes 1–4 was evaluated against two bacterial (Pseudomonas aeruginosa and Staphylococcus aureus) and two Candida (C. albicans and C. parapsilosis) species. Silver(I) complexes 3 and 4 have shown good antibacterial and antifungal properties with minimal inhibitory concentration (MIC) values ranging from 4.9 to 39.0 μM (3.9–31.2 μg mL−1). All complexes inhibited the filamentation of C. albicans and hyphae formation, while silver(I) complexes 3 and 4 had also the ability to inhibit the biofilm formation process of this fungus. The binding affinity of the complexes 1–4 with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) was studied by fluorescence emission spectroscopy to clarify the mode of their antimicrobial activity. Catechol oxidase biomimetic catalytic activity of copper(II) complexes 1 and 2 was additionally investigated by using 3,5-di-tert-butylcatechol (3,5-DTBC) and o-aminophenol (OAP) as substrates.
AB  - 1H NMR spectrum of py-2pz S5 1H NMR spectrum of complex 3 S6 1H NMR spectrum of complex 4 S7 Fig. S1 UV-Vis spectra of copper(II) complexes 1 and 2 recorded in DMSO at room  temperature. S8 Fig. S2 UV-Vis spectra of silver(I) complexes 3 and 4 in respect to the spectrum of  uncoordinated py-2pz recorded in DMSO at room temperature. S9 Fig. S3 Time-dependant UV-Vis spectra of copper(II) complex 2 and silver(I)  complex 3 recorded in DMSO/PBS (v/v 2 : 1 and 1 : 42.9 for 2 and 3, respectively)  at room temperature. S10 Fig. S4 Cyclic voltammogram of py-2pz ligand at GC electrode in DMSO (c = 1 ×  10-3 M) and 0.1 M TBAHP as a supporting electrolyte with a scan rate of 50  mV s-1 . S11 Fig. S5 Graphical representation of the spin density of the high-spin state of 1.  Isosurfaces were drawn at 0.003 a.u. with α-spin depicted by blue surfaces. S12 Fig. S6 Inhibition of violacein and prodigiosin production in the presence of  complexes 1 – 4 and py-2pz ligand tested on Chromobacterium violaceum CV026  and Serratia marcescens at 100 µg per disc concentration. DMSO was used as a  control. S13 Scheme S1 Catechol oxidase (CAO) and phenoxazinone synthase (PHS) activity. S14 Table S1 C. albicans ATCC10231 biofilm inhibition (%) in the presence of silver(I)  complexes 3 and 4 in range of subinhibitory concentrations. Table S2 Details of the crystal structure determination for copper(II) complexes  1 and 2 S16 Table S3 Details of the crystal structure determination for silver(I) complexes  3 and 4 S17 Cartesian coordinates of all DFT optimized structures S18.
PB  - Royal Society of Chemistry (RSC)
T2  - RSC Advances
T1  - Electronic Supplementary Information for: "Copper(II) and silver(I) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex"
DO  - 10.1039/D2RA07401J
ER  - 

@misc{
author = "Andrejević, Tina P. and Aleksić, Ivana and Kljun, Jakob and Počkaj, Marta and Zlatar, Matija and Vojnović, Sandra and Nikodinović-Runić, Jasmina and Turel, Iztok and Đuran, Miloš and Glišić, Biljana",
year = "2023",
abstract = "Dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz) was used as a ligand for the synthesis of new copper(II) and silver(I) complexes, [CuCl2(py-2pz)]2 (1), [Cu(CF3SO3)(H2O)(py-2pz)2]CF3SO3·2H2O (2), [Ag(py-2pz)2]PF6 (3) and {[Ag(NO3)(py-2pz)]·0.5H2O}n (4). The complexes were characterized by spectroscopic and electrochemical methods, while their structures were determined by single crystal X-ray diffraction analysis. The X-ray analysis revealed the bidentate coordination mode of py-2pz to the corresponding metal ion via its pyridine and pyrazine nitrogen atoms in all complexes, while in polynuclear complex 4, the heterocyclic pyrazine ring of one py-2pz additionally behaves as a bridging ligand between two Ag(I) ions. DFT calculations were performed to elucidate the structures of the investigated complexes in solution. The antimicrobial potential of the complexes 1–4 was evaluated against two bacterial (Pseudomonas aeruginosa and Staphylococcus aureus) and two Candida (C. albicans and C. parapsilosis) species. Silver(I) complexes 3 and 4 have shown good antibacterial and antifungal properties with minimal inhibitory concentration (MIC) values ranging from 4.9 to 39.0 μM (3.9–31.2 μg mL−1). All complexes inhibited the filamentation of C. albicans and hyphae formation, while silver(I) complexes 3 and 4 had also the ability to inhibit the biofilm formation process of this fungus. The binding affinity of the complexes 1–4 with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) was studied by fluorescence emission spectroscopy to clarify the mode of their antimicrobial activity. Catechol oxidase biomimetic catalytic activity of copper(II) complexes 1 and 2 was additionally investigated by using 3,5-di-tert-butylcatechol (3,5-DTBC) and o-aminophenol (OAP) as substrates., 1H NMR spectrum of py-2pz S5 1H NMR spectrum of complex 3 S6 1H NMR spectrum of complex 4 S7 Fig. S1 UV-Vis spectra of copper(II) complexes 1 and 2 recorded in DMSO at room  temperature. S8 Fig. S2 UV-Vis spectra of silver(I) complexes 3 and 4 in respect to the spectrum of  uncoordinated py-2pz recorded in DMSO at room temperature. S9 Fig. S3 Time-dependant UV-Vis spectra of copper(II) complex 2 and silver(I)  complex 3 recorded in DMSO/PBS (v/v 2 : 1 and 1 : 42.9 for 2 and 3, respectively)  at room temperature. S10 Fig. S4 Cyclic voltammogram of py-2pz ligand at GC electrode in DMSO (c = 1 ×  10-3 M) and 0.1 M TBAHP as a supporting electrolyte with a scan rate of 50  mV s-1 . S11 Fig. S5 Graphical representation of the spin density of the high-spin state of 1.  Isosurfaces were drawn at 0.003 a.u. with α-spin depicted by blue surfaces. S12 Fig. S6 Inhibition of violacein and prodigiosin production in the presence of  complexes 1 – 4 and py-2pz ligand tested on Chromobacterium violaceum CV026  and Serratia marcescens at 100 µg per disc concentration. DMSO was used as a  control. S13 Scheme S1 Catechol oxidase (CAO) and phenoxazinone synthase (PHS) activity. S14 Table S1 C. albicans ATCC10231 biofilm inhibition (%) in the presence of silver(I)  complexes 3 and 4 in range of subinhibitory concentrations. Table S2 Details of the crystal structure determination for copper(II) complexes  1 and 2 S16 Table S3 Details of the crystal structure determination for silver(I) complexes  3 and 4 S17 Cartesian coordinates of all DFT optimized structures S18.",
publisher = "Royal Society of Chemistry (RSC)",
journal = "RSC Advances",
title = "Electronic Supplementary Information for: "Copper(II) and silver(I) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex"",
doi = "10.1039/D2RA07401J"
}

Andrejević, T. P., Aleksić, I., Kljun, J., Počkaj, M., Zlatar, M., Vojnović, S., Nikodinović-Runić, J., Turel, I., Đuran, M.,& Glišić, B.. (2023). Electronic Supplementary Information for: "Copper(II) and silver(I) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex". in RSC Advances
Royal Society of Chemistry (RSC)..
https://doi.org/10.1039/D2RA07401J

Andrejević TP, Aleksić I, Kljun J, Počkaj M, Zlatar M, Vojnović S, Nikodinović-Runić J, Turel I, Đuran M, Glišić B. Electronic Supplementary Information for: "Copper(II) and silver(I) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex". in RSC Advances. 2023;.
doi:10.1039/D2RA07401J .

Andrejević, Tina P., Aleksić, Ivana, Kljun, Jakob, Počkaj, Marta, Zlatar, Matija, Vojnović, Sandra, Nikodinović-Runić, Jasmina, Turel, Iztok, Đuran, Miloš, Glišić, Biljana, "Electronic Supplementary Information for: "Copper(II) and silver(I) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex"" in RSC Advances (2023),
https://doi.org/10.1039/D2RA07401J . .

TY  - CONF
AU  - Pergal, Marija
AU  - Kodranov, Igor
AU  - Vasiljević-Radović, Dana
AU  - Nikodinović-Runić, Jasmina
AU  - Dojčinović, Biljana
AU  - Manojlović, Dragan
AU  - Antić, Bratislav
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6363
AB  - Polyurethane (PU) nanocomposites are highly utilized in biomedical devices/implants due to their excellent mechanical properties, good biocompatibility, and low cytotoxicity. These PU nanocomposites with silver nanoparticles are well known potent antimicrobial agents. Biocompatible magnetic nanoparticles such as ferrites has also gained attention especially in various fields of drug delivery, biosensing and magnetic resonance imaging which requires highly specific magnetic nanoparticle (MNP) properties such as uniform size distribution, less agglomeration and stability in the biological medium. Among MNP, copper and zinc ferrites have been broadly applicable in biomedical, optoelectronic, catalysis and drug delivery. With a view to design PU/ferrites nanocomposites and to explore their antimicrobial potential, the present preliminary study reports the preparation of PU nanocomposites with copper ferrite and zinc ferrite (1 wt.%) and with the same composition. The nanocomposites were characterized using water absorption and swelling measurements. The antimicrobial activity of these composites was investigated against four bacterial strains: Staphylococcus aureus, Enterococcus faecium, Pseudomonas aeruginosa, and Klebsiella pneumoniae, and one Candida strain, C. albicans and compared with those of PU nanocomposites with silver ferrite nanoparticles. PU nanocomposites based on zinc and copper ferrites did not show antimicrobial activity, on the contrary they supported microbial attachment and growth. However, PU nanocomposites with silver ferrite did not show significant antibacterial activity but show antifungal activity and it is related with hydrophilicity of the prepared materials.
PB  - Srbija,Niš : RAD  Centre
C3  - RAD 2022 : 10th Jubilee International Conference on Radiation in Various Fields of Research : the book of abstracts; July 25-29; Herceg Novi, Montenegro
T1  - Polyurethane/ferrites composite materials: A study on antimicrobial activity
SP  - 38
EP  - 38
DO  - 10.21175/rad.sum.abstr.book.2022.11.14
ER  - 

@conference{
author = "Pergal, Marija and Kodranov, Igor and Vasiljević-Radović, Dana and Nikodinović-Runić, Jasmina and Dojčinović, Biljana and Manojlović, Dragan and Antić, Bratislav",
year = "2022",
abstract = "Polyurethane (PU) nanocomposites are highly utilized in biomedical devices/implants due to their excellent mechanical properties, good biocompatibility, and low cytotoxicity. These PU nanocomposites with silver nanoparticles are well known potent antimicrobial agents. Biocompatible magnetic nanoparticles such as ferrites has also gained attention especially in various fields of drug delivery, biosensing and magnetic resonance imaging which requires highly specific magnetic nanoparticle (MNP) properties such as uniform size distribution, less agglomeration and stability in the biological medium. Among MNP, copper and zinc ferrites have been broadly applicable in biomedical, optoelectronic, catalysis and drug delivery. With a view to design PU/ferrites nanocomposites and to explore their antimicrobial potential, the present preliminary study reports the preparation of PU nanocomposites with copper ferrite and zinc ferrite (1 wt.%) and with the same composition. The nanocomposites were characterized using water absorption and swelling measurements. The antimicrobial activity of these composites was investigated against four bacterial strains: Staphylococcus aureus, Enterococcus faecium, Pseudomonas aeruginosa, and Klebsiella pneumoniae, and one Candida strain, C. albicans and compared with those of PU nanocomposites with silver ferrite nanoparticles. PU nanocomposites based on zinc and copper ferrites did not show antimicrobial activity, on the contrary they supported microbial attachment and growth. However, PU nanocomposites with silver ferrite did not show significant antibacterial activity but show antifungal activity and it is related with hydrophilicity of the prepared materials.",
publisher = "Srbija,Niš : RAD  Centre",
journal = "RAD 2022 : 10th Jubilee International Conference on Radiation in Various Fields of Research : the book of abstracts; July 25-29; Herceg Novi, Montenegro",
title = "Polyurethane/ferrites composite materials: A study on antimicrobial activity",
pages = "38-38",
doi = "10.21175/rad.sum.abstr.book.2022.11.14"
}

Pergal, M., Kodranov, I., Vasiljević-Radović, D., Nikodinović-Runić, J., Dojčinović, B., Manojlović, D.,& Antić, B.. (2022). Polyurethane/ferrites composite materials: A study on antimicrobial activity. in RAD 2022 : 10th Jubilee International Conference on Radiation in Various Fields of Research : the book of abstracts; July 25-29; Herceg Novi, Montenegro
Srbija,Niš : RAD  Centre., 38-38.
https://doi.org/10.21175/rad.sum.abstr.book.2022.11.14

Pergal M, Kodranov I, Vasiljević-Radović D, Nikodinović-Runić J, Dojčinović B, Manojlović D, Antić B. Polyurethane/ferrites composite materials: A study on antimicrobial activity. in RAD 2022 : 10th Jubilee International Conference on Radiation in Various Fields of Research : the book of abstracts; July 25-29; Herceg Novi, Montenegro. 2022;:38-38.
doi:10.21175/rad.sum.abstr.book.2022.11.14 .

Pergal, Marija, Kodranov, Igor, Vasiljević-Radović, Dana, Nikodinović-Runić, Jasmina, Dojčinović, Biljana, Manojlović, Dragan, Antić, Bratislav, "Polyurethane/ferrites composite materials: A study on antimicrobial activity" in RAD 2022 : 10th Jubilee International Conference on Radiation in Various Fields of Research : the book of abstracts; July 25-29; Herceg Novi, Montenegro (2022):38-38,
https://doi.org/10.21175/rad.sum.abstr.book.2022.11.14 . .

TY  - JOUR
AU  - Ponjavić, Marijana
AU  - Stevanović, Sanja
AU  - Nikodinović-Runić, Jasmina
AU  - Jeremić, Sanja
AU  - Ćosović, Vladan
AU  - Maksimović, Vesna
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5573
AB  - Bacterial nanocellulose, BNC, has emerged as a new class of nanomaterials recognized as renewable, biodegradable, biocompatible and material for versatile applications. BNC also proved as a perfect support matrix for metallic nanoparticle synthesis and appeared as suitable alternative for widely used carbon based materials. Following the idea to replace commonly used carbon based materials for platinum supports with the green and sustainable one, BNC appeared as an excellent candidate. Herein, microwave assisted synthesis has been reported for the first time for platinum nanoparticles supported on BNC as green material. Bacterial nanocelullose-platinum catalyst, Pt/BNC, was investigated by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), atomic force microscopy (AFM), X-ray diffractometry (XRD) and transmission-electron microscopy (TEM) analysis. The obtained results confirmed successful synthesis of new Pt-based catalyst. It was found that Pt/BNC catalyst has high electrocatalytic performance in methanol oxidation reaction. Green/sustainable catalytic system is highly desirable and provided by the elegant microwave assisted synthesis of Pt/BNC will pave the way for a larger scale application and expedite the market penetration of such fuel cells.
PB  - Elsevier BV
T2  - International Journal of Biological Macromolecules
T1  - Bacterial nanocellulose as green support of platinum nanoparticles for effective methanol oxidation
VL  - 223
SP  - 1474
EP  - 1484
DO  - 10.1016/j.ijbiomac.2022.10.278
ER  - 

@article{
author = "Ponjavić, Marijana and Stevanović, Sanja and Nikodinović-Runić, Jasmina and Jeremić, Sanja and Ćosović, Vladan and Maksimović, Vesna",
year = "2022",
abstract = "Bacterial nanocellulose, BNC, has emerged as a new class of nanomaterials recognized as renewable, biodegradable, biocompatible and material for versatile applications. BNC also proved as a perfect support matrix for metallic nanoparticle synthesis and appeared as suitable alternative for widely used carbon based materials. Following the idea to replace commonly used carbon based materials for platinum supports with the green and sustainable one, BNC appeared as an excellent candidate. Herein, microwave assisted synthesis has been reported for the first time for platinum nanoparticles supported on BNC as green material. Bacterial nanocelullose-platinum catalyst, Pt/BNC, was investigated by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), atomic force microscopy (AFM), X-ray diffractometry (XRD) and transmission-electron microscopy (TEM) analysis. The obtained results confirmed successful synthesis of new Pt-based catalyst. It was found that Pt/BNC catalyst has high electrocatalytic performance in methanol oxidation reaction. Green/sustainable catalytic system is highly desirable and provided by the elegant microwave assisted synthesis of Pt/BNC will pave the way for a larger scale application and expedite the market penetration of such fuel cells.",
publisher = "Elsevier BV",
journal = "International Journal of Biological Macromolecules",
title = "Bacterial nanocellulose as green support of platinum nanoparticles for effective methanol oxidation",
volume = "223",
pages = "1474-1484",
doi = "10.1016/j.ijbiomac.2022.10.278"
}

Ponjavić, M., Stevanović, S., Nikodinović-Runić, J., Jeremić, S., Ćosović, V.,& Maksimović, V.. (2022). Bacterial nanocellulose as green support of platinum nanoparticles for effective methanol oxidation. in International Journal of Biological Macromolecules
Elsevier BV., 223, 1474-1484.
https://doi.org/10.1016/j.ijbiomac.2022.10.278

Ponjavić M, Stevanović S, Nikodinović-Runić J, Jeremić S, Ćosović V, Maksimović V. Bacterial nanocellulose as green support of platinum nanoparticles for effective methanol oxidation. in International Journal of Biological Macromolecules. 2022;223:1474-1484.
doi:10.1016/j.ijbiomac.2022.10.278 .

Ponjavić, Marijana, Stevanović, Sanja, Nikodinović-Runić, Jasmina, Jeremić, Sanja, Ćosović, Vladan, Maksimović, Vesna, "Bacterial nanocellulose as green support of platinum nanoparticles for effective methanol oxidation" in International Journal of Biological Macromolecules, 223 (2022):1474-1484,
https://doi.org/10.1016/j.ijbiomac.2022.10.278 . .

TY  - JOUR
AU  - Atanase, Leonard Ionut
AU  - Salhi, Slim
AU  - Cucoveica, Oana
AU  - Ponjavić, Marijana
AU  - Nikodinović-Runić, Jasmina
AU  - Delaite, Christelle
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5581
AB  - Biodegradable polymers contain chains that are hydrolytically or enzymatically cleaved, resulting in soluble degradation products. Biodegradability is particularly desired in biomedical applications, in which degradation of the polymer ensures clearance from the body and eliminates the need for retrieval or explant. In this study, a homologues series of poly(ε-caprolactone)-b-poly(ethylene adipate)-b-poly(ε-caprolactone) (PCL-b-PEA-b-PCL) block copolymers, with constant PEA molar mass and different PCL sequence lengths was obtained. The starting point of these copolymers was a dihydroxy-PEA precursor with a molar mass (Mn) of 2500 g/mol. Mn values of the PCL varied between 1000 and 10,000 g/mol. Both the precursors and the copolymers were characterized using different physicochemical methods, such as: NMR, SEC, Maldi-TOFF, DSC, and ATG. The molecular characteristics of the copolymers were in a direct correlation with the sequence length of the PCL. Enzymatic degradability studies were also conducted by using cell-free extract containing Pseudomonas aeruginosa PAO1 for 10 and 21 days, and it appeared that the presence of the PEA central sequence has an important influence on the biodegradability of the copolymer samples. In fact, copolymer PCL7000-PEA2500-PCL7000 had a weight loss of around 50% after 10 days whereas the weight loss of the homopolymer PCL, with a similar Mn of 14,000 g/mol, was only 6%. The results obtained in this study indicate that these copolymer samples can be further used for the preparation of drug delivery systems with modulated biodegradability.
PB  - MDPI AG
T2  - Polymers
T1  - Biodegradability Assessment of Polyester Copolymers Based on Poly(ethylene adipate) and Poly(ε-caprolactone)
VL  - 14
IS  - 18
SP  - 3736
DO  - 10.3390/polym14183736
ER  - 

@article{
author = "Atanase, Leonard Ionut and Salhi, Slim and Cucoveica, Oana and Ponjavić, Marijana and Nikodinović-Runić, Jasmina and Delaite, Christelle",
year = "2022",
abstract = "Biodegradable polymers contain chains that are hydrolytically or enzymatically cleaved, resulting in soluble degradation products. Biodegradability is particularly desired in biomedical applications, in which degradation of the polymer ensures clearance from the body and eliminates the need for retrieval or explant. In this study, a homologues series of poly(ε-caprolactone)-b-poly(ethylene adipate)-b-poly(ε-caprolactone) (PCL-b-PEA-b-PCL) block copolymers, with constant PEA molar mass and different PCL sequence lengths was obtained. The starting point of these copolymers was a dihydroxy-PEA precursor with a molar mass (Mn) of 2500 g/mol. Mn values of the PCL varied between 1000 and 10,000 g/mol. Both the precursors and the copolymers were characterized using different physicochemical methods, such as: NMR, SEC, Maldi-TOFF, DSC, and ATG. The molecular characteristics of the copolymers were in a direct correlation with the sequence length of the PCL. Enzymatic degradability studies were also conducted by using cell-free extract containing Pseudomonas aeruginosa PAO1 for 10 and 21 days, and it appeared that the presence of the PEA central sequence has an important influence on the biodegradability of the copolymer samples. In fact, copolymer PCL7000-PEA2500-PCL7000 had a weight loss of around 50% after 10 days whereas the weight loss of the homopolymer PCL, with a similar Mn of 14,000 g/mol, was only 6%. The results obtained in this study indicate that these copolymer samples can be further used for the preparation of drug delivery systems with modulated biodegradability.",
publisher = "MDPI AG",
journal = "Polymers",
title = "Biodegradability Assessment of Polyester Copolymers Based on Poly(ethylene adipate) and Poly(ε-caprolactone)",
volume = "14",
number = "18",
pages = "3736",
doi = "10.3390/polym14183736"
}

Atanase, L. I., Salhi, S., Cucoveica, O., Ponjavić, M., Nikodinović-Runić, J.,& Delaite, C.. (2022). Biodegradability Assessment of Polyester Copolymers Based on Poly(ethylene adipate) and Poly(ε-caprolactone). in Polymers
MDPI AG., 14(18), 3736.
https://doi.org/10.3390/polym14183736

Atanase LI, Salhi S, Cucoveica O, Ponjavić M, Nikodinović-Runić J, Delaite C. Biodegradability Assessment of Polyester Copolymers Based on Poly(ethylene adipate) and Poly(ε-caprolactone). in Polymers. 2022;14(18):3736.
doi:10.3390/polym14183736 .

Atanase, Leonard Ionut, Salhi, Slim, Cucoveica, Oana, Ponjavić, Marijana, Nikodinović-Runić, Jasmina, Delaite, Christelle, "Biodegradability Assessment of Polyester Copolymers Based on Poly(ethylene adipate) and Poly(ε-caprolactone)" in Polymers, 14, no. 18 (2022):3736,
https://doi.org/10.3390/polym14183736 . .

TY  - CONF
AU  - Ponjavić, Marijana
AU  - Stevanović, Sanja
AU  - Jeremić, Sanja
AU  - Nikodinović-Runić, Jasmina
AU  - Ćosović, Vladan
AU  - Maksimović, Vesna
PY  - 2022
UR  - https://savjetovanje.tf.unibl.org/home/digital-library/book-of-abstracts/
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5939
AB  - The main objective of this work was to prepare new platinum supported catalyst on BNC/PVA composite as nanoparticles carrier, designed for electrocatalytic applications. For that purpose, BNC/Pt suspension was mixed with 1 wt% PVA solution and BNC/PVA/Pt catalyst in the form of film was successfully synthesized. The structure and thermal properties of catalyst were characterized by ATR-FTIR and TG analysis, respectively, while its crystallinity was investigated 
by XRD analysis. Electrocatalytic potential of BNC/PVA/Pt catalyst was tested in methanol 
oxidation reaction. Remarkable catalytic activity of new Pt based catalyst was confirmed. The 
obtained results for catalyst activity was comparable to those obtained for preferentially used 
carbon based Pt supports pointing that BNC based composited can be considered as great 
substitution of carbon based materials with the green one.
PB  - Banja Luka : University in Banjaluka, Faculty of Technology
C3  - Book of abstracts – XIV International scientific conference of chemists, technologists and environmentalists of Republic of Srpska, October 21-22, 2022, Banja Luka
T1  - Electrochemical potential of poly(viniyl acohol) modified bacterial nanocellulose as platinum nanoparticles support
SP  - 33
EP  - 33
UR  - https://hdl.handle.net/21.15107/rcub_cer_5939
ER  - 

@conference{
author = "Ponjavić, Marijana and Stevanović, Sanja and Jeremić, Sanja and Nikodinović-Runić, Jasmina and Ćosović, Vladan and Maksimović, Vesna",
year = "2022",
abstract = "The main objective of this work was to prepare new platinum supported catalyst on BNC/PVA composite as nanoparticles carrier, designed for electrocatalytic applications. For that purpose, BNC/Pt suspension was mixed with 1 wt% PVA solution and BNC/PVA/Pt catalyst in the form of film was successfully synthesized. The structure and thermal properties of catalyst were characterized by ATR-FTIR and TG analysis, respectively, while its crystallinity was investigated 
by XRD analysis. Electrocatalytic potential of BNC/PVA/Pt catalyst was tested in methanol 
oxidation reaction. Remarkable catalytic activity of new Pt based catalyst was confirmed. The 
obtained results for catalyst activity was comparable to those obtained for preferentially used 
carbon based Pt supports pointing that BNC based composited can be considered as great 
substitution of carbon based materials with the green one.",
publisher = "Banja Luka : University in Banjaluka, Faculty of Technology",
journal = "Book of abstracts – XIV International scientific conference of chemists, technologists and environmentalists of Republic of Srpska, October 21-22, 2022, Banja Luka",
title = "Electrochemical potential of poly(viniyl acohol) modified bacterial nanocellulose as platinum nanoparticles support",
pages = "33-33",
url = "https://hdl.handle.net/21.15107/rcub_cer_5939"
}

Ponjavić, M., Stevanović, S., Jeremić, S., Nikodinović-Runić, J., Ćosović, V.,& Maksimović, V.. (2022). Electrochemical potential of poly(viniyl acohol) modified bacterial nanocellulose as platinum nanoparticles support. in Book of abstracts – XIV International scientific conference of chemists, technologists and environmentalists of Republic of Srpska, October 21-22, 2022, Banja Luka
Banja Luka : University in Banjaluka, Faculty of Technology., 33-33.
https://hdl.handle.net/21.15107/rcub_cer_5939

Ponjavić M, Stevanović S, Jeremić S, Nikodinović-Runić J, Ćosović V, Maksimović V. Electrochemical potential of poly(viniyl acohol) modified bacterial nanocellulose as platinum nanoparticles support. in Book of abstracts – XIV International scientific conference of chemists, technologists and environmentalists of Republic of Srpska, October 21-22, 2022, Banja Luka. 2022;:33-33.
https://hdl.handle.net/21.15107/rcub_cer_5939 .

Ponjavić, Marijana, Stevanović, Sanja, Jeremić, Sanja, Nikodinović-Runić, Jasmina, Ćosović, Vladan, Maksimović, Vesna, "Electrochemical potential of poly(viniyl acohol) modified bacterial nanocellulose as platinum nanoparticles support" in Book of abstracts – XIV International scientific conference of chemists, technologists and environmentalists of Republic of Srpska, October 21-22, 2022, Banja Luka (2022):33-33,
https://hdl.handle.net/21.15107/rcub_cer_5939 .

TY  - JOUR
AU  - Pergal, Marija
AU  - Dojčinović, Biljana
AU  - Nikodinović-Runić, Jasmina
AU  - Dražić, Goran
AU  - Zabukovec Logar, Nataša
AU  - Ostojić, Sanja
AU  - Antić, Bratislav
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5586
AB  - In situ polymerization was used to produce novel AgFeO2@PEG/polyurethane network nanocomposites (NP-PUs) with 30–60 wt% of soft poly(dimethylsiloxane) segments in polyurethane (PU), containing 1 wt% of PEG-coated AgFeO2 nanoparticles, AgFeO2@PEG. Physicochemical properties and in vitro biological activity of the NP-PUs were systematically evaluated in terms of AgFeO2@PEG (NP) addition and soft segment content. High-angle annular dark-field transmission electron microscopy showed that the nanoparticles were generally uniformly distributed in the PU matrix. Increased soft segment content caused significantly increased intensity of the broad, amorphous X-ray diffraction peaks of crystalline AgFeO2, probably because the chemical composition of PU affected the distribution of nanoparticles. The Young modulus, hardness, and plasticity of the NP-PUs were higher than for pure PU and increased with decreasing soft segment content. Decreased soft segment content induced higher microphase separation, increased hydrophilicity and swelling ability, but decreased cross-linking density. Additionally, NP-PUs had higher glass transition temperatures, improved thermal stability, and enhanced nanomechanical performance over pure PU. The NP-PUs demonstrated good selective inhibition of Candida albicans and Candida parapsilosis (30–55%) and no pronounced cytotoxicity to MRC5 human lung fibroblasts. Among the investigated AgFeO2@PEG/PUs, the best antifungal activity was shown by composites with 30 and 40 wt% soft segments. Consequently, the novel AgFeO2@PEG/polyurethane network nanocomposites could be further optimized to be used as biocompatible surfaces that also prevent formation of fungal biofilms.
PB  - Springer
T2  - Journal of Materials Science
T1  - Synthesis, physicochemical, and antimicrobial characteristics of novel poly(urethane-siloxane) network/silver ferrite nanocomposites
VL  - 57
IS  - 16
SP  - 7827
EP  - 7848
DO  - 10.1007/s10853-022-07178-9
ER  - 

@article{
author = "Pergal, Marija and Dojčinović, Biljana and Nikodinović-Runić, Jasmina and Dražić, Goran and Zabukovec Logar, Nataša and Ostojić, Sanja and Antić, Bratislav",
year = "2022",
abstract = "In situ polymerization was used to produce novel AgFeO2@PEG/polyurethane network nanocomposites (NP-PUs) with 30–60 wt% of soft poly(dimethylsiloxane) segments in polyurethane (PU), containing 1 wt% of PEG-coated AgFeO2 nanoparticles, AgFeO2@PEG. Physicochemical properties and in vitro biological activity of the NP-PUs were systematically evaluated in terms of AgFeO2@PEG (NP) addition and soft segment content. High-angle annular dark-field transmission electron microscopy showed that the nanoparticles were generally uniformly distributed in the PU matrix. Increased soft segment content caused significantly increased intensity of the broad, amorphous X-ray diffraction peaks of crystalline AgFeO2, probably because the chemical composition of PU affected the distribution of nanoparticles. The Young modulus, hardness, and plasticity of the NP-PUs were higher than for pure PU and increased with decreasing soft segment content. Decreased soft segment content induced higher microphase separation, increased hydrophilicity and swelling ability, but decreased cross-linking density. Additionally, NP-PUs had higher glass transition temperatures, improved thermal stability, and enhanced nanomechanical performance over pure PU. The NP-PUs demonstrated good selective inhibition of Candida albicans and Candida parapsilosis (30–55%) and no pronounced cytotoxicity to MRC5 human lung fibroblasts. Among the investigated AgFeO2@PEG/PUs, the best antifungal activity was shown by composites with 30 and 40 wt% soft segments. Consequently, the novel AgFeO2@PEG/polyurethane network nanocomposites could be further optimized to be used as biocompatible surfaces that also prevent formation of fungal biofilms.",
publisher = "Springer",
journal = "Journal of Materials Science",
title = "Synthesis, physicochemical, and antimicrobial characteristics of novel poly(urethane-siloxane) network/silver ferrite nanocomposites",
volume = "57",
number = "16",
pages = "7827-7848",
doi = "10.1007/s10853-022-07178-9"
}

Pergal, M., Dojčinović, B., Nikodinović-Runić, J., Dražić, G., Zabukovec Logar, N., Ostojić, S.,& Antić, B.. (2022). Synthesis, physicochemical, and antimicrobial characteristics of novel poly(urethane-siloxane) network/silver ferrite nanocomposites. in Journal of Materials Science
Springer., 57(16), 7827-7848.
https://doi.org/10.1007/s10853-022-07178-9

Pergal M, Dojčinović B, Nikodinović-Runić J, Dražić G, Zabukovec Logar N, Ostojić S, Antić B. Synthesis, physicochemical, and antimicrobial characteristics of novel poly(urethane-siloxane) network/silver ferrite nanocomposites. in Journal of Materials Science. 2022;57(16):7827-7848.
doi:10.1007/s10853-022-07178-9 .

Pergal, Marija, Dojčinović, Biljana, Nikodinović-Runić, Jasmina, Dražić, Goran, Zabukovec Logar, Nataša, Ostojić, Sanja, Antić, Bratislav, "Synthesis, physicochemical, and antimicrobial characteristics of novel poly(urethane-siloxane) network/silver ferrite nanocomposites" in Journal of Materials Science, 57, no. 16 (2022):7827-7848,
https://doi.org/10.1007/s10853-022-07178-9 . .

TY  - JOUR
AU  - Babić Radić, Marija M.
AU  - Filipović, Vuk
AU  - Vukomanović, Marija
AU  - Nikodinović Runić, Jasmina
AU  - Tomić, Simonida
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5311
AB  - The design and evaluation of novel 2-hydroxyethyl methacrylate/gelatin/alginate/
graphene oxide hydrogels as innovative scaffolding biomaterials, which concurrently are the suitable
drug delivery carrier, was proposed. The hydrogels were prepared by the adapted porogen leaching
method; this is also the first time this method has been used to incorporate nanocolloidal graphene
oxide through the hydrogel and simultaneously form porous structures. The effects of a material’s
composition on its chemical, morphological, mechanical, and swelling properties, as well as on
cell viability and in vitro degradation, were assessed using Fourier transform infrared spectroscopy
(FTIR), scanning electron microscopy (SEM), measurements of Young’s modulus, gravimetric method
and MTT test, respectively. The engineered hydrogels show good swelling capacity, fully hydrophilic
surfaces, tunable porosity (from 56 to 76%) and mechanical properties (from 1.69 to 4.78 MPa),
curcumin entrapment efficiency above 99% and excellent curcumin release performances. In vitro
cytotoxicity on healthy human fibroblast (MRC5 cells) by MTT test reveal that the materials are
nontoxic and biocompatible, proposing novel hydrogels for in vivo clinical evaluation to optimize
tissue regeneration treatments by coupling the hydrogels with cells and different active agents to
create material/biofactor hybrids with new levels of biofunctionality.
PB  - MDPI
T2  - Gels
T1  - Degradable 2-Hydroxyethyl Methacrylate/Gelatin/Alginate Hydrogels Infused by Nanocolloidal Graphene Oxide as Promising Drug Delivery and Scaffolding Biomaterials
VL  - 8
IS  - 22
SP  - 2
EP  - 14
DO  - 10.3390/gels8010022
ER  - 

@article{
author = "Babić Radić, Marija M. and Filipović, Vuk and Vukomanović, Marija and Nikodinović Runić, Jasmina and Tomić, Simonida",
year = "2022",
abstract = "The design and evaluation of novel 2-hydroxyethyl methacrylate/gelatin/alginate/
graphene oxide hydrogels as innovative scaffolding biomaterials, which concurrently are the suitable
drug delivery carrier, was proposed. The hydrogels were prepared by the adapted porogen leaching
method; this is also the first time this method has been used to incorporate nanocolloidal graphene
oxide through the hydrogel and simultaneously form porous structures. The effects of a material’s
composition on its chemical, morphological, mechanical, and swelling properties, as well as on
cell viability and in vitro degradation, were assessed using Fourier transform infrared spectroscopy
(FTIR), scanning electron microscopy (SEM), measurements of Young’s modulus, gravimetric method
and MTT test, respectively. The engineered hydrogels show good swelling capacity, fully hydrophilic
surfaces, tunable porosity (from 56 to 76%) and mechanical properties (from 1.69 to 4.78 MPa),
curcumin entrapment efficiency above 99% and excellent curcumin release performances. In vitro
cytotoxicity on healthy human fibroblast (MRC5 cells) by MTT test reveal that the materials are
nontoxic and biocompatible, proposing novel hydrogels for in vivo clinical evaluation to optimize
tissue regeneration treatments by coupling the hydrogels with cells and different active agents to
create material/biofactor hybrids with new levels of biofunctionality.",
publisher = "MDPI",
journal = "Gels",
title = "Degradable 2-Hydroxyethyl Methacrylate/Gelatin/Alginate Hydrogels Infused by Nanocolloidal Graphene Oxide as Promising Drug Delivery and Scaffolding Biomaterials",
volume = "8",
number = "22",
pages = "2-14",
doi = "10.3390/gels8010022"
}

Babić Radić, M. M., Filipović, V., Vukomanović, M., Nikodinović Runić, J.,& Tomić, S.. (2022). Degradable 2-Hydroxyethyl Methacrylate/Gelatin/Alginate Hydrogels Infused by Nanocolloidal Graphene Oxide as Promising Drug Delivery and Scaffolding Biomaterials. in Gels
MDPI., 8(22), 2-14.
https://doi.org/10.3390/gels8010022

Babić Radić MM, Filipović V, Vukomanović M, Nikodinović Runić J, Tomić S. Degradable 2-Hydroxyethyl Methacrylate/Gelatin/Alginate Hydrogels Infused by Nanocolloidal Graphene Oxide as Promising Drug Delivery and Scaffolding Biomaterials. in Gels. 2022;8(22):2-14.
doi:10.3390/gels8010022 .

Babić Radić, Marija M., Filipović, Vuk, Vukomanović, Marija, Nikodinović Runić, Jasmina, Tomić, Simonida, "Degradable 2-Hydroxyethyl Methacrylate/Gelatin/Alginate Hydrogels Infused by Nanocolloidal Graphene Oxide as Promising Drug Delivery and Scaffolding Biomaterials" in Gels, 8, no. 22 (2022):2-14,
https://doi.org/10.3390/gels8010022 . .

TY  - JOUR
AU  - Pantelić, Brana
AU  - Ponjavić, Marijana
AU  - Janković, Vukašin
AU  - Aleksić, Ivana
AU  - Stevanović, Sanja
AU  - Murray, James
AU  - Fournet, Margaret Brennan
AU  - Nikodinović-Runić, Jasmina
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4870
AB  - Meeting the challenge of circularity for plastics requires amenability to repurposing post-use, as equivalent or upcycled products. In a compelling advancement, complete circularity for a biodegradable polyvinyl alcohol/thermoplastic starch (PVA/TPS) food packaging film was demonstrated by bioconversion to high-market-value biopigments and polyhydroxybutyrate (PHB) polyesters. The PVA/TPS film mechanical properties (tensile strength (σu), 22.2 ± 4.3 MPa; strain at break (εu), 325 ± 73%; and Young’s modulus (E), 53–250 MPa) compared closely with low-density polyethylene (LDPE) grades used for food packaging. Strong solubility of the PVA/TPS film in water was a pertinent feature, facilitating suitability as a carbon source for bioprocessing and microbial degradation. Biodegradability of the film with greater than 50% weight loss occurred within 30 days of incubation at 37◦C in a model compost. Up to 22% of the PVA/TPS film substrate conversion to biomass was achieved using three bacterial strains, Ralstonia eutropha H16 (Cupriavidus necator ATCC 17699), Streptomyces sp. JS520, and Bacillus subtilis ATCC6633. For the first time, production of the valuable biopigment (undecylprodigiosin) by Streptomyces sp. JS520 of 5.3 mg/mL and the production of PHB biopolymer at 7.8% of cell dry weight by Ralstonia eutropha H16 from this substrate were reported. This low-energy, low-carbon post-use PVA/TPS film upcycling model approach to plastic circularity demonstrates marked progress in the quest for sustainable and circular plastic solutions.
PB  - MDPI
T2  - Polymers
T1  - Upcycling biodegradable pva/starch film to a bacterial biopigment and biopolymer
VL  - 13
IS  - 21
SP  - 3692
DO  - 10.3390/polym13213692
ER  - 

@article{
author = "Pantelić, Brana and Ponjavić, Marijana and Janković, Vukašin and Aleksić, Ivana and Stevanović, Sanja and Murray, James and Fournet, Margaret Brennan and Nikodinović-Runić, Jasmina",
year = "2021",
abstract = "Meeting the challenge of circularity for plastics requires amenability to repurposing post-use, as equivalent or upcycled products. In a compelling advancement, complete circularity for a biodegradable polyvinyl alcohol/thermoplastic starch (PVA/TPS) food packaging film was demonstrated by bioconversion to high-market-value biopigments and polyhydroxybutyrate (PHB) polyesters. The PVA/TPS film mechanical properties (tensile strength (σu), 22.2 ± 4.3 MPa; strain at break (εu), 325 ± 73%; and Young’s modulus (E), 53–250 MPa) compared closely with low-density polyethylene (LDPE) grades used for food packaging. Strong solubility of the PVA/TPS film in water was a pertinent feature, facilitating suitability as a carbon source for bioprocessing and microbial degradation. Biodegradability of the film with greater than 50% weight loss occurred within 30 days of incubation at 37◦C in a model compost. Up to 22% of the PVA/TPS film substrate conversion to biomass was achieved using three bacterial strains, Ralstonia eutropha H16 (Cupriavidus necator ATCC 17699), Streptomyces sp. JS520, and Bacillus subtilis ATCC6633. For the first time, production of the valuable biopigment (undecylprodigiosin) by Streptomyces sp. JS520 of 5.3 mg/mL and the production of PHB biopolymer at 7.8% of cell dry weight by Ralstonia eutropha H16 from this substrate were reported. This low-energy, low-carbon post-use PVA/TPS film upcycling model approach to plastic circularity demonstrates marked progress in the quest for sustainable and circular plastic solutions.",
publisher = "MDPI",
journal = "Polymers",
title = "Upcycling biodegradable pva/starch film to a bacterial biopigment and biopolymer",
volume = "13",
number = "21",
pages = "3692",
doi = "10.3390/polym13213692"
}

Pantelić, B., Ponjavić, M., Janković, V., Aleksić, I., Stevanović, S., Murray, J., Fournet, M. B.,& Nikodinović-Runić, J.. (2021). Upcycling biodegradable pva/starch film to a bacterial biopigment and biopolymer. in Polymers
MDPI., 13(21), 3692.
https://doi.org/10.3390/polym13213692

Pantelić B, Ponjavić M, Janković V, Aleksić I, Stevanović S, Murray J, Fournet MB, Nikodinović-Runić J. Upcycling biodegradable pva/starch film to a bacterial biopigment and biopolymer. in Polymers. 2021;13(21):3692.
doi:10.3390/polym13213692 .

Pantelić, Brana, Ponjavić, Marijana, Janković, Vukašin, Aleksić, Ivana, Stevanović, Sanja, Murray, James, Fournet, Margaret Brennan, Nikodinović-Runić, Jasmina, "Upcycling biodegradable pva/starch film to a bacterial biopigment and biopolymer" in Polymers, 13, no. 21 (2021):3692,
https://doi.org/10.3390/polym13213692 . .

TY  - CONF
AU  - Stevanović, Sanja
AU  - Ponjavić, Marijana
AU  - Nikodinović-Runić, Jasmina
AU  - Maksimović, Vesna
AU  - Ćosović, Vladan
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4876
AB  - Catalysts support is essential for nanostructured noble metal catalysts activity and stability since that interaction between the metal particle and the support can affect metal particle size and dispersion. Over the last few decades, the most popular catalysts supports are carbon based materials: Vulcan XC-72 carbon black (CB), multi-walled carbon nanotubes (MWCNTs) and graphene. However, their cost-effective production remains a challenge since most of these materials are obtained by pyrolysis of coal or petroleum. Not less negligible is their negative impact on the environment during synthesis because these processes include release of carbon dioxide and other harmful organic products into the atmosphere. Applications of bacterial nanocelluloses as a catalyst support has attracted a great attention since it can be easily synthesized and is an inexpensive, biodegradable, sustainable and green material. Bacterial nanocellulose (BNC) was produced utilizing the Komagataeibacter medellinensis ID13488 strain. Stable Pt nanoparticles supported on BNC (Pt/BNC) have been synthetized from a precursor solution of H2PtCl6 by microwave assisted polyol procedure. Catalytic activity was tested for methanol oxidation reaction in sulfuric acid solution. The Fourier transform infrared spectroscopy was used to confirm the structure of bacterial nanocellulose as well as after synthesis of Pt-BNC catalyst. Coupled differential scanning calorimetry (DSC) / thermogravimetric (TG) analysis revealed no loss of platinum during synthesis process. XRD analysis showed characteristic peaks for fcc crystalline structure of Pt/BNC and particle size of 1,7 nm. The activity of the Pt/BNC, catalyst for methanol oxidation was evaluated from potentiodynamic measurements in 0.5 M H2SO4 + 0.5 M CH3OH solution. The results obtained indicate enhanced catalytic activities for methanol oxidation reaction.
AB  - Podloge katalizatora imaju veoma važnu ulogu tokom sinteze katalizatora sa plemenitim metalima obzirom da od njihove interakcije sa metalom zavisi veličina čestica i njihova disperzija tokom procesa sinteze. Tokom poslednjih nekoliko decenija kao najčešće korišćene podloge za platinske katalizatore su korišćene podloge na bazi uglljenika: ugalj razvijene površine (Vulcan XC), ugljenične nanotube ili grafen. Međutim, proces dobijanja ovih materijala ima visoke cene zbog toga što se za njihovo dobijanje koriste procesi pirolize uglja ili nafte. Ništa manje zanemarljiv je i negativan uticaj ovih procesa na okolinu pošto procesi sinteze uključuju oslobađanje ugljen dioksida i drugih štetnih materija u atmosferu. Primena bakterijskih nanoceluloza kao nosača katalizatora privukla je veliku pažnju jer se mogu lako sintetizovati i predstavljaju jeftin, biorazgradiv, održiv i zeleni materijal. Bakterijska nanoceluloza (BNC) proizvedena je upotrebom soja Komagataeibacter medellinensis ID13488. Stabilne Pt nanočestice suspendovane na BNC (Pt/BNC) sintetizovane su iz prekursorskog H2PtCl6 rastvora poliol postupkom uz pomoć mikrotalasne pećnice. Ispitivana je katalitička aktivnost reakcije oksidacije metanola u rastvoru sumporne kiseline. Infracrvena spektroskopija Fourierove transformacije je korišćena za potvrdu strukture same bakterijske nanoceluloze, kao i nakon sinteze Pt-BNC katalizatora. Diferencijalna skenirajuća kalorimetrija (DSC) / termogravimetrijska (TG) analiza nije otkrila gubitak platine tokom procesa sinteze. XRD analiza pokazala je karakteristične vrhove za fcc kristalnu strukturu Pt/BNC i veličinu čestica od 1,7 nm. Aktivnost Pt/BNC, katalizatora za oksidaciju metanola, procenjena je iz potenciodinamičkih merenja u 0,5 M H2SO4 + 0,5 M CH3OH rastvoru. Dobijeni rezultati ukazuju na pojačanu katalitičku aktivnost reakcije oksidacije metanola.
PB  - Belgrade : Serbian Society of Corrosion and Materials Protection (UISKOZAM)
C3  - Meeting point of the science and practice in the fields of corrosion, materials and environmental protection : proceedings XXII YuCorr International Conference / Stecište nauke i prakse u oblastima korozije, zaštite materijala i životne sredine : knjiga radova XXII YuCorr [Jugoslovenska korozija] Međunarodna konferencija
T1  - Bacterial nanocellulose as green support for platinum catalysts in methanol electrooxidation reaction
T1  - Bakterijska celuloza kao podloga za platinske kataliztore za reakciju elektrooksidacije metanola
SP  - 49
EP  - 50
UR  - https://hdl.handle.net/21.15107/rcub_cer_4876
ER  - 

@conference{
author = "Stevanović, Sanja and Ponjavić, Marijana and Nikodinović-Runić, Jasmina and Maksimović, Vesna and Ćosović, Vladan",
year = "2021",
abstract = "Catalysts support is essential for nanostructured noble metal catalysts activity and stability since that interaction between the metal particle and the support can affect metal particle size and dispersion. Over the last few decades, the most popular catalysts supports are carbon based materials: Vulcan XC-72 carbon black (CB), multi-walled carbon nanotubes (MWCNTs) and graphene. However, their cost-effective production remains a challenge since most of these materials are obtained by pyrolysis of coal or petroleum. Not less negligible is their negative impact on the environment during synthesis because these processes include release of carbon dioxide and other harmful organic products into the atmosphere. Applications of bacterial nanocelluloses as a catalyst support has attracted a great attention since it can be easily synthesized and is an inexpensive, biodegradable, sustainable and green material. Bacterial nanocellulose (BNC) was produced utilizing the Komagataeibacter medellinensis ID13488 strain. Stable Pt nanoparticles supported on BNC (Pt/BNC) have been synthetized from a precursor solution of H2PtCl6 by microwave assisted polyol procedure. Catalytic activity was tested for methanol oxidation reaction in sulfuric acid solution. The Fourier transform infrared spectroscopy was used to confirm the structure of bacterial nanocellulose as well as after synthesis of Pt-BNC catalyst. Coupled differential scanning calorimetry (DSC) / thermogravimetric (TG) analysis revealed no loss of platinum during synthesis process. XRD analysis showed characteristic peaks for fcc crystalline structure of Pt/BNC and particle size of 1,7 nm. The activity of the Pt/BNC, catalyst for methanol oxidation was evaluated from potentiodynamic measurements in 0.5 M H2SO4 + 0.5 M CH3OH solution. The results obtained indicate enhanced catalytic activities for methanol oxidation reaction., Podloge katalizatora imaju veoma važnu ulogu tokom sinteze katalizatora sa plemenitim metalima obzirom da od njihove interakcije sa metalom zavisi veličina čestica i njihova disperzija tokom procesa sinteze. Tokom poslednjih nekoliko decenija kao najčešće korišćene podloge za platinske katalizatore su korišćene podloge na bazi uglljenika: ugalj razvijene površine (Vulcan XC), ugljenične nanotube ili grafen. Međutim, proces dobijanja ovih materijala ima visoke cene zbog toga što se za njihovo dobijanje koriste procesi pirolize uglja ili nafte. Ništa manje zanemarljiv je i negativan uticaj ovih procesa na okolinu pošto procesi sinteze uključuju oslobađanje ugljen dioksida i drugih štetnih materija u atmosferu. Primena bakterijskih nanoceluloza kao nosača katalizatora privukla je veliku pažnju jer se mogu lako sintetizovati i predstavljaju jeftin, biorazgradiv, održiv i zeleni materijal. Bakterijska nanoceluloza (BNC) proizvedena je upotrebom soja Komagataeibacter medellinensis ID13488. Stabilne Pt nanočestice suspendovane na BNC (Pt/BNC) sintetizovane su iz prekursorskog H2PtCl6 rastvora poliol postupkom uz pomoć mikrotalasne pećnice. Ispitivana je katalitička aktivnost reakcije oksidacije metanola u rastvoru sumporne kiseline. Infracrvena spektroskopija Fourierove transformacije je korišćena za potvrdu strukture same bakterijske nanoceluloze, kao i nakon sinteze Pt-BNC katalizatora. Diferencijalna skenirajuća kalorimetrija (DSC) / termogravimetrijska (TG) analiza nije otkrila gubitak platine tokom procesa sinteze. XRD analiza pokazala je karakteristične vrhove za fcc kristalnu strukturu Pt/BNC i veličinu čestica od 1,7 nm. Aktivnost Pt/BNC, katalizatora za oksidaciju metanola, procenjena je iz potenciodinamičkih merenja u 0,5 M H2SO4 + 0,5 M CH3OH rastvoru. Dobijeni rezultati ukazuju na pojačanu katalitičku aktivnost reakcije oksidacije metanola.",
publisher = "Belgrade : Serbian Society of Corrosion and Materials Protection (UISKOZAM)",
journal = "Meeting point of the science and practice in the fields of corrosion, materials and environmental protection : proceedings XXII YuCorr International Conference / Stecište nauke i prakse u oblastima korozije, zaštite materijala i životne sredine : knjiga radova XXII YuCorr [Jugoslovenska korozija] Međunarodna konferencija",
title = "Bacterial nanocellulose as green support for platinum catalysts in methanol electrooxidation reaction, Bakterijska celuloza kao podloga za platinske kataliztore za reakciju elektrooksidacije metanola",
pages = "49-50",
url = "https://hdl.handle.net/21.15107/rcub_cer_4876"
}

Stevanović, S., Ponjavić, M., Nikodinović-Runić, J., Maksimović, V.,& Ćosović, V.. (2021). Bacterial nanocellulose as green support for platinum catalysts in methanol electrooxidation reaction. in Meeting point of the science and practice in the fields of corrosion, materials and environmental protection : proceedings XXII YuCorr International Conference / Stecište nauke i prakse u oblastima korozije, zaštite materijala i životne sredine : knjiga radova XXII YuCorr [Jugoslovenska korozija] Međunarodna konferencija
Belgrade : Serbian Society of Corrosion and Materials Protection (UISKOZAM)., 49-50.
https://hdl.handle.net/21.15107/rcub_cer_4876

Stevanović S, Ponjavić M, Nikodinović-Runić J, Maksimović V, Ćosović V. Bacterial nanocellulose as green support for platinum catalysts in methanol electrooxidation reaction. in Meeting point of the science and practice in the fields of corrosion, materials and environmental protection : proceedings XXII YuCorr International Conference / Stecište nauke i prakse u oblastima korozije, zaštite materijala i životne sredine : knjiga radova XXII YuCorr [Jugoslovenska korozija] Međunarodna konferencija. 2021;:49-50.
https://hdl.handle.net/21.15107/rcub_cer_4876 .

Stevanović, Sanja, Ponjavić, Marijana, Nikodinović-Runić, Jasmina, Maksimović, Vesna, Ćosović, Vladan, "Bacterial nanocellulose as green support for platinum catalysts in methanol electrooxidation reaction" in Meeting point of the science and practice in the fields of corrosion, materials and environmental protection : proceedings XXII YuCorr International Conference / Stecište nauke i prakse u oblastima korozije, zaštite materijala i životne sredine : knjiga radova XXII YuCorr [Jugoslovenska korozija] Međunarodna konferencija (2021):49-50,
https://hdl.handle.net/21.15107/rcub_cer_4876 .

TY  - JOUR
AU  - Đapović, Milica
AU  - Milivojević, Dušan
AU  - Ilić-Tomić, Tatjana
AU  - Lješević, Marija
AU  - Nikolaivits, Efstratios
AU  - Topakas, Evangelos
AU  - Maslak, Veselin
AU  - Nikodinović-Runić, Jasmina
PY  - 2021
UR  - https://www.sciencedirect.com/science/article/pii/S0045653521004744
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4658
AB  - Polyethylene terephthalate (PET) is widely used material and as such became highly enriched in nature. It is generally considered inert and safe plastic, but due to the recent increased efforts to break-down PET using biotechnological approaches, we realized the scarcity of information about structural analysis of possible degradation products and their ecotoxicological assessment. Therefore, in this study, 11 compounds belonging to the group of PET precursors and possible degradation products have been comprehensively characterized. Seven of these compounds including 1-(2-hydroxyethyl)-4-methylterephthalate, ethylene glycol bis(methyl terephthalate), methyl bis(2-hydroxyethyl terephtahalate), 1,4-benzenedicarboxylic acid, 1,4-bis[2-[[4-(methoxycarbonyl)benzoyl]oxy]ethyl] ester and methyl tris(2-hydroxyethyl terephthalate) corresponding to mono-, 1.5-, di-, 2,5- and trimer of PET were synthetized and structurally characterized for the first time. In-silico druglikeness and physico-chemical properties of these compounds were predicted using variety of platforms. No antimicrobial properties were detected even at 1000 μg/mL. Ecotoxicological impact of the compounds against marine bacteria Allivibrio fischeri proved that the 6 out of 11 tested PET-associated compounds may be classified as harmful to aquatic microorganisms, with PET trimer being one of the most toxic. In comparison, most of the compounds were not toxic on human lung fibroblasts (MRC-5) at 200 μg/mL with inhibiting concentration (IC50) values of 30 μg/mL and 50 μg/mL determined for PET dimer and trimer. Only three of these compounds including PET monomer were toxic to nematode Caenorhabditis elegans at high concentration of 500 μg/mL. In terms of the applicative potential, PET dimer can be used as suitable substrate for the screening, identification and characterization of novel PET-depolymerizing enzymes.
PB  - Elsevier
T2  - Chemosphere
T2  - ChemosphereChemosphere
T1  - Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases
VL  - 275
SP  - 130005
DO  - 10.1016/j.chemosphere.2021.130005
ER  - 

@article{
author = "Đapović, Milica and Milivojević, Dušan and Ilić-Tomić, Tatjana and Lješević, Marija and Nikolaivits, Efstratios and Topakas, Evangelos and Maslak, Veselin and Nikodinović-Runić, Jasmina",
year = "2021",
abstract = "Polyethylene terephthalate (PET) is widely used material and as such became highly enriched in nature. It is generally considered inert and safe plastic, but due to the recent increased efforts to break-down PET using biotechnological approaches, we realized the scarcity of information about structural analysis of possible degradation products and their ecotoxicological assessment. Therefore, in this study, 11 compounds belonging to the group of PET precursors and possible degradation products have been comprehensively characterized. Seven of these compounds including 1-(2-hydroxyethyl)-4-methylterephthalate, ethylene glycol bis(methyl terephthalate), methyl bis(2-hydroxyethyl terephtahalate), 1,4-benzenedicarboxylic acid, 1,4-bis[2-[[4-(methoxycarbonyl)benzoyl]oxy]ethyl] ester and methyl tris(2-hydroxyethyl terephthalate) corresponding to mono-, 1.5-, di-, 2,5- and trimer of PET were synthetized and structurally characterized for the first time. In-silico druglikeness and physico-chemical properties of these compounds were predicted using variety of platforms. No antimicrobial properties were detected even at 1000 μg/mL. Ecotoxicological impact of the compounds against marine bacteria Allivibrio fischeri proved that the 6 out of 11 tested PET-associated compounds may be classified as harmful to aquatic microorganisms, with PET trimer being one of the most toxic. In comparison, most of the compounds were not toxic on human lung fibroblasts (MRC-5) at 200 μg/mL with inhibiting concentration (IC50) values of 30 μg/mL and 50 μg/mL determined for PET dimer and trimer. Only three of these compounds including PET monomer were toxic to nematode Caenorhabditis elegans at high concentration of 500 μg/mL. In terms of the applicative potential, PET dimer can be used as suitable substrate for the screening, identification and characterization of novel PET-depolymerizing enzymes.",
publisher = "Elsevier",
journal = "Chemosphere, ChemosphereChemosphere",
title = "Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases",
volume = "275",
pages = "130005",
doi = "10.1016/j.chemosphere.2021.130005"
}

Đapović, M., Milivojević, D., Ilić-Tomić, T., Lješević, M., Nikolaivits, E., Topakas, E., Maslak, V.,& Nikodinović-Runić, J.. (2021). Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases. in Chemosphere
Elsevier., 275, 130005.
https://doi.org/10.1016/j.chemosphere.2021.130005

Đapović M, Milivojević D, Ilić-Tomić T, Lješević M, Nikolaivits E, Topakas E, Maslak V, Nikodinović-Runić J. Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases. in Chemosphere. 2021;275:130005.
doi:10.1016/j.chemosphere.2021.130005 .

Đapović, Milica, Milivojević, Dušan, Ilić-Tomić, Tatjana, Lješević, Marija, Nikolaivits, Efstratios, Topakas, Evangelos, Maslak, Veselin, Nikodinović-Runić, Jasmina, "Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases" in Chemosphere, 275 (2021):130005,
https://doi.org/10.1016/j.chemosphere.2021.130005 . .

TY  - JOUR
AU  - Đapović, Milica
AU  - Milivojević, Dušan
AU  - Ilić-Tomić, Tatjana
AU  - Lješević, Marija
AU  - Nikolaivits, Efstratios
AU  - Topakas, Evangelos
AU  - Maslak, Veselin
AU  - Nikodinović-Runić, Jasmina
PY  - 2021
UR  - https://www.sciencedirect.com/science/article/pii/S0045653521004744
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4659
AB  - Polyethylene terephthalate (PET) is widely used material and as such became highly enriched in nature. It is generally considered inert and safe plastic, but due to the recent increased efforts to break-down PET using biotechnological approaches, we realized the scarcity of information about structural analysis of possible degradation products and their ecotoxicological assessment. Therefore, in this study, 11 compounds belonging to the group of PET precursors and possible degradation products have been comprehensively characterized. Seven of these compounds including 1-(2-hydroxyethyl)-4-methylterephthalate, ethylene glycol bis(methyl terephthalate), methyl bis(2-hydroxyethyl terephtahalate), 1,4-benzenedicarboxylic acid, 1,4-bis[2-[[4-(methoxycarbonyl)benzoyl]oxy]ethyl] ester and methyl tris(2-hydroxyethyl terephthalate) corresponding to mono-, 1.5-, di-, 2,5- and trimer of PET were synthetized and structurally characterized for the first time. In-silico druglikeness and physico-chemical properties of these compounds were predicted using variety of platforms. No antimicrobial properties were detected even at 1000 μg/mL. Ecotoxicological impact of the compounds against marine bacteria Allivibrio fischeri proved that the 6 out of 11 tested PET-associated compounds may be classified as harmful to aquatic microorganisms, with PET trimer being one of the most toxic. In comparison, most of the compounds were not toxic on human lung fibroblasts (MRC-5) at 200 μg/mL with inhibiting concentration (IC50) values of 30 μg/mL and 50 μg/mL determined for PET dimer and trimer. Only three of these compounds including PET monomer were toxic to nematode Caenorhabditis elegans at high concentration of 500 μg/mL. In terms of the applicative potential, PET dimer can be used as suitable substrate for the screening, identification and characterization of novel PET-depolymerizing enzymes.
PB  - Elsevier
T2  - Chemosphere
T2  - ChemosphereChemosphere
T1  - Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases
VL  - 275
SP  - 130005
DO  - 10.1016/j.chemosphere.2021.130005
ER  - 

@article{
author = "Đapović, Milica and Milivojević, Dušan and Ilić-Tomić, Tatjana and Lješević, Marija and Nikolaivits, Efstratios and Topakas, Evangelos and Maslak, Veselin and Nikodinović-Runić, Jasmina",
year = "2021",
abstract = "Polyethylene terephthalate (PET) is widely used material and as such became highly enriched in nature. It is generally considered inert and safe plastic, but due to the recent increased efforts to break-down PET using biotechnological approaches, we realized the scarcity of information about structural analysis of possible degradation products and their ecotoxicological assessment. Therefore, in this study, 11 compounds belonging to the group of PET precursors and possible degradation products have been comprehensively characterized. Seven of these compounds including 1-(2-hydroxyethyl)-4-methylterephthalate, ethylene glycol bis(methyl terephthalate), methyl bis(2-hydroxyethyl terephtahalate), 1,4-benzenedicarboxylic acid, 1,4-bis[2-[[4-(methoxycarbonyl)benzoyl]oxy]ethyl] ester and methyl tris(2-hydroxyethyl terephthalate) corresponding to mono-, 1.5-, di-, 2,5- and trimer of PET were synthetized and structurally characterized for the first time. In-silico druglikeness and physico-chemical properties of these compounds were predicted using variety of platforms. No antimicrobial properties were detected even at 1000 μg/mL. Ecotoxicological impact of the compounds against marine bacteria Allivibrio fischeri proved that the 6 out of 11 tested PET-associated compounds may be classified as harmful to aquatic microorganisms, with PET trimer being one of the most toxic. In comparison, most of the compounds were not toxic on human lung fibroblasts (MRC-5) at 200 μg/mL with inhibiting concentration (IC50) values of 30 μg/mL and 50 μg/mL determined for PET dimer and trimer. Only three of these compounds including PET monomer were toxic to nematode Caenorhabditis elegans at high concentration of 500 μg/mL. In terms of the applicative potential, PET dimer can be used as suitable substrate for the screening, identification and characterization of novel PET-depolymerizing enzymes.",
publisher = "Elsevier",
journal = "Chemosphere, ChemosphereChemosphere",
title = "Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases",
volume = "275",
pages = "130005",
doi = "10.1016/j.chemosphere.2021.130005"
}

Đapović, M., Milivojević, D., Ilić-Tomić, T., Lješević, M., Nikolaivits, E., Topakas, E., Maslak, V.,& Nikodinović-Runić, J.. (2021). Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases. in Chemosphere
Elsevier., 275, 130005.
https://doi.org/10.1016/j.chemosphere.2021.130005

Đapović M, Milivojević D, Ilić-Tomić T, Lješević M, Nikolaivits E, Topakas E, Maslak V, Nikodinović-Runić J. Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases. in Chemosphere. 2021;275:130005.
doi:10.1016/j.chemosphere.2021.130005 .

Đapović, Milica, Milivojević, Dušan, Ilić-Tomić, Tatjana, Lješević, Marija, Nikolaivits, Efstratios, Topakas, Evangelos, Maslak, Veselin, Nikodinović-Runić, Jasmina, "Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases" in Chemosphere, 275 (2021):130005,
https://doi.org/10.1016/j.chemosphere.2021.130005 . .

TY  - DATA
AU  - Đapović, Milica
AU  - Milivojević, Dušan
AU  - Ilić-Tomić, Tatjana
AU  - Lješević, Marija
AU  - Nikolaivits, Efstratios
AU  - Topakas, Evangelos
AU  - Maslak, Veselin
AU  - Nikodinović-Runić, Jasmina
PY  - 2021
UR  - https://www.sciencedirect.com/science/article/pii/S0045653521004744
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4660
PB  - Elsevier
T2  - Chemosphere
T1  - Supplementary data for: "Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases"
UR  - https://hdl.handle.net/21.15107/rcub_cer_4660
ER  - 

@misc{
author = "Đapović, Milica and Milivojević, Dušan and Ilić-Tomić, Tatjana and Lješević, Marija and Nikolaivits, Efstratios and Topakas, Evangelos and Maslak, Veselin and Nikodinović-Runić, Jasmina",
year = "2021",
publisher = "Elsevier",
journal = "Chemosphere",
title = "Supplementary data for: "Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases"",
url = "https://hdl.handle.net/21.15107/rcub_cer_4660"
}

Đapović, M., Milivojević, D., Ilić-Tomić, T., Lješević, M., Nikolaivits, E., Topakas, E., Maslak, V.,& Nikodinović-Runić, J.. (2021). Supplementary data for: "Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases". in Chemosphere
Elsevier..
https://hdl.handle.net/21.15107/rcub_cer_4660

Đapović M, Milivojević D, Ilić-Tomić T, Lješević M, Nikolaivits E, Topakas E, Maslak V, Nikodinović-Runić J. Supplementary data for: "Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases". in Chemosphere. 2021;.
https://hdl.handle.net/21.15107/rcub_cer_4660 .

Đapović, Milica, Milivojević, Dušan, Ilić-Tomić, Tatjana, Lješević, Marija, Nikolaivits, Efstratios, Topakas, Evangelos, Maslak, Veselin, Nikodinović-Runić, Jasmina, "Supplementary data for: "Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases"" in Chemosphere (2021),
https://hdl.handle.net/21.15107/rcub_cer_4660 .