TY  - CONF
AU  - Milojković-Opsenica, Dušanka
AU  - Rosić, Anđelka
AU  - Krstić, Đurđa
AU  - Trifković, Jelena
AU  - Tosti, Tomislav
AU  - Šegan, Sandra
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6736
AB  - Honey is a natural sweet product of honeybees widely consumed by people as both a food and
a medicine. It is mainly composed of carbohydrates, primarily fructose and glucose, followed by
sucrose and other oligosaccharides present in lower quantity. Due to its nutritional and health
benefits and relatively high price, honey is frequently subjected to adulteration either by
addition of sugar syrups or cheaper and lower quality honey, or by mislabeling of declaration.
Numerous analytical methods, such as chromatographic, spectroscopic, isotopic, and
electrochemical, have been developed to detect honey adulterants.[1] Application of thin-layer
chromatography (TLC) in the detection of syrup adulterants is limited due to the hydrolysis of
polysaccharides and a presence of false positive components such as smaller oligosaccharides
(from 3 to 6 monosaccharide units). However, with the development of high-performance layers
and sophisticated instrumentation, high-performance TLC (HPTLC) should become a method of
choice in determination of honey authenticity.
PB  - Croatian Chemical Society
C3  - Book of abstracts - 27th Croatian Meeting of Chemists and Chemical Engineers / 5 th Symposium Vladimir Prelog, 5-8 October 2021, Veli Lošinj, Vitality Hotel Punta, Croatia
T1  - Development and validation of HPTLC method for determination of sugar profiles of honey and its syrup adulterants
SP  - 244
EP  - 244
UR  - https://hdl.handle.net/21.15107/rcub_cer_6736
ER  - 

@conference{
author = "Milojković-Opsenica, Dušanka and Rosić, Anđelka and Krstić, Đurđa and Trifković, Jelena and Tosti, Tomislav and Šegan, Sandra",
year = "2021",
abstract = "Honey is a natural sweet product of honeybees widely consumed by people as both a food and
a medicine. It is mainly composed of carbohydrates, primarily fructose and glucose, followed by
sucrose and other oligosaccharides present in lower quantity. Due to its nutritional and health
benefits and relatively high price, honey is frequently subjected to adulteration either by
addition of sugar syrups or cheaper and lower quality honey, or by mislabeling of declaration.
Numerous analytical methods, such as chromatographic, spectroscopic, isotopic, and
electrochemical, have been developed to detect honey adulterants.[1] Application of thin-layer
chromatography (TLC) in the detection of syrup adulterants is limited due to the hydrolysis of
polysaccharides and a presence of false positive components such as smaller oligosaccharides
(from 3 to 6 monosaccharide units). However, with the development of high-performance layers
and sophisticated instrumentation, high-performance TLC (HPTLC) should become a method of
choice in determination of honey authenticity.",
publisher = "Croatian Chemical Society",
journal = "Book of abstracts - 27th Croatian Meeting of Chemists and Chemical Engineers / 5 th Symposium Vladimir Prelog, 5-8 October 2021, Veli Lošinj, Vitality Hotel Punta, Croatia",
title = "Development and validation of HPTLC method for determination of sugar profiles of honey and its syrup adulterants",
pages = "244-244",
url = "https://hdl.handle.net/21.15107/rcub_cer_6736"
}

Milojković-Opsenica, D., Rosić, A., Krstić, Đ., Trifković, J., Tosti, T.,& Šegan, S.. (2021). Development and validation of HPTLC method for determination of sugar profiles of honey and its syrup adulterants. in Book of abstracts - 27th Croatian Meeting of Chemists and Chemical Engineers / 5 th Symposium Vladimir Prelog, 5-8 October 2021, Veli Lošinj, Vitality Hotel Punta, Croatia
Croatian Chemical Society., 244-244.
https://hdl.handle.net/21.15107/rcub_cer_6736

Milojković-Opsenica D, Rosić A, Krstić Đ, Trifković J, Tosti T, Šegan S. Development and validation of HPTLC method for determination of sugar profiles of honey and its syrup adulterants. in Book of abstracts - 27th Croatian Meeting of Chemists and Chemical Engineers / 5 th Symposium Vladimir Prelog, 5-8 October 2021, Veli Lošinj, Vitality Hotel Punta, Croatia. 2021;:244-244.
https://hdl.handle.net/21.15107/rcub_cer_6736 .

Milojković-Opsenica, Dušanka, Rosić, Anđelka, Krstić, Đurđa, Trifković, Jelena, Tosti, Tomislav, Šegan, Sandra, "Development and validation of HPTLC method for determination of sugar profiles of honey and its syrup adulterants" in Book of abstracts - 27th Croatian Meeting of Chemists and Chemical Engineers / 5 th Symposium Vladimir Prelog, 5-8 October 2021, Veli Lošinj, Vitality Hotel Punta, Croatia (2021):244-244,
https://hdl.handle.net/21.15107/rcub_cer_6736 .

TY  - JOUR
AU  - Spahic, Maja Poznanovic
AU  - Sakan, Sanja
AU  - Cvetkovic, Zeljko
AU  - Tančić, Pavle
AU  - Trifković, Jelena
AU  - Nikić, Zoran
AU  - Manojlović, Dragan
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2344
AB  - Content of potentially toxic elements was examined in soils from Srem (Vojvodina), to evaluate industrial facilities as pollution sources. Based on the distribution of the elements, the results of sequential extraction, enrichment factor (EF), ecological risk factor (Er), ecological risk index (RI), and statistical analysis, the current ecological status of the soils was determined. Elements in soils around the industrial facilities can be grouped into the five significant components derived by the principal component analysis (PCA), which explains 78.435% of the total variance. Al, Fe and Mg, and K and Mn are associated with two lithogenic components, respectively. Anthropogenic origin is identified for Hg and Cd. Mixed sources, geogenic and anthropogenic, are identified within two PCA components; one wich includes As, Pb, B, Zn, and the other: K and Cr, Ni and Cu. Cluster analysis (CA) corroborated the results obtained by PCA. The preliminary results revealed that the soils studied in a vicinity of industrial facilities in Srem have been exposed to different degrees of pollution. Among the characterized studied elements, Pb, Cd, Hg, Cu, Ni, and Cr are the main contaminants. Based on calculated EF, the studied soils show minor to severe enrichment with heavy metals. Ecological risk assessment results indicate that Cd and Hg carry the highest ecological risk level, and Zn and Cr the lowest.
PB  - Springer, Dordrecht
T2  - Environmental Monitoring and Assessment
T1  - Assessment of contamination, environmental risk, and origin of heavy metals in soils surrounding industrial facilities in Vojvodina, Serbia
VL  - 190
IS  - 4
SP  - 208
DO  - 10.1007/s10661-018-6583-9
ER  - 

@article{
author = "Spahic, Maja Poznanovic and Sakan, Sanja and Cvetkovic, Zeljko and Tančić, Pavle and Trifković, Jelena and Nikić, Zoran and Manojlović, Dragan",
year = "2018",
abstract = "Content of potentially toxic elements was examined in soils from Srem (Vojvodina), to evaluate industrial facilities as pollution sources. Based on the distribution of the elements, the results of sequential extraction, enrichment factor (EF), ecological risk factor (Er), ecological risk index (RI), and statistical analysis, the current ecological status of the soils was determined. Elements in soils around the industrial facilities can be grouped into the five significant components derived by the principal component analysis (PCA), which explains 78.435% of the total variance. Al, Fe and Mg, and K and Mn are associated with two lithogenic components, respectively. Anthropogenic origin is identified for Hg and Cd. Mixed sources, geogenic and anthropogenic, are identified within two PCA components; one wich includes As, Pb, B, Zn, and the other: K and Cr, Ni and Cu. Cluster analysis (CA) corroborated the results obtained by PCA. The preliminary results revealed that the soils studied in a vicinity of industrial facilities in Srem have been exposed to different degrees of pollution. Among the characterized studied elements, Pb, Cd, Hg, Cu, Ni, and Cr are the main contaminants. Based on calculated EF, the studied soils show minor to severe enrichment with heavy metals. Ecological risk assessment results indicate that Cd and Hg carry the highest ecological risk level, and Zn and Cr the lowest.",
publisher = "Springer, Dordrecht",
journal = "Environmental Monitoring and Assessment",
title = "Assessment of contamination, environmental risk, and origin of heavy metals in soils surrounding industrial facilities in Vojvodina, Serbia",
volume = "190",
number = "4",
pages = "208",
doi = "10.1007/s10661-018-6583-9"
}

Spahic, M. P., Sakan, S., Cvetkovic, Z., Tančić, P., Trifković, J., Nikić, Z.,& Manojlović, D.. (2018). Assessment of contamination, environmental risk, and origin of heavy metals in soils surrounding industrial facilities in Vojvodina, Serbia. in Environmental Monitoring and Assessment
Springer, Dordrecht., 190(4), 208.
https://doi.org/10.1007/s10661-018-6583-9

Spahic MP, Sakan S, Cvetkovic Z, Tančić P, Trifković J, Nikić Z, Manojlović D. Assessment of contamination, environmental risk, and origin of heavy metals in soils surrounding industrial facilities in Vojvodina, Serbia. in Environmental Monitoring and Assessment. 2018;190(4):208.
doi:10.1007/s10661-018-6583-9 .

Spahic, Maja Poznanovic, Sakan, Sanja, Cvetkovic, Zeljko, Tančić, Pavle, Trifković, Jelena, Nikić, Zoran, Manojlović, Dragan, "Assessment of contamination, environmental risk, and origin of heavy metals in soils surrounding industrial facilities in Vojvodina, Serbia" in Environmental Monitoring and Assessment, 190, no. 4 (2018):208,
https://doi.org/10.1007/s10661-018-6583-9 . .

TY  - JOUR
AU  - Milojković-Opsenica, Dušanka
AU  - Andrić, Filip
AU  - Šegan, Sandra
AU  - Trifković, Jelena
AU  - Tešić, Živoslav
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2475
AB  - The methods of correlating molecular structure of substances expressed as descriptors, to their biological activity are commonly denoted as Quantitative Structure-Activity Relationships (QSARs). This concept, typically applied in drug discovery processes, is also widely used for correlation of molecular structure and physicochemical properties of solutes in so-called quantitative structure-property relationship (QSPR) studies, as well as for explanation of chromatographic behavior, i.e., separation mechanisms of analytes, where is termed as quantitative structure-retention relationship (QSRR). Mathematical expressions of structural characteristics of substances, named as molecular descriptors, can be calculated by various computational techniques or experimentally determined by different analytical methods. Thin-layer chromatography as a rapid, sensitive, and economical liquid chromatographic method has been widely used for determination of various chromatographic descriptors applicable in QSAR/QSPR studies. An overview of recently published papers dealing with this concept is presented. [GRAPHICS] .
PB  - Taylor & Francis Inc, Philadelphia
T2  - Journal of Liquid Chromatography & Related Technologies
T1  - Thin-layer chromatography in quantitative structure-activity relationship studies
VL  - 41
IS  - 6
SP  - 272
EP  - 281
DO  - 10.1080/10826076.2018.1447892
ER  - 

@article{
author = "Milojković-Opsenica, Dušanka and Andrić, Filip and Šegan, Sandra and Trifković, Jelena and Tešić, Živoslav",
year = "2018",
abstract = "The methods of correlating molecular structure of substances expressed as descriptors, to their biological activity are commonly denoted as Quantitative Structure-Activity Relationships (QSARs). This concept, typically applied in drug discovery processes, is also widely used for correlation of molecular structure and physicochemical properties of solutes in so-called quantitative structure-property relationship (QSPR) studies, as well as for explanation of chromatographic behavior, i.e., separation mechanisms of analytes, where is termed as quantitative structure-retention relationship (QSRR). Mathematical expressions of structural characteristics of substances, named as molecular descriptors, can be calculated by various computational techniques or experimentally determined by different analytical methods. Thin-layer chromatography as a rapid, sensitive, and economical liquid chromatographic method has been widely used for determination of various chromatographic descriptors applicable in QSAR/QSPR studies. An overview of recently published papers dealing with this concept is presented. [GRAPHICS] .",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Journal of Liquid Chromatography & Related Technologies",
title = "Thin-layer chromatography in quantitative structure-activity relationship studies",
volume = "41",
number = "6",
pages = "272-281",
doi = "10.1080/10826076.2018.1447892"
}

Milojković-Opsenica, D., Andrić, F., Šegan, S., Trifković, J.,& Tešić, Ž.. (2018). Thin-layer chromatography in quantitative structure-activity relationship studies. in Journal of Liquid Chromatography & Related Technologies
Taylor & Francis Inc, Philadelphia., 41(6), 272-281.
https://doi.org/10.1080/10826076.2018.1447892

Milojković-Opsenica D, Andrić F, Šegan S, Trifković J, Tešić Ž. Thin-layer chromatography in quantitative structure-activity relationship studies. in Journal of Liquid Chromatography & Related Technologies. 2018;41(6):272-281.
doi:10.1080/10826076.2018.1447892 .

Milojković-Opsenica, Dušanka, Andrić, Filip, Šegan, Sandra, Trifković, Jelena, Tešić, Živoslav, "Thin-layer chromatography in quantitative structure-activity relationship studies" in Journal of Liquid Chromatography & Related Technologies, 41, no. 6 (2018):272-281,
https://doi.org/10.1080/10826076.2018.1447892 . .

TY  - JOUR
AU  - Vukojević, Vesna
AU  - Trifković, Jelena
AU  - Krgovic, Rada
AU  - Milojković-Opsenica, Dušanka
AU  - Marković, Marijana
AU  - Amaizah, Naser Ramdan R.
AU  - Mutić, Jelena
PY  - 2016
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1913
AB  - Fourteen metals and metalloids were determined in Conyza canadensis L. harvested from the fly ash landfill of the thermoelectric power plant "Kolubara" (Serbia). Fly ash samples were collected together with the plant samples and subjected to sequential extraction according to the three-step sequential extraction scheme proposed by the Community Bureau of Reference (BCR; now the Standards, Measurements and Testing Program). The contents of metals and metalloids were determined by inductively coupled plasma optical emission spectrometry (ICP-OES) in plant root and the aboveground part and correlated with their contents in the fly ash samples. The bioconcentration factor (BCF) and translocation factors (TF) were calculated to access uptake of metals from fly ash and their translocation to the aboveground part. Results regarding As revealed that fly ash samples in the proximity of the active cassette had higher amounts of the element. Principal component analysis (PCA) showed that As had no impact on the classification of plant parts. BCF for As ranged from 1.44 to 23.8 and varied, depending on the investigated area; TF for As ranged from 0.43 to 2.61, indicating that the plant translocated As from root to shoot. In addition to As, Conyza canadensis L. exhibited efficient uptake of other metals from fly ash. According to the calculated BCF and TF, the plant retained Al, Fe and Cr in the root and translocated Zn, Cd, Cu and As from root to shoot in the course of the detoxifying process.
PB  - Inst Bioloska Istrazivanja Sinisa Stankovic, Beograd
T2  - Archives of Biological Sciences
T1  - Uptake of metals and metalloids by conyza canadensis l. From a thermoelectric power plant landfill
VL  - 68
IS  - 4
SP  - 829
EP  - 835
DO  - 10.2298/ABS151011071V
ER  - 

@article{
author = "Vukojević, Vesna and Trifković, Jelena and Krgovic, Rada and Milojković-Opsenica, Dušanka and Marković, Marijana and Amaizah, Naser Ramdan R. and Mutić, Jelena",
year = "2016",
abstract = "Fourteen metals and metalloids were determined in Conyza canadensis L. harvested from the fly ash landfill of the thermoelectric power plant "Kolubara" (Serbia). Fly ash samples were collected together with the plant samples and subjected to sequential extraction according to the three-step sequential extraction scheme proposed by the Community Bureau of Reference (BCR; now the Standards, Measurements and Testing Program). The contents of metals and metalloids were determined by inductively coupled plasma optical emission spectrometry (ICP-OES) in plant root and the aboveground part and correlated with their contents in the fly ash samples. The bioconcentration factor (BCF) and translocation factors (TF) were calculated to access uptake of metals from fly ash and their translocation to the aboveground part. Results regarding As revealed that fly ash samples in the proximity of the active cassette had higher amounts of the element. Principal component analysis (PCA) showed that As had no impact on the classification of plant parts. BCF for As ranged from 1.44 to 23.8 and varied, depending on the investigated area; TF for As ranged from 0.43 to 2.61, indicating that the plant translocated As from root to shoot. In addition to As, Conyza canadensis L. exhibited efficient uptake of other metals from fly ash. According to the calculated BCF and TF, the plant retained Al, Fe and Cr in the root and translocated Zn, Cd, Cu and As from root to shoot in the course of the detoxifying process.",
publisher = "Inst Bioloska Istrazivanja Sinisa Stankovic, Beograd",
journal = "Archives of Biological Sciences",
title = "Uptake of metals and metalloids by conyza canadensis l. From a thermoelectric power plant landfill",
volume = "68",
number = "4",
pages = "829-835",
doi = "10.2298/ABS151011071V"
}

Vukojević, V., Trifković, J., Krgovic, R., Milojković-Opsenica, D., Marković, M., Amaizah, N. R. R.,& Mutić, J.. (2016). Uptake of metals and metalloids by conyza canadensis l. From a thermoelectric power plant landfill. in Archives of Biological Sciences
Inst Bioloska Istrazivanja Sinisa Stankovic, Beograd., 68(4), 829-835.
https://doi.org/10.2298/ABS151011071V

Vukojević V, Trifković J, Krgovic R, Milojković-Opsenica D, Marković M, Amaizah NRR, Mutić J. Uptake of metals and metalloids by conyza canadensis l. From a thermoelectric power plant landfill. in Archives of Biological Sciences. 2016;68(4):829-835.
doi:10.2298/ABS151011071V .

Vukojević, Vesna, Trifković, Jelena, Krgovic, Rada, Milojković-Opsenica, Dušanka, Marković, Marijana, Amaizah, Naser Ramdan R., Mutić, Jelena, "Uptake of metals and metalloids by conyza canadensis l. From a thermoelectric power plant landfill" in Archives of Biological Sciences, 68, no. 4 (2016):829-835,
https://doi.org/10.2298/ABS151011071V . .

TY  - JOUR
AU  - Kostić, Aleksandar Ž.
AU  - Pešić, Mirjana B.
AU  - Mosic, Mirjana D
AU  - Dojčinović, Biljana
AU  - Natić, Maja
AU  - Trifković, Jelena
PY  - 2015
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1678
AB  - In this study we analysed mineral composition of bee pollen of different plant origin collected across Serbia using inductively coupled plasma - optical emission spectrometry. The most abundant elements were potassium, calcium, and magnesium. The samples were also exceptionally rich in iron and zinc, which are very important as nutrients. Judging by our findings, mineral composition of bee pollen much more depends on the type of pollen-producing plant than on its geographical origin.
PB  - Inst Medical Research & Occupational Health, Zagreb
T2  - Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology
T1  - Mineral content of bee pollen from Serbia
VL  - 66
IS  - 4
SP  - 251
EP  - 258
DO  - 10.1515/aiht-2015-66-2630
ER  - 

@article{
author = "Kostić, Aleksandar Ž. and Pešić, Mirjana B. and Mosic, Mirjana D and Dojčinović, Biljana and Natić, Maja and Trifković, Jelena",
year = "2015",
abstract = "In this study we analysed mineral composition of bee pollen of different plant origin collected across Serbia using inductively coupled plasma - optical emission spectrometry. The most abundant elements were potassium, calcium, and magnesium. The samples were also exceptionally rich in iron and zinc, which are very important as nutrients. Judging by our findings, mineral composition of bee pollen much more depends on the type of pollen-producing plant than on its geographical origin.",
publisher = "Inst Medical Research & Occupational Health, Zagreb",
journal = "Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology",
title = "Mineral content of bee pollen from Serbia",
volume = "66",
number = "4",
pages = "251-258",
doi = "10.1515/aiht-2015-66-2630"
}

Kostić, A. Ž., Pešić, M. B., Mosic, M. D., Dojčinović, B., Natić, M.,& Trifković, J.. (2015). Mineral content of bee pollen from Serbia. in Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology
Inst Medical Research & Occupational Health, Zagreb., 66(4), 251-258.
https://doi.org/10.1515/aiht-2015-66-2630

Kostić AŽ, Pešić MB, Mosic MD, Dojčinović B, Natić M, Trifković J. Mineral content of bee pollen from Serbia. in Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology. 2015;66(4):251-258.
doi:10.1515/aiht-2015-66-2630 .

Kostić, Aleksandar Ž., Pešić, Mirjana B., Mosic, Mirjana D, Dojčinović, Biljana, Natić, Maja, Trifković, Jelena, "Mineral content of bee pollen from Serbia" in Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology, 66, no. 4 (2015):251-258,
https://doi.org/10.1515/aiht-2015-66-2630 . .

TY  - JOUR
AU  - Krgovic, Rada
AU  - Trifković, Jelena
AU  - Milojković-Opsenica, Dušanka
AU  - Manojlović, Dragan
AU  - Marković, Marijana
AU  - Mutić, Jelena
PY  - 2015
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1625
AB  - The objectives of this study were to determine the concentrations of Pb, Cd, As, Cr, Cu, Co, Ni, Zn, Ba, Fe, Al and Ag in Erigeron canadensis L. growing on fly ash landfill of power plant "Kolubara", Serbia. The content of each element was determined in every part of plant separately (root, stalk and inflorescence) and correlated with the content of elements in each phase of sequential extraction of fly ash. In order to ambiguously select the factors that are able to decidedly characterize the particular part of plant, principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) were performed. The bioconcentration factors and translocation factors for each metal were calculated in order to determine the feasibility of the use of plant E. canadensis L. for phytoremediation purpose. There were strong positive correlations between metals in every part of plant samples, and metals from pseudo total form of sequential extraction indicate that the bioavailability of elements in fly ash is similarly correlated with total form. Retained Al, Fe, Cr and Co in the root indicate its suitability for phytostabilization. This plant takes up Cd and Zn from the soil (bioconcentration factors (BCFs) greater than 1), transporting them through the stalk into the inflorescence (translocation factors (TFs) higher than 1). Regarding its dominance in vegetation cover and abundance, E. canadensis L. can be considered adequate for phytoextraction of Cd and Zn from coal ash landfills at Kolubara.
PB  - Springer Heidelberg, Heidelberg
T2  - Environmental Science and Pollution Research
T1  - Phytoextraction of metals by Erigeron canadensis L. from fly ash landfill of power plant "Kolubara"
VL  - 22
IS  - 14
SP  - 10506
EP  - 10515
DO  - 10.1007/s11356-015-4192-5
ER  - 

@article{
author = "Krgovic, Rada and Trifković, Jelena and Milojković-Opsenica, Dušanka and Manojlović, Dragan and Marković, Marijana and Mutić, Jelena",
year = "2015",
abstract = "The objectives of this study were to determine the concentrations of Pb, Cd, As, Cr, Cu, Co, Ni, Zn, Ba, Fe, Al and Ag in Erigeron canadensis L. growing on fly ash landfill of power plant "Kolubara", Serbia. The content of each element was determined in every part of plant separately (root, stalk and inflorescence) and correlated with the content of elements in each phase of sequential extraction of fly ash. In order to ambiguously select the factors that are able to decidedly characterize the particular part of plant, principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) were performed. The bioconcentration factors and translocation factors for each metal were calculated in order to determine the feasibility of the use of plant E. canadensis L. for phytoremediation purpose. There were strong positive correlations between metals in every part of plant samples, and metals from pseudo total form of sequential extraction indicate that the bioavailability of elements in fly ash is similarly correlated with total form. Retained Al, Fe, Cr and Co in the root indicate its suitability for phytostabilization. This plant takes up Cd and Zn from the soil (bioconcentration factors (BCFs) greater than 1), transporting them through the stalk into the inflorescence (translocation factors (TFs) higher than 1). Regarding its dominance in vegetation cover and abundance, E. canadensis L. can be considered adequate for phytoextraction of Cd and Zn from coal ash landfills at Kolubara.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Environmental Science and Pollution Research",
title = "Phytoextraction of metals by Erigeron canadensis L. from fly ash landfill of power plant "Kolubara"",
volume = "22",
number = "14",
pages = "10506-10515",
doi = "10.1007/s11356-015-4192-5"
}

Krgovic, R., Trifković, J., Milojković-Opsenica, D., Manojlović, D., Marković, M.,& Mutić, J.. (2015). Phytoextraction of metals by Erigeron canadensis L. from fly ash landfill of power plant "Kolubara". in Environmental Science and Pollution Research
Springer Heidelberg, Heidelberg., 22(14), 10506-10515.
https://doi.org/10.1007/s11356-015-4192-5

Krgovic R, Trifković J, Milojković-Opsenica D, Manojlović D, Marković M, Mutić J. Phytoextraction of metals by Erigeron canadensis L. from fly ash landfill of power plant "Kolubara". in Environmental Science and Pollution Research. 2015;22(14):10506-10515.
doi:10.1007/s11356-015-4192-5 .

Krgovic, Rada, Trifković, Jelena, Milojković-Opsenica, Dušanka, Manojlović, Dragan, Marković, Marijana, Mutić, Jelena, "Phytoextraction of metals by Erigeron canadensis L. from fly ash landfill of power plant "Kolubara"" in Environmental Science and Pollution Research, 22, no. 14 (2015):10506-10515,
https://doi.org/10.1007/s11356-015-4192-5 . .

TY  - JOUR
AU  - Stanojevic, Marija
AU  - Trifković, Jelena
AU  - Fotiric-Aksic, Milica M
AU  - Rakonjac, Vera
AU  - Nikolic, Dragan
AU  - Šegan, Sandra
AU  - Milojković-Opsenica, Dušanka
PY  - 2015
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1786
AB  - Large amounts of fruit seeds, especially peach, are discarded annually in juice or conserve producing industries which is a potential waste of valuable resource and serious disposal problem. Regarding the fact that peach seeds can be obtained as a byproduct from processing companies their exploitation should be greater and, consequently more information of cultivars' kernels and their composition is required. A total of 25 samples of kernels from various peach germplasm (including commercial cultivars, perspective hybrids and vineyard peach accessions) differing in origin and ripening time were characterized by evaluation of their sugar composition. Twenty characteristic carbohydrates and sugar alcohols were determined and quantified using high-performance anion-exchange chromatography with pulsed amperometric detection (HPAEC/PAD). Sucrose, glucose and fructose are the most important sugars in peach kernels similar to other representatives of the Rosaceae family. Also, high amounts of sugars in seeds of promising hybrids implies that through conventional breeding programs peach kernels with high sugar content can be obtained. In addition, by the means of several pattern recognition methods the variables that discriminate peach kernels arising from diverse germplasm and different stage of maturity were identified and successful models for further prediction were developed. Sugars such as ribose, trehalose, arabinose, galactitol, fructose, maltose, sorbitol, sucrose, iso-maltotriose were marked as most important for such discrimination.
PB  - Springer, Dordrecht
T2  - Plant Foods For Human Nutrition
T1  - Sugar Profile of Kernels as a Marker of Origin and Ripening Time of Peach (Prunus persicae L.)
VL  - 70
IS  - 4
SP  - 433
EP  - 440
DO  - 10.1007/s11130-015-0515-4
ER  - 

@article{
author = "Stanojevic, Marija and Trifković, Jelena and Fotiric-Aksic, Milica M and Rakonjac, Vera and Nikolic, Dragan and Šegan, Sandra and Milojković-Opsenica, Dušanka",
year = "2015",
abstract = "Large amounts of fruit seeds, especially peach, are discarded annually in juice or conserve producing industries which is a potential waste of valuable resource and serious disposal problem. Regarding the fact that peach seeds can be obtained as a byproduct from processing companies their exploitation should be greater and, consequently more information of cultivars' kernels and their composition is required. A total of 25 samples of kernels from various peach germplasm (including commercial cultivars, perspective hybrids and vineyard peach accessions) differing in origin and ripening time were characterized by evaluation of their sugar composition. Twenty characteristic carbohydrates and sugar alcohols were determined and quantified using high-performance anion-exchange chromatography with pulsed amperometric detection (HPAEC/PAD). Sucrose, glucose and fructose are the most important sugars in peach kernels similar to other representatives of the Rosaceae family. Also, high amounts of sugars in seeds of promising hybrids implies that through conventional breeding programs peach kernels with high sugar content can be obtained. In addition, by the means of several pattern recognition methods the variables that discriminate peach kernels arising from diverse germplasm and different stage of maturity were identified and successful models for further prediction were developed. Sugars such as ribose, trehalose, arabinose, galactitol, fructose, maltose, sorbitol, sucrose, iso-maltotriose were marked as most important for such discrimination.",
publisher = "Springer, Dordrecht",
journal = "Plant Foods For Human Nutrition",
title = "Sugar Profile of Kernels as a Marker of Origin and Ripening Time of Peach (Prunus persicae L.)",
volume = "70",
number = "4",
pages = "433-440",
doi = "10.1007/s11130-015-0515-4"
}

Stanojevic, M., Trifković, J., Fotiric-Aksic, M. M., Rakonjac, V., Nikolic, D., Šegan, S.,& Milojković-Opsenica, D.. (2015). Sugar Profile of Kernels as a Marker of Origin and Ripening Time of Peach (Prunus persicae L.). in Plant Foods For Human Nutrition
Springer, Dordrecht., 70(4), 433-440.
https://doi.org/10.1007/s11130-015-0515-4

Stanojevic M, Trifković J, Fotiric-Aksic MM, Rakonjac V, Nikolic D, Šegan S, Milojković-Opsenica D. Sugar Profile of Kernels as a Marker of Origin and Ripening Time of Peach (Prunus persicae L.). in Plant Foods For Human Nutrition. 2015;70(4):433-440.
doi:10.1007/s11130-015-0515-4 .

Stanojevic, Marija, Trifković, Jelena, Fotiric-Aksic, Milica M, Rakonjac, Vera, Nikolic, Dragan, Šegan, Sandra, Milojković-Opsenica, Dušanka, "Sugar Profile of Kernels as a Marker of Origin and Ripening Time of Peach (Prunus persicae L.)" in Plant Foods For Human Nutrition, 70, no. 4 (2015):433-440,
https://doi.org/10.1007/s11130-015-0515-4 . .

TY  - JOUR
AU  - Šegan, Sandra
AU  - Terzić Jovanović, Nataša
AU  - Milojković-Opsenica, Dušanka
AU  - Trifković, Jelena
AU  - Šolaja, Bogdan
AU  - Opsenica, Dejan
PY  - 2014
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1599
AB  - The chromatographic behavior of mixed 1,2,4,5-tetraoxanes, cholic and deoxycholic acid derivatives with distinct biological activity, was examined by high-performance thin-layer chromatography in order to correlate their structure and retention. Chromatographic systems were consisted of RP-18 or CN-silica as stationary phase, and binary mixtures of water with methanol, dioxane or acetone as mobile phase. Based on the respective retentions, the lipophilicity of the investigated compounds was determined. Multiple linear regression and partial least squares have been used to select variables that best describe the behavior of the investigated compounds in chromatographic systems and to quantify influences of most important parameters. The validation and cross-validation of the QSRR model suggest its applicability for prediction and understanding of retention of congeners. The models indicate the importance of nonpolar properties of the solutes and their ability for hydrophobic interactions, as well as the importance of proton donating abilities, hydrophilic and,pi interactions pointing out on that way the possible separation mechanism in the studied chromatographic systems. Observed correlations between structure and biological activity of mixed 1,2,4,5-tetraoxanes, indicate that the antimalarial activity against W2 and D6 Plasmodium falciparum strains, is governed by hydrophobic feature (measured with lipophilicity parameter), hydrophilic feature (measured with HLB, %HS, HB and HBA descriptors), and electronic feature (HOMO).
PB  - Elsevier
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Correlation study of retention data and antimalarial activity of 1,2,4,5-mixed tetraoxanes with their molecular structure descriptors and LSER parameters
VL  - 97
SP  - 178
EP  - 183
DO  - 10.1016/j.jpba.2014.04.029
ER  - 

@article{
author = "Šegan, Sandra and Terzić Jovanović, Nataša and Milojković-Opsenica, Dušanka and Trifković, Jelena and Šolaja, Bogdan and Opsenica, Dejan",
year = "2014",
abstract = "The chromatographic behavior of mixed 1,2,4,5-tetraoxanes, cholic and deoxycholic acid derivatives with distinct biological activity, was examined by high-performance thin-layer chromatography in order to correlate their structure and retention. Chromatographic systems were consisted of RP-18 or CN-silica as stationary phase, and binary mixtures of water with methanol, dioxane or acetone as mobile phase. Based on the respective retentions, the lipophilicity of the investigated compounds was determined. Multiple linear regression and partial least squares have been used to select variables that best describe the behavior of the investigated compounds in chromatographic systems and to quantify influences of most important parameters. The validation and cross-validation of the QSRR model suggest its applicability for prediction and understanding of retention of congeners. The models indicate the importance of nonpolar properties of the solutes and their ability for hydrophobic interactions, as well as the importance of proton donating abilities, hydrophilic and,pi interactions pointing out on that way the possible separation mechanism in the studied chromatographic systems. Observed correlations between structure and biological activity of mixed 1,2,4,5-tetraoxanes, indicate that the antimalarial activity against W2 and D6 Plasmodium falciparum strains, is governed by hydrophobic feature (measured with lipophilicity parameter), hydrophilic feature (measured with HLB, %HS, HB and HBA descriptors), and electronic feature (HOMO).",
publisher = "Elsevier",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Correlation study of retention data and antimalarial activity of 1,2,4,5-mixed tetraoxanes with their molecular structure descriptors and LSER parameters",
volume = "97",
pages = "178-183",
doi = "10.1016/j.jpba.2014.04.029"
}

Šegan, S., Terzić Jovanović, N., Milojković-Opsenica, D., Trifković, J., Šolaja, B.,& Opsenica, D.. (2014). Correlation study of retention data and antimalarial activity of 1,2,4,5-mixed tetraoxanes with their molecular structure descriptors and LSER parameters. in Journal of Pharmaceutical and Biomedical Analysis
Elsevier., 97, 178-183.
https://doi.org/10.1016/j.jpba.2014.04.029

Šegan S, Terzić Jovanović N, Milojković-Opsenica D, Trifković J, Šolaja B, Opsenica D. Correlation study of retention data and antimalarial activity of 1,2,4,5-mixed tetraoxanes with their molecular structure descriptors and LSER parameters. in Journal of Pharmaceutical and Biomedical Analysis. 2014;97:178-183.
doi:10.1016/j.jpba.2014.04.029 .

Šegan, Sandra, Terzić Jovanović, Nataša, Milojković-Opsenica, Dušanka, Trifković, Jelena, Šolaja, Bogdan, Opsenica, Dejan, "Correlation study of retention data and antimalarial activity of 1,2,4,5-mixed tetraoxanes with their molecular structure descriptors and LSER parameters" in Journal of Pharmaceutical and Biomedical Analysis, 97 (2014):178-183,
https://doi.org/10.1016/j.jpba.2014.04.029 . .

TY  - JOUR
AU  - Šegan, Sandra
AU  - Terzić-Jovanović, Nataša
AU  - Milojković-Opsenica, Dušanka
AU  - Trifković, Jelena
AU  - Šolaja, Bogdan
AU  - Opsenica, Dejan
PY  - 2014
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3166
AB  - The chromatographic behavior of mixed 1,2,4,5-tetraoxanes, cholic and deoxycholic acid derivatives with distinct biological activity, was examined by high-performance thin-layer chromatography in order to correlate their structure and retention. Chromatographic systems were consisted of RP-18 or CN-silica as stationary phase, and binary mixtures of water with methanol, dioxane or acetone as mobile phase. Based on the respective retentions, the lipophilicity of the investigated compounds was determined. Multiple linear regression and partial least squares have been used to select variables that best describe the behavior of the investigated compounds in chromatographic systems and to quantify influences of most important parameters. The validation and cross-validation of the QSRR model suggest its applicability for prediction and understanding of retention of congeners. The models indicate the importance of nonpolar properties of the solutes and their ability for hydrophobic interactions, as well as the importance of proton donating abilities, hydrophilic and,pi interactions pointing out on that way the possible separation mechanism in the studied chromatographic systems. Observed correlations between structure and biological activity of mixed 1,2,4,5-tetraoxanes, indicate that the antimalarial activity against W2 and D6 Plasmodium falciparum strains, is governed by hydrophobic feature (measured with lipophilicity parameter), hydrophilic feature (measured with HLB, %HS, HB and HBA descriptors), and electronic feature (HOMO).
PB  - Elsevier
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Correlation study of retention data and antimalarial activity of 1,2,4,5-mixed tetraoxanes with their molecular structure descriptors and LSER parameters
VL  - 97
SP  - 178
EP  - 183
DO  - 10.1016/j.jpba.2014.04.029
ER  - 

@article{
author = "Šegan, Sandra and Terzić-Jovanović, Nataša and Milojković-Opsenica, Dušanka and Trifković, Jelena and Šolaja, Bogdan and Opsenica, Dejan",
year = "2014",
abstract = "The chromatographic behavior of mixed 1,2,4,5-tetraoxanes, cholic and deoxycholic acid derivatives with distinct biological activity, was examined by high-performance thin-layer chromatography in order to correlate their structure and retention. Chromatographic systems were consisted of RP-18 or CN-silica as stationary phase, and binary mixtures of water with methanol, dioxane or acetone as mobile phase. Based on the respective retentions, the lipophilicity of the investigated compounds was determined. Multiple linear regression and partial least squares have been used to select variables that best describe the behavior of the investigated compounds in chromatographic systems and to quantify influences of most important parameters. The validation and cross-validation of the QSRR model suggest its applicability for prediction and understanding of retention of congeners. The models indicate the importance of nonpolar properties of the solutes and their ability for hydrophobic interactions, as well as the importance of proton donating abilities, hydrophilic and,pi interactions pointing out on that way the possible separation mechanism in the studied chromatographic systems. Observed correlations between structure and biological activity of mixed 1,2,4,5-tetraoxanes, indicate that the antimalarial activity against W2 and D6 Plasmodium falciparum strains, is governed by hydrophobic feature (measured with lipophilicity parameter), hydrophilic feature (measured with HLB, %HS, HB and HBA descriptors), and electronic feature (HOMO).",
publisher = "Elsevier",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Correlation study of retention data and antimalarial activity of 1,2,4,5-mixed tetraoxanes with their molecular structure descriptors and LSER parameters",
volume = "97",
pages = "178-183",
doi = "10.1016/j.jpba.2014.04.029"
}

Šegan, S., Terzić-Jovanović, N., Milojković-Opsenica, D., Trifković, J., Šolaja, B.,& Opsenica, D.. (2014). Correlation study of retention data and antimalarial activity of 1,2,4,5-mixed tetraoxanes with their molecular structure descriptors and LSER parameters. in Journal of Pharmaceutical and Biomedical Analysis
Elsevier., 97, 178-183.
https://doi.org/10.1016/j.jpba.2014.04.029

Šegan S, Terzić-Jovanović N, Milojković-Opsenica D, Trifković J, Šolaja B, Opsenica D. Correlation study of retention data and antimalarial activity of 1,2,4,5-mixed tetraoxanes with their molecular structure descriptors and LSER parameters. in Journal of Pharmaceutical and Biomedical Analysis. 2014;97:178-183.
doi:10.1016/j.jpba.2014.04.029 .

Šegan, Sandra, Terzić-Jovanović, Nataša, Milojković-Opsenica, Dušanka, Trifković, Jelena, Šolaja, Bogdan, Opsenica, Dejan, "Correlation study of retention data and antimalarial activity of 1,2,4,5-mixed tetraoxanes with their molecular structure descriptors and LSER parameters" in Journal of Pharmaceutical and Biomedical Analysis, 97 (2014):178-183,
https://doi.org/10.1016/j.jpba.2014.04.029 . .

TY  - JOUR
AU  - Stanojevic, Marija
AU  - Trifković, Jelena
AU  - Kostić Rajačić, Slađana
AU  - Šoškić, Vukić
AU  - Tešić, Živoslav
AU  - Milojković-Opsenica, Dušanka
PY  - 2014
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1551
AB  - The chromatographic behavior of arylureas and arylacetamides derivatives with observed biological activity toward dopamine D-2 and 5-hydroxytryptamine 5HT(1A) receptors were examined by high-performance thin-layer chromatography in order to determine their lipophilicity and to correlate their structure and retention. The binary water-dimethyl sulfoxid mobile phases and RP-18 silica as stationary phase were used in order to determine chromatographic descriptors R-M(0), b, and C-0, as a measure of the lipophilicity of tested compounds. Based on the respective retention, the lipophilicity of the investigated compounds was discussed. Principal component analysis followed by partial least squares was used to select variables that best describe the behavior of the investigated compounds in the chromatographic system and to quantify their influences. The models reveal the importance of nonpolar properties of the solutes and their ability for hydrophobic interactions, as well as the importance of proton donating abilities and the size and the shape of the molecule, pointing out on that way the possible separation mechanism in the studied chromatographic systems.
PB  - Taylor & Francis Inc, Philadelphia
T2  - Journal of Liquid Chromatography & Related Technologies
T1  - Assessment of lipophilicity of some biologically active arylpiperazines by rptlc and multivariate analysis
VL  - 37
IS  - 20
SP  - 2814
EP  - 2828
DO  - 10.1080/10826076.2014.907112
ER  - 

@article{
author = "Stanojevic, Marija and Trifković, Jelena and Kostić Rajačić, Slađana and Šoškić, Vukić and Tešić, Živoslav and Milojković-Opsenica, Dušanka",
year = "2014",
abstract = "The chromatographic behavior of arylureas and arylacetamides derivatives with observed biological activity toward dopamine D-2 and 5-hydroxytryptamine 5HT(1A) receptors were examined by high-performance thin-layer chromatography in order to determine their lipophilicity and to correlate their structure and retention. The binary water-dimethyl sulfoxid mobile phases and RP-18 silica as stationary phase were used in order to determine chromatographic descriptors R-M(0), b, and C-0, as a measure of the lipophilicity of tested compounds. Based on the respective retention, the lipophilicity of the investigated compounds was discussed. Principal component analysis followed by partial least squares was used to select variables that best describe the behavior of the investigated compounds in the chromatographic system and to quantify their influences. The models reveal the importance of nonpolar properties of the solutes and their ability for hydrophobic interactions, as well as the importance of proton donating abilities and the size and the shape of the molecule, pointing out on that way the possible separation mechanism in the studied chromatographic systems.",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Journal of Liquid Chromatography & Related Technologies",
title = "Assessment of lipophilicity of some biologically active arylpiperazines by rptlc and multivariate analysis",
volume = "37",
number = "20",
pages = "2814-2828",
doi = "10.1080/10826076.2014.907112"
}

Stanojevic, M., Trifković, J., Kostić Rajačić, S., Šoškić, V., Tešić, Ž.,& Milojković-Opsenica, D.. (2014). Assessment of lipophilicity of some biologically active arylpiperazines by rptlc and multivariate analysis. in Journal of Liquid Chromatography & Related Technologies
Taylor & Francis Inc, Philadelphia., 37(20), 2814-2828.
https://doi.org/10.1080/10826076.2014.907112

Stanojevic M, Trifković J, Kostić Rajačić S, Šoškić V, Tešić Ž, Milojković-Opsenica D. Assessment of lipophilicity of some biologically active arylpiperazines by rptlc and multivariate analysis. in Journal of Liquid Chromatography & Related Technologies. 2014;37(20):2814-2828.
doi:10.1080/10826076.2014.907112 .

Stanojevic, Marija, Trifković, Jelena, Kostić Rajačić, Slađana, Šoškić, Vukić, Tešić, Živoslav, Milojković-Opsenica, Dušanka, "Assessment of lipophilicity of some biologically active arylpiperazines by rptlc and multivariate analysis" in Journal of Liquid Chromatography & Related Technologies, 37, no. 20 (2014):2814-2828,
https://doi.org/10.1080/10826076.2014.907112 . .

TY  - JOUR
AU  - Šegan, Sandra
AU  - Trifković, Jelena
AU  - Verbić, Tatjana
AU  - Opsenica, Dejan
AU  - Zlatović, Mario
AU  - Burnett, James
AU  - Šolaja, Bogdan
AU  - Milojković-Opsenica, Dušanka
PY  - 2013
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1305
AB  - The physicochemical properties, retention parameters (R-M(0)), partition coefficients (log P-OW), and pK(a) values for a series of thirteen 1,7-bis(aminoalkyl) diazachrysene (1,7-DAAC) derivatives were determined in order to reveal the characteristics responsible for their biological behavior. The investigated compounds inhibit three unrelated pathogens (the Botulinum neurotoxin serotype A light chain (BoNT/A LC), Plasmodium falciparum malaria, and Ebola filovirus) via three different mechanisms of action. To determine the most influential factors governing the retention and activities of the investigated diazachrysenes, R-M(0), log P-OW, and biological activity values were correlated with 2D and 3D molecular descriptors, using a partial least squares regression. The resulting quantitative structure-retention (property) relationships indicate the importance of descriptors related to the hydrophobicity of the molecules (e.g., predicted partition coefficients and hydrophobic surface area). Quantitative structure-activity relationship models for describing biological activity against the BoNT/A LC and malarial strains also include overall compound polarity, electron density distribution, and proton donor/acceptor potential. Furthermore, models for Ebola filovirus inhibition are presented qualitatively to provide insights into parameters that may contribute to the compounds' antiviral activities. Overall, the models form the basis for selecting structural features that significantly affect the compound's absorption, distribution, metabolism, excretion, and toxicity profiles.
PB  - Elsevier
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Correlation between structure, retention, property, and activity of biologically relevant 1,7-bis(aminoalkyl)diazachrysene derivatives
VL  - 72
SP  - 231
EP  - 239
DO  - 10.1016/j.jpba.2012.08.025
ER  - 

@article{
author = "Šegan, Sandra and Trifković, Jelena and Verbić, Tatjana and Opsenica, Dejan and Zlatović, Mario and Burnett, James and Šolaja, Bogdan and Milojković-Opsenica, Dušanka",
year = "2013",
abstract = "The physicochemical properties, retention parameters (R-M(0)), partition coefficients (log P-OW), and pK(a) values for a series of thirteen 1,7-bis(aminoalkyl) diazachrysene (1,7-DAAC) derivatives were determined in order to reveal the characteristics responsible for their biological behavior. The investigated compounds inhibit three unrelated pathogens (the Botulinum neurotoxin serotype A light chain (BoNT/A LC), Plasmodium falciparum malaria, and Ebola filovirus) via three different mechanisms of action. To determine the most influential factors governing the retention and activities of the investigated diazachrysenes, R-M(0), log P-OW, and biological activity values were correlated with 2D and 3D molecular descriptors, using a partial least squares regression. The resulting quantitative structure-retention (property) relationships indicate the importance of descriptors related to the hydrophobicity of the molecules (e.g., predicted partition coefficients and hydrophobic surface area). Quantitative structure-activity relationship models for describing biological activity against the BoNT/A LC and malarial strains also include overall compound polarity, electron density distribution, and proton donor/acceptor potential. Furthermore, models for Ebola filovirus inhibition are presented qualitatively to provide insights into parameters that may contribute to the compounds' antiviral activities. Overall, the models form the basis for selecting structural features that significantly affect the compound's absorption, distribution, metabolism, excretion, and toxicity profiles.",
publisher = "Elsevier",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Correlation between structure, retention, property, and activity of biologically relevant 1,7-bis(aminoalkyl)diazachrysene derivatives",
volume = "72",
pages = "231-239",
doi = "10.1016/j.jpba.2012.08.025"
}

Šegan, S., Trifković, J., Verbić, T., Opsenica, D., Zlatović, M., Burnett, J., Šolaja, B.,& Milojković-Opsenica, D.. (2013). Correlation between structure, retention, property, and activity of biologically relevant 1,7-bis(aminoalkyl)diazachrysene derivatives. in Journal of Pharmaceutical and Biomedical Analysis
Elsevier., 72, 231-239.
https://doi.org/10.1016/j.jpba.2012.08.025

Šegan S, Trifković J, Verbić T, Opsenica D, Zlatović M, Burnett J, Šolaja B, Milojković-Opsenica D. Correlation between structure, retention, property, and activity of biologically relevant 1,7-bis(aminoalkyl)diazachrysene derivatives. in Journal of Pharmaceutical and Biomedical Analysis. 2013;72:231-239.
doi:10.1016/j.jpba.2012.08.025 .

Šegan, Sandra, Trifković, Jelena, Verbić, Tatjana, Opsenica, Dejan, Zlatović, Mario, Burnett, James, Šolaja, Bogdan, Milojković-Opsenica, Dušanka, "Correlation between structure, retention, property, and activity of biologically relevant 1,7-bis(aminoalkyl)diazachrysene derivatives" in Journal of Pharmaceutical and Biomedical Analysis, 72 (2013):231-239,
https://doi.org/10.1016/j.jpba.2012.08.025 . .

TY  - JOUR
AU  - Rabtti, El Hadi M. A.
AU  - Natić, Maja
AU  - Milojković-Opsenica, Dušanka
AU  - Trifković, Jelena
AU  - Tosti, Tomislav
AU  - Vučković, Ivan
AU  - Vajs, Vlatka
AU  - Tešić, Živoslav
PY  - 2012
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1554
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2721
AB  - Four lipophilicity descriptors (R-M(0), b, C-0 and PCl) for twelve coumarin derivatives were determined by reversed-phase thin-layer chromatography in order to analyze the descriptor which best describes the lipophilicity of the investigated coumarins. Moreover, possible chemical toxicity of coumarins, expressed as the probability of a compound to cause organ-specific health effects, was calculated using ACD/Tox Suite program. The quantitative relationships between toxicity and molecular descriptors, including experimentally determined lipophilicity descriptors obtained in current study were investigated using partial least square regression. The best models were obtained for kidney and liver health effects. Quantitative structure-toxicity relationship models revealed the importance of electric polarization descriptors, size descriptors and lipophilicity descriptors. The obtained models were used for the selection of the structural features of the compounds that are significantly affecting their absorption, distribution, metabolism, excretion and toxicity.
AB  - Primenom reverzno-fazne tankoslojne hromatografije na dvanaest derivata kumarina određena su četiri parametara lipofilnosti (RM0, b, C0 i PC1). Korelacijom dobijenih rezultata sa izračunatim log P vrednostima utvrđen je deskriptor koji na najbolji način opisuje lipofilnost ispitivanih kumarina. Pored toga izračunata je moguća hemijska toksičnost kumarina, izražena kao verovatnoća uticaja pomenutih jedinjenja na specifične organe (krv, kardiovaskularni sistem, gastrointestinalni sistem, bubrege, jetru i pluća) a koja je izračunata primenom ACD/Tox Suite programa. Dobijene vrednosti toksičnosti korelisane su sa molekulskim deskriptorima i eksperimentalno određenim parametrima lipofilnosti, primenom metode parcijalne regresije najmanjih kvadrata (partial least square regression). Uzimajući u obzir parametre koji opisuju kvalitet modela zavisnosti strukture i toksičnosti, utvrđeno je da su najbolji modeli dobijeni za uticaj kumarina na bubrege i jetru. Svi dobijeni modeli ukazuju na značaj električno polarizacionih deskriptora, kao i deskriptora koji opisuju veličinu i lipofilnost jedinjenja, a upotrebljeni su za utvrđivanje strukturnih karakteristika koje značajno utiču na njihovu apsorpciju, distribuciju, metabolizam, izlučivanje i toksičnost.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Quantitative structure-toxicity relationship study of some natural and synthetic coumarins using retention parameters
T1  - Analiza zavisnosti strukture i toksičnosti nekih prirodnih i sintetičkih kumarina korišćenjem retencionih parametara
VL  - 77
IS  - 10
SP  - 1443
EP  - 1456
DO  - 10.2298/JSC120716091R
ER  - 

@article{
author = "Rabtti, El Hadi M. A. and Natić, Maja and Milojković-Opsenica, Dušanka and Trifković, Jelena and Tosti, Tomislav and Vučković, Ivan and Vajs, Vlatka and Tešić, Živoslav",
year = "2012",
abstract = "Four lipophilicity descriptors (R-M(0), b, C-0 and PCl) for twelve coumarin derivatives were determined by reversed-phase thin-layer chromatography in order to analyze the descriptor which best describes the lipophilicity of the investigated coumarins. Moreover, possible chemical toxicity of coumarins, expressed as the probability of a compound to cause organ-specific health effects, was calculated using ACD/Tox Suite program. The quantitative relationships between toxicity and molecular descriptors, including experimentally determined lipophilicity descriptors obtained in current study were investigated using partial least square regression. The best models were obtained for kidney and liver health effects. Quantitative structure-toxicity relationship models revealed the importance of electric polarization descriptors, size descriptors and lipophilicity descriptors. The obtained models were used for the selection of the structural features of the compounds that are significantly affecting their absorption, distribution, metabolism, excretion and toxicity., Primenom reverzno-fazne tankoslojne hromatografije na dvanaest derivata kumarina određena su četiri parametara lipofilnosti (RM0, b, C0 i PC1). Korelacijom dobijenih rezultata sa izračunatim log P vrednostima utvrđen je deskriptor koji na najbolji način opisuje lipofilnost ispitivanih kumarina. Pored toga izračunata je moguća hemijska toksičnost kumarina, izražena kao verovatnoća uticaja pomenutih jedinjenja na specifične organe (krv, kardiovaskularni sistem, gastrointestinalni sistem, bubrege, jetru i pluća) a koja je izračunata primenom ACD/Tox Suite programa. Dobijene vrednosti toksičnosti korelisane su sa molekulskim deskriptorima i eksperimentalno određenim parametrima lipofilnosti, primenom metode parcijalne regresije najmanjih kvadrata (partial least square regression). Uzimajući u obzir parametre koji opisuju kvalitet modela zavisnosti strukture i toksičnosti, utvrđeno je da su najbolji modeli dobijeni za uticaj kumarina na bubrege i jetru. Svi dobijeni modeli ukazuju na značaj električno polarizacionih deskriptora, kao i deskriptora koji opisuju veličinu i lipofilnost jedinjenja, a upotrebljeni su za utvrđivanje strukturnih karakteristika koje značajno utiču na njihovu apsorpciju, distribuciju, metabolizam, izlučivanje i toksičnost.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Quantitative structure-toxicity relationship study of some natural and synthetic coumarins using retention parameters, Analiza zavisnosti strukture i toksičnosti nekih prirodnih i sintetičkih kumarina korišćenjem retencionih parametara",
volume = "77",
number = "10",
pages = "1443-1456",
doi = "10.2298/JSC120716091R"
}

Rabtti, E. H. M. A., Natić, M., Milojković-Opsenica, D., Trifković, J., Tosti, T., Vučković, I., Vajs, V.,& Tešić, Ž.. (2012). Quantitative structure-toxicity relationship study of some natural and synthetic coumarins using retention parameters. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 77(10), 1443-1456.
https://doi.org/10.2298/JSC120716091R

Rabtti EHMA, Natić M, Milojković-Opsenica D, Trifković J, Tosti T, Vučković I, Vajs V, Tešić Ž. Quantitative structure-toxicity relationship study of some natural and synthetic coumarins using retention parameters. in Journal of the Serbian Chemical Society. 2012;77(10):1443-1456.
doi:10.2298/JSC120716091R .

Rabtti, El Hadi M. A., Natić, Maja, Milojković-Opsenica, Dušanka, Trifković, Jelena, Tosti, Tomislav, Vučković, Ivan, Vajs, Vlatka, Tešić, Živoslav, "Quantitative structure-toxicity relationship study of some natural and synthetic coumarins using retention parameters" in Journal of the Serbian Chemical Society, 77, no. 10 (2012):1443-1456,
https://doi.org/10.2298/JSC120716091R . .

TY  - JOUR
AU  - Rabtti, El Hadi M. A.
AU  - Natić, Maja
AU  - Milojković-Opsenica, Dušanka
AU  - Trifković, Jelena
AU  - Vučković, Ivan
AU  - Vajs, Vlatka
AU  - Tešić, Živoslav
PY  - 2012
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2726
AB  - The lipophilic character of twelve coumarins was investigated by reversed-phase thin-layer chromatography (RP TLC) on RP-18 silica. The three different binary solvent systems composed of water and organic modifier (methanol, tetrahydrofuran or acetonitrile) were used in order to determine retention parameter (R-M(0)) and octanol-water partition coefficient (log P-OW) as a measure of the lipophilicity of the tested compounds. Lipophilicity parameter (log P-OW) was experimentally determined using eight standard solutes with known log P-OW values which were analyzed under the same chromatographic conditions as the target substances. Lipophilicity parameters together with 2D molecular descriptors were subjected to the multivariate statistical analysis (principal component analysis (PCA) and partial least square (PLS) regression) in order to reveal the most influential factors governing the retention, i.e., lipophilicity of the investigated compounds. The quantitative structure-retention relationship models reveal the importance of descriptors which describe the size and the shape of the molecule as well as their polar properties.
PB  - Soc Brasileira Quimica, Sao Paulo
T2  - Journal of the Brazilian Chemical Society
T1  - RP TLC-Based Lipophilicity Assessment of Some Natural and Synthetic Coumarins
VL  - 23
IS  - 3
SP  - 522
UR  - https://hdl.handle.net/21.15107/rcub_cherry_1274
ER  - 

@article{
author = "Rabtti, El Hadi M. A. and Natić, Maja and Milojković-Opsenica, Dušanka and Trifković, Jelena and Vučković, Ivan and Vajs, Vlatka and Tešić, Živoslav",
year = "2012",
abstract = "The lipophilic character of twelve coumarins was investigated by reversed-phase thin-layer chromatography (RP TLC) on RP-18 silica. The three different binary solvent systems composed of water and organic modifier (methanol, tetrahydrofuran or acetonitrile) were used in order to determine retention parameter (R-M(0)) and octanol-water partition coefficient (log P-OW) as a measure of the lipophilicity of the tested compounds. Lipophilicity parameter (log P-OW) was experimentally determined using eight standard solutes with known log P-OW values which were analyzed under the same chromatographic conditions as the target substances. Lipophilicity parameters together with 2D molecular descriptors were subjected to the multivariate statistical analysis (principal component analysis (PCA) and partial least square (PLS) regression) in order to reveal the most influential factors governing the retention, i.e., lipophilicity of the investigated compounds. The quantitative structure-retention relationship models reveal the importance of descriptors which describe the size and the shape of the molecule as well as their polar properties.",
publisher = "Soc Brasileira Quimica, Sao Paulo",
journal = "Journal of the Brazilian Chemical Society",
title = "RP TLC-Based Lipophilicity Assessment of Some Natural and Synthetic Coumarins",
volume = "23",
number = "3",
pages = "522",
url = "https://hdl.handle.net/21.15107/rcub_cherry_1274"
}

Rabtti, E. H. M. A., Natić, M., Milojković-Opsenica, D., Trifković, J., Vučković, I., Vajs, V.,& Tešić, Ž.. (2012). RP TLC-Based Lipophilicity Assessment of Some Natural and Synthetic Coumarins. in Journal of the Brazilian Chemical Society
Soc Brasileira Quimica, Sao Paulo., 23(3), 522.
https://hdl.handle.net/21.15107/rcub_cherry_1274

Rabtti EHMA, Natić M, Milojković-Opsenica D, Trifković J, Vučković I, Vajs V, Tešić Ž. RP TLC-Based Lipophilicity Assessment of Some Natural and Synthetic Coumarins. in Journal of the Brazilian Chemical Society. 2012;23(3):522.
https://hdl.handle.net/21.15107/rcub_cherry_1274 .

Rabtti, El Hadi M. A., Natić, Maja, Milojković-Opsenica, Dušanka, Trifković, Jelena, Vučković, Ivan, Vajs, Vlatka, Tešić, Živoslav, "RP TLC-Based Lipophilicity Assessment of Some Natural and Synthetic Coumarins" in Journal of the Brazilian Chemical Society, 23, no. 3 (2012):522,
https://hdl.handle.net/21.15107/rcub_cherry_1274 .

TY  - JOUR
AU  - Andrić, Filip
AU  - Trifković, Jelena
AU  - Radoičić, Aleksandra D.
AU  - Šegan, Sandra
AU  - Tešić, Živoslav
AU  - Milojković-Opsenica, Dušanka
PY  - 2010
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/707
AB  - In order to determine the soil-water partition coefficient for eleven mono- and poly-substituted phenolic compounds, for which there is still no literature data available. the possibility of using thin-layer chromatography (TLC) as a means for rapid and reliable log K-OC estimation was examined A series of chromatographically derived descriptors R-M(0), b, C-0 and PC1 (first principal component), calculated from retention data obtained under reversed-phase conditions, were used for the assessment of models as well as for a direct calibration procedure The final calibration models are discussed with regard to the achieved accuracy and statistical quality, the type of descriptors used and the corresponding chromatographic conditions The estimated log K-OC values of the studied phenols were compared with those obtained by other means (a) the present OECD guideline based on an HPLC technique, (b) the KOCWIN software package, available free of charge from the US Environmental Protection Agency web site and
PB  - Oxford : Pergamon-Elsevier Science Ltd
T2  - Chemosphere
T1  - Determination of the soil-water partition coefficients (log K-OC) of some mono- and poly-substituted phenols by reversed-phase thin-layer chromatography
VL  - 81
IS  - 3
SP  - 299
EP  - 305
DO  - 10.1016/j.chemosphere.2010.07.049
ER  - 

@article{
author = "Andrić, Filip and Trifković, Jelena and Radoičić, Aleksandra D. and Šegan, Sandra and Tešić, Živoslav and Milojković-Opsenica, Dušanka",
year = "2010",
abstract = "In order to determine the soil-water partition coefficient for eleven mono- and poly-substituted phenolic compounds, for which there is still no literature data available. the possibility of using thin-layer chromatography (TLC) as a means for rapid and reliable log K-OC estimation was examined A series of chromatographically derived descriptors R-M(0), b, C-0 and PC1 (first principal component), calculated from retention data obtained under reversed-phase conditions, were used for the assessment of models as well as for a direct calibration procedure The final calibration models are discussed with regard to the achieved accuracy and statistical quality, the type of descriptors used and the corresponding chromatographic conditions The estimated log K-OC values of the studied phenols were compared with those obtained by other means (a) the present OECD guideline based on an HPLC technique, (b) the KOCWIN software package, available free of charge from the US Environmental Protection Agency web site and",
publisher = "Oxford : Pergamon-Elsevier Science Ltd",
journal = "Chemosphere",
title = "Determination of the soil-water partition coefficients (log K-OC) of some mono- and poly-substituted phenols by reversed-phase thin-layer chromatography",
volume = "81",
number = "3",
pages = "299-305",
doi = "10.1016/j.chemosphere.2010.07.049"
}

Andrić, F., Trifković, J., Radoičić, A. D., Šegan, S., Tešić, Ž.,& Milojković-Opsenica, D.. (2010). Determination of the soil-water partition coefficients (log K-OC) of some mono- and poly-substituted phenols by reversed-phase thin-layer chromatography. in Chemosphere
Oxford : Pergamon-Elsevier Science Ltd., 81(3), 299-305.
https://doi.org/10.1016/j.chemosphere.2010.07.049

Andrić F, Trifković J, Radoičić AD, Šegan S, Tešić Ž, Milojković-Opsenica D. Determination of the soil-water partition coefficients (log K-OC) of some mono- and poly-substituted phenols by reversed-phase thin-layer chromatography. in Chemosphere. 2010;81(3):299-305.
doi:10.1016/j.chemosphere.2010.07.049 .

Andrić, Filip, Trifković, Jelena, Radoičić, Aleksandra D., Šegan, Sandra, Tešić, Živoslav, Milojković-Opsenica, Dušanka, "Determination of the soil-water partition coefficients (log K-OC) of some mono- and poly-substituted phenols by reversed-phase thin-layer chromatography" in Chemosphere, 81, no. 3 (2010):299-305,
https://doi.org/10.1016/j.chemosphere.2010.07.049 . .