TY  - JOUR
AU  - Kaluđerović, Goran N.
AU  - Hernandez-Corroto, Esther
AU  - Brandt, Wolfgang
AU  - Zmejkovski, Bojana
AU  - Gomez-Ruiz, Santiago
PY  - 2016
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2014
AB  - Four palladium(II) complexes with R-2 edda ligands, dichlorido(O,O-dialkylethylenediamine-N,N'-diacetate)palladium(II) monohydrates, [PdCl2(R(2)edda)].H2O, R=Me, Et, n-Pr, i-Bu, and the new ligand precursor i-Bu(2)edda.2HCl.H2O, O,O-diisobutylethylenediamine-N,N'-diacetate dihydrochloride monohydrate, were synthesized and characterized by IR, H-1 and C-13 NMR spectroscopy, and elemental analysis. DFT calculations were performed for the palladium(II) complexes and a high possibility for isomer formation due to stereogenic N ligand atoms was confirmed. Moreover, DFT simulations revealed energetic profile of isomer formation. Computational outcomes are in agreement with spectroscopic instrumental findings, both strongly indicating a non-stereoselective reaction between selected esters and K-2[PdCl4], forming isomers. [GRAPHICS]
PB  - Taylor & Francis Ltd, Abingdon
T2  - Journal of Coordination Chemistry
T1  - Palladium(II) complexes with R-2 edda-derived ligands
VL  - 69
IS  - 8
SP  - 1337
EP  - 1345
DO  - 10.1080/00958972.2016.1168519
ER  - 

@article{
author = "Kaluđerović, Goran N. and Hernandez-Corroto, Esther and Brandt, Wolfgang and Zmejkovski, Bojana and Gomez-Ruiz, Santiago",
year = "2016",
abstract = "Four palladium(II) complexes with R-2 edda ligands, dichlorido(O,O-dialkylethylenediamine-N,N'-diacetate)palladium(II) monohydrates, [PdCl2(R(2)edda)].H2O, R=Me, Et, n-Pr, i-Bu, and the new ligand precursor i-Bu(2)edda.2HCl.H2O, O,O-diisobutylethylenediamine-N,N'-diacetate dihydrochloride monohydrate, were synthesized and characterized by IR, H-1 and C-13 NMR spectroscopy, and elemental analysis. DFT calculations were performed for the palladium(II) complexes and a high possibility for isomer formation due to stereogenic N ligand atoms was confirmed. Moreover, DFT simulations revealed energetic profile of isomer formation. Computational outcomes are in agreement with spectroscopic instrumental findings, both strongly indicating a non-stereoselective reaction between selected esters and K-2[PdCl4], forming isomers. [GRAPHICS]",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Journal of Coordination Chemistry",
title = "Palladium(II) complexes with R-2 edda-derived ligands",
volume = "69",
number = "8",
pages = "1337-1345",
doi = "10.1080/00958972.2016.1168519"
}

Kaluđerović, G. N., Hernandez-Corroto, E., Brandt, W., Zmejkovski, B.,& Gomez-Ruiz, S.. (2016). Palladium(II) complexes with R-2 edda-derived ligands. in Journal of Coordination Chemistry
Taylor & Francis Ltd, Abingdon., 69(8), 1337-1345.
https://doi.org/10.1080/00958972.2016.1168519

Kaluđerović GN, Hernandez-Corroto E, Brandt W, Zmejkovski B, Gomez-Ruiz S. Palladium(II) complexes with R-2 edda-derived ligands. in Journal of Coordination Chemistry. 2016;69(8):1337-1345.
doi:10.1080/00958972.2016.1168519 .

Kaluđerović, Goran N., Hernandez-Corroto, Esther, Brandt, Wolfgang, Zmejkovski, Bojana, Gomez-Ruiz, Santiago, "Palladium(II) complexes with R-2 edda-derived ligands" in Journal of Coordination Chemistry, 69, no. 8 (2016):1337-1345,
https://doi.org/10.1080/00958972.2016.1168519 . .

TY  - JOUR
AU  - Dordevic, Milena
AU  - Jeremić, Dejan
AU  - Kaluđerović, Goran N.
AU  - Gómez-Ruiz, Santiago
AU  - Anđelković, Boban D.
AU  - Radanović, Dušanka
AU  - Brčeski, Ilija
PY  - 2014
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1429
AB  - Three new 1D coordination polymers, [Pb-2(CH3SO3)(4)(H2O)(2)](n), [Hg(CH3SO3)(2)(H2O)(2)](n) and [Sr(CH3SO3)(2)(H2O)](n), were synthesized as large single crystals. The crystals were analyzed and characterized by the means of X-ray analysis, IR and NMR spectroscopy, elemental analysis and solid state UV-Vis spectroscopy. The formation of 1D polymeric chains in the crystal structures of the title compounds is affected by the various bonding modes of the bridging methanesulfonate groups. The studied compounds showed no decomposition in the air.
PB  - Oxford : Pergamon-Elsevier Science Ltd
T2  - Polyhedron
T1  - Synthesis and spectroscopic properties of large single-crystals of Pb(II), Hg(II) and Sr(II) methanesulfonato 1D coordination polymers
VL  - 80
SP  - 282
EP  - 289
DO  - 10.1016/j.poly.2014.05.056
ER  - 

@article{
author = "Dordevic, Milena and Jeremić, Dejan and Kaluđerović, Goran N. and Gómez-Ruiz, Santiago and Anđelković, Boban D. and Radanović, Dušanka and Brčeski, Ilija",
year = "2014",
abstract = "Three new 1D coordination polymers, [Pb-2(CH3SO3)(4)(H2O)(2)](n), [Hg(CH3SO3)(2)(H2O)(2)](n) and [Sr(CH3SO3)(2)(H2O)](n), were synthesized as large single crystals. The crystals were analyzed and characterized by the means of X-ray analysis, IR and NMR spectroscopy, elemental analysis and solid state UV-Vis spectroscopy. The formation of 1D polymeric chains in the crystal structures of the title compounds is affected by the various bonding modes of the bridging methanesulfonate groups. The studied compounds showed no decomposition in the air.",
publisher = "Oxford : Pergamon-Elsevier Science Ltd",
journal = "Polyhedron",
title = "Synthesis and spectroscopic properties of large single-crystals of Pb(II), Hg(II) and Sr(II) methanesulfonato 1D coordination polymers",
volume = "80",
pages = "282-289",
doi = "10.1016/j.poly.2014.05.056"
}

Dordevic, M., Jeremić, D., Kaluđerović, G. N., Gómez-Ruiz, S., Anđelković, B. D., Radanović, D.,& Brčeski, I.. (2014). Synthesis and spectroscopic properties of large single-crystals of Pb(II), Hg(II) and Sr(II) methanesulfonato 1D coordination polymers. in Polyhedron
Oxford : Pergamon-Elsevier Science Ltd., 80, 282-289.
https://doi.org/10.1016/j.poly.2014.05.056

Dordevic M, Jeremić D, Kaluđerović GN, Gómez-Ruiz S, Anđelković BD, Radanović D, Brčeski I. Synthesis and spectroscopic properties of large single-crystals of Pb(II), Hg(II) and Sr(II) methanesulfonato 1D coordination polymers. in Polyhedron. 2014;80:282-289.
doi:10.1016/j.poly.2014.05.056 .

Dordevic, Milena, Jeremić, Dejan, Kaluđerović, Goran N., Gómez-Ruiz, Santiago, Anđelković, Boban D., Radanović, Dušanka, Brčeski, Ilija, "Synthesis and spectroscopic properties of large single-crystals of Pb(II), Hg(II) and Sr(II) methanesulfonato 1D coordination polymers" in Polyhedron, 80 (2014):282-289,
https://doi.org/10.1016/j.poly.2014.05.056 . .

TY  - JOUR
AU  - Dordevic, Milena
AU  - Jeremić, Dejan
AU  - Kaluđerović, Goran N.
AU  - Gómez-Ruiz, Santiago
AU  - Anđelković, Boban D.
AU  - Radanović, Dušanka
AU  - Brčeski, Ilija
PY  - 2014
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3164
AB  - Three new 1D coordination polymers, [Pb-2(CH3SO3)(4)(H2O)(2)](n), [Hg(CH3SO3)(2)(H2O)(2)](n) and [Sr(CH3SO3)(2)(H2O)](n), were synthesized as large single crystals. The crystals were analyzed and characterized by the means of X-ray analysis, IR and NMR spectroscopy, elemental analysis and solid state UV-Vis spectroscopy. The formation of 1D polymeric chains in the crystal structures of the title compounds is affected by the various bonding modes of the bridging methanesulfonate groups. The studied compounds showed no decomposition in the air.
PB  - Oxford : Pergamon-Elsevier Science Ltd
T2  - Polyhedron
T1  - Synthesis and spectroscopic properties of large single-crystals of Pb(II), Hg(II) and Sr(II) methanesulfonato 1D coordination polymers
VL  - 80
SP  - 282
EP  - 289
DO  - 10.1016/j.poly.2014.05.056
ER  - 

@article{
author = "Dordevic, Milena and Jeremić, Dejan and Kaluđerović, Goran N. and Gómez-Ruiz, Santiago and Anđelković, Boban D. and Radanović, Dušanka and Brčeski, Ilija",
year = "2014",
abstract = "Three new 1D coordination polymers, [Pb-2(CH3SO3)(4)(H2O)(2)](n), [Hg(CH3SO3)(2)(H2O)(2)](n) and [Sr(CH3SO3)(2)(H2O)](n), were synthesized as large single crystals. The crystals were analyzed and characterized by the means of X-ray analysis, IR and NMR spectroscopy, elemental analysis and solid state UV-Vis spectroscopy. The formation of 1D polymeric chains in the crystal structures of the title compounds is affected by the various bonding modes of the bridging methanesulfonate groups. The studied compounds showed no decomposition in the air.",
publisher = "Oxford : Pergamon-Elsevier Science Ltd",
journal = "Polyhedron",
title = "Synthesis and spectroscopic properties of large single-crystals of Pb(II), Hg(II) and Sr(II) methanesulfonato 1D coordination polymers",
volume = "80",
pages = "282-289",
doi = "10.1016/j.poly.2014.05.056"
}

Dordevic, M., Jeremić, D., Kaluđerović, G. N., Gómez-Ruiz, S., Anđelković, B. D., Radanović, D.,& Brčeski, I.. (2014). Synthesis and spectroscopic properties of large single-crystals of Pb(II), Hg(II) and Sr(II) methanesulfonato 1D coordination polymers. in Polyhedron
Oxford : Pergamon-Elsevier Science Ltd., 80, 282-289.
https://doi.org/10.1016/j.poly.2014.05.056

Dordevic M, Jeremić D, Kaluđerović GN, Gómez-Ruiz S, Anđelković BD, Radanović D, Brčeski I. Synthesis and spectroscopic properties of large single-crystals of Pb(II), Hg(II) and Sr(II) methanesulfonato 1D coordination polymers. in Polyhedron. 2014;80:282-289.
doi:10.1016/j.poly.2014.05.056 .

Dordevic, Milena, Jeremić, Dejan, Kaluđerović, Goran N., Gómez-Ruiz, Santiago, Anđelković, Boban D., Radanović, Dušanka, Brčeski, Ilija, "Synthesis and spectroscopic properties of large single-crystals of Pb(II), Hg(II) and Sr(II) methanesulfonato 1D coordination polymers" in Polyhedron, 80 (2014):282-289,
https://doi.org/10.1016/j.poly.2014.05.056 . .

TY  - JOUR
AU  - Kaluđerović, Goran N.
AU  - Mijatović, Sanja
AU  - Zmejkovski, Bojana
AU  - Bulatović, Mirna
AU  - Gómez-Ruiz, Santiago
AU  - Mojic, Marija K.
AU  - Steinborn, Dirk
AU  - Miljkovic, Djordje M.
AU  - Schmidt, Harry
AU  - Stosic-Grujicic, Stanislava D.
AU  - Sabo, Tibor
AU  - Maksimović-Ivanić, Danijela D.
PY  - 2012
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1112
AB  - Several new R(2)eddp (R = i-Pr, i-Bu; eddp = ethylenediamine-N,N'-di-3-propionate) esters and corresponding platinum(II) and platinum(IV) complexes of the general formula [PtCln(R(2)edda-type)] (n = 2, 4) were synthesized and characterized by spectroscopic methods (IR, H-1 and C-13 NMR) and elemental analysis. The crystal structure of platinum(IV) complex [PtCl4{(c-Pe)(2)eddip}] (3a) was resolved and is given herein. Ligand precursors, platinum(II), and platinum(IV) complexes were tested against eight tumor cell lines (CT26CL25, HTC116, SW620, PC3, LNCaP, U251, A375, and B16). Selectivity in the action of those compounds between tumor and two normal primary cells (fibroblasts and keratinocytes) are discussed. A structure-activity relationship of these compounds is discussed. Furthermore, cell cycle distribution, induction of necrosis, apoptosis, autophagy, anoikis, caspase activation, ROS, and RNS are presented on the cisplatin-resistant colon carcinoma HCT116 cell line.
PB  - Royal Soc Chemistry, Cambridge
T2  - Metallomics
T1  - Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells
VL  - 4
IS  - 9
SP  - 979
EP  - 987
DO  - 10.1039/c2mt20058a
ER  - 

@article{
author = "Kaluđerović, Goran N. and Mijatović, Sanja and Zmejkovski, Bojana and Bulatović, Mirna and Gómez-Ruiz, Santiago and Mojic, Marija K. and Steinborn, Dirk and Miljkovic, Djordje M. and Schmidt, Harry and Stosic-Grujicic, Stanislava D. and Sabo, Tibor and Maksimović-Ivanić, Danijela D.",
year = "2012",
abstract = "Several new R(2)eddp (R = i-Pr, i-Bu; eddp = ethylenediamine-N,N'-di-3-propionate) esters and corresponding platinum(II) and platinum(IV) complexes of the general formula [PtCln(R(2)edda-type)] (n = 2, 4) were synthesized and characterized by spectroscopic methods (IR, H-1 and C-13 NMR) and elemental analysis. The crystal structure of platinum(IV) complex [PtCl4{(c-Pe)(2)eddip}] (3a) was resolved and is given herein. Ligand precursors, platinum(II), and platinum(IV) complexes were tested against eight tumor cell lines (CT26CL25, HTC116, SW620, PC3, LNCaP, U251, A375, and B16). Selectivity in the action of those compounds between tumor and two normal primary cells (fibroblasts and keratinocytes) are discussed. A structure-activity relationship of these compounds is discussed. Furthermore, cell cycle distribution, induction of necrosis, apoptosis, autophagy, anoikis, caspase activation, ROS, and RNS are presented on the cisplatin-resistant colon carcinoma HCT116 cell line.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "Metallomics",
title = "Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells",
volume = "4",
number = "9",
pages = "979-987",
doi = "10.1039/c2mt20058a"
}

Kaluđerović, G. N., Mijatović, S., Zmejkovski, B., Bulatović, M., Gómez-Ruiz, S., Mojic, M. K., Steinborn, D., Miljkovic, D. M., Schmidt, H., Stosic-Grujicic, S. D., Sabo, T.,& Maksimović-Ivanić, D. D.. (2012). Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells. in Metallomics
Royal Soc Chemistry, Cambridge., 4(9), 979-987.
https://doi.org/10.1039/c2mt20058a

Kaluđerović GN, Mijatović S, Zmejkovski B, Bulatović M, Gómez-Ruiz S, Mojic MK, Steinborn D, Miljkovic DM, Schmidt H, Stosic-Grujicic SD, Sabo T, Maksimović-Ivanić DD. Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells. in Metallomics. 2012;4(9):979-987.
doi:10.1039/c2mt20058a .

Kaluđerović, Goran N., Mijatović, Sanja, Zmejkovski, Bojana, Bulatović, Mirna, Gómez-Ruiz, Santiago, Mojic, Marija K., Steinborn, Dirk, Miljkovic, Djordje M., Schmidt, Harry, Stosic-Grujicic, Stanislava D., Sabo, Tibor, Maksimović-Ivanić, Danijela D., "Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells" in Metallomics, 4, no. 9 (2012):979-987,
https://doi.org/10.1039/c2mt20058a . .

TY  - JOUR
AU  - Pérez‐Quintanilla, Damian
AU  - Gómez‐Ruiz, Santiago
AU  - Žižak, Željko
AU  - Sierra, Isabel
AU  - Prashar, Sanjiv
AU  - del Hierro, Isabel
AU  - Fajardo, Mariano
AU  - Juranić, Zorica
AU  - Kaluđerović, Goran N.
PY  - 2009
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4124
AB  - Dehydroxylated MCM-41 and SBA-15 surfaces were modified by the grafting of two different titanocene complexes ([Ti(Tη5-C5H 4Me)2Cl2] and [Ti(Me2Si(η 5-C5Me4) (η5-C5H 4)}Cl2]) to give new materials, which have been characterized by powder X-ray diffraction, X-ray fluorescence, nitrogen gas sorption, MAS-NMR spectroscopy, thermogravimetry, SEM, and TEM. The toxicity of the resulting materials toward human adenocarcinoma HeLa, human myelogenous leukemia K562, human malignant melanoma Fem-x, and normal immunocompetent cells, such as peripheral blood mononuclear cells PBMC has been studied. Estimation of the number of particles per gram of material led to the calculation of O 50 values for these samples, which is the number of particles required to inhibit normal cell growth by 50%. In addition, M50 values (quantity of material needed to inhibit normal cell growth by 50%) of the studied surfaces is also reported. Nonfunctionalized MCM-41 and SBA-15 did not show notable antiproliferative activity, whereas functionalization of these materials with different titanocene based anticancer drugs led to very promising antitumoral activity. The best Q50 values correspond to titanocene functionalized MCM-41 surfaces (MCM-41/[Ti(η5C5H 4Me)2Cl2] (1) and MCM-41/[TiIMe 2Si(Tf-C5Me4)(Tf-C5H 4)(Cl2] (2)) with Q50 values between 3.8 ± 0.6 x 108 and 24.5 ±3.0 x 108 particles. Titanocene functionalized SBA-15 surfaces (SBA-15/[Ti(η5-C 5H4Me)2Cl2] (3) and SBA-15/[Ti{Me2Si(η5-C5Me 4)(η5C5H4)}Cl2] (4)) gave higher Q50 values, showing lower activity from 73.2 ± 9.9 x 108 to 362±7×l08 particles. The best response of the studied materials in terms of M50 values was observed against Fem-x (309 ± 42 g for 4) and K562 (338±18 g for 2), whereas moderate activities were observed in HeLa cells (from 508±63g of 2 to 912 ± 10g of 1). In addition, the analyzed surfaces presented only marginal activity against unstimulated and stimulated PBMC, showing a slight selectivity on human cancer cells. Comparison of the in vitro cytotoxicity in solution of the titanocene complexes/[Ti(η5-C5H 4Me)2Cl2] (3) and SBA-15/[Ti{Me 2Si(η5-C5Me4) (η5C5H4)}Cl2] (4)) gave higher Q50 va and the corresponding titanocene functionalized materials is also described.
PB  - Wiley
T2  - Chemistry a European Journal
T1  - A New Generation of Anticancer Drugs: Mesoporous Materials Modified with Titanocene Complexes
VL  - 15
IS  - 22
SP  - 5588
EP  - 5597
DO  - 10.1002/chem.200900151
ER  - 

@article{
author = "Pérez‐Quintanilla, Damian and Gómez‐Ruiz, Santiago and Žižak, Željko and Sierra, Isabel and Prashar, Sanjiv and del Hierro, Isabel and Fajardo, Mariano and Juranić, Zorica and Kaluđerović, Goran N.",
year = "2009",
abstract = "Dehydroxylated MCM-41 and SBA-15 surfaces were modified by the grafting of two different titanocene complexes ([Ti(Tη5-C5H 4Me)2Cl2] and [Ti(Me2Si(η 5-C5Me4) (η5-C5H 4)}Cl2]) to give new materials, which have been characterized by powder X-ray diffraction, X-ray fluorescence, nitrogen gas sorption, MAS-NMR spectroscopy, thermogravimetry, SEM, and TEM. The toxicity of the resulting materials toward human adenocarcinoma HeLa, human myelogenous leukemia K562, human malignant melanoma Fem-x, and normal immunocompetent cells, such as peripheral blood mononuclear cells PBMC has been studied. Estimation of the number of particles per gram of material led to the calculation of O 50 values for these samples, which is the number of particles required to inhibit normal cell growth by 50%. In addition, M50 values (quantity of material needed to inhibit normal cell growth by 50%) of the studied surfaces is also reported. Nonfunctionalized MCM-41 and SBA-15 did not show notable antiproliferative activity, whereas functionalization of these materials with different titanocene based anticancer drugs led to very promising antitumoral activity. The best Q50 values correspond to titanocene functionalized MCM-41 surfaces (MCM-41/[Ti(η5C5H 4Me)2Cl2] (1) and MCM-41/[TiIMe 2Si(Tf-C5Me4)(Tf-C5H 4)(Cl2] (2)) with Q50 values between 3.8 ± 0.6 x 108 and 24.5 ±3.0 x 108 particles. Titanocene functionalized SBA-15 surfaces (SBA-15/[Ti(η5-C 5H4Me)2Cl2] (3) and SBA-15/[Ti{Me2Si(η5-C5Me 4)(η5C5H4)}Cl2] (4)) gave higher Q50 values, showing lower activity from 73.2 ± 9.9 x 108 to 362±7×l08 particles. The best response of the studied materials in terms of M50 values was observed against Fem-x (309 ± 42 g for 4) and K562 (338±18 g for 2), whereas moderate activities were observed in HeLa cells (from 508±63g of 2 to 912 ± 10g of 1). In addition, the analyzed surfaces presented only marginal activity against unstimulated and stimulated PBMC, showing a slight selectivity on human cancer cells. Comparison of the in vitro cytotoxicity in solution of the titanocene complexes/[Ti(η5-C5H 4Me)2Cl2] (3) and SBA-15/[Ti{Me 2Si(η5-C5Me4) (η5C5H4)}Cl2] (4)) gave higher Q50 va and the corresponding titanocene functionalized materials is also described.",
publisher = "Wiley",
journal = "Chemistry a European Journal",
title = "A New Generation of Anticancer Drugs: Mesoporous Materials Modified with Titanocene Complexes",
volume = "15",
number = "22",
pages = "5588-5597",
doi = "10.1002/chem.200900151"
}

Pérez‐Quintanilla, D., Gómez‐Ruiz, S., Žižak, Ž., Sierra, I., Prashar, S., del Hierro, I., Fajardo, M., Juranić, Z.,& Kaluđerović, G. N.. (2009). A New Generation of Anticancer Drugs: Mesoporous Materials Modified with Titanocene Complexes. in Chemistry a European Journal
Wiley., 15(22), 5588-5597.
https://doi.org/10.1002/chem.200900151

Pérez‐Quintanilla D, Gómez‐Ruiz S, Žižak Ž, Sierra I, Prashar S, del Hierro I, Fajardo M, Juranić Z, Kaluđerović GN. A New Generation of Anticancer Drugs: Mesoporous Materials Modified with Titanocene Complexes. in Chemistry a European Journal. 2009;15(22):5588-5597.
doi:10.1002/chem.200900151 .

Pérez‐Quintanilla, Damian, Gómez‐Ruiz, Santiago, Žižak, Željko, Sierra, Isabel, Prashar, Sanjiv, del Hierro, Isabel, Fajardo, Mariano, Juranić, Zorica, Kaluđerović, Goran N., "A New Generation of Anticancer Drugs: Mesoporous Materials Modified with Titanocene Complexes" in Chemistry a European Journal, 15, no. 22 (2009):5588-5597,
https://doi.org/10.1002/chem.200900151 . .

TY  - JOUR
AU  - Zmejkovski, Bojana
AU  - Kaluđerović, Goran N.
AU  - Gómez-Ruiz, Santiago
AU  - Sabo, Tibor
PY  - 2009
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/498
AB  - A new R2edda-type ester, diisobutyl (S,S)-2,2'-(1,2-ethane-diyldiimino) di(4-methylpentanoate) dihydrochloride, [(S,S)-H2iBu2eddl]Cl2, 1, and its palladium(II) complex, dichloro(diisobutyl (S,S)-2,2'-(1,2-ethanediyldiimino) di(4-methylpentanoate))palladium(II), [PdCl2{(S,S)-iBu2eddl}], 2, were synthesized and characterized by elemental analysis, as well as IR and NMR spectroscopy. It was found that complex 2 was obtained as mixture of two diastereoisomers, observed in NMR spectra. The crystal structure of compound 1 was determined by X-ray diffraction studies and is described. The isolated crystals consisted of one dicationic species [(S,S)-H2iBu2eddl]2+ and two Cl-. The crystal system was tetragonal with the space group P42. Hydrogen bonds significant for the manner of packing are N-H1N···Cl, 3.049(3) Å, 159(3)° and N-H2N···Cl, 3.100(3) Å, 164(3)°. An infinite chain was formed building a one layer structure, usual for these types of compounds. The C2 symmetry axis of the compound passes through the C1-C1i bond vector and lies perpendicular to the plane N2Cl2.
AB  - Novi estar R2edda-tipa diizobutil-(S,S)-2,2'-(1,2-etandiildiimino)-di(4-metilpen-tanoat)-dihidrohlorid [(S,S)-H2iBu2eddl]Cl2,1, i njegov kompleks paladijuma(II), dihlorodiizobutil-(S,S)-2,2'-(1,2-etandiildiimino)-di(4-metilpentanoat)-paladijum(II) [PdCl2{(S,S)-iBu2eddl}], 2, sintetisani su i okarakterisani uz pomoć elementalne analize, IR i NMR spektroskopije. Nađeno je da je kompleks 2 dobijen kao smeša dva dijastereoizomera, što je primećeno u NMR spektrima. Kristalna struktura 1 je rešena i opisana. Izolovani kristali se sastoje iz jedne dikatjonske vrste [(S,S)-H2iBu2eddl]2+ i dva Cl-. Kristalni sistem je tetragonalan sa prostornim grupom P42. Značajne vodonične veze za način pakovanja su N-H1N•••Cl, 3,049(3) Å, 159(3)°i N-H2N...Cl, 3,100(3) Å, 164(3)°. Time se formira beskonačan lanac i jednoslojna struktura, koji su uobičajeni za ove tipove struktura. Osa simetrije C2 jedinjenja prolazi kroz C1-C1i vektor veze i leži normalno na N2Cl2 ravan. PR Projekat Ministarstva nauke Republike Srbije, br. 142010.
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Palladium(II) complexes with R2edda derived ligands, Part III: Diisobutyl (s,s)-2,2'-(1,2-ethanediyldiimino)di(4-methylpentanoate) and its palladium(II) complex: Synthesis and characterization
T1  - Kompleksi paladijuma(II) sa ligandima R2edda tipa, deo III - diizobutil-(s,s)-2,2'-(1,2,-etandiildiimino)-di(4-metilpentanoat)-dihidrohlorid i njegov kompleks sa paladijumom(II) - sinteza i karakterizacija
VL  - 74
IS  - 11
SP  - 1249
EP  - 1258
DO  - 10.2298/JSC0911249Z
ER  - 

@article{
author = "Zmejkovski, Bojana and Kaluđerović, Goran N. and Gómez-Ruiz, Santiago and Sabo, Tibor",
year = "2009",
abstract = "A new R2edda-type ester, diisobutyl (S,S)-2,2'-(1,2-ethane-diyldiimino) di(4-methylpentanoate) dihydrochloride, [(S,S)-H2iBu2eddl]Cl2, 1, and its palladium(II) complex, dichloro(diisobutyl (S,S)-2,2'-(1,2-ethanediyldiimino) di(4-methylpentanoate))palladium(II), [PdCl2{(S,S)-iBu2eddl}], 2, were synthesized and characterized by elemental analysis, as well as IR and NMR spectroscopy. It was found that complex 2 was obtained as mixture of two diastereoisomers, observed in NMR spectra. The crystal structure of compound 1 was determined by X-ray diffraction studies and is described. The isolated crystals consisted of one dicationic species [(S,S)-H2iBu2eddl]2+ and two Cl-. The crystal system was tetragonal with the space group P42. Hydrogen bonds significant for the manner of packing are N-H1N···Cl, 3.049(3) Å, 159(3)° and N-H2N···Cl, 3.100(3) Å, 164(3)°. An infinite chain was formed building a one layer structure, usual for these types of compounds. The C2 symmetry axis of the compound passes through the C1-C1i bond vector and lies perpendicular to the plane N2Cl2., Novi estar R2edda-tipa diizobutil-(S,S)-2,2'-(1,2-etandiildiimino)-di(4-metilpen-tanoat)-dihidrohlorid [(S,S)-H2iBu2eddl]Cl2,1, i njegov kompleks paladijuma(II), dihlorodiizobutil-(S,S)-2,2'-(1,2-etandiildiimino)-di(4-metilpentanoat)-paladijum(II) [PdCl2{(S,S)-iBu2eddl}], 2, sintetisani su i okarakterisani uz pomoć elementalne analize, IR i NMR spektroskopije. Nađeno je da je kompleks 2 dobijen kao smeša dva dijastereoizomera, što je primećeno u NMR spektrima. Kristalna struktura 1 je rešena i opisana. Izolovani kristali se sastoje iz jedne dikatjonske vrste [(S,S)-H2iBu2eddl]2+ i dva Cl-. Kristalni sistem je tetragonalan sa prostornim grupom P42. Značajne vodonične veze za način pakovanja su N-H1N•••Cl, 3,049(3) Å, 159(3)°i N-H2N...Cl, 3,100(3) Å, 164(3)°. Time se formira beskonačan lanac i jednoslojna struktura, koji su uobičajeni za ove tipove struktura. Osa simetrije C2 jedinjenja prolazi kroz C1-C1i vektor veze i leži normalno na N2Cl2 ravan. PR Projekat Ministarstva nauke Republike Srbije, br. 142010.",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Palladium(II) complexes with R2edda derived ligands, Part III: Diisobutyl (s,s)-2,2'-(1,2-ethanediyldiimino)di(4-methylpentanoate) and its palladium(II) complex: Synthesis and characterization, Kompleksi paladijuma(II) sa ligandima R2edda tipa, deo III - diizobutil-(s,s)-2,2'-(1,2,-etandiildiimino)-di(4-metilpentanoat)-dihidrohlorid i njegov kompleks sa paladijumom(II) - sinteza i karakterizacija",
volume = "74",
number = "11",
pages = "1249-1258",
doi = "10.2298/JSC0911249Z"
}

Zmejkovski, B., Kaluđerović, G. N., Gómez-Ruiz, S.,& Sabo, T.. (2009). Palladium(II) complexes with R2edda derived ligands, Part III: Diisobutyl (s,s)-2,2'-(1,2-ethanediyldiimino)di(4-methylpentanoate) and its palladium(II) complex: Synthesis and characterization. in Journal of the Serbian Chemical Society
Serbian Chemical Society., 74(11), 1249-1258.
https://doi.org/10.2298/JSC0911249Z

Zmejkovski B, Kaluđerović GN, Gómez-Ruiz S, Sabo T. Palladium(II) complexes with R2edda derived ligands, Part III: Diisobutyl (s,s)-2,2'-(1,2-ethanediyldiimino)di(4-methylpentanoate) and its palladium(II) complex: Synthesis and characterization. in Journal of the Serbian Chemical Society. 2009;74(11):1249-1258.
doi:10.2298/JSC0911249Z .

Zmejkovski, Bojana, Kaluđerović, Goran N., Gómez-Ruiz, Santiago, Sabo, Tibor, "Palladium(II) complexes with R2edda derived ligands, Part III: Diisobutyl (s,s)-2,2'-(1,2-ethanediyldiimino)di(4-methylpentanoate) and its palladium(II) complex: Synthesis and characterization" in Journal of the Serbian Chemical Society, 74, no. 11 (2009):1249-1258,
https://doi.org/10.2298/JSC0911249Z . .

TY  - JOUR
AU  - Gómez-Ruiz, Santiago
AU  - Kaluđerović, Goran N.
AU  - Prashar, Sanjiv
AU  - Hey-Hawkins, Evamarie
AU  - Erić, Aleksandra
AU  - Žižak, Željko
AU  - Juranić, Zorica
PY  - 2008
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4125
AB  - The reaction of 3-methoxyphenylacetic acid (3-MPAH), 4-methoxyphenylacetic acid (4-MPAH), 2,5-
dimethyl-3-furoic acid (DMFUH) or 1,4-benzodioxane-6-carboxylic acid (BZDOH) with triphenyltin(IV)
chloride (1:1) or diphenyltin(IV) dichloride (2:1) in the presence of triethylamine yielded the compounds
[SnPh3(3-MPA)] (1), [SnPh3(4-MPA)] (2), [SnPh3(DMFU)] (3), [SnPh3(BZDO)] (4), [SnPh2(3-MPA)2] (5),
[SnPh2(4-MPA)2] (6), [SnPh2(DMFU)2] (7) and [SnPh2(BZDO)2] (8), respectively. The tetranuclear complex
[{Me2(DMFU)SnOSn(DMFU)Me2}2] (9) was prepared by the reaction of dimethyltin(IV) oxide and 2,5-
dimethyl-3-furoic acid (DMFUH). The molecular structures of 3, 4 and 9, were determined by X-ray diffraction
studies. The cytotoxic activity of the carboxylic acids (3-MPAH, 4-MPAH, BZDOH and DMFUH)
and di (5–8) and triphenyltin(IV) complexes (2–4) was tested against tumor cell lines human adenocarcinoma
HeLa, human myelogenous leukemia K562, human malignant melanoma Fem-x and normal
immunocompetent cells, peripheral blood mononuclear cells PBMC. Triphenyltin(IV) complexes show
higher activities than the diphenyltin(IV) derivatives. The most active compound is [SnPh3(DMFU)] (3)
with IC50 value of 0.15  } 0.01, 0.051  } 0.004, 0.074  } 0.004, 0.20  } 0.01, 0.15  } 0.02 on HeLa, K562, Femx,
rested and stimulated PBMC, respectively, while the most selective are [SnPh2(3-MPA)2] (5),
[SnPh2(DMFU)2] (7) and [SnPh2(BZDO)2] (8). Compounds 3, 5, 7 and 8 present higher activities than cisplatin
in all the tested cells and relative high selectivity especially on K562 cells.
PB  - Elsevier
T2  - Journal of Inorganic Biochemistry
T1  - Study of the cytotoxic activity of di and triphenyltin(IV) carboxylate complexes
VL  - 102
IS  - 12
SP  - 2087
EP  - 2096
DO  - 10.1016/j.jinorgbio.2008.07.009
ER  - 

@article{
author = "Gómez-Ruiz, Santiago and Kaluđerović, Goran N. and Prashar, Sanjiv and Hey-Hawkins, Evamarie and Erić, Aleksandra and Žižak, Željko and Juranić, Zorica",
year = "2008",
abstract = "The reaction of 3-methoxyphenylacetic acid (3-MPAH), 4-methoxyphenylacetic acid (4-MPAH), 2,5-
dimethyl-3-furoic acid (DMFUH) or 1,4-benzodioxane-6-carboxylic acid (BZDOH) with triphenyltin(IV)
chloride (1:1) or diphenyltin(IV) dichloride (2:1) in the presence of triethylamine yielded the compounds
[SnPh3(3-MPA)] (1), [SnPh3(4-MPA)] (2), [SnPh3(DMFU)] (3), [SnPh3(BZDO)] (4), [SnPh2(3-MPA)2] (5),
[SnPh2(4-MPA)2] (6), [SnPh2(DMFU)2] (7) and [SnPh2(BZDO)2] (8), respectively. The tetranuclear complex
[{Me2(DMFU)SnOSn(DMFU)Me2}2] (9) was prepared by the reaction of dimethyltin(IV) oxide and 2,5-
dimethyl-3-furoic acid (DMFUH). The molecular structures of 3, 4 and 9, were determined by X-ray diffraction
studies. The cytotoxic activity of the carboxylic acids (3-MPAH, 4-MPAH, BZDOH and DMFUH)
and di (5–8) and triphenyltin(IV) complexes (2–4) was tested against tumor cell lines human adenocarcinoma
HeLa, human myelogenous leukemia K562, human malignant melanoma Fem-x and normal
immunocompetent cells, peripheral blood mononuclear cells PBMC. Triphenyltin(IV) complexes show
higher activities than the diphenyltin(IV) derivatives. The most active compound is [SnPh3(DMFU)] (3)
with IC50 value of 0.15  } 0.01, 0.051  } 0.004, 0.074  } 0.004, 0.20  } 0.01, 0.15  } 0.02 on HeLa, K562, Femx,
rested and stimulated PBMC, respectively, while the most selective are [SnPh2(3-MPA)2] (5),
[SnPh2(DMFU)2] (7) and [SnPh2(BZDO)2] (8). Compounds 3, 5, 7 and 8 present higher activities than cisplatin
in all the tested cells and relative high selectivity especially on K562 cells.",
publisher = "Elsevier",
journal = "Journal of Inorganic Biochemistry",
title = "Study of the cytotoxic activity of di and triphenyltin(IV) carboxylate complexes",
volume = "102",
number = "12",
pages = "2087-2096",
doi = "10.1016/j.jinorgbio.2008.07.009"
}

Gómez-Ruiz, S., Kaluđerović, G. N., Prashar, S., Hey-Hawkins, E., Erić, A., Žižak, Ž.,& Juranić, Z.. (2008). Study of the cytotoxic activity of di and triphenyltin(IV) carboxylate complexes. in Journal of Inorganic Biochemistry
Elsevier., 102(12), 2087-2096.
https://doi.org/10.1016/j.jinorgbio.2008.07.009

Gómez-Ruiz S, Kaluđerović GN, Prashar S, Hey-Hawkins E, Erić A, Žižak Ž, Juranić Z. Study of the cytotoxic activity of di and triphenyltin(IV) carboxylate complexes. in Journal of Inorganic Biochemistry. 2008;102(12):2087-2096.
doi:10.1016/j.jinorgbio.2008.07.009 .

Gómez-Ruiz, Santiago, Kaluđerović, Goran N., Prashar, Sanjiv, Hey-Hawkins, Evamarie, Erić, Aleksandra, Žižak, Željko, Juranić, Zorica, "Study of the cytotoxic activity of di and triphenyltin(IV) carboxylate complexes" in Journal of Inorganic Biochemistry, 102, no. 12 (2008):2087-2096,
https://doi.org/10.1016/j.jinorgbio.2008.07.009 . .

TY  - JOUR
AU  - Gomez-Ruiz, Santiago
AU  - Kaluđerović, Goran N.
AU  - Prashar, Sanjiv
AU  - Polo-Ceron, Dorian
AU  - Fajardo, Mariano
AU  - Žižak, Željko
AU  - Sabo, Tibor
AU  - Juranić, Zorica
PY  - 2008
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4130
AB  - A variety of substituted titanocene and ansa-titanocene complexes have been synthesized and characterized using traditional methods.
The cytotoxic activity of the different titanocene complexes was tested against tumour cell lines human adenocarcinoma HeLa, human
myelogenous leukemia K562, human malignant melanoma Fem-x and normal immunocompetent cells, peripheral blood mononuclear
cells PBMC. Alkenyl substitution, either on the cyclopentadienyl ring or on the silicon-atom ansa-bridge of the titanocene compounds
[Ti{Me2Si(g5-C5Me4)(g5-C5H3{CMe2CH2CH2CH@CH2})}Cl2] (8), [Ti{Me(CH2@CH)Si(g5-C5Me4)(g5-C5H4)}Cl2] (9) and [Ti(g5-
C5H4{CMe2CH2CH2CH@CH2})2Cl2] (12) showed higher cytotoxic activities (IC50 values from 24  } 3 to 151  } 10 lM) relative to complexes
bearing an additional alkenyl-substituted silyl substituent on the silicon bridge [Ti{Me{(CH2@CH)Me2SiCH2CH2}Si(g5-
C5Me4)(g5-C5H4)}Cl2] (10) and [Ti{Me{(CH2@CH)3SiCH2CH2}Si(g5-C5Me4)(g5-C5H4)}Cl2] (11) which causes a dramatic decrease
of the cytotoxicity (IC50 values from 155  } 9 to >200 lM). In addition, the synthesis of the analogous niobocene complex [Nb(g5-
C5H4{CMe2CH2CH2CH=CH2})2Cl2] (13), is described. Structural studies based on DFT calculations of the most active complexes 8,
9 and 12 and the X-ray crystal structure of 13 are reported.
PB  - Elsevier
T2  - Journal of Inorganic Biochemistry
T1  - Cytotoxic studies of substituted titanocene and ansa-titanocene anticancer drugs
VL  - 102
IS  - 8
SP  - 1558
EP  - 1570
DO  - 10.1016/j.jinorgbio.2008.02.001
ER  - 

@article{
author = "Gomez-Ruiz, Santiago and Kaluđerović, Goran N. and Prashar, Sanjiv and Polo-Ceron, Dorian and Fajardo, Mariano and Žižak, Željko and Sabo, Tibor and Juranić, Zorica",
year = "2008",
abstract = "A variety of substituted titanocene and ansa-titanocene complexes have been synthesized and characterized using traditional methods.
The cytotoxic activity of the different titanocene complexes was tested against tumour cell lines human adenocarcinoma HeLa, human
myelogenous leukemia K562, human malignant melanoma Fem-x and normal immunocompetent cells, peripheral blood mononuclear
cells PBMC. Alkenyl substitution, either on the cyclopentadienyl ring or on the silicon-atom ansa-bridge of the titanocene compounds
[Ti{Me2Si(g5-C5Me4)(g5-C5H3{CMe2CH2CH2CH@CH2})}Cl2] (8), [Ti{Me(CH2@CH)Si(g5-C5Me4)(g5-C5H4)}Cl2] (9) and [Ti(g5-
C5H4{CMe2CH2CH2CH@CH2})2Cl2] (12) showed higher cytotoxic activities (IC50 values from 24  } 3 to 151  } 10 lM) relative to complexes
bearing an additional alkenyl-substituted silyl substituent on the silicon bridge [Ti{Me{(CH2@CH)Me2SiCH2CH2}Si(g5-
C5Me4)(g5-C5H4)}Cl2] (10) and [Ti{Me{(CH2@CH)3SiCH2CH2}Si(g5-C5Me4)(g5-C5H4)}Cl2] (11) which causes a dramatic decrease
of the cytotoxicity (IC50 values from 155  } 9 to >200 lM). In addition, the synthesis of the analogous niobocene complex [Nb(g5-
C5H4{CMe2CH2CH2CH=CH2})2Cl2] (13), is described. Structural studies based on DFT calculations of the most active complexes 8,
9 and 12 and the X-ray crystal structure of 13 are reported.",
publisher = "Elsevier",
journal = "Journal of Inorganic Biochemistry",
title = "Cytotoxic studies of substituted titanocene and ansa-titanocene anticancer drugs",
volume = "102",
number = "8",
pages = "1558-1570",
doi = "10.1016/j.jinorgbio.2008.02.001"
}

Gomez-Ruiz, S., Kaluđerović, G. N., Prashar, S., Polo-Ceron, D., Fajardo, M., Žižak, Ž., Sabo, T.,& Juranić, Z.. (2008). Cytotoxic studies of substituted titanocene and ansa-titanocene anticancer drugs. in Journal of Inorganic Biochemistry
Elsevier., 102(8), 1558-1570.
https://doi.org/10.1016/j.jinorgbio.2008.02.001

Gomez-Ruiz S, Kaluđerović GN, Prashar S, Polo-Ceron D, Fajardo M, Žižak Ž, Sabo T, Juranić Z. Cytotoxic studies of substituted titanocene and ansa-titanocene anticancer drugs. in Journal of Inorganic Biochemistry. 2008;102(8):1558-1570.
doi:10.1016/j.jinorgbio.2008.02.001 .

Gomez-Ruiz, Santiago, Kaluđerović, Goran N., Prashar, Sanjiv, Polo-Ceron, Dorian, Fajardo, Mariano, Žižak, Željko, Sabo, Tibor, Juranić, Zorica, "Cytotoxic studies of substituted titanocene and ansa-titanocene anticancer drugs" in Journal of Inorganic Biochemistry, 102, no. 8 (2008):1558-1570,
https://doi.org/10.1016/j.jinorgbio.2008.02.001 . .