TY  - JOUR
AU  - Marković, Maja D.
AU  - Svetozarević, Milica
AU  - Panić, Vesna V.
AU  - Savić, Sanja I.
AU  - Mašulović, Aleksandra D.
AU  - Spasojević, Pavle
AU  - Pjanović, Rada
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5666
AB  - This study reports successful free radical synthesis of pH-sensitive hydrogels based on poly(methacrylic acid) (PMAA) by using new green initiation system based on vitamin C and hydrogen peroxide (VC/H2O2). The application of proposed initiation system provides many advantages, above all cost effective and eco-friendly synthesis which can be carried out under ambient conditions. The obtained PMAA hydrogels are analyzed by various technics: Differential Scanning Calorimetry, Fourier Transform Infrared spectroscopy, Scanning Electron Microscopy and by using single compression tests. In line with the intended application, PMAA hydrogels are further investigated in terms of their potential to be used for encapsulation and controlled release of active substances such as antioxidant phenolic compounds. To keep it green, the total phenolic compounds (TPC) were obtained from orange peels waste by applying ultrasonic-assisted extraction and deep eutectic solvent (DES) based on glycerol:urea:water. The TPC were successfully encapsulated into the PMAA hydrogels which were previously estimated to have the optimal mechanical and swelling properties with respect to the final application. The swelling behavior of the PMAA hydrogels and controlled release of the TPC were tested as a function of the various synthesis parameters in several media with different pH values. It was shown that TPC can be released in control manner in medium which simulates the environment in human intestines, finally resulting in enhanced bioavailability of TPC, reduced side effects and improved therapeutic effects.
PB  - Elsevier B.V.
T2  - Chemical Engineering Journal
T1  - Novel eco-friendly initiation system based on vitamin C for energy efficient synthesis of PMAA hydrogel used for delivery of phenolic compounds
VL  - 459
SP  - 141580
DO  - 10.1016/j.cej.2023.141580
ER  - 

@article{
author = "Marković, Maja D. and Svetozarević, Milica and Panić, Vesna V. and Savić, Sanja I. and Mašulović, Aleksandra D. and Spasojević, Pavle and Pjanović, Rada",
year = "2023",
abstract = "This study reports successful free radical synthesis of pH-sensitive hydrogels based on poly(methacrylic acid) (PMAA) by using new green initiation system based on vitamin C and hydrogen peroxide (VC/H2O2). The application of proposed initiation system provides many advantages, above all cost effective and eco-friendly synthesis which can be carried out under ambient conditions. The obtained PMAA hydrogels are analyzed by various technics: Differential Scanning Calorimetry, Fourier Transform Infrared spectroscopy, Scanning Electron Microscopy and by using single compression tests. In line with the intended application, PMAA hydrogels are further investigated in terms of their potential to be used for encapsulation and controlled release of active substances such as antioxidant phenolic compounds. To keep it green, the total phenolic compounds (TPC) were obtained from orange peels waste by applying ultrasonic-assisted extraction and deep eutectic solvent (DES) based on glycerol:urea:water. The TPC were successfully encapsulated into the PMAA hydrogels which were previously estimated to have the optimal mechanical and swelling properties with respect to the final application. The swelling behavior of the PMAA hydrogels and controlled release of the TPC were tested as a function of the various synthesis parameters in several media with different pH values. It was shown that TPC can be released in control manner in medium which simulates the environment in human intestines, finally resulting in enhanced bioavailability of TPC, reduced side effects and improved therapeutic effects.",
publisher = "Elsevier B.V.",
journal = "Chemical Engineering Journal",
title = "Novel eco-friendly initiation system based on vitamin C for energy efficient synthesis of PMAA hydrogel used for delivery of phenolic compounds",
volume = "459",
pages = "141580",
doi = "10.1016/j.cej.2023.141580"
}

Marković, M. D., Svetozarević, M., Panić, V. V., Savić, S. I., Mašulović, A. D., Spasojević, P.,& Pjanović, R.. (2023). Novel eco-friendly initiation system based on vitamin C for energy efficient synthesis of PMAA hydrogel used for delivery of phenolic compounds. in Chemical Engineering Journal
Elsevier B.V.., 459, 141580.
https://doi.org/10.1016/j.cej.2023.141580

Marković MD, Svetozarević M, Panić VV, Savić SI, Mašulović AD, Spasojević P, Pjanović R. Novel eco-friendly initiation system based on vitamin C for energy efficient synthesis of PMAA hydrogel used for delivery of phenolic compounds. in Chemical Engineering Journal. 2023;459:141580.
doi:10.1016/j.cej.2023.141580 .

Marković, Maja D., Svetozarević, Milica, Panić, Vesna V., Savić, Sanja I., Mašulović, Aleksandra D., Spasojević, Pavle, Pjanović, Rada, "Novel eco-friendly initiation system based on vitamin C for energy efficient synthesis of PMAA hydrogel used for delivery of phenolic compounds" in Chemical Engineering Journal, 459 (2023):141580,
https://doi.org/10.1016/j.cej.2023.141580 . .

TY  - PAT
AU  - Marković, Maja
AU  - Tadić, Julijana
AU  - Šešlija, Sanja
AU  - Mijin, Dušan
AU  - Panić, Vesna
AU  - Spasojević, Pavle
AU  - Pjanović, Rada
AU  - Ugrinović, Vukašin
PY  - 2023
UR  - http://pub.zis.gov.rs/rs-pubserver/document?iDocId=103007&iepatch=.pdf
UR  - https://hdl.handle.net/21.15107/rcub_technorep_5950
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6138
AB  - Predmetnim pronalaskom postignuta je inkapsulacija slabo vodorastvorne aktivne supstance heterocikličnog azo jedinjenja sa antikancerogenim svojstvima u hidrofilni hidrogel na bazi poli(metakrilne kiseline) modifikovanog amfifilnim kazeinom, ciljana dostava inkapsuliranog azo derivata i njegovo kontrolisano i produženo otpuštanje (i do 72h) bez naglog inicijalnog oslobadanja iz hidrofilnog hidrogela. Takođe, predmetnim pronalaskom su dobijeni nosači koji bi imali potencijalnu primenu u tretmanu hronične mijeloidne leukemije (HML), čijom bi se primenom smanjio broj potrebnih terapeutskih doza i redukovali neželjeni efekti (kao što je povraćanje i iritacija gastrointestinalnog trakta) koji se najčešće javljaju kod primene lekova za terapiju HML.
PB  - Beograd, Srbija : Zavod za intelektualnu svojinu
T2  - Republika Srbija - Patentni spis
T1  - Sistem na bazi poli (metakrilne kiseline) i kazeina za kontrolisano otpuštanje heterocikličnog azo jedinjenja sa potencijalnom primenom u tretmanu malignog oboljenja belih krvnih ćelija
SP  - RS 63926
UR  - https://hdl.handle.net/21.15107/rcub_cer_6138
ER  - 

@misc{
author = "Marković, Maja and Tadić, Julijana and Šešlija, Sanja and Mijin, Dušan and Panić, Vesna and Spasojević, Pavle and Pjanović, Rada and Ugrinović, Vukašin",
year = "2023",
abstract = "Predmetnim pronalaskom postignuta je inkapsulacija slabo vodorastvorne aktivne supstance heterocikličnog azo jedinjenja sa antikancerogenim svojstvima u hidrofilni hidrogel na bazi poli(metakrilne kiseline) modifikovanog amfifilnim kazeinom, ciljana dostava inkapsuliranog azo derivata i njegovo kontrolisano i produženo otpuštanje (i do 72h) bez naglog inicijalnog oslobadanja iz hidrofilnog hidrogela. Takođe, predmetnim pronalaskom su dobijeni nosači koji bi imali potencijalnu primenu u tretmanu hronične mijeloidne leukemije (HML), čijom bi se primenom smanjio broj potrebnih terapeutskih doza i redukovali neželjeni efekti (kao što je povraćanje i iritacija gastrointestinalnog trakta) koji se najčešće javljaju kod primene lekova za terapiju HML.",
publisher = "Beograd, Srbija : Zavod za intelektualnu svojinu",
journal = "Republika Srbija - Patentni spis",
title = "Sistem na bazi poli (metakrilne kiseline) i kazeina za kontrolisano otpuštanje heterocikličnog azo jedinjenja sa potencijalnom primenom u tretmanu malignog oboljenja belih krvnih ćelija",
pages = "RS 63926",
url = "https://hdl.handle.net/21.15107/rcub_cer_6138"
}

Marković, M., Tadić, J., Šešlija, S., Mijin, D., Panić, V., Spasojević, P., Pjanović, R.,& Ugrinović, V.. (2023). Sistem na bazi poli (metakrilne kiseline) i kazeina za kontrolisano otpuštanje heterocikličnog azo jedinjenja sa potencijalnom primenom u tretmanu malignog oboljenja belih krvnih ćelija. in Republika Srbija - Patentni spis
Beograd, Srbija : Zavod za intelektualnu svojinu., RS 63926.
https://hdl.handle.net/21.15107/rcub_cer_6138

Marković M, Tadić J, Šešlija S, Mijin D, Panić V, Spasojević P, Pjanović R, Ugrinović V. Sistem na bazi poli (metakrilne kiseline) i kazeina za kontrolisano otpuštanje heterocikličnog azo jedinjenja sa potencijalnom primenom u tretmanu malignog oboljenja belih krvnih ćelija. in Republika Srbija - Patentni spis. 2023;:RS 63926.
https://hdl.handle.net/21.15107/rcub_cer_6138 .

Marković, Maja, Tadić, Julijana, Šešlija, Sanja, Mijin, Dušan, Panić, Vesna, Spasojević, Pavle, Pjanović, Rada, Ugrinović, Vukašin, "Sistem na bazi poli (metakrilne kiseline) i kazeina za kontrolisano otpuštanje heterocikličnog azo jedinjenja sa potencijalnom primenom u tretmanu malignog oboljenja belih krvnih ćelija" in Republika Srbija - Patentni spis (2023):RS 63926,
https://hdl.handle.net/21.15107/rcub_cer_6138 .

TY  - JOUR
AU  - Batinić, Petar M.
AU  - Đorđević, Verica
AU  - Obradović, Nataša S.
AU  - Krstić, Aleksandar D.
AU  - Stevanović, Sanja
AU  - Balanč, Bojana
AU  - Marković, Smilja
AU  - Pjanović, Rada
AU  - Mijin, Dušan
AU  - Bugarski, Branko
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6422
AB  - Liposome-encapsulated folic acid was incorporated into the films made from sodium carboxymethyl cellulose (CMC) (2 mas%) and a mixture of carboxymethyl cellulose and solagum (9:1 w/w) using the film-forming cast solution method. Histidine was used to increase solubility for folic acid in liposomes (1-5 mg/ml), and propylene glycol was used as a film plasticizer (2.6 mas%). The obtained films (50-60 µm tick) containing 3.12-20.19 mg of folic acid per gram of film are envisaged to be used as patches for transdermal delivery of folic acid. Therefore, some physical, mechanical, release and structural attributes of the films were scrutinized. Folic acid gave yellow color to the films and contributed to stronger chemical bonds which resulted in improved strength of the film. Liposomes prolonged the release of folic acid from films to 24 h without adverse effects on mechanical properties of the films, but degraded homogeneity of the films, which could be ascribed to its agglomeration within the film matrix as revealed by AFM. According to the release at pH 5.5, the film formulation based on a blend of CMC and solagum containing 3 mg/ml liposome-encapsulated folic acid is recommended from the point of view of release kinetics determined by its solubility.  Practical application: Folic acid is effective in reducing oxidative stress levels in the skin and neutralizing the harmful free radicals and is also essential for various metabolic reactions in the body. However, the limited solubility of folic acid linked with its poor absorption in an organism, low storage stability, short half-life upon oral consumption, specific food preferences of some people, extensive liver metabolism, and pregnancy-induced vomiting point to a large potential in transdermal usage of folic acid. This has motivated us to design new multicomponent polymer-lipid systems as an alternative solution to overcome some of these drawbacks. The results obtained for these multicomponent films pointed to their potential for prolonged release of folic acid to 24 h, which can also be useful for scientists interested in encapsulating similar poorly soluble compounds in CMC patches. The finding can be also valuable information for pharmaceutical manufacturers and scientists worldwide.
PB  - Wiley
T2  - European Journal of Lipid Science and Technology
T1  - Polymer‐lipid matrice based on carboxymethyl cellulose/solagum and liposomes for controlled release of folic acid
SP  - 2200169
DO  - 10.1002/ejlt.202200169
ER  - 

@article{
author = "Batinić, Petar M. and Đorđević, Verica and Obradović, Nataša S. and Krstić, Aleksandar D. and Stevanović, Sanja and Balanč, Bojana and Marković, Smilja and Pjanović, Rada and Mijin, Dušan and Bugarski, Branko",
year = "2023",
abstract = "Liposome-encapsulated folic acid was incorporated into the films made from sodium carboxymethyl cellulose (CMC) (2 mas%) and a mixture of carboxymethyl cellulose and solagum (9:1 w/w) using the film-forming cast solution method. Histidine was used to increase solubility for folic acid in liposomes (1-5 mg/ml), and propylene glycol was used as a film plasticizer (2.6 mas%). The obtained films (50-60 µm tick) containing 3.12-20.19 mg of folic acid per gram of film are envisaged to be used as patches for transdermal delivery of folic acid. Therefore, some physical, mechanical, release and structural attributes of the films were scrutinized. Folic acid gave yellow color to the films and contributed to stronger chemical bonds which resulted in improved strength of the film. Liposomes prolonged the release of folic acid from films to 24 h without adverse effects on mechanical properties of the films, but degraded homogeneity of the films, which could be ascribed to its agglomeration within the film matrix as revealed by AFM. According to the release at pH 5.5, the film formulation based on a blend of CMC and solagum containing 3 mg/ml liposome-encapsulated folic acid is recommended from the point of view of release kinetics determined by its solubility.  Practical application: Folic acid is effective in reducing oxidative stress levels in the skin and neutralizing the harmful free radicals and is also essential for various metabolic reactions in the body. However, the limited solubility of folic acid linked with its poor absorption in an organism, low storage stability, short half-life upon oral consumption, specific food preferences of some people, extensive liver metabolism, and pregnancy-induced vomiting point to a large potential in transdermal usage of folic acid. This has motivated us to design new multicomponent polymer-lipid systems as an alternative solution to overcome some of these drawbacks. The results obtained for these multicomponent films pointed to their potential for prolonged release of folic acid to 24 h, which can also be useful for scientists interested in encapsulating similar poorly soluble compounds in CMC patches. The finding can be also valuable information for pharmaceutical manufacturers and scientists worldwide.",
publisher = "Wiley",
journal = "European Journal of Lipid Science and Technology",
title = "Polymer‐lipid matrice based on carboxymethyl cellulose/solagum and liposomes for controlled release of folic acid",
pages = "2200169",
doi = "10.1002/ejlt.202200169"
}

Batinić, P. M., Đorđević, V., Obradović, N. S., Krstić, A. D., Stevanović, S., Balanč, B., Marković, S., Pjanović, R., Mijin, D.,& Bugarski, B.. (2023). Polymer‐lipid matrice based on carboxymethyl cellulose/solagum and liposomes for controlled release of folic acid. in European Journal of Lipid Science and Technology
Wiley., 2200169.
https://doi.org/10.1002/ejlt.202200169

Batinić PM, Đorđević V, Obradović NS, Krstić AD, Stevanović S, Balanč B, Marković S, Pjanović R, Mijin D, Bugarski B. Polymer‐lipid matrice based on carboxymethyl cellulose/solagum and liposomes for controlled release of folic acid. in European Journal of Lipid Science and Technology. 2023;:2200169.
doi:10.1002/ejlt.202200169 .

Batinić, Petar M., Đorđević, Verica, Obradović, Nataša S., Krstić, Aleksandar D., Stevanović, Sanja, Balanč, Bojana, Marković, Smilja, Pjanović, Rada, Mijin, Dušan, Bugarski, Branko, "Polymer‐lipid matrice based on carboxymethyl cellulose/solagum and liposomes for controlled release of folic acid" in European Journal of Lipid Science and Technology (2023):2200169,
https://doi.org/10.1002/ejlt.202200169 . .

TY  - JOUR
AU  - Batinić, Petar M.
AU  - Đorđević, Verica
AU  - Obradović, Nataša S.
AU  - Krstić, Aleksandar D.
AU  - Stevanović, Sanja
AU  - Balanč, Bojana
AU  - Marković, Smilja
AU  - Pjanović, Rada
AU  - Mijin, Dušan
AU  - Bugarski, Branko
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6421
AB  - Liposome-encapsulated folic acid was incorporated into the films made from sodium carboxymethyl cellulose (CMC) (2 mas%) and a mixture of carboxymethyl cellulose and solagum (9:1 w/w) using the film-forming cast solution method. Histidine was used to increase solubility for folic acid in liposomes (1-5 mg/ml), and propylene glycol was used as a film plasticizer (2.6 mas%). The obtained films (50-60 µm tick) containing 3.12-20.19 mg of folic acid per gram of film are envisaged to be used as patches for transdermal delivery of folic acid. Therefore, some physical, mechanical, release and structural attributes of the films were scrutinized. Folic acid gave yellow color to the films and contributed to stronger chemical bonds which resulted in improved strength of the film. Liposomes prolonged the release of folic acid from films to 24 h without adverse effects on mechanical properties of the films, but degraded homogeneity of the films, which could be ascribed to its agglomeration within the film matrix as revealed by AFM. According to the release at pH 5.5, the film formulation based on a blend of CMC and solagum containing 3 mg/ml liposome-encapsulated folic acid is recommended from the point of view of release kinetics determined by its solubility.  Practical application: Folic acid is effective in reducing oxidative stress levels in the skin and neutralizing the harmful free radicals and is also essential for various metabolic reactions in the body. However, the limited solubility of folic acid linked with its poor absorption in an organism, low storage stability, short half-life upon oral consumption, specific food preferences of some people, extensive liver metabolism, and pregnancy-induced vomiting point to a large potential in transdermal usage of folic acid. This has motivated us to design new multicomponent polymer-lipid systems as an alternative solution to overcome some of these drawbacks. The results obtained for these multicomponent films pointed to their potential for prolonged release of folic acid to 24 h, which can also be useful for scientists interested in encapsulating similar poorly soluble compounds in CMC patches. The finding can be also valuable information for pharmaceutical manufacturers and scientists worldwide.
PB  - Wiley
T2  - European Journal of Lipid Science and Technology
T1  - Polymer‐lipid matrice based on carboxymethyl cellulose/solagum and liposomes for controlled release of folic acid
SP  - 2200169
DO  - 10.1002/ejlt.202200169
ER  - 

@article{
author = "Batinić, Petar M. and Đorđević, Verica and Obradović, Nataša S. and Krstić, Aleksandar D. and Stevanović, Sanja and Balanč, Bojana and Marković, Smilja and Pjanović, Rada and Mijin, Dušan and Bugarski, Branko",
year = "2023",
abstract = "Liposome-encapsulated folic acid was incorporated into the films made from sodium carboxymethyl cellulose (CMC) (2 mas%) and a mixture of carboxymethyl cellulose and solagum (9:1 w/w) using the film-forming cast solution method. Histidine was used to increase solubility for folic acid in liposomes (1-5 mg/ml), and propylene glycol was used as a film plasticizer (2.6 mas%). The obtained films (50-60 µm tick) containing 3.12-20.19 mg of folic acid per gram of film are envisaged to be used as patches for transdermal delivery of folic acid. Therefore, some physical, mechanical, release and structural attributes of the films were scrutinized. Folic acid gave yellow color to the films and contributed to stronger chemical bonds which resulted in improved strength of the film. Liposomes prolonged the release of folic acid from films to 24 h without adverse effects on mechanical properties of the films, but degraded homogeneity of the films, which could be ascribed to its agglomeration within the film matrix as revealed by AFM. According to the release at pH 5.5, the film formulation based on a blend of CMC and solagum containing 3 mg/ml liposome-encapsulated folic acid is recommended from the point of view of release kinetics determined by its solubility.  Practical application: Folic acid is effective in reducing oxidative stress levels in the skin and neutralizing the harmful free radicals and is also essential for various metabolic reactions in the body. However, the limited solubility of folic acid linked with its poor absorption in an organism, low storage stability, short half-life upon oral consumption, specific food preferences of some people, extensive liver metabolism, and pregnancy-induced vomiting point to a large potential in transdermal usage of folic acid. This has motivated us to design new multicomponent polymer-lipid systems as an alternative solution to overcome some of these drawbacks. The results obtained for these multicomponent films pointed to their potential for prolonged release of folic acid to 24 h, which can also be useful for scientists interested in encapsulating similar poorly soluble compounds in CMC patches. The finding can be also valuable information for pharmaceutical manufacturers and scientists worldwide.",
publisher = "Wiley",
journal = "European Journal of Lipid Science and Technology",
title = "Polymer‐lipid matrice based on carboxymethyl cellulose/solagum and liposomes for controlled release of folic acid",
pages = "2200169",
doi = "10.1002/ejlt.202200169"
}

Batinić, P. M., Đorđević, V., Obradović, N. S., Krstić, A. D., Stevanović, S., Balanč, B., Marković, S., Pjanović, R., Mijin, D.,& Bugarski, B.. (2023). Polymer‐lipid matrice based on carboxymethyl cellulose/solagum and liposomes for controlled release of folic acid. in European Journal of Lipid Science and Technology
Wiley., 2200169.
https://doi.org/10.1002/ejlt.202200169

Batinić PM, Đorđević V, Obradović NS, Krstić AD, Stevanović S, Balanč B, Marković S, Pjanović R, Mijin D, Bugarski B. Polymer‐lipid matrice based on carboxymethyl cellulose/solagum and liposomes for controlled release of folic acid. in European Journal of Lipid Science and Technology. 2023;:2200169.
doi:10.1002/ejlt.202200169 .

Batinić, Petar M., Đorđević, Verica, Obradović, Nataša S., Krstić, Aleksandar D., Stevanović, Sanja, Balanč, Bojana, Marković, Smilja, Pjanović, Rada, Mijin, Dušan, Bugarski, Branko, "Polymer‐lipid matrice based on carboxymethyl cellulose/solagum and liposomes for controlled release of folic acid" in European Journal of Lipid Science and Technology (2023):2200169,
https://doi.org/10.1002/ejlt.202200169 . .

TY  - JOUR
AU  - Marković, Maja D.
AU  - Panić, Vesna
AU  - Savić, Sanja I.
AU  - Ugrinović, Vukašin
AU  - Pjanović, Rada
AU  - Spasojević, Milica
AU  - Spasojević, Pavle
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5295
AB  - Materials sensitive to external stimuli are recognized as safe and effective tool able to respond to specific demands in the therapy of various diseases. Thermo sensitive hydrogels based on poly(N-isopropylacrylamide) (P(NIPAAM)) are widely investigated for targeted drug delivery. Still, the abundance of the stimuli in the human body often requires more than one responsive group able to act simultaneously to achieve optimal therapeutic effects. Due to its pH sensitivity and bio-based production, crotonic acid (CA) was a monomer of choice for preparation of eco-friendly copolymer hydrogels based on NIPAAM and CA (P(NIPAAMcoCA)), which turned to be thermo and pH sensitive at the same time. The potential of the P(NIPAAMcoCA) system for encapsulation and controlled release of drugs with different solubility was investigated engaging water-soluble lidocaine hydrochloride and poorly water-soluble ibuprofen as model drugs. The hydrogels were characterized by various technics: FTIR, DSC, SEM and single compressive tests, while swelling behavior and controlled release of the drugs were analyzed with respect to the CA amount in two environments with different pH values at 25 °C and 37 °C. It was demonstrated that due to their dual responsiveness the P(NIPAAMcoCA) hydrogels have potential for controlled release of drugs with different solubility.
PB  - Elsevier
T2  - Microporous and Mesoporous Materials
T1  - Biobased thermo/pH sensitive poly(N-isopropylacrylamide-co-crotonic acid) hydrogels for targeted drug delivery
VL  - 335
SP  - 111817
DO  - 10.1016/j.micromeso.2022.111817
ER  - 

@article{
author = "Marković, Maja D. and Panić, Vesna and Savić, Sanja I. and Ugrinović, Vukašin and Pjanović, Rada and Spasojević, Milica and Spasojević, Pavle",
year = "2022",
abstract = "Materials sensitive to external stimuli are recognized as safe and effective tool able to respond to specific demands in the therapy of various diseases. Thermo sensitive hydrogels based on poly(N-isopropylacrylamide) (P(NIPAAM)) are widely investigated for targeted drug delivery. Still, the abundance of the stimuli in the human body often requires more than one responsive group able to act simultaneously to achieve optimal therapeutic effects. Due to its pH sensitivity and bio-based production, crotonic acid (CA) was a monomer of choice for preparation of eco-friendly copolymer hydrogels based on NIPAAM and CA (P(NIPAAMcoCA)), which turned to be thermo and pH sensitive at the same time. The potential of the P(NIPAAMcoCA) system for encapsulation and controlled release of drugs with different solubility was investigated engaging water-soluble lidocaine hydrochloride and poorly water-soluble ibuprofen as model drugs. The hydrogels were characterized by various technics: FTIR, DSC, SEM and single compressive tests, while swelling behavior and controlled release of the drugs were analyzed with respect to the CA amount in two environments with different pH values at 25 °C and 37 °C. It was demonstrated that due to their dual responsiveness the P(NIPAAMcoCA) hydrogels have potential for controlled release of drugs with different solubility.",
publisher = "Elsevier",
journal = "Microporous and Mesoporous Materials",
title = "Biobased thermo/pH sensitive poly(N-isopropylacrylamide-co-crotonic acid) hydrogels for targeted drug delivery",
volume = "335",
pages = "111817",
doi = "10.1016/j.micromeso.2022.111817"
}

Marković, M. D., Panić, V., Savić, S. I., Ugrinović, V., Pjanović, R., Spasojević, M.,& Spasojević, P.. (2022). Biobased thermo/pH sensitive poly(N-isopropylacrylamide-co-crotonic acid) hydrogels for targeted drug delivery. in Microporous and Mesoporous Materials
Elsevier., 335, 111817.
https://doi.org/10.1016/j.micromeso.2022.111817

Marković MD, Panić V, Savić SI, Ugrinović V, Pjanović R, Spasojević M, Spasojević P. Biobased thermo/pH sensitive poly(N-isopropylacrylamide-co-crotonic acid) hydrogels for targeted drug delivery. in Microporous and Mesoporous Materials. 2022;335:111817.
doi:10.1016/j.micromeso.2022.111817 .

Marković, Maja D., Panić, Vesna, Savić, Sanja I., Ugrinović, Vukašin, Pjanović, Rada, Spasojević, Milica, Spasojević, Pavle, "Biobased thermo/pH sensitive poly(N-isopropylacrylamide-co-crotonic acid) hydrogels for targeted drug delivery" in Microporous and Mesoporous Materials, 335 (2022):111817,
https://doi.org/10.1016/j.micromeso.2022.111817 . .

TY  - JOUR
AU  - Pantić, Olga
AU  - Pjanović, Rada
AU  - Panić, Vesna
AU  - Savić, Sanja
AU  - Spasojević, Pavle
AU  - Marković, Maja D.
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6955
AB  - Drug delivery system is an amazing tool which is widely used for drugprotection and its controlled release in order to enhance drug bioavailability,reduce side effects and therefore to improve overall therapy. Hydrogels havebeen attracted great attention as drug carriers due to their great physicochemicalproperties, similarity to the living tissues and biocompatibility. One group ofpH sensitive hydrogels are based on poly(methacrylic acid) (PMAA). Thesenon-toxic hydrogels are used as drug delivery system because they swell asa response to the change in pH of external environment and drug is beingreleased during the process. In present study, in order to improve the control ofdrug release rate, caffeine was encapsulated in liposomes which were furtherembedded into PMC hydrogel (PMCL). It was investigated how the change inneutralization degree of methacrylic acid affect the swelling degree of PMCLhydrogels and caffeine release in two environments at 37 °C for 24 h: 0.1 Mhydrochloride acid (pH 1) and phosphate buffer with pH value of 6.8 (pH 6.8), asa simulation of pH environment in human stomach and intestines, respectively.Obtained results show that PMCL hydrogels have great potential for controlledrelease of poorly water-soluble drugs in human intestines.
PB  - The Faculty of Technology, University of Banja Luka
T2  - Journal of Chemists, Technologists and Environmentalists
T1  - Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release
VL  - 3
IS  - 1
SP  - 1
EP  - 5
DO  - 10.7251/JCTE2203001P
ER  - 

@article{
author = "Pantić, Olga and Pjanović, Rada and Panić, Vesna and Savić, Sanja and Spasojević, Pavle and Marković, Maja D.",
year = "2022",
abstract = "Drug delivery system is an amazing tool which is widely used for drugprotection and its controlled release in order to enhance drug bioavailability,reduce side effects and therefore to improve overall therapy. Hydrogels havebeen attracted great attention as drug carriers due to their great physicochemicalproperties, similarity to the living tissues and biocompatibility. One group ofpH sensitive hydrogels are based on poly(methacrylic acid) (PMAA). Thesenon-toxic hydrogels are used as drug delivery system because they swell asa response to the change in pH of external environment and drug is beingreleased during the process. In present study, in order to improve the control ofdrug release rate, caffeine was encapsulated in liposomes which were furtherembedded into PMC hydrogel (PMCL). It was investigated how the change inneutralization degree of methacrylic acid affect the swelling degree of PMCLhydrogels and caffeine release in two environments at 37 °C for 24 h: 0.1 Mhydrochloride acid (pH 1) and phosphate buffer with pH value of 6.8 (pH 6.8), asa simulation of pH environment in human stomach and intestines, respectively.Obtained results show that PMCL hydrogels have great potential for controlledrelease of poorly water-soluble drugs in human intestines.",
publisher = "The Faculty of Technology, University of Banja Luka",
journal = "Journal of Chemists, Technologists and Environmentalists",
title = "Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release",
volume = "3",
number = "1",
pages = "1-5",
doi = "10.7251/JCTE2203001P"
}

Pantić, O., Pjanović, R., Panić, V., Savić, S., Spasojević, P.,& Marković, M. D.. (2022). Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release. in Journal of Chemists, Technologists and Environmentalists
The Faculty of Technology, University of Banja Luka., 3(1), 1-5.
https://doi.org/10.7251/JCTE2203001P

Pantić O, Pjanović R, Panić V, Savić S, Spasojević P, Marković MD. Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release. in Journal of Chemists, Technologists and Environmentalists. 2022;3(1):1-5.
doi:10.7251/JCTE2203001P .

Pantić, Olga, Pjanović, Rada, Panić, Vesna, Savić, Sanja, Spasojević, Pavle, Marković, Maja D., "Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release" in Journal of Chemists, Technologists and Environmentalists, 3, no. 1 (2022):1-5,
https://doi.org/10.7251/JCTE2203001P . .

TY  - CONF
AU  - Pantić, Olga
AU  - Pjanović, Rada
AU  - Panić, Vesna
AU  - Savić, Sanja
AU  - Spasojević, Pavle
AU  - Marković, Maja
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6954
AB  - Drug delivery system is an amazing tool which is widely used for drug protection and its controlled 
release in order to enhance drug bioavailability, reduce side effects and therefore to improve overall 
therapy. Hydrogels have been attracted great attention as drug carriers due to their great 
physicochemical properties, similarity to the living tissues and biocompatibility. One group of pH 
sensitive hydrogels are based on poly(methacrylic acid) (PMAA). These non-toxic hydrogels are 
used as drug delivery system because they swell as a response to the change in pH of external 
environment and drug is being released during the process. In our previous research we modified 
hydrophilic PMAA with amphiphilic casein (PMC) and enabled in that manner the encapsulation of 
poorly water-soluble caffein and its controlled release. Casein is non-toxic, pH sensitive and 
biocompatible natural polymer which improved mechanical properties of PMAA, as well. In 
present study, in order to improve the control of drug release rate, caffeine was encapsulated in 
liposomes which were further embedded into PMC hydrogel (PMCL). It was investigated how the 
change in neutralization degree of methacrylic acid affect the swelling degree of PMCL hydrogels 
and caffeine release in two environments at 37 ℃ for 24 h: 0.1 M hydrochloride acid (PH 1) and 
phosphate buffer with pH value of 6.8 (PH 6.8), as a simulation of pH environment in human 
stomach and intestines, respectively. Obtained results show that PMCL hydrogels have great 
potential for controlled release of poorly water-soluble drugs in human intestines.
PB  - Banja Luka : University in Banjaluka, Faculty of Technology
C3  - Book of proceedings - XIV Conference of Chemists, Technologists and Environmentalists of Republic of Srpska, Banja Luka, October 21-22, 2022
T1  - Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release
SP  - 43
EP  - 43
UR  - https://hdl.handle.net/21.15107/rcub_cer_6954
ER  - 

@conference{
author = "Pantić, Olga and Pjanović, Rada and Panić, Vesna and Savić, Sanja and Spasojević, Pavle and Marković, Maja",
year = "2022",
abstract = "Drug delivery system is an amazing tool which is widely used for drug protection and its controlled 
release in order to enhance drug bioavailability, reduce side effects and therefore to improve overall 
therapy. Hydrogels have been attracted great attention as drug carriers due to their great 
physicochemical properties, similarity to the living tissues and biocompatibility. One group of pH 
sensitive hydrogels are based on poly(methacrylic acid) (PMAA). These non-toxic hydrogels are 
used as drug delivery system because they swell as a response to the change in pH of external 
environment and drug is being released during the process. In our previous research we modified 
hydrophilic PMAA with amphiphilic casein (PMC) and enabled in that manner the encapsulation of 
poorly water-soluble caffein and its controlled release. Casein is non-toxic, pH sensitive and 
biocompatible natural polymer which improved mechanical properties of PMAA, as well. In 
present study, in order to improve the control of drug release rate, caffeine was encapsulated in 
liposomes which were further embedded into PMC hydrogel (PMCL). It was investigated how the 
change in neutralization degree of methacrylic acid affect the swelling degree of PMCL hydrogels 
and caffeine release in two environments at 37 ℃ for 24 h: 0.1 M hydrochloride acid (PH 1) and 
phosphate buffer with pH value of 6.8 (PH 6.8), as a simulation of pH environment in human 
stomach and intestines, respectively. Obtained results show that PMCL hydrogels have great 
potential for controlled release of poorly water-soluble drugs in human intestines.",
publisher = "Banja Luka : University in Banjaluka, Faculty of Technology",
journal = "Book of proceedings - XIV Conference of Chemists, Technologists and Environmentalists of Republic of Srpska, Banja Luka, October 21-22, 2022",
title = "Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release",
pages = "43-43",
url = "https://hdl.handle.net/21.15107/rcub_cer_6954"
}

Pantić, O., Pjanović, R., Panić, V., Savić, S., Spasojević, P.,& Marković, M.. (2022). Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release. in Book of proceedings - XIV Conference of Chemists, Technologists and Environmentalists of Republic of Srpska, Banja Luka, October 21-22, 2022
Banja Luka : University in Banjaluka, Faculty of Technology., 43-43.
https://hdl.handle.net/21.15107/rcub_cer_6954

Pantić O, Pjanović R, Panić V, Savić S, Spasojević P, Marković M. Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release. in Book of proceedings - XIV Conference of Chemists, Technologists and Environmentalists of Republic of Srpska, Banja Luka, October 21-22, 2022. 2022;:43-43.
https://hdl.handle.net/21.15107/rcub_cer_6954 .

Pantić, Olga, Pjanović, Rada, Panić, Vesna, Savić, Sanja, Spasojević, Pavle, Marković, Maja, "Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release" in Book of proceedings - XIV Conference of Chemists, Technologists and Environmentalists of Republic of Srpska, Banja Luka, October 21-22, 2022 (2022):43-43,
https://hdl.handle.net/21.15107/rcub_cer_6954 .

TY  - JOUR
AU  - Jaćimovski, Darko
AU  - Brzić, Danica
AU  - Garić Grulović, Radmila
AU  - Pjanović, Rada
AU  - Đuriš, Mihal
AU  - Arsenijević, Zorana
AU  - Bošković-Vragolović, Nevenka
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5248
AB  - In this work the theoretical model for heat transfer from a wall to aliquid-solid fluidized bed by liquid convective mechanism has been proposed.The model is based on thickness of boundary layer and film theory. The keyparameter in the model is the distance between two adjacent particles whichcollide with the wall. According to the proposed model, the liquid convectiveheat transfer in a fluidized bed is 4 to 5 times more intense than in a single-phaseflow. Additionally, the wall-to-bed heat transfer coefficient has been measuredexperimentally in water –glass particles fluidized bed, for different particle sizes.Comparison of the model prediction with experimental data has shown that sizeof the particles strongly influences the mechanism of heat transfer. For fineparticles of 0.8 mm in diameter, the liquid convective heat transfer modelrepresents adequately the experimental data, indicating that particle convectivemechanism is negligible. For coarse particles of 1.5 - 2 mm in diameter, theliquid convective heat transfer mechanism accounts for 60 % of the overall heattransfer coefficient
AB  - У овом раду развијен је теоријски модел преноса топлоте конвективним механизмомса зида колоне на течност у партикулативно флуидизованом слоју. Модел је заснован надебљини граничног слоја и теорији филма. Кључни параметар модела је растојање измеђудвe суседне честице које се сударају са зидом колоне. Према предложеном моделу преностоплоте конвекцијом на течност у флуидизованом слоју је 4 до 5 пута интензивнији него уједнофазном току. Коефицијенти преноса топлоте су експериментално одређени уфлуидизованом слоју вода-стаклене сфере, за различите пречнике честица. Поређењеексперименталних резултата и предвиђања модела је показало да пречник честица значајноутиче на механизам преноса топлоте. За веома ситне честице пречника 0.8 mm, моделпреноса топлоте конвекцијом на течност у потпуности репрезентује експерименталнерезултате, указујући да је пренос топлоте честицама занемарљив. За крупне честице,пречника 1.5 -2 mm, конвективни пренос на течност чини 60 % од укупног коефицијентапреноса топлоте
PB  - Belgrade : Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Heat transfer by liquid convection in particulate fluidized beds
T1  - Пренос топлоте конвективним механизмом у партикулативно флуидизованом слоју
VL  - 87
IS  - 7-8
SP  - 911
EP  - 924
DO  - 10.2298/JSC211216020J
ER  - 

@article{
author = "Jaćimovski, Darko and Brzić, Danica and Garić Grulović, Radmila and Pjanović, Rada and Đuriš, Mihal and Arsenijević, Zorana and Bošković-Vragolović, Nevenka",
year = "2022",
abstract = "In this work the theoretical model for heat transfer from a wall to aliquid-solid fluidized bed by liquid convective mechanism has been proposed.The model is based on thickness of boundary layer and film theory. The keyparameter in the model is the distance between two adjacent particles whichcollide with the wall. According to the proposed model, the liquid convectiveheat transfer in a fluidized bed is 4 to 5 times more intense than in a single-phaseflow. Additionally, the wall-to-bed heat transfer coefficient has been measuredexperimentally in water –glass particles fluidized bed, for different particle sizes.Comparison of the model prediction with experimental data has shown that sizeof the particles strongly influences the mechanism of heat transfer. For fineparticles of 0.8 mm in diameter, the liquid convective heat transfer modelrepresents adequately the experimental data, indicating that particle convectivemechanism is negligible. For coarse particles of 1.5 - 2 mm in diameter, theliquid convective heat transfer mechanism accounts for 60 % of the overall heattransfer coefficient, У овом раду развијен је теоријски модел преноса топлоте конвективним механизмомса зида колоне на течност у партикулативно флуидизованом слоју. Модел је заснован надебљини граничног слоја и теорији филма. Кључни параметар модела је растојање измеђудвe суседне честице које се сударају са зидом колоне. Према предложеном моделу преностоплоте конвекцијом на течност у флуидизованом слоју је 4 до 5 пута интензивнији него уједнофазном току. Коефицијенти преноса топлоте су експериментално одређени уфлуидизованом слоју вода-стаклене сфере, за различите пречнике честица. Поређењеексперименталних резултата и предвиђања модела је показало да пречник честица значајноутиче на механизам преноса топлоте. За веома ситне честице пречника 0.8 mm, моделпреноса топлоте конвекцијом на течност у потпуности репрезентује експерименталнерезултате, указујући да је пренос топлоте честицама занемарљив. За крупне честице,пречника 1.5 -2 mm, конвективни пренос на течност чини 60 % од укупног коефицијентапреноса топлоте",
publisher = "Belgrade : Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Heat transfer by liquid convection in particulate fluidized beds, Пренос топлоте конвективним механизмом у партикулативно флуидизованом слоју",
volume = "87",
number = "7-8",
pages = "911-924",
doi = "10.2298/JSC211216020J"
}

Jaćimovski, D., Brzić, D., Garić Grulović, R., Pjanović, R., Đuriš, M., Arsenijević, Z.,& Bošković-Vragolović, N.. (2022). Heat transfer by liquid convection in particulate fluidized beds. in Journal of the Serbian Chemical Society
Belgrade : Serbian Chemical Society., 87(7-8), 911-924.
https://doi.org/10.2298/JSC211216020J

Jaćimovski D, Brzić D, Garić Grulović R, Pjanović R, Đuriš M, Arsenijević Z, Bošković-Vragolović N. Heat transfer by liquid convection in particulate fluidized beds. in Journal of the Serbian Chemical Society. 2022;87(7-8):911-924.
doi:10.2298/JSC211216020J .

Jaćimovski, Darko, Brzić, Danica, Garić Grulović, Radmila, Pjanović, Rada, Đuriš, Mihal, Arsenijević, Zorana, Bošković-Vragolović, Nevenka, "Heat transfer by liquid convection in particulate fluidized beds" in Journal of the Serbian Chemical Society, 87, no. 7-8 (2022):911-924,
https://doi.org/10.2298/JSC211216020J . .

TY  - JOUR
AU  - Marković, Maja D.
AU  - Šešlija, Sanja
AU  - Ugrinović, Vukašin
AU  - Kunaver, Matjaz
AU  - Panić, Vesna
AU  - Pjanović, Rada
AU  - Spasojević, Pavle
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4807
AB  - pH- and magnetic-sensitive hybrid hydrogels based on poly(methacrylic acid) (PMAA), nanocellulose (NC), carboxymethyl cellulose (CMC) and magnetite particles (MN) were prepared as ibuprofen delivery system. NC was isolated from wood waste material and added to highly hydrophilic PMAA in order to improve the mechanical properties of PMAA and enable the encapsulation of poorly water-soluble ibuprofen. CMC was added in order to stabilize magnetite particles. The pH- and magnetic-sensitivity of the obtained hybrid hydrogels (originated from PMAA and MN, respectively) provided targeted delivery and controlled release of ibuprofen. Hybrid hydrogels were characterized by various technics: FTIR, SEM, XRD, VSM, the modified Faraday method, photon correlation spectroscopy and by using single compression tests. The swelling behavior of hybrid hydrogels and cumulative ibuprofen release were investigated depending on wt% of NC and MN in two media which were simulating pH environments in human stomach and intestines. The swelling degree of hybrid hydrogels and the percent of cumulative ibuprofen release decreased with the increase in wt% of NC. The same was found for increasing wt% of MN. Ibuprofen release kinetics was investigated with Korsmeyer–Peppas model. The obtained results showed that the prepared green dual responsive hybrid hydrogels were excellent candidates for the controlled release of ibuprofen, showing that the release kinetic can be easily tuned by changing only one hydrogel component.
PB  - Springer
T2  - Cellulose
T1  - Green pH- and magnetic-responsive hybrid hydrogels based on poly(methacrylic acid) and Eucalyptus wood nanocellulose for controlled release of ibuprofen
DO  - 10.1007/s10570-021-04222-w
ER  - 

@article{
author = "Marković, Maja D. and Šešlija, Sanja and Ugrinović, Vukašin and Kunaver, Matjaz and Panić, Vesna and Pjanović, Rada and Spasojević, Pavle",
year = "2021",
abstract = "pH- and magnetic-sensitive hybrid hydrogels based on poly(methacrylic acid) (PMAA), nanocellulose (NC), carboxymethyl cellulose (CMC) and magnetite particles (MN) were prepared as ibuprofen delivery system. NC was isolated from wood waste material and added to highly hydrophilic PMAA in order to improve the mechanical properties of PMAA and enable the encapsulation of poorly water-soluble ibuprofen. CMC was added in order to stabilize magnetite particles. The pH- and magnetic-sensitivity of the obtained hybrid hydrogels (originated from PMAA and MN, respectively) provided targeted delivery and controlled release of ibuprofen. Hybrid hydrogels were characterized by various technics: FTIR, SEM, XRD, VSM, the modified Faraday method, photon correlation spectroscopy and by using single compression tests. The swelling behavior of hybrid hydrogels and cumulative ibuprofen release were investigated depending on wt% of NC and MN in two media which were simulating pH environments in human stomach and intestines. The swelling degree of hybrid hydrogels and the percent of cumulative ibuprofen release decreased with the increase in wt% of NC. The same was found for increasing wt% of MN. Ibuprofen release kinetics was investigated with Korsmeyer–Peppas model. The obtained results showed that the prepared green dual responsive hybrid hydrogels were excellent candidates for the controlled release of ibuprofen, showing that the release kinetic can be easily tuned by changing only one hydrogel component.",
publisher = "Springer",
journal = "Cellulose",
title = "Green pH- and magnetic-responsive hybrid hydrogels based on poly(methacrylic acid) and Eucalyptus wood nanocellulose for controlled release of ibuprofen",
doi = "10.1007/s10570-021-04222-w"
}

Marković, M. D., Šešlija, S., Ugrinović, V., Kunaver, M., Panić, V., Pjanović, R.,& Spasojević, P.. (2021). Green pH- and magnetic-responsive hybrid hydrogels based on poly(methacrylic acid) and Eucalyptus wood nanocellulose for controlled release of ibuprofen. in Cellulose
Springer..
https://doi.org/10.1007/s10570-021-04222-w

Marković MD, Šešlija S, Ugrinović V, Kunaver M, Panić V, Pjanović R, Spasojević P. Green pH- and magnetic-responsive hybrid hydrogels based on poly(methacrylic acid) and Eucalyptus wood nanocellulose for controlled release of ibuprofen. in Cellulose. 2021;.
doi:10.1007/s10570-021-04222-w .

Marković, Maja D., Šešlija, Sanja, Ugrinović, Vukašin, Kunaver, Matjaz, Panić, Vesna, Pjanović, Rada, Spasojević, Pavle, "Green pH- and magnetic-responsive hybrid hydrogels based on poly(methacrylic acid) and Eucalyptus wood nanocellulose for controlled release of ibuprofen" in Cellulose (2021),
https://doi.org/10.1007/s10570-021-04222-w . .

TY  - JOUR
AU  - Marković, Maja
AU  - Panić, Vesna
AU  - Šešlija, Sanja
AU  - Milivojević, Ana D.
AU  - Spasojević, Pavle
AU  - Bošković-Vragolović, Nevenka
AU  - Pjanović, Rada
PY  - 2020
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3604
AB  - Carriers for targeted delivery and controlled release of poorly water-soluble active
substances (PWSAS) are facing three challenges: (a) the encapsulation issues, (b)
limitations of PWSAS water solubility, and (c) burst drug release which can be
pharmacologically dangerous and economically inefficient. The present study
brings a novel strategy for encapsulation and controlled release of PWSAS—
caffeine in concentrations which are higher than its maximal water solubility
without the possibility of burst effect. The modification of hydrophilic carrier
based on poly(methacylic acid) was done using casein and liposomes. To further
increase the maximal caffeine loading inside the carrier nicotinamide was used.
The release study of the encapsulated PWSAS was elaborated with respect to morphology
of the carriers and interactions that could be established between its
structural components. The carriers swelling and the release of caffeine and nicotinamide
were also investigated depending on caffeine concentration, the presence
of different liposomal formulations and the volume ratio of liposomal formulation,
in three media with different pH simulating the path of the carrier through the
human gastrointestinal tract. The synthesized carriers are promising candidates
for encapsulation of PWSAS in concentrations which are higher than its maximal
water solubility and for the targeted delivery of those dosages.
PB  - Wiley
T2  - Polymer Engineering & Science
T1  - Novel strategy for encapsulation and targeted delivery of poorly water-soluble active substances
VL  - 60
SP  - 2008
EP  - 2022
DO  - 10.1002/pen.25448
ER  - 

@article{
author = "Marković, Maja and Panić, Vesna and Šešlija, Sanja and Milivojević, Ana D. and Spasojević, Pavle and Bošković-Vragolović, Nevenka and Pjanović, Rada",
year = "2020",
abstract = "Carriers for targeted delivery and controlled release of poorly water-soluble active
substances (PWSAS) are facing three challenges: (a) the encapsulation issues, (b)
limitations of PWSAS water solubility, and (c) burst drug release which can be
pharmacologically dangerous and economically inefficient. The present study
brings a novel strategy for encapsulation and controlled release of PWSAS—
caffeine in concentrations which are higher than its maximal water solubility
without the possibility of burst effect. The modification of hydrophilic carrier
based on poly(methacylic acid) was done using casein and liposomes. To further
increase the maximal caffeine loading inside the carrier nicotinamide was used.
The release study of the encapsulated PWSAS was elaborated with respect to morphology
of the carriers and interactions that could be established between its
structural components. The carriers swelling and the release of caffeine and nicotinamide
were also investigated depending on caffeine concentration, the presence
of different liposomal formulations and the volume ratio of liposomal formulation,
in three media with different pH simulating the path of the carrier through the
human gastrointestinal tract. The synthesized carriers are promising candidates
for encapsulation of PWSAS in concentrations which are higher than its maximal
water solubility and for the targeted delivery of those dosages.",
publisher = "Wiley",
journal = "Polymer Engineering & Science",
title = "Novel strategy for encapsulation and targeted delivery of poorly water-soluble active substances",
volume = "60",
pages = "2008-2022",
doi = "10.1002/pen.25448"
}

Marković, M., Panić, V., Šešlija, S., Milivojević, A. D., Spasojević, P., Bošković-Vragolović, N.,& Pjanović, R.. (2020). Novel strategy for encapsulation and targeted delivery of poorly water-soluble active substances. in Polymer Engineering & Science
Wiley., 60, 2008-2022.
https://doi.org/10.1002/pen.25448

Marković M, Panić V, Šešlija S, Milivojević AD, Spasojević P, Bošković-Vragolović N, Pjanović R. Novel strategy for encapsulation and targeted delivery of poorly water-soluble active substances. in Polymer Engineering & Science. 2020;60:2008-2022.
doi:10.1002/pen.25448 .

Marković, Maja, Panić, Vesna, Šešlija, Sanja, Milivojević, Ana D., Spasojević, Pavle, Bošković-Vragolović, Nevenka, Pjanović, Rada, "Novel strategy for encapsulation and targeted delivery of poorly water-soluble active substances" in Polymer Engineering & Science, 60 (2020):2008-2022,
https://doi.org/10.1002/pen.25448 . .

TY  - JOUR
AU  - Marković, Maja
AU  - Panić, Vesna
AU  - Šešlija, Sanja
AU  - Spasojević, Pavle
AU  - Ugrinović, Vukašin
AU  - Bošković-Vragolović, Nevenka
AU  - Pjanović, Rada
PY  - 2020
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3641
AB  - pH sensitive, nontoxic, and biocompatible poly(methacrylic) acid (PMAA) based soft networks have been extensively used in the design of systems for targeted drug delivery. Still, their highly hydrophilic nature limits their potential to be used as a carrier of poorly water-soluble substances. With the aim to overcome this limitation, the present study details a new approach for modification of PMAA based carriers using two amphiphilic components: casein and liposomes. The FTIR analysis revealed structural features of each component as well as the synergetic effect that originated from the formation of specific interactions. Namely, hydrophobic interactions between the poorly water-soluble model drug (caffeine) and casein enabled caffeine encapsulation and controlled release, while addition of liposomes ensured better control of the release rate. The morphological properties of the carriers, swelling behavior, and release kinetics of caffeine were investigated depending on the variable synthesis parameters (neutralization degree of methacrylic acid, concentration of caffeine, presence/absence of liposomes) in two different media simulating the pH environment of human intestines and stomach. The data obtained from in vitro caffeine release were correlated and analyzed in detail using several mathematical models, indicating significant potential of investigated carriers for targeted delivery and controlled release of poorly water-soluble substances.
PB  - John Wiley and Sons Inc
T2  - Polymer Engineering and Science
T1  - Modification of hydrophilic polymer network to design a carrier for a poorly water-soluble substance
VL  - 60
SP  - 2496
EP  - 2510
DO  - 10.1002/pen.25487
ER  - 

@article{
author = "Marković, Maja and Panić, Vesna and Šešlija, Sanja and Spasojević, Pavle and Ugrinović, Vukašin and Bošković-Vragolović, Nevenka and Pjanović, Rada",
year = "2020",
abstract = "pH sensitive, nontoxic, and biocompatible poly(methacrylic) acid (PMAA) based soft networks have been extensively used in the design of systems for targeted drug delivery. Still, their highly hydrophilic nature limits their potential to be used as a carrier of poorly water-soluble substances. With the aim to overcome this limitation, the present study details a new approach for modification of PMAA based carriers using two amphiphilic components: casein and liposomes. The FTIR analysis revealed structural features of each component as well as the synergetic effect that originated from the formation of specific interactions. Namely, hydrophobic interactions between the poorly water-soluble model drug (caffeine) and casein enabled caffeine encapsulation and controlled release, while addition of liposomes ensured better control of the release rate. The morphological properties of the carriers, swelling behavior, and release kinetics of caffeine were investigated depending on the variable synthesis parameters (neutralization degree of methacrylic acid, concentration of caffeine, presence/absence of liposomes) in two different media simulating the pH environment of human intestines and stomach. The data obtained from in vitro caffeine release were correlated and analyzed in detail using several mathematical models, indicating significant potential of investigated carriers for targeted delivery and controlled release of poorly water-soluble substances.",
publisher = "John Wiley and Sons Inc",
journal = "Polymer Engineering and Science",
title = "Modification of hydrophilic polymer network to design a carrier for a poorly water-soluble substance",
volume = "60",
pages = "2496-2510",
doi = "10.1002/pen.25487"
}

Marković, M., Panić, V., Šešlija, S., Spasojević, P., Ugrinović, V., Bošković-Vragolović, N.,& Pjanović, R.. (2020). Modification of hydrophilic polymer network to design a carrier for a poorly water-soluble substance. in Polymer Engineering and Science
John Wiley and Sons Inc., 60, 2496-2510.
https://doi.org/10.1002/pen.25487

Marković M, Panić V, Šešlija S, Spasojević P, Ugrinović V, Bošković-Vragolović N, Pjanović R. Modification of hydrophilic polymer network to design a carrier for a poorly water-soluble substance. in Polymer Engineering and Science. 2020;60:2496-2510.
doi:10.1002/pen.25487 .

Marković, Maja, Panić, Vesna, Šešlija, Sanja, Spasojević, Pavle, Ugrinović, Vukašin, Bošković-Vragolović, Nevenka, Pjanović, Rada, "Modification of hydrophilic polymer network to design a carrier for a poorly water-soluble substance" in Polymer Engineering and Science, 60 (2020):2496-2510,
https://doi.org/10.1002/pen.25487 . .

TY  - JOUR
AU  - Marković, Maja D.
AU  - Spasojević, Pavle
AU  - Šešlija, Sanja
AU  - Popović, Ivanka G.
AU  - Veljović, Đorđe
AU  - Pjanović, Rada
AU  - Panić, Vesna
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2990
AB  - The design of complex polymeric materials with predefined task-specific properties meets challenging issues: to establish synthesis-structure-properties relationship, as well as to understand the arrangement and interactions of the involved components. Hybrid networks of protein (casein) and polyelectrolyte (poly(methacrylic acid)) were synthesized and their swelling, dynamic-mechanical and morphological properties were investigated as functions of the neutralization degree of methacrylic acid and the concentrations of caseinate and crosslinker. The domination of different interactions between components led to diverse forms of casein macromolecules- from micelles to unfold chains. That resulted in very different structures and thereby properties of derived hybrid networks: from porous unswellable to highly swellable and reinforced ones. A great opportunity to easily modulate the final characteristics of the reported hybrid system to fit the need of specific application just through the change of one synthesis parameter was thereby demonstrated.
PB  - Elsevier
T2  - European Polymer Journal
T1  - Casein-poly(methacrylic acid) hybrid soft networks with easy tunable properties
VL  - 113
SP  - 276
EP  - 288
DO  - 10.1016/j.eurpolymj.2019.01.065
ER  - 

@article{
author = "Marković, Maja D. and Spasojević, Pavle and Šešlija, Sanja and Popović, Ivanka G. and Veljović, Đorđe and Pjanović, Rada and Panić, Vesna",
year = "2019",
abstract = "The design of complex polymeric materials with predefined task-specific properties meets challenging issues: to establish synthesis-structure-properties relationship, as well as to understand the arrangement and interactions of the involved components. Hybrid networks of protein (casein) and polyelectrolyte (poly(methacrylic acid)) were synthesized and their swelling, dynamic-mechanical and morphological properties were investigated as functions of the neutralization degree of methacrylic acid and the concentrations of caseinate and crosslinker. The domination of different interactions between components led to diverse forms of casein macromolecules- from micelles to unfold chains. That resulted in very different structures and thereby properties of derived hybrid networks: from porous unswellable to highly swellable and reinforced ones. A great opportunity to easily modulate the final characteristics of the reported hybrid system to fit the need of specific application just through the change of one synthesis parameter was thereby demonstrated.",
publisher = "Elsevier",
journal = "European Polymer Journal",
title = "Casein-poly(methacrylic acid) hybrid soft networks with easy tunable properties",
volume = "113",
pages = "276-288",
doi = "10.1016/j.eurpolymj.2019.01.065"
}

Marković, M. D., Spasojević, P., Šešlija, S., Popović, I. G., Veljović, Đ., Pjanović, R.,& Panić, V.. (2019). Casein-poly(methacrylic acid) hybrid soft networks with easy tunable properties. in European Polymer Journal
Elsevier., 113, 276-288.
https://doi.org/10.1016/j.eurpolymj.2019.01.065

Marković MD, Spasojević P, Šešlija S, Popović IG, Veljović Đ, Pjanović R, Panić V. Casein-poly(methacrylic acid) hybrid soft networks with easy tunable properties. in European Polymer Journal. 2019;113:276-288.
doi:10.1016/j.eurpolymj.2019.01.065 .

Marković, Maja D., Spasojević, Pavle, Šešlija, Sanja, Popović, Ivanka G., Veljović, Đorđe, Pjanović, Rada, Panić, Vesna, "Casein-poly(methacrylic acid) hybrid soft networks with easy tunable properties" in European Polymer Journal, 113 (2019):276-288,
https://doi.org/10.1016/j.eurpolymj.2019.01.065 . .

TY  - JOUR
AU  - Jaćimovski, Darko
AU  - Garić Grulović, Radmila
AU  - Vucetic, Nemanja
AU  - Pjanović, Rada
AU  - Bošković-Vragolović, Nevenka
PY  - 2016
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1931
AB  - The aim of this study was to analyze the concentration boundary layer for a comprehensive description of the mass transfer in systems with fluidized particles. Mass transfer from the wall of the column to the fluid in the presence of inert fluidized particles was experimentally investigated using the dissolution method. Experiments were carried out in a column 34 mm in diameter, divided by height into six segments. In all runs, mass transfer rates were determined in the presence of fluidized spherical glass particles 1.10 mm, 1.94 mm and 2.98 mm in diameter, using water as the fluidized medium. The analysis of the boundary layer shows the effect of particles presence on mass transfer in fluidized systems. The theoretical model was established based on boundary layer theory, and the impact of particles on the shortening of the boundary layer length, due to their collision with the wall of the column. The theoretically derived model was compared with experimentally obtained data and with data calculated from available literature correlations. Very good agreement was found between the model, experimental data, and published correlations (especially the correlation by Pickett et al. 12]).
PB  - Elsevier
T2  - Powder Technology
T1  - Mass transfer and concentration boundary layer in a particulate fluidized bed
VL  - 303
SP  - 68
EP  - 75
DO  - 10.1016/j.powtec.2016.09.025
ER  - 

@article{
author = "Jaćimovski, Darko and Garić Grulović, Radmila and Vucetic, Nemanja and Pjanović, Rada and Bošković-Vragolović, Nevenka",
year = "2016",
abstract = "The aim of this study was to analyze the concentration boundary layer for a comprehensive description of the mass transfer in systems with fluidized particles. Mass transfer from the wall of the column to the fluid in the presence of inert fluidized particles was experimentally investigated using the dissolution method. Experiments were carried out in a column 34 mm in diameter, divided by height into six segments. In all runs, mass transfer rates were determined in the presence of fluidized spherical glass particles 1.10 mm, 1.94 mm and 2.98 mm in diameter, using water as the fluidized medium. The analysis of the boundary layer shows the effect of particles presence on mass transfer in fluidized systems. The theoretical model was established based on boundary layer theory, and the impact of particles on the shortening of the boundary layer length, due to their collision with the wall of the column. The theoretically derived model was compared with experimentally obtained data and with data calculated from available literature correlations. Very good agreement was found between the model, experimental data, and published correlations (especially the correlation by Pickett et al. 12]).",
publisher = "Elsevier",
journal = "Powder Technology",
title = "Mass transfer and concentration boundary layer in a particulate fluidized bed",
volume = "303",
pages = "68-75",
doi = "10.1016/j.powtec.2016.09.025"
}

Jaćimovski, D., Garić Grulović, R., Vucetic, N., Pjanović, R.,& Bošković-Vragolović, N.. (2016). Mass transfer and concentration boundary layer in a particulate fluidized bed. in Powder Technology
Elsevier., 303, 68-75.
https://doi.org/10.1016/j.powtec.2016.09.025

Jaćimovski D, Garić Grulović R, Vucetic N, Pjanović R, Bošković-Vragolović N. Mass transfer and concentration boundary layer in a particulate fluidized bed. in Powder Technology. 2016;303:68-75.
doi:10.1016/j.powtec.2016.09.025 .

Jaćimovski, Darko, Garić Grulović, Radmila, Vucetic, Nemanja, Pjanović, Rada, Bošković-Vragolović, Nevenka, "Mass transfer and concentration boundary layer in a particulate fluidized bed" in Powder Technology, 303 (2016):68-75,
https://doi.org/10.1016/j.powtec.2016.09.025 . .

TY  - JOUR
AU  - Bošković-Vragolović, Nevenka
AU  - Garić Grulović, Radmila
AU  - Pjanović, Rada
AU  - Grbavčić, Željko
PY  - 2013
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1294
AB  - Mass transfer coefficient in single phase flow around short cylinder, has been studied experimentally using adsorption method. Experiments were conducted in "two-dimensional" column 140 x 10 x 200 mm. The mass transfer data were obtained by studying transfer for flow past single cylinder, 30 mm in diameter. This paper, also, discusses the possibilities of application of the adsorption method for fluid flow visualization. Local and average mass transfer coefficients were determined from color intensity on the surface of foils of silica gel. Experimental correlations for Sh = f (Re) and j(D) = f (Re) were established using mass transfer coefficients data.
PB  - Oxford : Pergamon-Elsevier Science Ltd
T2  - International Journal of Heat and Mass Transfer
T1  - Mass transfer and fluid flow visualization for single cylinder by the adsorption method
VL  - 59
SP  - 155
EP  - 160
DO  - 10.1016/j.ijheatmasstransfer.2012.11.077
ER  - 

@article{
author = "Bošković-Vragolović, Nevenka and Garić Grulović, Radmila and Pjanović, Rada and Grbavčić, Željko",
year = "2013",
abstract = "Mass transfer coefficient in single phase flow around short cylinder, has been studied experimentally using adsorption method. Experiments were conducted in "two-dimensional" column 140 x 10 x 200 mm. The mass transfer data were obtained by studying transfer for flow past single cylinder, 30 mm in diameter. This paper, also, discusses the possibilities of application of the adsorption method for fluid flow visualization. Local and average mass transfer coefficients were determined from color intensity on the surface of foils of silica gel. Experimental correlations for Sh = f (Re) and j(D) = f (Re) were established using mass transfer coefficients data.",
publisher = "Oxford : Pergamon-Elsevier Science Ltd",
journal = "International Journal of Heat and Mass Transfer",
title = "Mass transfer and fluid flow visualization for single cylinder by the adsorption method",
volume = "59",
pages = "155-160",
doi = "10.1016/j.ijheatmasstransfer.2012.11.077"
}

Bošković-Vragolović, N., Garić Grulović, R., Pjanović, R.,& Grbavčić, Ž.. (2013). Mass transfer and fluid flow visualization for single cylinder by the adsorption method. in International Journal of Heat and Mass Transfer
Oxford : Pergamon-Elsevier Science Ltd., 59, 155-160.
https://doi.org/10.1016/j.ijheatmasstransfer.2012.11.077

Bošković-Vragolović N, Garić Grulović R, Pjanović R, Grbavčić Ž. Mass transfer and fluid flow visualization for single cylinder by the adsorption method. in International Journal of Heat and Mass Transfer. 2013;59:155-160.
doi:10.1016/j.ijheatmasstransfer.2012.11.077 .

Bošković-Vragolović, Nevenka, Garić Grulović, Radmila, Pjanović, Rada, Grbavčić, Željko, "Mass transfer and fluid flow visualization for single cylinder by the adsorption method" in International Journal of Heat and Mass Transfer, 59 (2013):155-160,
https://doi.org/10.1016/j.ijheatmasstransfer.2012.11.077 . .

TY  - JOUR
AU  - Pjanović, Rada
AU  - Bošković-Vragolović, Nevenka
AU  - Veljkovic-Giga, Jelena
AU  - Garić Grulović, Radmila
AU  - Pejanović, Srđan
AU  - Bugarski, Branko
PY  - 2010
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/661
AB  - BACKGROUND: The mass transfer of model drugs Lidocaine hydrochloride and Dihydroquercetin from hydrogels (the usual carriers for topical drugs), and hydrogels containing liposomes, as novel drug vehicles, was studied. Diffusion experiments were performed using a Franz diffusion cell. Experimental data were used to calculate drug diffusion coefficients across membranes, and their effective diffusion coefficients from hydrogels and liposome containing hydrogels. For the first time the diffusion resistance of all drug carriers was determined from corresponding diffusion coefficients. The main aim of this work was the study of drug diffusion coefficients from liposomes and their comparison with related diffusion coefficients from hydrogels to find how liposomes contribute to prolonged and controlled drug release. RESULTS: Drug diffusion coefficients were: 1.38 . 10(-8)-m(2) s(-1) for Lidocaine hydrochloride and 5.96 . 10(-9)m(-2) s(-1) for Dihydroquercetin, while corresponding effective diffusion coefficients from hydrogels were: 7.82 . 10(-10)m(2) s(-1) and 7.98 . 10(-10)m(2) s(-1), respectively. Effective diffusion coefficients from liposome-containing hydrogels were:4.82 . 10(-10)m(2) s(-1) (Lidocaine hydrochloride) and 4.305 . 10(-10)m(2) s(-1) (Dihydroquercetin). Diffusion resistances for the two hydrogels were almost the same. Very similar values of diffusion resistances for all liposome dispersions were obtained. CONCLUSION: Calculated diffusion coefficients and resistances demonstrate that liposomes, as drug carriers, significantly affect diffusion rates. The results obtained could be used whenever diffusion-controlled drug release is required.
PB  - John Wiley & Sons Ltd, Chichester
T2  - Journal of Chemical Technology and Biotechnology
T1  - Diffusion of drugs from hydrogels and liposomes as drug carriers
VL  - 85
IS  - 5
SP  - 693
EP  - 698
DO  - 10.1002/jctb.2357
ER  - 

@article{
author = "Pjanović, Rada and Bošković-Vragolović, Nevenka and Veljkovic-Giga, Jelena and Garić Grulović, Radmila and Pejanović, Srđan and Bugarski, Branko",
year = "2010",
abstract = "BACKGROUND: The mass transfer of model drugs Lidocaine hydrochloride and Dihydroquercetin from hydrogels (the usual carriers for topical drugs), and hydrogels containing liposomes, as novel drug vehicles, was studied. Diffusion experiments were performed using a Franz diffusion cell. Experimental data were used to calculate drug diffusion coefficients across membranes, and their effective diffusion coefficients from hydrogels and liposome containing hydrogels. For the first time the diffusion resistance of all drug carriers was determined from corresponding diffusion coefficients. The main aim of this work was the study of drug diffusion coefficients from liposomes and their comparison with related diffusion coefficients from hydrogels to find how liposomes contribute to prolonged and controlled drug release. RESULTS: Drug diffusion coefficients were: 1.38 . 10(-8)-m(2) s(-1) for Lidocaine hydrochloride and 5.96 . 10(-9)m(-2) s(-1) for Dihydroquercetin, while corresponding effective diffusion coefficients from hydrogels were: 7.82 . 10(-10)m(2) s(-1) and 7.98 . 10(-10)m(2) s(-1), respectively. Effective diffusion coefficients from liposome-containing hydrogels were:4.82 . 10(-10)m(2) s(-1) (Lidocaine hydrochloride) and 4.305 . 10(-10)m(2) s(-1) (Dihydroquercetin). Diffusion resistances for the two hydrogels were almost the same. Very similar values of diffusion resistances for all liposome dispersions were obtained. CONCLUSION: Calculated diffusion coefficients and resistances demonstrate that liposomes, as drug carriers, significantly affect diffusion rates. The results obtained could be used whenever diffusion-controlled drug release is required.",
publisher = "John Wiley & Sons Ltd, Chichester",
journal = "Journal of Chemical Technology and Biotechnology",
title = "Diffusion of drugs from hydrogels and liposomes as drug carriers",
volume = "85",
number = "5",
pages = "693-698",
doi = "10.1002/jctb.2357"
}

Pjanović, R., Bošković-Vragolović, N., Veljkovic-Giga, J., Garić Grulović, R., Pejanović, S.,& Bugarski, B.. (2010). Diffusion of drugs from hydrogels and liposomes as drug carriers. in Journal of Chemical Technology and Biotechnology
John Wiley & Sons Ltd, Chichester., 85(5), 693-698.
https://doi.org/10.1002/jctb.2357

Pjanović R, Bošković-Vragolović N, Veljkovic-Giga J, Garić Grulović R, Pejanović S, Bugarski B. Diffusion of drugs from hydrogels and liposomes as drug carriers. in Journal of Chemical Technology and Biotechnology. 2010;85(5):693-698.
doi:10.1002/jctb.2357 .

Pjanović, Rada, Bošković-Vragolović, Nevenka, Veljkovic-Giga, Jelena, Garić Grulović, Radmila, Pejanović, Srđan, Bugarski, Branko, "Diffusion of drugs from hydrogels and liposomes as drug carriers" in Journal of Chemical Technology and Biotechnology, 85, no. 5 (2010):693-698,
https://doi.org/10.1002/jctb.2357 . .

TY  - JOUR
AU  - Bošković-Vragolović, Nevenka
AU  - Garić Grulović, Radmila
AU  - Grbavčić, Željko
AU  - Pjanović, Rada
PY  - 2009
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/523
AB  - A mass transfer coefficient between: A liquid and single sphere and a liquid And a column wall in packed and fluidized beds of a spherical inert Particle have been studied experimentally using the adsorption method. The experiments were conducted in a column 40 mm in diameter for packed and fluidized beds, and in a two-dimensional column 140 mm×10 mm for the flow past single sphere. In all runs, the mass transfer rates were determined in the presence of spherical glass particles, 3 mm in diameter, for packed and fluidized beds. The mass transfer data were obtained by studying transfer for flow past single sphere, 20 mm in diameter. This paper discusses the possibilities of application of the adsorption method for fluid flow visualization. Local and average mass transfer coefficients were determined from the color intensity of the surface of the foils of silica gel. Correlations, Sh = f(Re) and jD = f(Re), were derived using the mass transfer coefficient data.
PB  - Association of the Chemical Engineers of Serbia
T2  - Chemical Industry and Chemical Engineering Quarterly / CICEQ
T1  - A mass transfer heterogeneous in systems by the adsorption method
VL  - 15
IS  - 1
SP  - 25
EP  - 28
DO  - 10.2298/CICEQ0901025B
ER  - 

@article{
author = "Bošković-Vragolović, Nevenka and Garić Grulović, Radmila and Grbavčić, Željko and Pjanović, Rada",
year = "2009",
abstract = "A mass transfer coefficient between: A liquid and single sphere and a liquid And a column wall in packed and fluidized beds of a spherical inert Particle have been studied experimentally using the adsorption method. The experiments were conducted in a column 40 mm in diameter for packed and fluidized beds, and in a two-dimensional column 140 mm×10 mm for the flow past single sphere. In all runs, the mass transfer rates were determined in the presence of spherical glass particles, 3 mm in diameter, for packed and fluidized beds. The mass transfer data were obtained by studying transfer for flow past single sphere, 20 mm in diameter. This paper discusses the possibilities of application of the adsorption method for fluid flow visualization. Local and average mass transfer coefficients were determined from the color intensity of the surface of the foils of silica gel. Correlations, Sh = f(Re) and jD = f(Re), were derived using the mass transfer coefficient data.",
publisher = "Association of the Chemical Engineers of Serbia",
journal = "Chemical Industry and Chemical Engineering Quarterly / CICEQ",
title = "A mass transfer heterogeneous in systems by the adsorption method",
volume = "15",
number = "1",
pages = "25-28",
doi = "10.2298/CICEQ0901025B"
}

Bošković-Vragolović, N., Garić Grulović, R., Grbavčić, Ž.,& Pjanović, R.. (2009). A mass transfer heterogeneous in systems by the adsorption method. in Chemical Industry and Chemical Engineering Quarterly / CICEQ
Association of the Chemical Engineers of Serbia., 15(1), 25-28.
https://doi.org/10.2298/CICEQ0901025B

Bošković-Vragolović N, Garić Grulović R, Grbavčić Ž, Pjanović R. A mass transfer heterogeneous in systems by the adsorption method. in Chemical Industry and Chemical Engineering Quarterly / CICEQ. 2009;15(1):25-28.
doi:10.2298/CICEQ0901025B .

Bošković-Vragolović, Nevenka, Garić Grulović, Radmila, Grbavčić, Željko, Pjanović, Rada, "A mass transfer heterogeneous in systems by the adsorption method" in Chemical Industry and Chemical Engineering Quarterly / CICEQ, 15, no. 1 (2009):25-28,
https://doi.org/10.2298/CICEQ0901025B . .

TY  - CONF
AU  - Bošković-Vragolović, Nevenka
AU  - Garić Grulović, Radmila
AU  - Grbavčić, Željko
AU  - Pjanović, Rada
PY  - 2009
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/573
AB  - Mass transfer coefficient (j D ) between fluid and column wall in liquid packed and fluidized beds of spherical inert particle has been studied experimentally using adsorption method. Experiments were conducted in column 40 mm in diameter for packed and fluidized beds. In all runs mass transfer rates were determined in presence of spherical glass particles 2.06 mm in diameter. This paper introduced adsorption method as very suitable method for studies of mass transfer and for fluid flow visualization. The adsorption method is based on the dynamic adsorption of an organic dye onto a surface covered with a thin layer of a porous adsorbent. Local and average mass transfer coefficients were determinated from the surface color intensity of the foils of silica gel. Correlation j D = f(Re) was derived using mass transfer coefficients data.
PB  - Maik Nauka/Interperiodica/Springer, New York
C3  - Russian Journal of Physical Chemistry A
T1  - Mass transfer and fluid flow visualization in packed and fluidized beds by the adsorption method
VL  - 83
IS  - 9
SP  - 1550
EP  - 1553
DO  - 10.1134/S0036024409090246
ER  - 

@conference{
author = "Bošković-Vragolović, Nevenka and Garić Grulović, Radmila and Grbavčić, Željko and Pjanović, Rada",
year = "2009",
abstract = "Mass transfer coefficient (j D ) between fluid and column wall in liquid packed and fluidized beds of spherical inert particle has been studied experimentally using adsorption method. Experiments were conducted in column 40 mm in diameter for packed and fluidized beds. In all runs mass transfer rates were determined in presence of spherical glass particles 2.06 mm in diameter. This paper introduced adsorption method as very suitable method for studies of mass transfer and for fluid flow visualization. The adsorption method is based on the dynamic adsorption of an organic dye onto a surface covered with a thin layer of a porous adsorbent. Local and average mass transfer coefficients were determinated from the surface color intensity of the foils of silica gel. Correlation j D = f(Re) was derived using mass transfer coefficients data.",
publisher = "Maik Nauka/Interperiodica/Springer, New York",
journal = "Russian Journal of Physical Chemistry A",
title = "Mass transfer and fluid flow visualization in packed and fluidized beds by the adsorption method",
volume = "83",
number = "9",
pages = "1550-1553",
doi = "10.1134/S0036024409090246"
}

Bošković-Vragolović, N., Garić Grulović, R., Grbavčić, Ž.,& Pjanović, R.. (2009). Mass transfer and fluid flow visualization in packed and fluidized beds by the adsorption method. in Russian Journal of Physical Chemistry A
Maik Nauka/Interperiodica/Springer, New York., 83(9), 1550-1553.
https://doi.org/10.1134/S0036024409090246

Bošković-Vragolović N, Garić Grulović R, Grbavčić Ž, Pjanović R. Mass transfer and fluid flow visualization in packed and fluidized beds by the adsorption method. in Russian Journal of Physical Chemistry A. 2009;83(9):1550-1553.
doi:10.1134/S0036024409090246 .

Bošković-Vragolović, Nevenka, Garić Grulović, Radmila, Grbavčić, Željko, Pjanović, Rada, "Mass transfer and fluid flow visualization in packed and fluidized beds by the adsorption method" in Russian Journal of Physical Chemistry A, 83, no. 9 (2009):1550-1553,
https://doi.org/10.1134/S0036024409090246 . .