TY  - JOUR
AU  - Trifunović-Macedoljan, Jelena
AU  - Pantelić, Nebojša Đ.
AU  - Jadranin, Milka
AU  - Juranić, Ivan
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3261
AB  - The biosynthetic pathway of biogenic amines is very active during the growth of many tumour cells. Non-Hodgkin lymphoma represents a very heterogeneous group of malignancies. The concentration level of some biogenic amines (putrescine, histamine, spermidine, epinephrine, and spermine) was investigated to elucidate whether they could be observed as markers for the patients with non-Hodgkin’s lymphoma. In this study, the method of acidic extraction of five biogenic amines from human serum, dansyl chloride pre-column derivatization, and LC/DAD analysis were used to determine the content of biogenic amines in biological fluids. The results indicate that statistically significant differences exist in putrescine, spermidine and histamine contents in non-Hodgkin’s patients versus healthy controls. The concentrations of putrescine, spermidine and epinephrine were elevated, and histamine was lower compared to controls. Based on their content, serum biogenic amines could be considered as potential tumour markers.
PB  - Editura Academiei Romane
T2  - Revue Roumaine de Chimie
T1  - Biogenic amines content in the serum of patients with non-Hodgkin’s lymphoma
VL  - 64
IS  - 8
SP  - 681
EP  - 686
DO  - 10.3224/rrch.2019.64.8.05
ER  - 

@article{
author = "Trifunović-Macedoljan, Jelena and Pantelić, Nebojša Đ. and Jadranin, Milka and Juranić, Ivan",
year = "2019",
abstract = "The biosynthetic pathway of biogenic amines is very active during the growth of many tumour cells. Non-Hodgkin lymphoma represents a very heterogeneous group of malignancies. The concentration level of some biogenic amines (putrescine, histamine, spermidine, epinephrine, and spermine) was investigated to elucidate whether they could be observed as markers for the patients with non-Hodgkin’s lymphoma. In this study, the method of acidic extraction of five biogenic amines from human serum, dansyl chloride pre-column derivatization, and LC/DAD analysis were used to determine the content of biogenic amines in biological fluids. The results indicate that statistically significant differences exist in putrescine, spermidine and histamine contents in non-Hodgkin’s patients versus healthy controls. The concentrations of putrescine, spermidine and epinephrine were elevated, and histamine was lower compared to controls. Based on their content, serum biogenic amines could be considered as potential tumour markers.",
publisher = "Editura Academiei Romane",
journal = "Revue Roumaine de Chimie",
title = "Biogenic amines content in the serum of patients with non-Hodgkin’s lymphoma",
volume = "64",
number = "8",
pages = "681-686",
doi = "10.3224/rrch.2019.64.8.05"
}

Trifunović-Macedoljan, J., Pantelić, N. Đ., Jadranin, M.,& Juranić, I.. (2019). Biogenic amines content in the serum of patients with non-Hodgkin’s lymphoma. in Revue Roumaine de Chimie
Editura Academiei Romane., 64(8), 681-686.
https://doi.org/10.3224/rrch.2019.64.8.05

Trifunović-Macedoljan J, Pantelić NĐ, Jadranin M, Juranić I. Biogenic amines content in the serum of patients with non-Hodgkin’s lymphoma. in Revue Roumaine de Chimie. 2019;64(8):681-686.
doi:10.3224/rrch.2019.64.8.05 .

Trifunović-Macedoljan, Jelena, Pantelić, Nebojša Đ., Jadranin, Milka, Juranić, Ivan, "Biogenic amines content in the serum of patients with non-Hodgkin’s lymphoma" in Revue Roumaine de Chimie, 64, no. 8 (2019):681-686,
https://doi.org/10.3224/rrch.2019.64.8.05 . .