TY  - CONF
AU  - Marković, Olivera
AU  - Marjanović, Nemanja Ž.
AU  - Patel, Nirali
AU  - Serajuddin, Abu T. M.
AU  - Avdeef, Alex
AU  - Verbić, Tatjana
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4730
AB  - Solubility is important physicochemical parameter and determines drug stability, bioavailability and 
therapeutic action. The aim of this study was to examine solubility of nortriptyline hydrochloride in 
a wide pH range, using pH-Ramp Shake-Flask method, already applied to desipramine 
hydrochloride [1] and based of recently published recommendations [2]. Solubility was measured in phosphate buffer, in chloride-free media and phoshate-free media, using both nortriptyline base and nortriptyline hydrochloride as starting material. Elemental analysis, termogravimetric analysis, 
differential scaning calorimetric analysis and powder X-ray diffraction analysis were used for solid 
precipitate analysis.
AB  - Rastvorljivost je značajno fizičko-hemijsko svojstvo biološki aktivnih i potencijalno biološki 
aktivnih supstancija, koje određuje stabilnost, biodostupnost i terapeutsko dejstvo leka. Cilj ovog 
rada je ispitivanje rastvorljivosti nortriptilin-hidrohlorida, pomoću pH-Ramp Shake-Flask metode, 
prethodno primenjene na desipramin-hidrohlorid [1]. Eksperimenti su izvedeni prema novim 
preporukama iz literature [2]. Rastvorljivost je određena u fosfatnom puferu, u sistemu bez hlorida i 
sistemu bez fosfata, koristeći nortriptilin bazu i nortriptilin-hidrohlorid. Urađena je i katakterizacija
čvrste faze pomoću elementalne analize, termogravimetrije, diferencijalne skenirajuće kalorimetrije 
i difrakcije X-zraka.
PB  - Belgrade : Serbian Chemical Society
C3  - Book of abstracts / Proceedings 57th Meeting of the Serbian Chemical Society // Kratki izvodi radova / Knjiga radova 57. Savetovanje Srpskog hemijskog društva
T1  - pH-Dependent solubility profile of nortriptyline hydrochloride
SP  - 32
EP  - 32
UR  - https://hdl.handle.net/21.15107/rcub_cer_4730
ER  - 

@conference{
author = "Marković, Olivera and Marjanović, Nemanja Ž. and Patel, Nirali and Serajuddin, Abu T. M. and Avdeef, Alex and Verbić, Tatjana",
year = "2021",
abstract = "Solubility is important physicochemical parameter and determines drug stability, bioavailability and 
therapeutic action. The aim of this study was to examine solubility of nortriptyline hydrochloride in 
a wide pH range, using pH-Ramp Shake-Flask method, already applied to desipramine 
hydrochloride [1] and based of recently published recommendations [2]. Solubility was measured in phosphate buffer, in chloride-free media and phoshate-free media, using both nortriptyline base and nortriptyline hydrochloride as starting material. Elemental analysis, termogravimetric analysis, 
differential scaning calorimetric analysis and powder X-ray diffraction analysis were used for solid 
precipitate analysis., Rastvorljivost je značajno fizičko-hemijsko svojstvo biološki aktivnih i potencijalno biološki 
aktivnih supstancija, koje određuje stabilnost, biodostupnost i terapeutsko dejstvo leka. Cilj ovog 
rada je ispitivanje rastvorljivosti nortriptilin-hidrohlorida, pomoću pH-Ramp Shake-Flask metode, 
prethodno primenjene na desipramin-hidrohlorid [1]. Eksperimenti su izvedeni prema novim 
preporukama iz literature [2]. Rastvorljivost je određena u fosfatnom puferu, u sistemu bez hlorida i 
sistemu bez fosfata, koristeći nortriptilin bazu i nortriptilin-hidrohlorid. Urađena je i katakterizacija
čvrste faze pomoću elementalne analize, termogravimetrije, diferencijalne skenirajuće kalorimetrije 
i difrakcije X-zraka.",
publisher = "Belgrade : Serbian Chemical Society",
journal = "Book of abstracts / Proceedings 57th Meeting of the Serbian Chemical Society // Kratki izvodi radova / Knjiga radova 57. Savetovanje Srpskog hemijskog društva",
title = "pH-Dependent solubility profile of nortriptyline hydrochloride",
pages = "32-32",
url = "https://hdl.handle.net/21.15107/rcub_cer_4730"
}

Marković, O., Marjanović, N. Ž., Patel, N., Serajuddin, A. T. M., Avdeef, A.,& Verbić, T.. (2021). pH-Dependent solubility profile of nortriptyline hydrochloride. in Book of abstracts / Proceedings 57th Meeting of the Serbian Chemical Society // Kratki izvodi radova / Knjiga radova 57. Savetovanje Srpskog hemijskog društva
Belgrade : Serbian Chemical Society., 32-32.
https://hdl.handle.net/21.15107/rcub_cer_4730

Marković O, Marjanović NŽ, Patel N, Serajuddin ATM, Avdeef A, Verbić T. pH-Dependent solubility profile of nortriptyline hydrochloride. in Book of abstracts / Proceedings 57th Meeting of the Serbian Chemical Society // Kratki izvodi radova / Knjiga radova 57. Savetovanje Srpskog hemijskog društva. 2021;:32-32.
https://hdl.handle.net/21.15107/rcub_cer_4730 .

Marković, Olivera, Marjanović, Nemanja Ž., Patel, Nirali, Serajuddin, Abu T. M., Avdeef, Alex, Verbić, Tatjana, "pH-Dependent solubility profile of nortriptyline hydrochloride" in Book of abstracts / Proceedings 57th Meeting of the Serbian Chemical Society // Kratki izvodi radova / Knjiga radova 57. Savetovanje Srpskog hemijskog društva (2021):32-32,
https://hdl.handle.net/21.15107/rcub_cer_4730 .