TY  - CONF
AU  - Acković, Jovana
AU  - Nedić, Zoran
AU  - Petrović, Tamara
AU  - Micić, Ružica
AU  - Pagnacco, Maja
AU  - Tančić, Pavle
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6628
AB  - In this work, synthesized 12-tungstenphosphoric acid (H3PW12O40 ∙ nH2O, PWA) was further
ionically exchanged with Fe3+ ions, which led to the formation of the FePWA salt (FePW12O40 x nH2O). FePWA was then subjected to thermal analysis (TGA/DTA), which determined the phase transition temperature ( i.e., when the Keggin anion collapses). The temperature of collapsing the Keggin anion is about 600 °C, at which phosphate tungsten bronzes doped with iron (FePWB) are obtained. Obtained FePWB was further characterized by XRPD and FTIR, which confirmed the formation of the desired structure. FePWA and FePWB were examined as an electrode material for aqueous rechargeable batteries due to the channels and cavities present in their structure. Experiments were done in aqueous solutions of 6 M LiNO3 by cyclic voltammetry. The differences in the redox processes of heteropoly acid salts and iron-doped bronze were discussed thoroughly and correlated with the XRPD and FTIR results. The catalytic activity is also investigated by Briggs-Rauscher method followed potentiometricaly.
PB  - Serbian Ceramic Society
C3  - Program and book of abstracts - Serbian Ceramics Society Conference - Advanced Ceramics and Application XI, New Frontiers in Multifunctional Material Science and Processing,18-20 th September 2023. Belgrade, Serbia
T1  - Electrochemical testing of iron phosphor tungsten bronzes as potential electrode material
SP  - 55
EP  - 55
UR  - https://hdl.handle.net/21.15107/rcub_cer_6628
ER  - 

@conference{
author = "Acković, Jovana and Nedić, Zoran and Petrović, Tamara and Micić, Ružica and Pagnacco, Maja and Tančić, Pavle",
year = "2023",
abstract = "In this work, synthesized 12-tungstenphosphoric acid (H3PW12O40 ∙ nH2O, PWA) was further
ionically exchanged with Fe3+ ions, which led to the formation of the FePWA salt (FePW12O40 x nH2O). FePWA was then subjected to thermal analysis (TGA/DTA), which determined the phase transition temperature ( i.e., when the Keggin anion collapses). The temperature of collapsing the Keggin anion is about 600 °C, at which phosphate tungsten bronzes doped with iron (FePWB) are obtained. Obtained FePWB was further characterized by XRPD and FTIR, which confirmed the formation of the desired structure. FePWA and FePWB were examined as an electrode material for aqueous rechargeable batteries due to the channels and cavities present in their structure. Experiments were done in aqueous solutions of 6 M LiNO3 by cyclic voltammetry. The differences in the redox processes of heteropoly acid salts and iron-doped bronze were discussed thoroughly and correlated with the XRPD and FTIR results. The catalytic activity is also investigated by Briggs-Rauscher method followed potentiometricaly.",
publisher = "Serbian Ceramic Society",
journal = "Program and book of abstracts - Serbian Ceramics Society Conference - Advanced Ceramics and Application XI, New Frontiers in Multifunctional Material Science and Processing,18-20 th September 2023. Belgrade, Serbia",
title = "Electrochemical testing of iron phosphor tungsten bronzes as potential electrode material",
pages = "55-55",
url = "https://hdl.handle.net/21.15107/rcub_cer_6628"
}

Acković, J., Nedić, Z., Petrović, T., Micić, R., Pagnacco, M.,& Tančić, P.. (2023). Electrochemical testing of iron phosphor tungsten bronzes as potential electrode material. in Program and book of abstracts - Serbian Ceramics Society Conference - Advanced Ceramics and Application XI, New Frontiers in Multifunctional Material Science and Processing,18-20 th September 2023. Belgrade, Serbia
Serbian Ceramic Society., 55-55.
https://hdl.handle.net/21.15107/rcub_cer_6628

Acković J, Nedić Z, Petrović T, Micić R, Pagnacco M, Tančić P. Electrochemical testing of iron phosphor tungsten bronzes as potential electrode material. in Program and book of abstracts - Serbian Ceramics Society Conference - Advanced Ceramics and Application XI, New Frontiers in Multifunctional Material Science and Processing,18-20 th September 2023. Belgrade, Serbia. 2023;:55-55.
https://hdl.handle.net/21.15107/rcub_cer_6628 .

Acković, Jovana, Nedić, Zoran, Petrović, Tamara, Micić, Ružica, Pagnacco, Maja, Tančić, Pavle, "Electrochemical testing of iron phosphor tungsten bronzes as potential electrode material" in Program and book of abstracts - Serbian Ceramics Society Conference - Advanced Ceramics and Application XI, New Frontiers in Multifunctional Material Science and Processing,18-20 th September 2023. Belgrade, Serbia (2023):55-55,
https://hdl.handle.net/21.15107/rcub_cer_6628 .

TY  - JOUR
AU  - Acković, Jovana
AU  - Micić, Ružica
AU  - Nedić, Zoran
AU  - Petrović, Tamara
AU  - Senćanski, Jelena
AU  - Pagnacco, Maja
AU  - Tančić, Pavle
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/7006
AB  - In this work, synthesized 12-tungstenphosphoric acid (H3PW12O40 × nH2O; PWA) was further ionically exchanged with Fe3+ ions, which led to the formation of the 12-tungstophosporic acid iron salt, (FePW12O40 × nH2O; Fe-PWA). Fe-PWA was then subjected to thermal analysis (TGA/DTA), determining the phase transition temperature of 576 °C from Fe-PWA to its corresponding phosphate tungsten bronze doped with iron, Fe-PWB. Using the X-ray powder diffraction (XRPD), Fourier-transform infrared spectroscopy (FTIR), and Scanning electron microscopy with an energy dispersive X-ray spectroscopy (SEM-EDS) method, the obtained Fe-PWA and Fe-PWB were additionally characterized, and compared. Due to channels and cavities in their structures, Fe-PWA and Fe-PWB were next examined as electrode materials for aqueous rechargeable batteries. Electrochemical measurements were done in aqueous solutions of 6 M LiNO3 by cyclic voltammetry. Fe-PWA and Fe-PWB exhibit different redox processes, which are discussed thoroughly in this work. Electrochemical results are showing that within the Fe-PWA structure, more Li+ ions can be intercalated in the first discharge cycle, but consecutive cycling leads to a fast capacity fade. While the Fe-PWB redox process was stable during cycling, its specific capacity is limited by the material's poor electrical conductivity. Improvements in Fe-PWB conductivity must be addressed in future studies in order to boost material’s electrochemical performance.
AB  - У овом раду синтетисана је 12-волфрам фосфорна киселина (H3PW12О40 × nH2О; PWA), која је даље јонски допирана са Fe3+ јонима, што је довело до формирања соли гвожђа 12-волфрам фосфорне киселине Fe-PWA соли (FePW12О40×nH2О). Fe-PWA је затим испитан помоћу термијске анализе (TGA/DTА), фазни прелаз Fe-PWA одиграва се на температури од 576 oC, формирајући фосфат волфрамову бронзу допирану гвожђем Fe-PWB. Применом 
метода дифракције рендгенских зрака на праху, инфрацрвене спектроскопије са Фуријеовом трансформацијом и скенирајуће електронске микроскопије уз енергетску дисперзивну рендгенску спектроскопију, добијени Fe-PWB је додатно карактерисан, чиме је потврђена жељена структура. Због канала и шупљина у њиховим структурама, Fe-PWA и Fe-PWB су затим испитани као електродни материјали за пуњиве батерије. Електрохемијска мерења вршена су у воденим растворима 6М LiNО3 цикличном волтаметријом. Електрохемијски резултати показују да унутар структуре Fe-PWA, више Li+ јона може бити интеркалирано 
у првом циклусу пражњења, али даље циклирање доводи до брзог смањења капацитета. Док је редокс процес Fe-PWB био стабилан током циклирања, његов специфични капацитет је ограничен слабом електричном проводљивошћу материјала. Специфични капацитет Fe-PWB је скоро незнатан, па је неопходно оптимизовати његове физичко-хемијске особине како би се вредност његовог специфичног капацитета повећала. Побољшање проводљивости Fe-PWB биће истраживана у будућим студијама, како би се побољшале електрохемијске 
перформансе материјала.
PB  - Association for ETRAN Society
T2  - Science of Sintering
T1  - Synthesis, characterization and electrochemical properties of iron doped phosphate tungsten heteropoly acid (Fe-PWA) and it’s bronze (Fe-PWB): Comparative study
DO  - 10.2298/SOS230812053A
ER  - 

@article{
author = "Acković, Jovana and Micić, Ružica and Nedić, Zoran and Petrović, Tamara and Senćanski, Jelena and Pagnacco, Maja and Tančić, Pavle",
year = "2023",
abstract = "In this work, synthesized 12-tungstenphosphoric acid (H3PW12O40 × nH2O; PWA) was further ionically exchanged with Fe3+ ions, which led to the formation of the 12-tungstophosporic acid iron salt, (FePW12O40 × nH2O; Fe-PWA). Fe-PWA was then subjected to thermal analysis (TGA/DTA), determining the phase transition temperature of 576 °C from Fe-PWA to its corresponding phosphate tungsten bronze doped with iron, Fe-PWB. Using the X-ray powder diffraction (XRPD), Fourier-transform infrared spectroscopy (FTIR), and Scanning electron microscopy with an energy dispersive X-ray spectroscopy (SEM-EDS) method, the obtained Fe-PWA and Fe-PWB were additionally characterized, and compared. Due to channels and cavities in their structures, Fe-PWA and Fe-PWB were next examined as electrode materials for aqueous rechargeable batteries. Electrochemical measurements were done in aqueous solutions of 6 M LiNO3 by cyclic voltammetry. Fe-PWA and Fe-PWB exhibit different redox processes, which are discussed thoroughly in this work. Electrochemical results are showing that within the Fe-PWA structure, more Li+ ions can be intercalated in the first discharge cycle, but consecutive cycling leads to a fast capacity fade. While the Fe-PWB redox process was stable during cycling, its specific capacity is limited by the material's poor electrical conductivity. Improvements in Fe-PWB conductivity must be addressed in future studies in order to boost material’s electrochemical performance., У овом раду синтетисана је 12-волфрам фосфорна киселина (H3PW12О40 × nH2О; PWA), која је даље јонски допирана са Fe3+ јонима, што је довело до формирања соли гвожђа 12-волфрам фосфорне киселине Fe-PWA соли (FePW12О40×nH2О). Fe-PWA је затим испитан помоћу термијске анализе (TGA/DTА), фазни прелаз Fe-PWA одиграва се на температури од 576 oC, формирајући фосфат волфрамову бронзу допирану гвожђем Fe-PWB. Применом 
метода дифракције рендгенских зрака на праху, инфрацрвене спектроскопије са Фуријеовом трансформацијом и скенирајуће електронске микроскопије уз енергетску дисперзивну рендгенску спектроскопију, добијени Fe-PWB је додатно карактерисан, чиме је потврђена жељена структура. Због канала и шупљина у њиховим структурама, Fe-PWA и Fe-PWB су затим испитани као електродни материјали за пуњиве батерије. Електрохемијска мерења вршена су у воденим растворима 6М LiNО3 цикличном волтаметријом. Електрохемијски резултати показују да унутар структуре Fe-PWA, више Li+ јона може бити интеркалирано 
у првом циклусу пражњења, али даље циклирање доводи до брзог смањења капацитета. Док је редокс процес Fe-PWB био стабилан током циклирања, његов специфични капацитет је ограничен слабом електричном проводљивошћу материјала. Специфични капацитет Fe-PWB је скоро незнатан, па је неопходно оптимизовати његове физичко-хемијске особине како би се вредност његовог специфичног капацитета повећала. Побољшање проводљивости Fe-PWB биће истраживана у будућим студијама, како би се побољшале електрохемијске 
перформансе материјала.",
publisher = "Association for ETRAN Society",
journal = "Science of Sintering",
title = "Synthesis, characterization and electrochemical properties of iron doped phosphate tungsten heteropoly acid (Fe-PWA) and it’s bronze (Fe-PWB): Comparative study",
doi = "10.2298/SOS230812053A"
}

Acković, J., Micić, R., Nedić, Z., Petrović, T., Senćanski, J., Pagnacco, M.,& Tančić, P.. (2023). Synthesis, characterization and electrochemical properties of iron doped phosphate tungsten heteropoly acid (Fe-PWA) and it’s bronze (Fe-PWB): Comparative study. in Science of Sintering
Association for ETRAN Society..
https://doi.org/10.2298/SOS230812053A

Acković J, Micić R, Nedić Z, Petrović T, Senćanski J, Pagnacco M, Tančić P. Synthesis, characterization and electrochemical properties of iron doped phosphate tungsten heteropoly acid (Fe-PWA) and it’s bronze (Fe-PWB): Comparative study. in Science of Sintering. 2023;.
doi:10.2298/SOS230812053A .

Acković, Jovana, Micić, Ružica, Nedić, Zoran, Petrović, Tamara, Senćanski, Jelena, Pagnacco, Maja, Tančić, Pavle, "Synthesis, characterization and electrochemical properties of iron doped phosphate tungsten heteropoly acid (Fe-PWA) and it’s bronze (Fe-PWB): Comparative study" in Science of Sintering (2023),
https://doi.org/10.2298/SOS230812053A . .

TY  - JOUR
AU  - Gavrilović, Branka R.
AU  - Petrović, Tamara G.
AU  - Radovanović, Tijana B.
AU  - Despotović, Svetlana G.
AU  - Gavrić, Jelena P.
AU  - Krizmanić, Imre I.
AU  - Ćirić, Miloš
AU  - Prokić, Marko D.
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3675
AB  - Although the long-term exposure of aquatic organisms to cyanobacterial blooms is a regular occurrence in the environment, the prooxidant and neurotoxic effects of such conditions are still insufficiently investigated in situ. We examined the temporal dynamics of the biochemical parameters in the liver of Pelophylax kl. esculentus frogs that inhabit the northern (N) side of Lake Ludaš (Serbia) with microcystins (MCs) produced in a cyanobacterial bloom over three summer months. The obtained data were compared with data on frogs that live on the southern (S), MC-free side of the same lake. Our results showed that the MC-producing bloom induced oxidative damage to proteins and lipids, observed as a decrease in the concentration of protein -SH groups and increased lipid peroxidation (LPO) in the liver of N frogs in comparison to S frogs. Glutathione (GSH) played a key role in the transient defense against the MC-induced development of LPO. The low glutathione peroxidase (GPx) activity detected in all groups of frogs from the N site was crucial for the observed prooxidant consequences. The bloom impaired cholinergic homeostasis as a result of a decrease in ChE activity. A delayed neurotoxic effect in relation to the prooxidant outcomes was observed. Our results also showed that even though the integrated biomarker response (IBR) of the antioxidant biomarkers increased during exposure, the individual biochemical parameters did not exhibit a well-defined time-dependent pattern because of specific adaptation dynamics and/or additional effects of the physicochemical parameters of the water. This comprehensive environmental ecotoxicological evaluation of the cyanobacterial bloom-induced biochemical alterations in the liver of frogs provides a new basis for further investigations of the prolonged, real-life ecotoxicity of the blooms.
PB  - Elsevier
T2  - Science of the Total Environment
T1  - Hepatic oxidative stress and neurotoxicity in Pelophylax kl. esculentus frogs: Influence of long-term exposure to a cyanobacterial bloom
VL  - 750
SP  - 141569
DO  - 10.1016/j.scitotenv.2020.141569
ER  - 

@article{
author = "Gavrilović, Branka R. and Petrović, Tamara G. and Radovanović, Tijana B. and Despotović, Svetlana G. and Gavrić, Jelena P. and Krizmanić, Imre I. and Ćirić, Miloš and Prokić, Marko D.",
year = "2021",
abstract = "Although the long-term exposure of aquatic organisms to cyanobacterial blooms is a regular occurrence in the environment, the prooxidant and neurotoxic effects of such conditions are still insufficiently investigated in situ. We examined the temporal dynamics of the biochemical parameters in the liver of Pelophylax kl. esculentus frogs that inhabit the northern (N) side of Lake Ludaš (Serbia) with microcystins (MCs) produced in a cyanobacterial bloom over three summer months. The obtained data were compared with data on frogs that live on the southern (S), MC-free side of the same lake. Our results showed that the MC-producing bloom induced oxidative damage to proteins and lipids, observed as a decrease in the concentration of protein -SH groups and increased lipid peroxidation (LPO) in the liver of N frogs in comparison to S frogs. Glutathione (GSH) played a key role in the transient defense against the MC-induced development of LPO. The low glutathione peroxidase (GPx) activity detected in all groups of frogs from the N site was crucial for the observed prooxidant consequences. The bloom impaired cholinergic homeostasis as a result of a decrease in ChE activity. A delayed neurotoxic effect in relation to the prooxidant outcomes was observed. Our results also showed that even though the integrated biomarker response (IBR) of the antioxidant biomarkers increased during exposure, the individual biochemical parameters did not exhibit a well-defined time-dependent pattern because of specific adaptation dynamics and/or additional effects of the physicochemical parameters of the water. This comprehensive environmental ecotoxicological evaluation of the cyanobacterial bloom-induced biochemical alterations in the liver of frogs provides a new basis for further investigations of the prolonged, real-life ecotoxicity of the blooms.",
publisher = "Elsevier",
journal = "Science of the Total Environment",
title = "Hepatic oxidative stress and neurotoxicity in Pelophylax kl. esculentus frogs: Influence of long-term exposure to a cyanobacterial bloom",
volume = "750",
pages = "141569",
doi = "10.1016/j.scitotenv.2020.141569"
}

Gavrilović, B. R., Petrović, T. G., Radovanović, T. B., Despotović, S. G., Gavrić, J. P., Krizmanić, I. I., Ćirić, M.,& Prokić, M. D.. (2021). Hepatic oxidative stress and neurotoxicity in Pelophylax kl. esculentus frogs: Influence of long-term exposure to a cyanobacterial bloom. in Science of the Total Environment
Elsevier., 750, 141569.
https://doi.org/10.1016/j.scitotenv.2020.141569

Gavrilović BR, Petrović TG, Radovanović TB, Despotović SG, Gavrić JP, Krizmanić II, Ćirić M, Prokić MD. Hepatic oxidative stress and neurotoxicity in Pelophylax kl. esculentus frogs: Influence of long-term exposure to a cyanobacterial bloom. in Science of the Total Environment. 2021;750:141569.
doi:10.1016/j.scitotenv.2020.141569 .

Gavrilović, Branka R., Petrović, Tamara G., Radovanović, Tijana B., Despotović, Svetlana G., Gavrić, Jelena P., Krizmanić, Imre I., Ćirić, Miloš, Prokić, Marko D., "Hepatic oxidative stress and neurotoxicity in Pelophylax kl. esculentus frogs: Influence of long-term exposure to a cyanobacterial bloom" in Science of the Total Environment, 750 (2021):141569,
https://doi.org/10.1016/j.scitotenv.2020.141569 . .

TY  - JOUR
AU  - Gavrilović, Branka R.
AU  - Petrović, Tamara G.
AU  - Radovanović, Tijana B.
AU  - Despotović, Svetlana G.
AU  - Gavrić, Jelena P.
AU  - Krizmanić, Imre I.
AU  - Ćirić, Miloš
AU  - Prokić, Marko D.
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3677
AB  - Although the long-term exposure of aquatic organisms to cyanobacterial blooms is a regular occurrence in the environment, the prooxidant and neurotoxic effects of such conditions are still insufficiently investigated in situ. We examined the temporal dynamics of the biochemical parameters in the liver of Pelophylax kl. esculentus frogs that inhabit the northern (N) side of Lake Ludaš (Serbia) with microcystins (MCs) produced in a cyanobacterial bloom over three summer months. The obtained data were compared with data on frogs that live on the southern (S), MC-free side of the same lake. Our results showed that the MC-producing bloom induced oxidative damage to proteins and lipids, observed as a decrease in the concentration of protein -SH groups and increased lipid peroxidation (LPO) in the liver of N frogs in comparison to S frogs. Glutathione (GSH) played a key role in the transient defense against the MC-induced development of LPO. The low glutathione peroxidase (GPx) activity detected in all groups of frogs from the N site was crucial for the observed prooxidant consequences. The bloom impaired cholinergic homeostasis as a result of a decrease in ChE activity. A delayed neurotoxic effect in relation to the prooxidant outcomes was observed. Our results also showed that even though the integrated biomarker response (IBR) of the antioxidant biomarkers increased during exposure, the individual biochemical parameters did not exhibit a well-defined time-dependent pattern because of specific adaptation dynamics and/or additional effects of the physicochemical parameters of the water. This comprehensive environmental ecotoxicological evaluation of the cyanobacterial bloom-induced biochemical alterations in the liver of frogs provides a new basis for further investigations of the prolonged, real-life ecotoxicity of the blooms.
PB  - Elsevier
T2  - Science of the Total Environment
T1  - Hepatic oxidative stress and neurotoxicity in Pelophylax kl. esculentus frogs: Influence of long-term exposure to a cyanobacterial bloom
VL  - 750
SP  - 141569
DO  - 10.1016/j.scitotenv.2020.141569
ER  - 

@article{
author = "Gavrilović, Branka R. and Petrović, Tamara G. and Radovanović, Tijana B. and Despotović, Svetlana G. and Gavrić, Jelena P. and Krizmanić, Imre I. and Ćirić, Miloš and Prokić, Marko D.",
year = "2021",
abstract = "Although the long-term exposure of aquatic organisms to cyanobacterial blooms is a regular occurrence in the environment, the prooxidant and neurotoxic effects of such conditions are still insufficiently investigated in situ. We examined the temporal dynamics of the biochemical parameters in the liver of Pelophylax kl. esculentus frogs that inhabit the northern (N) side of Lake Ludaš (Serbia) with microcystins (MCs) produced in a cyanobacterial bloom over three summer months. The obtained data were compared with data on frogs that live on the southern (S), MC-free side of the same lake. Our results showed that the MC-producing bloom induced oxidative damage to proteins and lipids, observed as a decrease in the concentration of protein -SH groups and increased lipid peroxidation (LPO) in the liver of N frogs in comparison to S frogs. Glutathione (GSH) played a key role in the transient defense against the MC-induced development of LPO. The low glutathione peroxidase (GPx) activity detected in all groups of frogs from the N site was crucial for the observed prooxidant consequences. The bloom impaired cholinergic homeostasis as a result of a decrease in ChE activity. A delayed neurotoxic effect in relation to the prooxidant outcomes was observed. Our results also showed that even though the integrated biomarker response (IBR) of the antioxidant biomarkers increased during exposure, the individual biochemical parameters did not exhibit a well-defined time-dependent pattern because of specific adaptation dynamics and/or additional effects of the physicochemical parameters of the water. This comprehensive environmental ecotoxicological evaluation of the cyanobacterial bloom-induced biochemical alterations in the liver of frogs provides a new basis for further investigations of the prolonged, real-life ecotoxicity of the blooms.",
publisher = "Elsevier",
journal = "Science of the Total Environment",
title = "Hepatic oxidative stress and neurotoxicity in Pelophylax kl. esculentus frogs: Influence of long-term exposure to a cyanobacterial bloom",
volume = "750",
pages = "141569",
doi = "10.1016/j.scitotenv.2020.141569"
}

Gavrilović, B. R., Petrović, T. G., Radovanović, T. B., Despotović, S. G., Gavrić, J. P., Krizmanić, I. I., Ćirić, M.,& Prokić, M. D.. (2021). Hepatic oxidative stress and neurotoxicity in Pelophylax kl. esculentus frogs: Influence of long-term exposure to a cyanobacterial bloom. in Science of the Total Environment
Elsevier., 750, 141569.
https://doi.org/10.1016/j.scitotenv.2020.141569

Gavrilović BR, Petrović TG, Radovanović TB, Despotović SG, Gavrić JP, Krizmanić II, Ćirić M, Prokić MD. Hepatic oxidative stress and neurotoxicity in Pelophylax kl. esculentus frogs: Influence of long-term exposure to a cyanobacterial bloom. in Science of the Total Environment. 2021;750:141569.
doi:10.1016/j.scitotenv.2020.141569 .

Gavrilović, Branka R., Petrović, Tamara G., Radovanović, Tijana B., Despotović, Svetlana G., Gavrić, Jelena P., Krizmanić, Imre I., Ćirić, Miloš, Prokić, Marko D., "Hepatic oxidative stress and neurotoxicity in Pelophylax kl. esculentus frogs: Influence of long-term exposure to a cyanobacterial bloom" in Science of the Total Environment, 750 (2021):141569,
https://doi.org/10.1016/j.scitotenv.2020.141569 . .

TY  - JOUR
AU  - Pavlović, Marijana
AU  - Tadić, Ana
AU  - Gligorijević, Nevenka
AU  - Poljarević, Jelena
AU  - Petrović, Tamara G.
AU  - Dojčinović, Biljana
AU  - Savić, Aleksandar
AU  - Radulović, Siniša
PY  - 2020
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3634
AB  - Inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1) showed remarkable clinical efficacy in BRCA-mutated tumors. Based on the rational drug design, derivatives of PARP inhibitor 3-aminobenzamide (3-AB), 2-amino-4-methylbenzamide (L1) and 3-amino-N-methylbenzamide (L2), were coordinated to the ruthenium(II) ion, to form potential drugs affecting DNA and inhibiting PARP enzyme. The four conjugated complexes of formula: C1 [(ƞ6-toluene)Ru(L1)Cl]PF6, C2 [(ƞ6-p-cymene)Ru(L1)Cl]PF6, C3 [(ƞ6-toluene)Ru(L2)Cl2] and C4 [(ƞ6-p-cymene)Ru(L2)Cl2], have been synthesized and characterized. Colorimetric 3-(4.5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide (MTT) assay showed the highest antiproliferative activity of C1 in HCC1937, MDA-MB-231, and MCF-7 breast cancer cells. Efficiency of inhibition of PARP-1 enzymatic activity in vitro decreased in order: C2 > C4 > 3-AB>C1 > C3. ICP-MS study of intracellular accumulation and distribution in BRCA1-mutated HCC1937 revealed that C1-C4 entered cells within 24 h. The complex C1 showed the highest intracellular accumulation, nuclear-targeting properties, and exhibited the highest DNA binding (39.2 ± 0.6 pg of Ru per μg of DNA) that resulted in the cell cycle arrest in the S phase.
PB  - Elsevier
T2  - Journal of Inorganic Biochemistry
T1  - Synthesis, chemical characterization, PARP inhibition, DNA binding and cellular uptake of novel ruthenium(II)-arene complexes bearing benzamide derivatives in human breast cancer cells
VL  - 210
SP  - 111155
DO  - 10.1016/j.jinorgbio.2020.111155
ER  - 

@article{
author = "Pavlović, Marijana and Tadić, Ana and Gligorijević, Nevenka and Poljarević, Jelena and Petrović, Tamara G. and Dojčinović, Biljana and Savić, Aleksandar and Radulović, Siniša",
year = "2020",
abstract = "Inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1) showed remarkable clinical efficacy in BRCA-mutated tumors. Based on the rational drug design, derivatives of PARP inhibitor 3-aminobenzamide (3-AB), 2-amino-4-methylbenzamide (L1) and 3-amino-N-methylbenzamide (L2), were coordinated to the ruthenium(II) ion, to form potential drugs affecting DNA and inhibiting PARP enzyme. The four conjugated complexes of formula: C1 [(ƞ6-toluene)Ru(L1)Cl]PF6, C2 [(ƞ6-p-cymene)Ru(L1)Cl]PF6, C3 [(ƞ6-toluene)Ru(L2)Cl2] and C4 [(ƞ6-p-cymene)Ru(L2)Cl2], have been synthesized and characterized. Colorimetric 3-(4.5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide (MTT) assay showed the highest antiproliferative activity of C1 in HCC1937, MDA-MB-231, and MCF-7 breast cancer cells. Efficiency of inhibition of PARP-1 enzymatic activity in vitro decreased in order: C2 > C4 > 3-AB>C1 > C3. ICP-MS study of intracellular accumulation and distribution in BRCA1-mutated HCC1937 revealed that C1-C4 entered cells within 24 h. The complex C1 showed the highest intracellular accumulation, nuclear-targeting properties, and exhibited the highest DNA binding (39.2 ± 0.6 pg of Ru per μg of DNA) that resulted in the cell cycle arrest in the S phase.",
publisher = "Elsevier",
journal = "Journal of Inorganic Biochemistry",
title = "Synthesis, chemical characterization, PARP inhibition, DNA binding and cellular uptake of novel ruthenium(II)-arene complexes bearing benzamide derivatives in human breast cancer cells",
volume = "210",
pages = "111155",
doi = "10.1016/j.jinorgbio.2020.111155"
}

Pavlović, M., Tadić, A., Gligorijević, N., Poljarević, J., Petrović, T. G., Dojčinović, B., Savić, A.,& Radulović, S.. (2020). Synthesis, chemical characterization, PARP inhibition, DNA binding and cellular uptake of novel ruthenium(II)-arene complexes bearing benzamide derivatives in human breast cancer cells. in Journal of Inorganic Biochemistry
Elsevier., 210, 111155.
https://doi.org/10.1016/j.jinorgbio.2020.111155

Pavlović M, Tadić A, Gligorijević N, Poljarević J, Petrović TG, Dojčinović B, Savić A, Radulović S. Synthesis, chemical characterization, PARP inhibition, DNA binding and cellular uptake of novel ruthenium(II)-arene complexes bearing benzamide derivatives in human breast cancer cells. in Journal of Inorganic Biochemistry. 2020;210:111155.
doi:10.1016/j.jinorgbio.2020.111155 .

Pavlović, Marijana, Tadić, Ana, Gligorijević, Nevenka, Poljarević, Jelena, Petrović, Tamara G., Dojčinović, Biljana, Savić, Aleksandar, Radulović, Siniša, "Synthesis, chemical characterization, PARP inhibition, DNA binding and cellular uptake of novel ruthenium(II)-arene complexes bearing benzamide derivatives in human breast cancer cells" in Journal of Inorganic Biochemistry, 210 (2020):111155,
https://doi.org/10.1016/j.jinorgbio.2020.111155 . .

TY  - JOUR
AU  - Pavlović, Marijana
AU  - Tadić, Ana
AU  - Gligorijević, Nevenka
AU  - Poljarević, Jelena
AU  - Petrović, Tamara G.
AU  - Dojčinović, Biljana
AU  - Savić, Aleksandar
AU  - Radulović, Siniša
PY  - 2020
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3713
AB  - Inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1) showed remarkable clinical efficacy in BRCA-mutated tumors. Based on the rational drug design, derivatives of PARP inhibitor 3-aminobenzamide (3-AB), 2-amino-4-methylbenzamide (L1) and 3-amino-N-methylbenzamide (L2), were coordinated to the ruthenium(II) ion, to form potential drugs affecting DNA and inhibiting PARP enzyme. The four conjugated complexes of formula: C1 [(ƞ6-toluene)Ru(L1)Cl]PF6, C2 [(ƞ6-p-cymene)Ru(L1)Cl]PF6, C3 [(ƞ6-toluene)Ru(L2)Cl2] and C4 [(ƞ6-p-cymene)Ru(L2)Cl2], have been synthesized and characterized. Colorimetric 3-(4.5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide (MTT) assay showed the highest antiproliferative activity of C1 in HCC1937, MDA-MB-231, and MCF-7 breast cancer cells. Efficiency of inhibition of PARP-1 enzymatic activity in vitro decreased in order: C2 > C4 > 3-AB>C1 > C3. ICP-MS study of intracellular accumulation and distribution in BRCA1-mutated HCC1937 revealed that C1-C4 entered cells within 24 h. The complex C1 showed the highest intracellular accumulation, nuclear-targeting properties, and exhibited the highest DNA binding (39.2 ± 0.6 pg of Ru per μg of DNA) that resulted in the cell cycle arrest in the S phase.
PB  - Elsevier
T2  - Journal of Inorganic Biochemistry
T1  - Synthesis, chemical characterization, PARP inhibition, DNA binding and cellular uptake of novel ruthenium(II)-arene complexes bearing benzamide derivatives in human breast cancer cells
VL  - 210
SP  - 111155
DO  - 10.1016/j.jinorgbio.2020.111155
ER  - 

@article{
author = "Pavlović, Marijana and Tadić, Ana and Gligorijević, Nevenka and Poljarević, Jelena and Petrović, Tamara G. and Dojčinović, Biljana and Savić, Aleksandar and Radulović, Siniša",
year = "2020",
abstract = "Inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1) showed remarkable clinical efficacy in BRCA-mutated tumors. Based on the rational drug design, derivatives of PARP inhibitor 3-aminobenzamide (3-AB), 2-amino-4-methylbenzamide (L1) and 3-amino-N-methylbenzamide (L2), were coordinated to the ruthenium(II) ion, to form potential drugs affecting DNA and inhibiting PARP enzyme. The four conjugated complexes of formula: C1 [(ƞ6-toluene)Ru(L1)Cl]PF6, C2 [(ƞ6-p-cymene)Ru(L1)Cl]PF6, C3 [(ƞ6-toluene)Ru(L2)Cl2] and C4 [(ƞ6-p-cymene)Ru(L2)Cl2], have been synthesized and characterized. Colorimetric 3-(4.5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide (MTT) assay showed the highest antiproliferative activity of C1 in HCC1937, MDA-MB-231, and MCF-7 breast cancer cells. Efficiency of inhibition of PARP-1 enzymatic activity in vitro decreased in order: C2 > C4 > 3-AB>C1 > C3. ICP-MS study of intracellular accumulation and distribution in BRCA1-mutated HCC1937 revealed that C1-C4 entered cells within 24 h. The complex C1 showed the highest intracellular accumulation, nuclear-targeting properties, and exhibited the highest DNA binding (39.2 ± 0.6 pg of Ru per μg of DNA) that resulted in the cell cycle arrest in the S phase.",
publisher = "Elsevier",
journal = "Journal of Inorganic Biochemistry",
title = "Synthesis, chemical characterization, PARP inhibition, DNA binding and cellular uptake of novel ruthenium(II)-arene complexes bearing benzamide derivatives in human breast cancer cells",
volume = "210",
pages = "111155",
doi = "10.1016/j.jinorgbio.2020.111155"
}

Pavlović, M., Tadić, A., Gligorijević, N., Poljarević, J., Petrović, T. G., Dojčinović, B., Savić, A.,& Radulović, S.. (2020). Synthesis, chemical characterization, PARP inhibition, DNA binding and cellular uptake of novel ruthenium(II)-arene complexes bearing benzamide derivatives in human breast cancer cells. in Journal of Inorganic Biochemistry
Elsevier., 210, 111155.
https://doi.org/10.1016/j.jinorgbio.2020.111155

Pavlović M, Tadić A, Gligorijević N, Poljarević J, Petrović TG, Dojčinović B, Savić A, Radulović S. Synthesis, chemical characterization, PARP inhibition, DNA binding and cellular uptake of novel ruthenium(II)-arene complexes bearing benzamide derivatives in human breast cancer cells. in Journal of Inorganic Biochemistry. 2020;210:111155.
doi:10.1016/j.jinorgbio.2020.111155 .

Pavlović, Marijana, Tadić, Ana, Gligorijević, Nevenka, Poljarević, Jelena, Petrović, Tamara G., Dojčinović, Biljana, Savić, Aleksandar, Radulović, Siniša, "Synthesis, chemical characterization, PARP inhibition, DNA binding and cellular uptake of novel ruthenium(II)-arene complexes bearing benzamide derivatives in human breast cancer cells" in Journal of Inorganic Biochemistry, 210 (2020):111155,
https://doi.org/10.1016/j.jinorgbio.2020.111155 . .

TY  - JOUR
AU  - Gavrilović, Branka R.
AU  - Prokić, Marko D.
AU  - Petrović, Tamara G.
AU  - Despotović, Svetlana G.
AU  - Radovanović, Tijana B.
AU  - Krizmanić, Imre I.
AU  - Ćirić, Miloš
AU  - Gavrić, Jelena P.
PY  - 2020
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3343
AB  - There is little information in scientific literature as to how conditions created by a microcystin (MC) producing cyanobacterial bloom affect the oxidant/antioxidant, biotransformation and neurotoxicity parameters in adult frogs in situ. We investigated biochemical parameters in the skin and muscle of Pelophylax kl. esculentus from Lake Ludaš (Serbia) by comparing frogs that live on the northern bloom side (BS) of the lake with those that inhabit the southern no-bloom side (NBS). A higher protein carbonylation level and lower antioxidant defense system capability in the skin of frogs living in conditions of the cyanobacterial bloom were observed. Inhibition of glutathione-dependent machinery was the major mechanism responsible for the induction of cyanobacterial bloom-mediated oxidative stress in frog skin. On the other hand, the detected higher ability of muscle to overcome bloom prooxidant toxicity was linked to a higher efficiency of the biotransformation system through glutathione-S-transferase activity and/or was the consequence of indirect exposure of the tissue to the bloom. Our results have also revealed that the cyanobacterial bloom conditions induced the cholinergic neurotransmitter system in both tissues. This study provides a better understanding of the ecotoxicological impact of the MC producing cyanobacterial bloom on frogs in situ. However, further investigations of the complex mechanism involved in cyanobacterial bloom toxicity in real environmental conditions are required.
PB  - Elsevier
T2  - Aquatic Toxicology
T1  - Biochemical parameters in skin and muscle of Pelophylax kl. esculentus frogs: Influence of a cyanobacterial bloom in situ
VL  - 220
SP  - 105399
DO  - 10.1016/j.aquatox.2019.105399
ER  - 

@article{
author = "Gavrilović, Branka R. and Prokić, Marko D. and Petrović, Tamara G. and Despotović, Svetlana G. and Radovanović, Tijana B. and Krizmanić, Imre I. and Ćirić, Miloš and Gavrić, Jelena P.",
year = "2020",
abstract = "There is little information in scientific literature as to how conditions created by a microcystin (MC) producing cyanobacterial bloom affect the oxidant/antioxidant, biotransformation and neurotoxicity parameters in adult frogs in situ. We investigated biochemical parameters in the skin and muscle of Pelophylax kl. esculentus from Lake Ludaš (Serbia) by comparing frogs that live on the northern bloom side (BS) of the lake with those that inhabit the southern no-bloom side (NBS). A higher protein carbonylation level and lower antioxidant defense system capability in the skin of frogs living in conditions of the cyanobacterial bloom were observed. Inhibition of glutathione-dependent machinery was the major mechanism responsible for the induction of cyanobacterial bloom-mediated oxidative stress in frog skin. On the other hand, the detected higher ability of muscle to overcome bloom prooxidant toxicity was linked to a higher efficiency of the biotransformation system through glutathione-S-transferase activity and/or was the consequence of indirect exposure of the tissue to the bloom. Our results have also revealed that the cyanobacterial bloom conditions induced the cholinergic neurotransmitter system in both tissues. This study provides a better understanding of the ecotoxicological impact of the MC producing cyanobacterial bloom on frogs in situ. However, further investigations of the complex mechanism involved in cyanobacterial bloom toxicity in real environmental conditions are required.",
publisher = "Elsevier",
journal = "Aquatic Toxicology",
title = "Biochemical parameters in skin and muscle of Pelophylax kl. esculentus frogs: Influence of a cyanobacterial bloom in situ",
volume = "220",
pages = "105399",
doi = "10.1016/j.aquatox.2019.105399"
}

Gavrilović, B. R., Prokić, M. D., Petrović, T. G., Despotović, S. G., Radovanović, T. B., Krizmanić, I. I., Ćirić, M.,& Gavrić, J. P.. (2020). Biochemical parameters in skin and muscle of Pelophylax kl. esculentus frogs: Influence of a cyanobacterial bloom in situ. in Aquatic Toxicology
Elsevier., 220, 105399.
https://doi.org/10.1016/j.aquatox.2019.105399

Gavrilović BR, Prokić MD, Petrović TG, Despotović SG, Radovanović TB, Krizmanić II, Ćirić M, Gavrić JP. Biochemical parameters in skin and muscle of Pelophylax kl. esculentus frogs: Influence of a cyanobacterial bloom in situ. in Aquatic Toxicology. 2020;220:105399.
doi:10.1016/j.aquatox.2019.105399 .

Gavrilović, Branka R., Prokić, Marko D., Petrović, Tamara G., Despotović, Svetlana G., Radovanović, Tijana B., Krizmanić, Imre I., Ćirić, Miloš, Gavrić, Jelena P., "Biochemical parameters in skin and muscle of Pelophylax kl. esculentus frogs: Influence of a cyanobacterial bloom in situ" in Aquatic Toxicology, 220 (2020):105399,
https://doi.org/10.1016/j.aquatox.2019.105399 . .