TY  - JOUR
AU  - Solarz, Daria
AU  - Witko, Tomasz
AU  - Karcz, Robert
AU  - Malagurski, Ivana
AU  - Ponjavić, Marijana
AU  - Levic, Steva
AU  - Nešić, Aleksandra
AU  - Guzik, Maciej
AU  - Savić, Sanja
AU  - Nikodinović-Runić, Jasmina
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/7170
AB  - Polyhydroxyoctanoate, as a biocompatible and biodegradable biopolymer, represents an ideal candidate for biomedical applications. However, physical properties make it unsuitable for electrospinning, currently the most widely used technique for fabrication of fibrous scaffolds. To overcome this, it was blended with polylactic acid and polymer blend fibrous biomaterials were produced by electrospinning. The obtained PLA/PHO fibers were cylindrical, smaller in size, more hydrophilic and had a higher degree of biopolymer crystallinity and more favorable mechanical properties in comparison to the pure PLA sample. Cytotoxicity evaluation with human lung fibroblasts (MRC5 cells) combined with confocal microscopy were used to visualize mouse embryonic fibroblasts (MEF 3T3 cell line) migration and distribution showed that PLA/PHO samples support exceptional cell adhesion and viability, indicating excellent biocompatibility. The obtained results suggest that PLA/PHO fibrous biomaterials can be potentially used as biocompatible, biomimetic scaffolds for tissue engineering applications.
PB  - Royal Society of Chemistry (RSC)
T2  - RSC Advances
T1  - Biological and physiochemical studies of electrospun polylactid/polyhydroxyoctanoate PLA/ P(3HO) scaffolds for tissue engineering applications
VL  - 13
IS  - 34
SP  - 24112
EP  - 24128
DO  - 10.1039/D3RA03021K
ER  - 

@article{
author = "Solarz, Daria and Witko, Tomasz and Karcz, Robert and Malagurski, Ivana and Ponjavić, Marijana and Levic, Steva and Nešić, Aleksandra and Guzik, Maciej and Savić, Sanja and Nikodinović-Runić, Jasmina",
year = "2023",
abstract = "Polyhydroxyoctanoate, as a biocompatible and biodegradable biopolymer, represents an ideal candidate for biomedical applications. However, physical properties make it unsuitable for electrospinning, currently the most widely used technique for fabrication of fibrous scaffolds. To overcome this, it was blended with polylactic acid and polymer blend fibrous biomaterials were produced by electrospinning. The obtained PLA/PHO fibers were cylindrical, smaller in size, more hydrophilic and had a higher degree of biopolymer crystallinity and more favorable mechanical properties in comparison to the pure PLA sample. Cytotoxicity evaluation with human lung fibroblasts (MRC5 cells) combined with confocal microscopy were used to visualize mouse embryonic fibroblasts (MEF 3T3 cell line) migration and distribution showed that PLA/PHO samples support exceptional cell adhesion and viability, indicating excellent biocompatibility. The obtained results suggest that PLA/PHO fibrous biomaterials can be potentially used as biocompatible, biomimetic scaffolds for tissue engineering applications.",
publisher = "Royal Society of Chemistry (RSC)",
journal = "RSC Advances",
title = "Biological and physiochemical studies of electrospun polylactid/polyhydroxyoctanoate PLA/ P(3HO) scaffolds for tissue engineering applications",
volume = "13",
number = "34",
pages = "24112-24128",
doi = "10.1039/D3RA03021K"
}

Solarz, D., Witko, T., Karcz, R., Malagurski, I., Ponjavić, M., Levic, S., Nešić, A., Guzik, M., Savić, S.,& Nikodinović-Runić, J.. (2023). Biological and physiochemical studies of electrospun polylactid/polyhydroxyoctanoate PLA/ P(3HO) scaffolds for tissue engineering applications. in RSC Advances
Royal Society of Chemistry (RSC)., 13(34), 24112-24128.
https://doi.org/10.1039/D3RA03021K

Solarz D, Witko T, Karcz R, Malagurski I, Ponjavić M, Levic S, Nešić A, Guzik M, Savić S, Nikodinović-Runić J. Biological and physiochemical studies of electrospun polylactid/polyhydroxyoctanoate PLA/ P(3HO) scaffolds for tissue engineering applications. in RSC Advances. 2023;13(34):24112-24128.
doi:10.1039/D3RA03021K .

Solarz, Daria, Witko, Tomasz, Karcz, Robert, Malagurski, Ivana, Ponjavić, Marijana, Levic, Steva, Nešić, Aleksandra, Guzik, Maciej, Savić, Sanja, Nikodinović-Runić, Jasmina, "Biological and physiochemical studies of electrospun polylactid/polyhydroxyoctanoate PLA/ P(3HO) scaffolds for tissue engineering applications" in RSC Advances, 13, no. 34 (2023):24112-24128,
https://doi.org/10.1039/D3RA03021K . .

TY  - CONF
AU  - Pantić, Olga
AU  - Savić, Sanja
AU  - Panić, Vesna
AU  - Marković, Maja
AU  - Spasojević, Pavle
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6972
AB  - The importance of producing thermoset polymers from natural resources has grown due to environmental concerns. Implementing the biorefinery concept is vital for replacing petroleum-based raw materials and transferring to cleaner technologies. Unsaturated polyester resins (UPRs) are a significant class of thermosetting polymers, with a wide range of properties gained from a 
 considerable number of materials that are used for their synthesis. They can be used as pure resins or resins reinforced with suitable fillers in composite material production, which is the focus of this research. Generally, UPRs consist of two main components, prepolymer and reactive diluents, commercially both of which are commonly derived from petroleum. So, it is important to find an adequate bio-based alternative not only for styrene as a reactive diluent, but also for monomers that are used for prepolymer synthesis. Many bio-based monomers (propylene glycol, isosorbide, neopentyl glycol) and reactive diluents (vinyl levulinate, butanediol dimethacrylate, dimethyl itaconate) were investigated in formulating a bio-based UPR. Alongside this, many different bio-based fillers (hemp fibres, spent coffee grounds, rosehip seed flour) were also examined, to conclusively obtain a fully bio-based composite material. Sole introduction of bio-based raw 
materials is insufficient for proper implementation of the biorefinery principle. It is equally important that the final formulation of the obtained composite material demonstrates that it is environmentally and economically feasible. The quality and market price of the bio-based composite material must be at least be comparable to or better than those of a product from a conventional process in order to be competitive.
PB  - Ljubljana : National Institute of Chemistry, Department of Catalysis and Chemical Reaction Engineering
C3  - Book of Abstracts - Next Challenges of Biorefineries, 3rd BioSPRINT Workshop, 2nd Bilateral Workshop Portugal-Slovenia, June 14-15, 2023
T1  - Bio-based unsaturated polyester resins – A step towards a biorefinery solution
SP  - 14
EP  - 14
UR  - https://hdl.handle.net/21.15107/rcub_cer_6972
ER  - 

@conference{
author = "Pantić, Olga and Savić, Sanja and Panić, Vesna and Marković, Maja and Spasojević, Pavle",
year = "2023",
abstract = "The importance of producing thermoset polymers from natural resources has grown due to environmental concerns. Implementing the biorefinery concept is vital for replacing petroleum-based raw materials and transferring to cleaner technologies. Unsaturated polyester resins (UPRs) are a significant class of thermosetting polymers, with a wide range of properties gained from a 
 considerable number of materials that are used for their synthesis. They can be used as pure resins or resins reinforced with suitable fillers in composite material production, which is the focus of this research. Generally, UPRs consist of two main components, prepolymer and reactive diluents, commercially both of which are commonly derived from petroleum. So, it is important to find an adequate bio-based alternative not only for styrene as a reactive diluent, but also for monomers that are used for prepolymer synthesis. Many bio-based monomers (propylene glycol, isosorbide, neopentyl glycol) and reactive diluents (vinyl levulinate, butanediol dimethacrylate, dimethyl itaconate) were investigated in formulating a bio-based UPR. Alongside this, many different bio-based fillers (hemp fibres, spent coffee grounds, rosehip seed flour) were also examined, to conclusively obtain a fully bio-based composite material. Sole introduction of bio-based raw 
materials is insufficient for proper implementation of the biorefinery principle. It is equally important that the final formulation of the obtained composite material demonstrates that it is environmentally and economically feasible. The quality and market price of the bio-based composite material must be at least be comparable to or better than those of a product from a conventional process in order to be competitive.",
publisher = "Ljubljana : National Institute of Chemistry, Department of Catalysis and Chemical Reaction Engineering",
journal = "Book of Abstracts - Next Challenges of Biorefineries, 3rd BioSPRINT Workshop, 2nd Bilateral Workshop Portugal-Slovenia, June 14-15, 2023",
title = "Bio-based unsaturated polyester resins – A step towards a biorefinery solution",
pages = "14-14",
url = "https://hdl.handle.net/21.15107/rcub_cer_6972"
}

Pantić, O., Savić, S., Panić, V., Marković, M.,& Spasojević, P.. (2023). Bio-based unsaturated polyester resins – A step towards a biorefinery solution. in Book of Abstracts - Next Challenges of Biorefineries, 3rd BioSPRINT Workshop, 2nd Bilateral Workshop Portugal-Slovenia, June 14-15, 2023
Ljubljana : National Institute of Chemistry, Department of Catalysis and Chemical Reaction Engineering., 14-14.
https://hdl.handle.net/21.15107/rcub_cer_6972

Pantić O, Savić S, Panić V, Marković M, Spasojević P. Bio-based unsaturated polyester resins – A step towards a biorefinery solution. in Book of Abstracts - Next Challenges of Biorefineries, 3rd BioSPRINT Workshop, 2nd Bilateral Workshop Portugal-Slovenia, June 14-15, 2023. 2023;:14-14.
https://hdl.handle.net/21.15107/rcub_cer_6972 .

Pantić, Olga, Savić, Sanja, Panić, Vesna, Marković, Maja, Spasojević, Pavle, "Bio-based unsaturated polyester resins – A step towards a biorefinery solution" in Book of Abstracts - Next Challenges of Biorefineries, 3rd BioSPRINT Workshop, 2nd Bilateral Workshop Portugal-Slovenia, June 14-15, 2023 (2023):14-14,
https://hdl.handle.net/21.15107/rcub_cer_6972 .

TY  - CONF
AU  - Pantić, Olga
AU  - Panić, Vesna
AU  - Marković, Maja
AU  - Spasojević Savković, Milica
AU  - Savić, Sanja
AU  - Kalagasidis Krušić, Melina
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6958
AB  - Biocomposites are materials that are composed of a matrix and fillers both of which derived from renewable resources. They offer an alternative to traditional petroleum-based composites and have gained interest due to potential environmental benefits and sustainability. Guided by this idea, itaconic and succinic acids and propylene glycol were used in the synthesis of a biobased unsaturated polyester, diluted with biobased reactive diluent, dimethyl itaconate, to cure fully biobased unsaturated polyester resin (UPR). Despite having a low environmental impact, the mechanical properties of biobased UPRs are not considered commercially viable compared to their petroleum-based counterparts. To lessen the discrepancy between the two, nanocellulose (NC) was incorporated into the biobased UPR in two ways. Firstly, NC was added during synthesis, while secondly it was added after the synthesis of UPR was completed. Both series implied the use of three different quantities of NC (1, 2, 3 wt.%). FTIR spectroscopy, gel content analysis, SEM, dynamic mechanical analysis, and uniaxial tensile test were used to characterize obtained biocomposites. It was demonstrated that when NC was added during the synthesis, it had no effect on UPR viscosity. On the other hand, adding NC after the synthesis significantly increased viscosity. Overall results showed that higher quantities of NC increased tensile strength, storage modulus at lower frequencies, and decreased glass transition temperature.
PB  - Nice, France : Université Côte d’Azur, University of the French Riviera
C3  - Book of Abstracts - 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France
T1  - Advancing Biocomposites: Introduction of Nanocellulose as a Sustainable Filler of Biobased Unsaturated Polyester Resins
SP  - 52
EP  - 52
UR  - https://hdl.handle.net/21.15107/rcub_cer_6958
ER  - 

@conference{
author = "Pantić, Olga and Panić, Vesna and Marković, Maja and Spasojević Savković, Milica and Savić, Sanja and Kalagasidis Krušić, Melina",
year = "2023",
abstract = "Biocomposites are materials that are composed of a matrix and fillers both of which derived from renewable resources. They offer an alternative to traditional petroleum-based composites and have gained interest due to potential environmental benefits and sustainability. Guided by this idea, itaconic and succinic acids and propylene glycol were used in the synthesis of a biobased unsaturated polyester, diluted with biobased reactive diluent, dimethyl itaconate, to cure fully biobased unsaturated polyester resin (UPR). Despite having a low environmental impact, the mechanical properties of biobased UPRs are not considered commercially viable compared to their petroleum-based counterparts. To lessen the discrepancy between the two, nanocellulose (NC) was incorporated into the biobased UPR in two ways. Firstly, NC was added during synthesis, while secondly it was added after the synthesis of UPR was completed. Both series implied the use of three different quantities of NC (1, 2, 3 wt.%). FTIR spectroscopy, gel content analysis, SEM, dynamic mechanical analysis, and uniaxial tensile test were used to characterize obtained biocomposites. It was demonstrated that when NC was added during the synthesis, it had no effect on UPR viscosity. On the other hand, adding NC after the synthesis significantly increased viscosity. Overall results showed that higher quantities of NC increased tensile strength, storage modulus at lower frequencies, and decreased glass transition temperature.",
publisher = "Nice, France : Université Côte d’Azur, University of the French Riviera",
journal = "Book of Abstracts - 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France",
title = "Advancing Biocomposites: Introduction of Nanocellulose as a Sustainable Filler of Biobased Unsaturated Polyester Resins",
pages = "52-52",
url = "https://hdl.handle.net/21.15107/rcub_cer_6958"
}

Pantić, O., Panić, V., Marković, M., Spasojević Savković, M., Savić, S.,& Kalagasidis Krušić, M.. (2023). Advancing Biocomposites: Introduction of Nanocellulose as a Sustainable Filler of Biobased Unsaturated Polyester Resins. in Book of Abstracts - 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France
Nice, France : Université Côte d’Azur, University of the French Riviera., 52-52.
https://hdl.handle.net/21.15107/rcub_cer_6958

Pantić O, Panić V, Marković M, Spasojević Savković M, Savić S, Kalagasidis Krušić M. Advancing Biocomposites: Introduction of Nanocellulose as a Sustainable Filler of Biobased Unsaturated Polyester Resins. in Book of Abstracts - 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France. 2023;:52-52.
https://hdl.handle.net/21.15107/rcub_cer_6958 .

Pantić, Olga, Panić, Vesna, Marković, Maja, Spasojević Savković, Milica, Savić, Sanja, Kalagasidis Krušić, Melina, "Advancing Biocomposites: Introduction of Nanocellulose as a Sustainable Filler of Biobased Unsaturated Polyester Resins" in Book of Abstracts - 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France (2023):52-52,
https://hdl.handle.net/21.15107/rcub_cer_6958 .

TY  - CONF
AU  - Savić, Sanja
AU  - Panić, Vesna
AU  - Spasojević, Pavle
AU  - Pantić, Olga
AU  - Marković, Maja
AU  - Vicente, Filipa A.
AU  - Novak, Uroš
AU  - Likozar, Blaž
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6976
AB  - The present study reports the development of the lab-scale procedure for extraction of pectin from the waste industrial apple pomace using deep eutectic solvents (DES) as extraction medium.  Compared with conventional extraction solvents, DES have attracted considerable attention due to the fact that they not only are eco-friendly, non-toxic, and biodegradable organic compounds but also have a low cost, being easy to produce in the own laboratory. The research included screening study that covered extraction using different DES based on choline chloride ([Ch]Cl) as hydrogen bond acceptor (HBA), and organic acids as hydrogen bond donors (HBD). The applied HBA:HBD molar ratio was 1:2. The pectin was extracted by employing solid-liquid  (SLE) and ultrasound assisted extraction (UAE). The DES based on [Ch]Cl and lactic acid turned to be most promising in terms of obtained extraction yields, that reached 35% when applying UAE. It has been shown that structure of HBD plays a major role with its hydrophilicity and hydrophobicity
influencing the number of established bonds. The HBD with lower amount of carbon molecules and higher number of hydroxyl and carboxylic groups formed DES that are more efficient at extracting pectin. Hidotopy study showed significant influence of water on pectin yield due to more prominent hydrogen interaction established in the system.  Depending on the type of DES, the highest yields were obtained at 30-50 wt% of water, while an additional increase in water content resulted in reduced yield.  The structural properties of extracted pectin, including esterification degree, was determined using FTIR spectroscopy.
PB  - Nice, France : Université Côte d’Azur, University of the French Riviera
C3  - Book of Abstracts - 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France
T1  - Perspectives of deep eutectic solvents for extraction of pectin from waste apple pomace
SP  - 54
EP  - 54
UR  - https://hdl.handle.net/21.15107/rcub_cer_6976
ER  - 

@conference{
author = "Savić, Sanja and Panić, Vesna and Spasojević, Pavle and Pantić, Olga and Marković, Maja and Vicente, Filipa A. and Novak, Uroš and Likozar, Blaž",
year = "2023",
abstract = "The present study reports the development of the lab-scale procedure for extraction of pectin from the waste industrial apple pomace using deep eutectic solvents (DES) as extraction medium.  Compared with conventional extraction solvents, DES have attracted considerable attention due to the fact that they not only are eco-friendly, non-toxic, and biodegradable organic compounds but also have a low cost, being easy to produce in the own laboratory. The research included screening study that covered extraction using different DES based on choline chloride ([Ch]Cl) as hydrogen bond acceptor (HBA), and organic acids as hydrogen bond donors (HBD). The applied HBA:HBD molar ratio was 1:2. The pectin was extracted by employing solid-liquid  (SLE) and ultrasound assisted extraction (UAE). The DES based on [Ch]Cl and lactic acid turned to be most promising in terms of obtained extraction yields, that reached 35% when applying UAE. It has been shown that structure of HBD plays a major role with its hydrophilicity and hydrophobicity
influencing the number of established bonds. The HBD with lower amount of carbon molecules and higher number of hydroxyl and carboxylic groups formed DES that are more efficient at extracting pectin. Hidotopy study showed significant influence of water on pectin yield due to more prominent hydrogen interaction established in the system.  Depending on the type of DES, the highest yields were obtained at 30-50 wt% of water, while an additional increase in water content resulted in reduced yield.  The structural properties of extracted pectin, including esterification degree, was determined using FTIR spectroscopy.",
publisher = "Nice, France : Université Côte d’Azur, University of the French Riviera",
journal = "Book of Abstracts - 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France",
title = "Perspectives of deep eutectic solvents for extraction of pectin from waste apple pomace",
pages = "54-54",
url = "https://hdl.handle.net/21.15107/rcub_cer_6976"
}

Savić, S., Panić, V., Spasojević, P., Pantić, O., Marković, M., Vicente, F. A., Novak, U.,& Likozar, B.. (2023). Perspectives of deep eutectic solvents for extraction of pectin from waste apple pomace. in Book of Abstracts - 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France
Nice, France : Université Côte d’Azur, University of the French Riviera., 54-54.
https://hdl.handle.net/21.15107/rcub_cer_6976

Savić S, Panić V, Spasojević P, Pantić O, Marković M, Vicente FA, Novak U, Likozar B. Perspectives of deep eutectic solvents for extraction of pectin from waste apple pomace. in Book of Abstracts - 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France. 2023;:54-54.
https://hdl.handle.net/21.15107/rcub_cer_6976 .

Savić, Sanja, Panić, Vesna, Spasojević, Pavle, Pantić, Olga, Marković, Maja, Vicente, Filipa A., Novak, Uroš, Likozar, Blaž, "Perspectives of deep eutectic solvents for extraction of pectin from waste apple pomace" in Book of Abstracts - 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France (2023):54-54,
https://hdl.handle.net/21.15107/rcub_cer_6976 .

TY  - CONF
AU  - Panić, Vesna
AU  - Jovanović, Jelena D.
AU  - Savić, Sanja I.
AU  - Marković, Maja D.
AU  - Radulović, Aleksandra
AU  - Pantić, Olga
AU  - Adnađević, Borivoj K.
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/7403
AB  - The preparation of zeolite rich polymeric materials presents a challenge due to the zeolite settlingduring synthesis, poor miscibility, the phase separation and generally insufficient interactionsbetween polymers and zeolites. Combination of LTA, i.e. MFI, zeolite and poly(methacrylic acid) in theform of soft hydrogel network provided the stabilization of the zeolite particles and enabled synthesisof composite hydrogels with very high zeolite concentrations (26-52 mass%).The investigated morphological, mechanical and primary structural properties, water swelling abilityand thermal stability revealed high dependence on zeolite concentration and type. Zeolite particleswere uniformly dispersed in PMAA matrix as confirmed by SEM and there was no agglomeration orzeolite leaching despite very high concentrations. FTIR spectra disclosed the existence of functionalgroups of PMAA network and both zeolite types that interacted mutually and led to increasedcrosslinking density. The established interactions changed the PMAA chain dynamics around theparticles, especially of the LTA type, as showed by XRD. Having much more surface groups capable togenerate interaction with PMAA, LTA zeolite stronger affected all of the investigated properties.Composites’ mechanics was improved both in dry and swollen state compared to the PMAA hydrogel(up to 21.8 times for the sample with the highest LTA concentration). Thermal stability of thecomposites increased with increasing zeolite concentration.The composition-property correlations were determined making this work the base for furtherdevelopment of tailor-made zeolite-PMAA composite hydrogels aimed for specific application.Composites were tested as low-cost, regenerative, environmentally friendly sorbents and showedbetter removal of cationic dye compared to both components (PMAA and zeolite) alone.
PB  - Yuktan Technologies
C3  - Abstract Book / 4th International Conference on Advanced Polymer Science and Engineering, 23-25 October, 2023, Valencia, Spain
T1  - Insight and Comparison of Property Improvement in LTA and MFI Zeolite Reinforced Poly(methacrylic acid) Highly Concentrated Composite Hydrogels
SP  - 67
EP  - 67
UR  - https://hdl.handle.net/21.15107/rcub_cer_7403
ER  - 

@conference{
author = "Panić, Vesna and Jovanović, Jelena D. and Savić, Sanja I. and Marković, Maja D. and Radulović, Aleksandra and Pantić, Olga and Adnađević, Borivoj K.",
year = "2023",
abstract = "The preparation of zeolite rich polymeric materials presents a challenge due to the zeolite settlingduring synthesis, poor miscibility, the phase separation and generally insufficient interactionsbetween polymers and zeolites. Combination of LTA, i.e. MFI, zeolite and poly(methacrylic acid) in theform of soft hydrogel network provided the stabilization of the zeolite particles and enabled synthesisof composite hydrogels with very high zeolite concentrations (26-52 mass%).The investigated morphological, mechanical and primary structural properties, water swelling abilityand thermal stability revealed high dependence on zeolite concentration and type. Zeolite particleswere uniformly dispersed in PMAA matrix as confirmed by SEM and there was no agglomeration orzeolite leaching despite very high concentrations. FTIR spectra disclosed the existence of functionalgroups of PMAA network and both zeolite types that interacted mutually and led to increasedcrosslinking density. The established interactions changed the PMAA chain dynamics around theparticles, especially of the LTA type, as showed by XRD. Having much more surface groups capable togenerate interaction with PMAA, LTA zeolite stronger affected all of the investigated properties.Composites’ mechanics was improved both in dry and swollen state compared to the PMAA hydrogel(up to 21.8 times for the sample with the highest LTA concentration). Thermal stability of thecomposites increased with increasing zeolite concentration.The composition-property correlations were determined making this work the base for furtherdevelopment of tailor-made zeolite-PMAA composite hydrogels aimed for specific application.Composites were tested as low-cost, regenerative, environmentally friendly sorbents and showedbetter removal of cationic dye compared to both components (PMAA and zeolite) alone.",
publisher = "Yuktan Technologies",
journal = "Abstract Book / 4th International Conference on Advanced Polymer Science and Engineering, 23-25 October, 2023, Valencia, Spain",
title = "Insight and Comparison of Property Improvement in LTA and MFI Zeolite Reinforced Poly(methacrylic acid) Highly Concentrated Composite Hydrogels",
pages = "67-67",
url = "https://hdl.handle.net/21.15107/rcub_cer_7403"
}

Panić, V., Jovanović, J. D., Savić, S. I., Marković, M. D., Radulović, A., Pantić, O.,& Adnađević, B. K.. (2023). Insight and Comparison of Property Improvement in LTA and MFI Zeolite Reinforced Poly(methacrylic acid) Highly Concentrated Composite Hydrogels. in Abstract Book / 4th International Conference on Advanced Polymer Science and Engineering, 23-25 October, 2023, Valencia, Spain
Yuktan Technologies., 67-67.
https://hdl.handle.net/21.15107/rcub_cer_7403

Panić V, Jovanović JD, Savić SI, Marković MD, Radulović A, Pantić O, Adnađević BK. Insight and Comparison of Property Improvement in LTA and MFI Zeolite Reinforced Poly(methacrylic acid) Highly Concentrated Composite Hydrogels. in Abstract Book / 4th International Conference on Advanced Polymer Science and Engineering, 23-25 October, 2023, Valencia, Spain. 2023;:67-67.
https://hdl.handle.net/21.15107/rcub_cer_7403 .

Panić, Vesna, Jovanović, Jelena D., Savić, Sanja I., Marković, Maja D., Radulović, Aleksandra, Pantić, Olga, Adnađević, Borivoj K., "Insight and Comparison of Property Improvement in LTA and MFI Zeolite Reinforced Poly(methacrylic acid) Highly Concentrated Composite Hydrogels" in Abstract Book / 4th International Conference on Advanced Polymer Science and Engineering, 23-25 October, 2023, Valencia, Spain (2023):67-67,
https://hdl.handle.net/21.15107/rcub_cer_7403 .

TY  - CONF
AU  - Marković, Maja D.
AU  - Spasojević, Pavle M.
AU  - Savić, Sanja I.
AU  - Pantić, Olga
AU  - Panić, Vesna V.
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/7348
AB  - Modern society are faced with lot of challenges in the treatment of many diseases, especiallywith serious ones such as cancer. Safer and more efficient treatment of the cancer patients are maingoals which researchers are aiming. One of the good approaches can be drug delivery systems.Still, a lot of anticancer drugs are poorly water-soluble and their encapsulation and controlled releasecan be quite challenging. Present study is focused to improve drug delivery system based onhydrophilic poly(methacrylic acid) and amphiphilic casein with encapsulated poorly water-solublecaffeine, which has been developed through our previous research. The hydrogels with 1.6mol% ofcrosslinker and 100% of neutralization degree of methacrylic acid are synthetized (PMAC-100N-4M). The swelling process of the PMAC-100N-4M hydrogels and caffeine release are analyzed intwo environments which simulate human stomach and intestines. It is also investigated how thechange in the encapsulated caffeine weight and the addition of liposomes with encapsulated caffeine,affect swelling degree of the PMAC-100N-4M hydrogels and release of caffeine. The resultsshow that controlled release of caffeine is improved, therefore overall therapy can be enhanced.
AB  - Savremeno društvo je suočeno sa mnogim izazovima u tretamanu raznih bolesti, naročito ozbiljnih oboljenja kao što je rak. Glavni ciljevi naučnika su da se postigne bezbednija i efikasnija terapija pacijenata koji se leče od raka. Jedan od dobrih načina da se to postigne su sistemi za dostavu lekova. Ipak, mnogi antikancerogeni lekovi su slabovodorastvorni, pa bi veliki izazov mogao da bude inakpsulacija i njihovo kontorlisano otpuštanje iz sistema za dostavu lekova. Cilj ovog rada je da se unapredi sistem za dostavu lekova na bazi hidrofilne poli(metakrilne kiseline) i amfifilnog kazeina sa inkapsuliarnim slabo vodorastvornim kofeinom, koji je razvijen tokom našeg prethodnog istraživanja. U ovom radu sintetisani su hidrogelovi sa 1,6mol% umreživača i 100% neutralisanom metakrilnom kiselinom (PMAC-100N-4M). Procesi bubrenja PMAC-100N-4M hidrogelova i kontrolisanog otpuštanja kofeina su ispitivani u dve sredine koje simuliraju želudac i tanko crevo čoveka. Takođe je ispitano kako promena količine inkapsuliranog kofeina i dodatak lipozomne suspenzije sa inkapsuliranim kofeinom utiče na procese bubrenja PMAC-100N-4M hidorgelova i otpuštanje kofeina. Rezultati pokazuju da je proces kontrolisanog otpuštanje kofeina unapređen, a samim tim je moguće unaprediti i celokupnu terapiju.
PB  - Beograd : Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS), Društvo za procesnu tehniku
C3  - Zbornik radova / 36. Međunarodni kongres o procesnoj industriji, PROCESING '23, 1 i 2. jun 2023, Šabac
T1  - Biobased poly(methacrylic acid) hydrogels: swelling properties and contorlled release of caffeine
T1  - Biohidrogelovi poli(metakrilne kiseline): bubrenje i kontrolisano otpuštanje kofeina
SP  - 181
EP  - 187
UR  - https://hdl.handle.net/21.15107/rcub_cer_7348
ER  - 

@conference{
author = "Marković, Maja D. and Spasojević, Pavle M. and Savić, Sanja I. and Pantić, Olga and Panić, Vesna V.",
year = "2023",
abstract = "Modern society are faced with lot of challenges in the treatment of many diseases, especiallywith serious ones such as cancer. Safer and more efficient treatment of the cancer patients are maingoals which researchers are aiming. One of the good approaches can be drug delivery systems.Still, a lot of anticancer drugs are poorly water-soluble and their encapsulation and controlled releasecan be quite challenging. Present study is focused to improve drug delivery system based onhydrophilic poly(methacrylic acid) and amphiphilic casein with encapsulated poorly water-solublecaffeine, which has been developed through our previous research. The hydrogels with 1.6mol% ofcrosslinker and 100% of neutralization degree of methacrylic acid are synthetized (PMAC-100N-4M). The swelling process of the PMAC-100N-4M hydrogels and caffeine release are analyzed intwo environments which simulate human stomach and intestines. It is also investigated how thechange in the encapsulated caffeine weight and the addition of liposomes with encapsulated caffeine,affect swelling degree of the PMAC-100N-4M hydrogels and release of caffeine. The resultsshow that controlled release of caffeine is improved, therefore overall therapy can be enhanced., Savremeno društvo je suočeno sa mnogim izazovima u tretamanu raznih bolesti, naročito ozbiljnih oboljenja kao što je rak. Glavni ciljevi naučnika su da se postigne bezbednija i efikasnija terapija pacijenata koji se leče od raka. Jedan od dobrih načina da se to postigne su sistemi za dostavu lekova. Ipak, mnogi antikancerogeni lekovi su slabovodorastvorni, pa bi veliki izazov mogao da bude inakpsulacija i njihovo kontorlisano otpuštanje iz sistema za dostavu lekova. Cilj ovog rada je da se unapredi sistem za dostavu lekova na bazi hidrofilne poli(metakrilne kiseline) i amfifilnog kazeina sa inkapsuliarnim slabo vodorastvornim kofeinom, koji je razvijen tokom našeg prethodnog istraživanja. U ovom radu sintetisani su hidrogelovi sa 1,6mol% umreživača i 100% neutralisanom metakrilnom kiselinom (PMAC-100N-4M). Procesi bubrenja PMAC-100N-4M hidrogelova i kontrolisanog otpuštanja kofeina su ispitivani u dve sredine koje simuliraju želudac i tanko crevo čoveka. Takođe je ispitano kako promena količine inkapsuliranog kofeina i dodatak lipozomne suspenzije sa inkapsuliranim kofeinom utiče na procese bubrenja PMAC-100N-4M hidorgelova i otpuštanje kofeina. Rezultati pokazuju da je proces kontrolisanog otpuštanje kofeina unapređen, a samim tim je moguće unaprediti i celokupnu terapiju.",
publisher = "Beograd : Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS), Društvo za procesnu tehniku",
journal = "Zbornik radova / 36. Međunarodni kongres o procesnoj industriji, PROCESING '23, 1 i 2. jun 2023, Šabac",
title = "Biobased poly(methacrylic acid) hydrogels: swelling properties and contorlled release of caffeine, Biohidrogelovi poli(metakrilne kiseline): bubrenje i kontrolisano otpuštanje kofeina",
pages = "181-187",
url = "https://hdl.handle.net/21.15107/rcub_cer_7348"
}

Marković, M. D., Spasojević, P. M., Savić, S. I., Pantić, O.,& Panić, V. V.. (2023). Biobased poly(methacrylic acid) hydrogels: swelling properties and contorlled release of caffeine. in Zbornik radova / 36. Međunarodni kongres o procesnoj industriji, PROCESING '23, 1 i 2. jun 2023, Šabac
Beograd : Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS), Društvo za procesnu tehniku., 181-187.
https://hdl.handle.net/21.15107/rcub_cer_7348

Marković MD, Spasojević PM, Savić SI, Pantić O, Panić VV. Biobased poly(methacrylic acid) hydrogels: swelling properties and contorlled release of caffeine. in Zbornik radova / 36. Međunarodni kongres o procesnoj industriji, PROCESING '23, 1 i 2. jun 2023, Šabac. 2023;:181-187.
https://hdl.handle.net/21.15107/rcub_cer_7348 .

Marković, Maja D., Spasojević, Pavle M., Savić, Sanja I., Pantić, Olga, Panić, Vesna V., "Biobased poly(methacrylic acid) hydrogels: swelling properties and contorlled release of caffeine" in Zbornik radova / 36. Međunarodni kongres o procesnoj industriji, PROCESING '23, 1 i 2. jun 2023, Šabac (2023):181-187,
https://hdl.handle.net/21.15107/rcub_cer_7348 .

TY  - CONF
AU  - Pantić, Olga
AU  - Panić, Vesna
AU  - Marković, Maja
AU  - Spasojević, Pavle
AU  - Savić, Sanja
AU  - Kalagasidis Krušić, Melina
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6974
AB  - Development of biobased thermoset polymers encourages the strategic use of biobased 
resources and migrating to greener technologies. Unsaturated polyester resins have an 
extensive array of properties which makes them the most used thermoset resins in the 
production of polymer composite materials. Waste materials, such as eggshells left over 
from the usage of chicken eggs, are abundant and non-hazardous materials which offer 
many benefits in potential use as a filler in developing a biobased composite material. 
Itaconic acid, succinic acid, and neopentyl glycol were employed in unsaturated polyester 
synthesis, while dimethyl itaconate was used as a reactive diluent. Characterization of the 
resulting composite materials included assessing mechanical properties (uniaxial tensile 
test, three-point bending test), FTIR spectroscopy, and gel content analysis.
AB  - Novi trendovi u polimernoj industriji podstiču upotrebu sirovina dobijenih iz bioobnovljivih izvora kao i prelazak na zelenu tehnologiju. Nezasićene poliestarske smole su najzastupljenije termoreaktivne smole u proizvodnji polimernih kompozitnih materijala. Otpadni materijali, kao što su ljuske preostale od upotrebe kokošijih jaja, nastaju u velikim količinama, pri čemu ne predstavljaju opasan otpad zbog čega su korišćena kao punila za proizvodnju polimernih kompozitnih materijala. Za sintezu matrice korišćene su itakonska kiselina, ćilibarna kiselina, neopentil glikol, pri čemu je kao reaktivni rastvarač korišćen dimetil itakonat. Karakterizacija dobijenih kompozitnih materijala se sastojala od mehaničkog ispitivanja jednoosnim istezanjem kao i savijanjem u tri tačke, dok su 
promene u hemijskoj strukturi ispitivane FTIR spektroskopijom, a stepen umreženja je određivan analizom sadržaja gel faze.
PB  - Belgrade : Serbian Chemical Society
C3  - Kratki izvodi radova, knjiga radova - 59. Savetovanje Srpskog hemijskog društva, 1. i 2. jun 2023. godine, Novi Sad / Book of Abstracts, Proceedings - 59th Meeting of the Serbian Chemical Society, June 1-2, 2023, Novi Sad, Serbia
T1  - Composite materials Prepared From Waste Eggshells And Biobased Unsaturated Polyester Resin
T1  - Kompozitni materijali na bazi otpadne ljuske jajeta i nezasićenih  poliestarskih smola dobijenih iz bioobnovljivih izvora
SP  - 148
EP  - 148
UR  - https://hdl.handle.net/21.15107/rcub_cer_6974
ER  - 

@conference{
author = "Pantić, Olga and Panić, Vesna and Marković, Maja and Spasojević, Pavle and Savić, Sanja and Kalagasidis Krušić, Melina",
year = "2023",
abstract = "Development of biobased thermoset polymers encourages the strategic use of biobased 
resources and migrating to greener technologies. Unsaturated polyester resins have an 
extensive array of properties which makes them the most used thermoset resins in the 
production of polymer composite materials. Waste materials, such as eggshells left over 
from the usage of chicken eggs, are abundant and non-hazardous materials which offer 
many benefits in potential use as a filler in developing a biobased composite material. 
Itaconic acid, succinic acid, and neopentyl glycol were employed in unsaturated polyester 
synthesis, while dimethyl itaconate was used as a reactive diluent. Characterization of the 
resulting composite materials included assessing mechanical properties (uniaxial tensile 
test, three-point bending test), FTIR spectroscopy, and gel content analysis., Novi trendovi u polimernoj industriji podstiču upotrebu sirovina dobijenih iz bioobnovljivih izvora kao i prelazak na zelenu tehnologiju. Nezasićene poliestarske smole su najzastupljenije termoreaktivne smole u proizvodnji polimernih kompozitnih materijala. Otpadni materijali, kao što su ljuske preostale od upotrebe kokošijih jaja, nastaju u velikim količinama, pri čemu ne predstavljaju opasan otpad zbog čega su korišćena kao punila za proizvodnju polimernih kompozitnih materijala. Za sintezu matrice korišćene su itakonska kiselina, ćilibarna kiselina, neopentil glikol, pri čemu je kao reaktivni rastvarač korišćen dimetil itakonat. Karakterizacija dobijenih kompozitnih materijala se sastojala od mehaničkog ispitivanja jednoosnim istezanjem kao i savijanjem u tri tačke, dok su 
promene u hemijskoj strukturi ispitivane FTIR spektroskopijom, a stepen umreženja je određivan analizom sadržaja gel faze.",
publisher = "Belgrade : Serbian Chemical Society",
journal = "Kratki izvodi radova, knjiga radova - 59. Savetovanje Srpskog hemijskog društva, 1. i 2. jun 2023. godine, Novi Sad / Book of Abstracts, Proceedings - 59th Meeting of the Serbian Chemical Society, June 1-2, 2023, Novi Sad, Serbia",
title = "Composite materials Prepared From Waste Eggshells And Biobased Unsaturated Polyester Resin, Kompozitni materijali na bazi otpadne ljuske jajeta i nezasićenih  poliestarskih smola dobijenih iz bioobnovljivih izvora",
pages = "148-148",
url = "https://hdl.handle.net/21.15107/rcub_cer_6974"
}

Pantić, O., Panić, V., Marković, M., Spasojević, P., Savić, S.,& Kalagasidis Krušić, M.. (2023). Composite materials Prepared From Waste Eggshells And Biobased Unsaturated Polyester Resin. in Kratki izvodi radova, knjiga radova - 59. Savetovanje Srpskog hemijskog društva, 1. i 2. jun 2023. godine, Novi Sad / Book of Abstracts, Proceedings - 59th Meeting of the Serbian Chemical Society, June 1-2, 2023, Novi Sad, Serbia
Belgrade : Serbian Chemical Society., 148-148.
https://hdl.handle.net/21.15107/rcub_cer_6974

Pantić O, Panić V, Marković M, Spasojević P, Savić S, Kalagasidis Krušić M. Composite materials Prepared From Waste Eggshells And Biobased Unsaturated Polyester Resin. in Kratki izvodi radova, knjiga radova - 59. Savetovanje Srpskog hemijskog društva, 1. i 2. jun 2023. godine, Novi Sad / Book of Abstracts, Proceedings - 59th Meeting of the Serbian Chemical Society, June 1-2, 2023, Novi Sad, Serbia. 2023;:148-148.
https://hdl.handle.net/21.15107/rcub_cer_6974 .

Pantić, Olga, Panić, Vesna, Marković, Maja, Spasojević, Pavle, Savić, Sanja, Kalagasidis Krušić, Melina, "Composite materials Prepared From Waste Eggshells And Biobased Unsaturated Polyester Resin" in Kratki izvodi radova, knjiga radova - 59. Savetovanje Srpskog hemijskog društva, 1. i 2. jun 2023. godine, Novi Sad / Book of Abstracts, Proceedings - 59th Meeting of the Serbian Chemical Society, June 1-2, 2023, Novi Sad, Serbia (2023):148-148,
https://hdl.handle.net/21.15107/rcub_cer_6974 .

TY  - CONF
AU  - Savić, Sanja
AU  - Pantić, Olga
AU  - Vicente, Filipa A.
AU  - Novak, Uroš
AU  - Likozar, Blaž
AU  - Panić, Vesna
AU  - Marković, Maja
AU  - Spasojević, Pavle
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6957
AB  - Fruits are the most utilized commodities among all horticultural crops. They are consumed raw, minimally processed, due to their nutrients and health-promoting compounds. With the growing population and changing diet habits, the production and processing of fruits, have increased very significantly to fulfil the increasing demands. Significant losses and waste in the fresh and processing industries are becoming a serious nutritional, economical, and environmental problem. The fruit waste is composed mainly of seed, skin, rind, and pomace, containing good sources of potentially valuable bioactive compounds. The apple pomace is rich in pectic substances and represents important raw material for pectin production all around the world. For example, the portion of residual apple pomace makes about 13 % of the total waste material and on the basis of dry mass, it contains 10–15% pectin. Currently, it is either used for animal feeding or is disposed of as an industrial waste. The extraction of pectin is usually performed using mineral acids, yielding a reasonable quantity of product while also saving time in the process. Even though pectin has various applications in the food manufacturing industry, consumers have a negative perception upon learning that strong acids are used in pectin extraction. Furthermore, high acidity speeds up corrosion and rust formation of the apparatus, leading to water pollution which contributes to environmental concerns. 
The present study reports the lab-scale procedure for extraction of pectin from the waste industrial apple pomace using deep eutectic solvents (DESs) as extraction medium. DESs turned to be an excellent choice for extraction because they are non-volatile at room temperature and non-toxic, while the majority of DESs are water-miscible depending on their components. The process consisted of the processing of apples, employing milling, enzymatic digestion and pressing. The further analysis included temperature and ultrasound assisted extraction and purification of pectin as well as the detailed physicochemical analysis of the obtained product. The applied procedure has resulted in satisfactory yields under mild extraction conditions, optimal extraction time and industrially preferred properties of the isolated pectin.
PB  - Ljubljana : National Institute of Chemistry, Department of Catalysis and Chemical Reaction Engineering
C3  - Book of Abstracts - Next Challenges of Biorefineries, 3rd BioSPRINT Workshop, 2nd Bilateral Workshop Portugal-Slovenia, June 14-15, 2023
T1  - Deep eutectic solvents mediated extraction of pectin from apple pomace: Optimization and characterization studies
SP  - 25
EP  - 25
UR  - https://hdl.handle.net/21.15107/rcub_cer_6957
ER  - 

@conference{
author = "Savić, Sanja and Pantić, Olga and Vicente, Filipa A. and Novak, Uroš and Likozar, Blaž and Panić, Vesna and Marković, Maja and Spasojević, Pavle",
year = "2023",
abstract = "Fruits are the most utilized commodities among all horticultural crops. They are consumed raw, minimally processed, due to their nutrients and health-promoting compounds. With the growing population and changing diet habits, the production and processing of fruits, have increased very significantly to fulfil the increasing demands. Significant losses and waste in the fresh and processing industries are becoming a serious nutritional, economical, and environmental problem. The fruit waste is composed mainly of seed, skin, rind, and pomace, containing good sources of potentially valuable bioactive compounds. The apple pomace is rich in pectic substances and represents important raw material for pectin production all around the world. For example, the portion of residual apple pomace makes about 13 % of the total waste material and on the basis of dry mass, it contains 10–15% pectin. Currently, it is either used for animal feeding or is disposed of as an industrial waste. The extraction of pectin is usually performed using mineral acids, yielding a reasonable quantity of product while also saving time in the process. Even though pectin has various applications in the food manufacturing industry, consumers have a negative perception upon learning that strong acids are used in pectin extraction. Furthermore, high acidity speeds up corrosion and rust formation of the apparatus, leading to water pollution which contributes to environmental concerns. 
The present study reports the lab-scale procedure for extraction of pectin from the waste industrial apple pomace using deep eutectic solvents (DESs) as extraction medium. DESs turned to be an excellent choice for extraction because they are non-volatile at room temperature and non-toxic, while the majority of DESs are water-miscible depending on their components. The process consisted of the processing of apples, employing milling, enzymatic digestion and pressing. The further analysis included temperature and ultrasound assisted extraction and purification of pectin as well as the detailed physicochemical analysis of the obtained product. The applied procedure has resulted in satisfactory yields under mild extraction conditions, optimal extraction time and industrially preferred properties of the isolated pectin.",
publisher = "Ljubljana : National Institute of Chemistry, Department of Catalysis and Chemical Reaction Engineering",
journal = "Book of Abstracts - Next Challenges of Biorefineries, 3rd BioSPRINT Workshop, 2nd Bilateral Workshop Portugal-Slovenia, June 14-15, 2023",
title = "Deep eutectic solvents mediated extraction of pectin from apple pomace: Optimization and characterization studies",
pages = "25-25",
url = "https://hdl.handle.net/21.15107/rcub_cer_6957"
}

Savić, S., Pantić, O., Vicente, F. A., Novak, U., Likozar, B., Panić, V., Marković, M.,& Spasojević, P.. (2023). Deep eutectic solvents mediated extraction of pectin from apple pomace: Optimization and characterization studies. in Book of Abstracts - Next Challenges of Biorefineries, 3rd BioSPRINT Workshop, 2nd Bilateral Workshop Portugal-Slovenia, June 14-15, 2023
Ljubljana : National Institute of Chemistry, Department of Catalysis and Chemical Reaction Engineering., 25-25.
https://hdl.handle.net/21.15107/rcub_cer_6957

Savić S, Pantić O, Vicente FA, Novak U, Likozar B, Panić V, Marković M, Spasojević P. Deep eutectic solvents mediated extraction of pectin from apple pomace: Optimization and characterization studies. in Book of Abstracts - Next Challenges of Biorefineries, 3rd BioSPRINT Workshop, 2nd Bilateral Workshop Portugal-Slovenia, June 14-15, 2023. 2023;:25-25.
https://hdl.handle.net/21.15107/rcub_cer_6957 .

Savić, Sanja, Pantić, Olga, Vicente, Filipa A., Novak, Uroš, Likozar, Blaž, Panić, Vesna, Marković, Maja, Spasojević, Pavle, "Deep eutectic solvents mediated extraction of pectin from apple pomace: Optimization and characterization studies" in Book of Abstracts - Next Challenges of Biorefineries, 3rd BioSPRINT Workshop, 2nd Bilateral Workshop Portugal-Slovenia, June 14-15, 2023 (2023):25-25,
https://hdl.handle.net/21.15107/rcub_cer_6957 .

TY  - CONF
AU  - Spasojević, Pavle
AU  - Savić, Sanja
AU  - Panić, Vesna
AU  - Spasojević Savković, Milica
AU  - Marković, Maja
AU  - Pantić, Olga
AU  - Popović, Ivanka
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6975
AB  - Emerging efforts in the field of biocomposites established novel combinations of biobased matrix materials and reinforcements, as well as the optimization of curing conditions, to enhace their properties and expand their range od applications. The curing conditions of nanocellulose reinforced biobased unsaturated polyester reins (UPR) based on itaconic acid and it derivatives were examined in this work. Since the curing process of biobased UPR required the presence of both initiatior and an activator, the optimization was conducted in two phases. The first phase investigated the effect of different concentrations of an activator, cobalt octoate, (0.5, 1.0 and 1.5 mass%) with a constant concentration of an initiator, a mixture of dibenzoyl peroxide (DBP) and methyl ethyl ketone peroxide (MEKP) (DBP to MEKP ratio 1.5:1.0, 2.5 mass% total). The ratios of DBP and MEKP were varied in the second phase of experiments in the following manner: 2.5:0, 1.75:0.75, 0.75:1.75 and 0:2.5 (keeping the total initiator mass% of 2.5). The effect of the different curing conditions on the UPR properties was monitored via the gel content analysis and the uniaxial tensile test. It was shown that the increase in activator concentration led to the decrease in gel content, tensile strenght and elongation at break. On the other hand, the increase in dibenzoyl peroxide concentration in the initiator mixture revealed enhanced overall mechanical properties. The optimal curing conditions were found to be 0.5 mass% of activator, and 1.75:0.75 DBP to MEKP ratio in the initiator mixture. Thereby obtained UPR biocomposite showed a significant increase in elastic attributes suggesting that these materials can be used where high elasticity is needed.
PB  - Nice, France : Université Côte d’Azur, University of the French Riviera
C3  - Book of Abstracts - 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France
T1  - Optimization of Curing Conditions for Nanocellulose Reinforced Biobased Unsaturated Polyester Resin
SP  - 56
EP  - 56
UR  - https://hdl.handle.net/21.15107/rcub_cer_6975
ER  - 

@conference{
author = "Spasojević, Pavle and Savić, Sanja and Panić, Vesna and Spasojević Savković, Milica and Marković, Maja and Pantić, Olga and Popović, Ivanka",
year = "2023",
abstract = "Emerging efforts in the field of biocomposites established novel combinations of biobased matrix materials and reinforcements, as well as the optimization of curing conditions, to enhace their properties and expand their range od applications. The curing conditions of nanocellulose reinforced biobased unsaturated polyester reins (UPR) based on itaconic acid and it derivatives were examined in this work. Since the curing process of biobased UPR required the presence of both initiatior and an activator, the optimization was conducted in two phases. The first phase investigated the effect of different concentrations of an activator, cobalt octoate, (0.5, 1.0 and 1.5 mass%) with a constant concentration of an initiator, a mixture of dibenzoyl peroxide (DBP) and methyl ethyl ketone peroxide (MEKP) (DBP to MEKP ratio 1.5:1.0, 2.5 mass% total). The ratios of DBP and MEKP were varied in the second phase of experiments in the following manner: 2.5:0, 1.75:0.75, 0.75:1.75 and 0:2.5 (keeping the total initiator mass% of 2.5). The effect of the different curing conditions on the UPR properties was monitored via the gel content analysis and the uniaxial tensile test. It was shown that the increase in activator concentration led to the decrease in gel content, tensile strenght and elongation at break. On the other hand, the increase in dibenzoyl peroxide concentration in the initiator mixture revealed enhanced overall mechanical properties. The optimal curing conditions were found to be 0.5 mass% of activator, and 1.75:0.75 DBP to MEKP ratio in the initiator mixture. Thereby obtained UPR biocomposite showed a significant increase in elastic attributes suggesting that these materials can be used where high elasticity is needed.",
publisher = "Nice, France : Université Côte d’Azur, University of the French Riviera",
journal = "Book of Abstracts - 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France",
title = "Optimization of Curing Conditions for Nanocellulose Reinforced Biobased Unsaturated Polyester Resin",
pages = "56-56",
url = "https://hdl.handle.net/21.15107/rcub_cer_6975"
}

Spasojević, P., Savić, S., Panić, V., Spasojević Savković, M., Marković, M., Pantić, O.,& Popović, I.. (2023). Optimization of Curing Conditions for Nanocellulose Reinforced Biobased Unsaturated Polyester Resin. in Book of Abstracts - 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France
Nice, France : Université Côte d’Azur, University of the French Riviera., 56-56.
https://hdl.handle.net/21.15107/rcub_cer_6975

Spasojević P, Savić S, Panić V, Spasojević Savković M, Marković M, Pantić O, Popović I. Optimization of Curing Conditions for Nanocellulose Reinforced Biobased Unsaturated Polyester Resin. in Book of Abstracts - 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France. 2023;:56-56.
https://hdl.handle.net/21.15107/rcub_cer_6975 .

Spasojević, Pavle, Savić, Sanja, Panić, Vesna, Spasojević Savković, Milica, Marković, Maja, Pantić, Olga, Popović, Ivanka, "Optimization of Curing Conditions for Nanocellulose Reinforced Biobased Unsaturated Polyester Resin" in Book of Abstracts - 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France (2023):56-56,
https://hdl.handle.net/21.15107/rcub_cer_6975 .

TY  - JOUR
AU  - Marković, Maja D.
AU  - Svetozarević, Milica
AU  - Panić, Vesna V.
AU  - Savić, Sanja I.
AU  - Mašulović, Aleksandra D.
AU  - Spasojević, Pavle
AU  - Pjanović, Rada
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5666
AB  - This study reports successful free radical synthesis of pH-sensitive hydrogels based on poly(methacrylic acid) (PMAA) by using new green initiation system based on vitamin C and hydrogen peroxide (VC/H2O2). The application of proposed initiation system provides many advantages, above all cost effective and eco-friendly synthesis which can be carried out under ambient conditions. The obtained PMAA hydrogels are analyzed by various technics: Differential Scanning Calorimetry, Fourier Transform Infrared spectroscopy, Scanning Electron Microscopy and by using single compression tests. In line with the intended application, PMAA hydrogels are further investigated in terms of their potential to be used for encapsulation and controlled release of active substances such as antioxidant phenolic compounds. To keep it green, the total phenolic compounds (TPC) were obtained from orange peels waste by applying ultrasonic-assisted extraction and deep eutectic solvent (DES) based on glycerol:urea:water. The TPC were successfully encapsulated into the PMAA hydrogels which were previously estimated to have the optimal mechanical and swelling properties with respect to the final application. The swelling behavior of the PMAA hydrogels and controlled release of the TPC were tested as a function of the various synthesis parameters in several media with different pH values. It was shown that TPC can be released in control manner in medium which simulates the environment in human intestines, finally resulting in enhanced bioavailability of TPC, reduced side effects and improved therapeutic effects.
PB  - Elsevier B.V.
T2  - Chemical Engineering Journal
T1  - Novel eco-friendly initiation system based on vitamin C for energy efficient synthesis of PMAA hydrogel used for delivery of phenolic compounds
VL  - 459
SP  - 141580
DO  - 10.1016/j.cej.2023.141580
ER  - 

@article{
author = "Marković, Maja D. and Svetozarević, Milica and Panić, Vesna V. and Savić, Sanja I. and Mašulović, Aleksandra D. and Spasojević, Pavle and Pjanović, Rada",
year = "2023",
abstract = "This study reports successful free radical synthesis of pH-sensitive hydrogels based on poly(methacrylic acid) (PMAA) by using new green initiation system based on vitamin C and hydrogen peroxide (VC/H2O2). The application of proposed initiation system provides many advantages, above all cost effective and eco-friendly synthesis which can be carried out under ambient conditions. The obtained PMAA hydrogels are analyzed by various technics: Differential Scanning Calorimetry, Fourier Transform Infrared spectroscopy, Scanning Electron Microscopy and by using single compression tests. In line with the intended application, PMAA hydrogels are further investigated in terms of their potential to be used for encapsulation and controlled release of active substances such as antioxidant phenolic compounds. To keep it green, the total phenolic compounds (TPC) were obtained from orange peels waste by applying ultrasonic-assisted extraction and deep eutectic solvent (DES) based on glycerol:urea:water. The TPC were successfully encapsulated into the PMAA hydrogels which were previously estimated to have the optimal mechanical and swelling properties with respect to the final application. The swelling behavior of the PMAA hydrogels and controlled release of the TPC were tested as a function of the various synthesis parameters in several media with different pH values. It was shown that TPC can be released in control manner in medium which simulates the environment in human intestines, finally resulting in enhanced bioavailability of TPC, reduced side effects and improved therapeutic effects.",
publisher = "Elsevier B.V.",
journal = "Chemical Engineering Journal",
title = "Novel eco-friendly initiation system based on vitamin C for energy efficient synthesis of PMAA hydrogel used for delivery of phenolic compounds",
volume = "459",
pages = "141580",
doi = "10.1016/j.cej.2023.141580"
}

Marković, M. D., Svetozarević, M., Panić, V. V., Savić, S. I., Mašulović, A. D., Spasojević, P.,& Pjanović, R.. (2023). Novel eco-friendly initiation system based on vitamin C for energy efficient synthesis of PMAA hydrogel used for delivery of phenolic compounds. in Chemical Engineering Journal
Elsevier B.V.., 459, 141580.
https://doi.org/10.1016/j.cej.2023.141580

Marković MD, Svetozarević M, Panić VV, Savić SI, Mašulović AD, Spasojević P, Pjanović R. Novel eco-friendly initiation system based on vitamin C for energy efficient synthesis of PMAA hydrogel used for delivery of phenolic compounds. in Chemical Engineering Journal. 2023;459:141580.
doi:10.1016/j.cej.2023.141580 .

Marković, Maja D., Svetozarević, Milica, Panić, Vesna V., Savić, Sanja I., Mašulović, Aleksandra D., Spasojević, Pavle, Pjanović, Rada, "Novel eco-friendly initiation system based on vitamin C for energy efficient synthesis of PMAA hydrogel used for delivery of phenolic compounds" in Chemical Engineering Journal, 459 (2023):141580,
https://doi.org/10.1016/j.cej.2023.141580 . .

TY  - JOUR
AU  - Panić, Vesna
AU  - Jovanović, Jelena
AU  - Popović, Ivanka
AU  - Savić, Sanja
AU  - Marković, Maja
AU  - Spasojević, Pavle
AU  - Adnadjević, Borivoj
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5713
AB  - High concentrations of hydrophobic MFI zeolite (26.0–51.3 wt%) were successfully embedded in poly(methacrylic acid) (PMAA) network in simple, one-pot synthesis of PMAA-MFI composite hydrogels. The effects of zeolite concentration regarding pure PMAA xerogel, for all of the investigated properties (primary structural parameters, morphological properties, water swelling ability, thermal degradation mechanism and stability, and mechanical properties) were determined and discussed. The PMAA-MFI composite hydrogels had remarkably higher density than PMAA xerogel (1660/1420 kg m−3), higher crosslinking density (29/1.0 × 10−4), improved mechanics in the dry and swollen state (up to 4.9 times higher storage modulus) and lower swelling degree (42/420 g g−1), average molar mass between the network crosslinks (3.6/110 × 104 g mol−1), and distance between the macromolecular chains (64/710 nm). Despite high zeolite concentration, the composites kept porous hydrogel structure with uniformly dispersed zeolite particles. FTIR spectra disclosed the existence of functional groups of PMAA network and MFI zeolite that interacted mutually and led to increased crosslinking density. The effect of zeolite concentration on the thermal degradation mechanism was established. The composition-properties correlations were determined and described by the adequate linear or power law equations revealing the additive nature of the composites and the fractal structure of the networks. These correlations enable the achievement of desired properties by simple adjustment of the initial composition, i.e. zeolite concentration. Therefore, this work presents the base for further development of tailor-made PMAA-MFI composite hydrogels aimed for specific application.
PB  - Elsevier
T2  - Polymer
T1  - The study of composition-properties relationships for composite hydrogels based on poly(methacrylic acid) and high concentrations of MFI zeolite
VL  - 269
SP  - 125750
DO  - 10.1016/j.polymer.2023.125750
ER  - 

@article{
author = "Panić, Vesna and Jovanović, Jelena and Popović, Ivanka and Savić, Sanja and Marković, Maja and Spasojević, Pavle and Adnadjević, Borivoj",
year = "2023",
abstract = "High concentrations of hydrophobic MFI zeolite (26.0–51.3 wt%) were successfully embedded in poly(methacrylic acid) (PMAA) network in simple, one-pot synthesis of PMAA-MFI composite hydrogels. The effects of zeolite concentration regarding pure PMAA xerogel, for all of the investigated properties (primary structural parameters, morphological properties, water swelling ability, thermal degradation mechanism and stability, and mechanical properties) were determined and discussed. The PMAA-MFI composite hydrogels had remarkably higher density than PMAA xerogel (1660/1420 kg m−3), higher crosslinking density (29/1.0 × 10−4), improved mechanics in the dry and swollen state (up to 4.9 times higher storage modulus) and lower swelling degree (42/420 g g−1), average molar mass between the network crosslinks (3.6/110 × 104 g mol−1), and distance between the macromolecular chains (64/710 nm). Despite high zeolite concentration, the composites kept porous hydrogel structure with uniformly dispersed zeolite particles. FTIR spectra disclosed the existence of functional groups of PMAA network and MFI zeolite that interacted mutually and led to increased crosslinking density. The effect of zeolite concentration on the thermal degradation mechanism was established. The composition-properties correlations were determined and described by the adequate linear or power law equations revealing the additive nature of the composites and the fractal structure of the networks. These correlations enable the achievement of desired properties by simple adjustment of the initial composition, i.e. zeolite concentration. Therefore, this work presents the base for further development of tailor-made PMAA-MFI composite hydrogels aimed for specific application.",
publisher = "Elsevier",
journal = "Polymer",
title = "The study of composition-properties relationships for composite hydrogels based on poly(methacrylic acid) and high concentrations of MFI zeolite",
volume = "269",
pages = "125750",
doi = "10.1016/j.polymer.2023.125750"
}

Panić, V., Jovanović, J., Popović, I., Savić, S., Marković, M., Spasojević, P.,& Adnadjević, B.. (2023). The study of composition-properties relationships for composite hydrogels based on poly(methacrylic acid) and high concentrations of MFI zeolite. in Polymer
Elsevier., 269, 125750.
https://doi.org/10.1016/j.polymer.2023.125750

Panić V, Jovanović J, Popović I, Savić S, Marković M, Spasojević P, Adnadjević B. The study of composition-properties relationships for composite hydrogels based on poly(methacrylic acid) and high concentrations of MFI zeolite. in Polymer. 2023;269:125750.
doi:10.1016/j.polymer.2023.125750 .

Panić, Vesna, Jovanović, Jelena, Popović, Ivanka, Savić, Sanja, Marković, Maja, Spasojević, Pavle, Adnadjević, Borivoj, "The study of composition-properties relationships for composite hydrogels based on poly(methacrylic acid) and high concentrations of MFI zeolite" in Polymer, 269 (2023):125750,
https://doi.org/10.1016/j.polymer.2023.125750 . .

TY  - JOUR
AU  - Stefanović, Ivan
AU  - Džunuzović, Jasna
AU  - Džunuzović, Enis
AU  - Stevanović, Sanja
AU  - Dapčević, Aleksandra
AU  - Savić, Sanja
AU  - Giuseppe, Lama
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6119
AB  - The influence of soft segment (SS) content on the properties of novel polyurethane networks (PUNs), prepared by a two-step polymerization in a solvent mixture, was investigated in this work. Hyperbranched polyester of the third pseudo generation (BH-30) was used as a crosslinker, and together with isophorone diisocyanate (IPDI) was applied to build hard segments (HS) in PUNs. On the other hand, SS of the prepared PUNs are based on polycaprolactone (PCL). The content of SS in PUNs varied from 10 to 50 wt%. The structural, thermal and mechanical properties, swelling behavior, as well as morphology of PUNs, were explored by various experimental methods. Performed investigations have shown that the use of BH-30 led to the emergence of relatively high crosslinking density and good mechanical properties, and that all features of PUNs significantly depend on the SS content. Higher PCL content caused presence of certain crystallinity, better thermal stability, more pronounced microphase separated morphology, but also lower degree of hydrogen bonding, crosslinking density and storage modulus of the prepared PUNs. The obtained results have shown that the properties of PUNs can be easily varied and customized to different practical needs.
PB  - Elsevier
T2  - Materials Today Communications
T1  - The impact of the polycaprolactone content on the properties of polyurethane networks
VL  - 35
SP  - 105721
DO  - 10.1016/j.mtcomm.2023.105721
ER  - 

@article{
author = "Stefanović, Ivan and Džunuzović, Jasna and Džunuzović, Enis and Stevanović, Sanja and Dapčević, Aleksandra and Savić, Sanja and Giuseppe, Lama",
year = "2023",
abstract = "The influence of soft segment (SS) content on the properties of novel polyurethane networks (PUNs), prepared by a two-step polymerization in a solvent mixture, was investigated in this work. Hyperbranched polyester of the third pseudo generation (BH-30) was used as a crosslinker, and together with isophorone diisocyanate (IPDI) was applied to build hard segments (HS) in PUNs. On the other hand, SS of the prepared PUNs are based on polycaprolactone (PCL). The content of SS in PUNs varied from 10 to 50 wt%. The structural, thermal and mechanical properties, swelling behavior, as well as morphology of PUNs, were explored by various experimental methods. Performed investigations have shown that the use of BH-30 led to the emergence of relatively high crosslinking density and good mechanical properties, and that all features of PUNs significantly depend on the SS content. Higher PCL content caused presence of certain crystallinity, better thermal stability, more pronounced microphase separated morphology, but also lower degree of hydrogen bonding, crosslinking density and storage modulus of the prepared PUNs. The obtained results have shown that the properties of PUNs can be easily varied and customized to different practical needs.",
publisher = "Elsevier",
journal = "Materials Today Communications",
title = "The impact of the polycaprolactone content on the properties of polyurethane networks",
volume = "35",
pages = "105721",
doi = "10.1016/j.mtcomm.2023.105721"
}

Stefanović, I., Džunuzović, J., Džunuzović, E., Stevanović, S., Dapčević, A., Savić, S.,& Giuseppe, L.. (2023). The impact of the polycaprolactone content on the properties of polyurethane networks. in Materials Today Communications
Elsevier., 35, 105721.
https://doi.org/10.1016/j.mtcomm.2023.105721

Stefanović I, Džunuzović J, Džunuzović E, Stevanović S, Dapčević A, Savić S, Giuseppe L. The impact of the polycaprolactone content on the properties of polyurethane networks. in Materials Today Communications. 2023;35:105721.
doi:10.1016/j.mtcomm.2023.105721 .

Stefanović, Ivan, Džunuzović, Jasna, Džunuzović, Enis, Stevanović, Sanja, Dapčević, Aleksandra, Savić, Sanja, Giuseppe, Lama, "The impact of the polycaprolactone content on the properties of polyurethane networks" in Materials Today Communications, 35 (2023):105721,
https://doi.org/10.1016/j.mtcomm.2023.105721 . .

TY  - PAT
AU  - Marković, Maja
AU  - Tadić, Julijana
AU  - Šešlija, Sanja
AU  - Mijin, Dušan
AU  - Panić, Vesna
AU  - Spasojević, Pavle
AU  - Pjanović, Rada
AU  - Ugrinović, Vukašin
PY  - 2023
UR  - http://pub.zis.gov.rs/rs-pubserver/document?iDocId=103007&iepatch=.pdf
UR  - https://hdl.handle.net/21.15107/rcub_technorep_5950
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6138
AB  - Predmetnim pronalaskom postignuta je inkapsulacija slabo vodorastvorne aktivne supstance heterocikličnog azo jedinjenja sa antikancerogenim svojstvima u hidrofilni hidrogel na bazi poli(metakrilne kiseline) modifikovanog amfifilnim kazeinom, ciljana dostava inkapsuliranog azo derivata i njegovo kontrolisano i produženo otpuštanje (i do 72h) bez naglog inicijalnog oslobadanja iz hidrofilnog hidrogela. Takođe, predmetnim pronalaskom su dobijeni nosači koji bi imali potencijalnu primenu u tretmanu hronične mijeloidne leukemije (HML), čijom bi se primenom smanjio broj potrebnih terapeutskih doza i redukovali neželjeni efekti (kao što je povraćanje i iritacija gastrointestinalnog trakta) koji se najčešće javljaju kod primene lekova za terapiju HML.
PB  - Beograd, Srbija : Zavod za intelektualnu svojinu
T2  - Republika Srbija - Patentni spis
T1  - Sistem na bazi poli (metakrilne kiseline) i kazeina za kontrolisano otpuštanje heterocikličnog azo jedinjenja sa potencijalnom primenom u tretmanu malignog oboljenja belih krvnih ćelija
SP  - RS 63926
UR  - https://hdl.handle.net/21.15107/rcub_cer_6138
ER  - 

@misc{
author = "Marković, Maja and Tadić, Julijana and Šešlija, Sanja and Mijin, Dušan and Panić, Vesna and Spasojević, Pavle and Pjanović, Rada and Ugrinović, Vukašin",
year = "2023",
abstract = "Predmetnim pronalaskom postignuta je inkapsulacija slabo vodorastvorne aktivne supstance heterocikličnog azo jedinjenja sa antikancerogenim svojstvima u hidrofilni hidrogel na bazi poli(metakrilne kiseline) modifikovanog amfifilnim kazeinom, ciljana dostava inkapsuliranog azo derivata i njegovo kontrolisano i produženo otpuštanje (i do 72h) bez naglog inicijalnog oslobadanja iz hidrofilnog hidrogela. Takođe, predmetnim pronalaskom su dobijeni nosači koji bi imali potencijalnu primenu u tretmanu hronične mijeloidne leukemije (HML), čijom bi se primenom smanjio broj potrebnih terapeutskih doza i redukovali neželjeni efekti (kao što je povraćanje i iritacija gastrointestinalnog trakta) koji se najčešće javljaju kod primene lekova za terapiju HML.",
publisher = "Beograd, Srbija : Zavod za intelektualnu svojinu",
journal = "Republika Srbija - Patentni spis",
title = "Sistem na bazi poli (metakrilne kiseline) i kazeina za kontrolisano otpuštanje heterocikličnog azo jedinjenja sa potencijalnom primenom u tretmanu malignog oboljenja belih krvnih ćelija",
pages = "RS 63926",
url = "https://hdl.handle.net/21.15107/rcub_cer_6138"
}

Marković, M., Tadić, J., Šešlija, S., Mijin, D., Panić, V., Spasojević, P., Pjanović, R.,& Ugrinović, V.. (2023). Sistem na bazi poli (metakrilne kiseline) i kazeina za kontrolisano otpuštanje heterocikličnog azo jedinjenja sa potencijalnom primenom u tretmanu malignog oboljenja belih krvnih ćelija. in Republika Srbija - Patentni spis
Beograd, Srbija : Zavod za intelektualnu svojinu., RS 63926.
https://hdl.handle.net/21.15107/rcub_cer_6138

Marković M, Tadić J, Šešlija S, Mijin D, Panić V, Spasojević P, Pjanović R, Ugrinović V. Sistem na bazi poli (metakrilne kiseline) i kazeina za kontrolisano otpuštanje heterocikličnog azo jedinjenja sa potencijalnom primenom u tretmanu malignog oboljenja belih krvnih ćelija. in Republika Srbija - Patentni spis. 2023;:RS 63926.
https://hdl.handle.net/21.15107/rcub_cer_6138 .

Marković, Maja, Tadić, Julijana, Šešlija, Sanja, Mijin, Dušan, Panić, Vesna, Spasojević, Pavle, Pjanović, Rada, Ugrinović, Vukašin, "Sistem na bazi poli (metakrilne kiseline) i kazeina za kontrolisano otpuštanje heterocikličnog azo jedinjenja sa potencijalnom primenom u tretmanu malignog oboljenja belih krvnih ćelija" in Republika Srbija - Patentni spis (2023):RS 63926,
https://hdl.handle.net/21.15107/rcub_cer_6138 .

TY  - JOUR
AU  - Marković, Maja D.
AU  - Šešlija, Sanja
AU  - Panić, Vesna V.
AU  - Spasojević, Pavle M.
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/7395
AB  - Inteligentni hidrogelovi, kao što su pH osetljivi hidrogelovi na bazi poli(metakrilne kiseline) (PMAA), imaju veliku primenu u ciljanoj dostavi lekova. Međutim, slaba mehanička svojstva često ograničavaju primenu PMAA. Kako bi se prevazišlo navedeno ograničenje, nanoceluloza (NC) je prvo ekstrakovana iz drvnog otpadnog materijala, a zatim dodata u PMAA, zato što je NC biokompatibilna, netoksična i ima odlična mehanička svojstva. Zatim je dodata karboskimetil celuloza (CMC) (celulozni derivat koji se često koristi za kontrolisano otpuštanje lekova). CMC može da stabilizuje nanočestice magnetita (MN) koje su takođe dodate. MN mogu značajno da poboljšaju mehanička svojstva hidrogelova i takođe poseduju magnetna svojstva zbog čega imaju primenu za ciljano otpuštanje lekova. Ovako dobijeni materijal bi mogao da zaštiti lek, dostavi ga do mesta delovanja, kontroliše brzinu njegovog otpuštanja i na taj način omogući efikasno dejstvo leka sa smanjenim neželjenim efektima. Lokalni anestetik – lidokain hidrohlorid (LH) se često u tretmanima injektira što može imati ozbiljne neželjene efekte. Inkapsulacijom LH u hidrogelove na bazi PMAA, NC, CMC i MN (PMNC/MN-L) rešen je navedeni problem. Karakterizacija PMNC/MN-L hidrogelova je izvedena primenom FTIR i SEM spektroskopija i kompresionim testovima, a zatim je analizirano bubrenje hidrogelova i otpuštanje LH. U ovom radu predstavljen je jedinstveni način „zelene” sinteze hibridnih hidrogelova osetljivih na spoljne stimulanse unapređenih svojstava i njihove primene za kontrolisano otpuštanje lokalnog anestetika sa smanjenim neželjnim efektima.
PB  - Union of Mechanical and Electrotechnical Engineers and Technicians of Serbia (SMEITS)
T2  - Procesna tehnika
T1  - Dual responsive hybrid hydrogels for controlled release of local anesthetic
VL  - 33
IS  - 2
SP  - 18
DO  - 10.24094/ptc.021.33.2.18
ER  - 

@article{
author = "Marković, Maja D. and Šešlija, Sanja and Panić, Vesna V. and Spasojević, Pavle M.",
year = "2022",
abstract = "Inteligentni hidrogelovi, kao što su pH osetljivi hidrogelovi na bazi poli(metakrilne kiseline) (PMAA), imaju veliku primenu u ciljanoj dostavi lekova. Međutim, slaba mehanička svojstva često ograničavaju primenu PMAA. Kako bi se prevazišlo navedeno ograničenje, nanoceluloza (NC) je prvo ekstrakovana iz drvnog otpadnog materijala, a zatim dodata u PMAA, zato što je NC biokompatibilna, netoksična i ima odlična mehanička svojstva. Zatim je dodata karboskimetil celuloza (CMC) (celulozni derivat koji se često koristi za kontrolisano otpuštanje lekova). CMC može da stabilizuje nanočestice magnetita (MN) koje su takođe dodate. MN mogu značajno da poboljšaju mehanička svojstva hidrogelova i takođe poseduju magnetna svojstva zbog čega imaju primenu za ciljano otpuštanje lekova. Ovako dobijeni materijal bi mogao da zaštiti lek, dostavi ga do mesta delovanja, kontroliše brzinu njegovog otpuštanja i na taj način omogući efikasno dejstvo leka sa smanjenim neželjenim efektima. Lokalni anestetik – lidokain hidrohlorid (LH) se često u tretmanima injektira što može imati ozbiljne neželjene efekte. Inkapsulacijom LH u hidrogelove na bazi PMAA, NC, CMC i MN (PMNC/MN-L) rešen je navedeni problem. Karakterizacija PMNC/MN-L hidrogelova je izvedena primenom FTIR i SEM spektroskopija i kompresionim testovima, a zatim je analizirano bubrenje hidrogelova i otpuštanje LH. U ovom radu predstavljen je jedinstveni način „zelene” sinteze hibridnih hidrogelova osetljivih na spoljne stimulanse unapređenih svojstava i njihove primene za kontrolisano otpuštanje lokalnog anestetika sa smanjenim neželjnim efektima.",
publisher = "Union of Mechanical and Electrotechnical Engineers and Technicians of Serbia (SMEITS)",
journal = "Procesna tehnika",
title = "Dual responsive hybrid hydrogels for controlled release of local anesthetic",
volume = "33",
number = "2",
pages = "18",
doi = "10.24094/ptc.021.33.2.18"
}

Marković, M. D., Šešlija, S., Panić, V. V.,& Spasojević, P. M.. (2022). Dual responsive hybrid hydrogels for controlled release of local anesthetic. in Procesna tehnika
Union of Mechanical and Electrotechnical Engineers and Technicians of Serbia (SMEITS)., 33(2), 18.
https://doi.org/10.24094/ptc.021.33.2.18

Marković MD, Šešlija S, Panić VV, Spasojević PM. Dual responsive hybrid hydrogels for controlled release of local anesthetic. in Procesna tehnika. 2022;33(2):18.
doi:10.24094/ptc.021.33.2.18 .

Marković, Maja D., Šešlija, Sanja, Panić, Vesna V., Spasojević, Pavle M., "Dual responsive hybrid hydrogels for controlled release of local anesthetic" in Procesna tehnika, 33, no. 2 (2022):18,
https://doi.org/10.24094/ptc.021.33.2.18 . .

TY  - CONF
AU  - Pantić, Olga
AU  - Spasojević, Pavle
AU  - Panić, Vesna
AU  - Marković, Maja D.
AU  - Savić, Sanja I.
AU  - Kalagasidis Krušić, Melina
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5241
AB  - Pectin and pectin derived oligosaccharides can be obtained from waste apple pomace(biomass). Traditional method for pectin extraction involves use of diluted mineral acids atelevated temperatures, with yields of about 10 to 15%. As an alternative to conventionalmethods, the use of eutectic solvents is increasing because of their superior propertieswhen it comes to targeted extraction of certain components from biomass. The aim of thispaper is ultrasound assisted extraction of pectin from waste apple pomace using cholinechloride based eutectic solvents and lactic acid. Properties of extracted products wereexamined using FTIR spectroscopy and differential scanning calorimetry.
AB  - Pektin i pektinski oligosaharidi mogu se dobiti iz otpadne jabučne kaše. Ovaj prirodni  polimer ima široku primenu u industriji. Tradicionalna metoda za ekstrakciju pektina  podrazumeva tretman razblaženim mineralnim kiselinama na povišenoj temperaturi, pri  čemu se prinosi ostvaruju od oko 10 do 15%. Kao alternativa tradicionalnim rastvaračima  sve češće se koriste i eutektički rastvarači, koje odlikuju daleko superiornija svojstva kada  je reč o ciljanoj ekstrakciji određenih komponenti iz biomase. Cilj ovog rada je ultrazvučna  ekstrakcija pektina primenom eutektičkih rastvarača na bazi holin hlorida i mlečne  kiseline. Svojstva ekstrahovanog proizvoda ispitana su primenom FTIR spektroskopije i  diferencijalne skenirajuće kalorimetrije.
PB  - Serbian Chemical Society
C3  - Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, June 9-10, 2022 / Kratki izvodi radova, kjniga radova - 58. Savetovanje Srpskog hemijskog društva, Beograd 9. - 10. jun 2022.
T1  - Ultrasound assisted extraction of pectin from waste apple pomace using choline chloride based eutectic solvents
T1  - Ultrazvučna ekstrakcija pektina iz otpadne jabučne kaše  primenom eutektičkih rastvarača na bazi holin hlorida
SP  - 170
EP  - 170
UR  - https://hdl.handle.net/21.15107/rcub_cer_5241
ER  - 

@conference{
author = "Pantić, Olga and Spasojević, Pavle and Panić, Vesna and Marković, Maja D. and Savić, Sanja I. and Kalagasidis Krušić, Melina",
year = "2022",
abstract = "Pectin and pectin derived oligosaccharides can be obtained from waste apple pomace(biomass). Traditional method for pectin extraction involves use of diluted mineral acids atelevated temperatures, with yields of about 10 to 15%. As an alternative to conventionalmethods, the use of eutectic solvents is increasing because of their superior propertieswhen it comes to targeted extraction of certain components from biomass. The aim of thispaper is ultrasound assisted extraction of pectin from waste apple pomace using cholinechloride based eutectic solvents and lactic acid. Properties of extracted products wereexamined using FTIR spectroscopy and differential scanning calorimetry., Pektin i pektinski oligosaharidi mogu se dobiti iz otpadne jabučne kaše. Ovaj prirodni  polimer ima široku primenu u industriji. Tradicionalna metoda za ekstrakciju pektina  podrazumeva tretman razblaženim mineralnim kiselinama na povišenoj temperaturi, pri  čemu se prinosi ostvaruju od oko 10 do 15%. Kao alternativa tradicionalnim rastvaračima  sve češće se koriste i eutektički rastvarači, koje odlikuju daleko superiornija svojstva kada  je reč o ciljanoj ekstrakciji određenih komponenti iz biomase. Cilj ovog rada je ultrazvučna  ekstrakcija pektina primenom eutektičkih rastvarača na bazi holin hlorida i mlečne  kiseline. Svojstva ekstrahovanog proizvoda ispitana su primenom FTIR spektroskopije i  diferencijalne skenirajuće kalorimetrije.",
publisher = "Serbian Chemical Society",
journal = "Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, June 9-10, 2022 / Kratki izvodi radova, kjniga radova - 58. Savetovanje Srpskog hemijskog društva, Beograd 9. - 10. jun 2022.",
title = "Ultrasound assisted extraction of pectin from waste apple pomace using choline chloride based eutectic solvents, Ultrazvučna ekstrakcija pektina iz otpadne jabučne kaše  primenom eutektičkih rastvarača na bazi holin hlorida",
pages = "170-170",
url = "https://hdl.handle.net/21.15107/rcub_cer_5241"
}

Pantić, O., Spasojević, P., Panić, V., Marković, M. D., Savić, S. I.,& Kalagasidis Krušić, M.. (2022). Ultrasound assisted extraction of pectin from waste apple pomace using choline chloride based eutectic solvents. in Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, June 9-10, 2022 / Kratki izvodi radova, kjniga radova - 58. Savetovanje Srpskog hemijskog društva, Beograd 9. - 10. jun 2022.
Serbian Chemical Society., 170-170.
https://hdl.handle.net/21.15107/rcub_cer_5241

Pantić O, Spasojević P, Panić V, Marković MD, Savić SI, Kalagasidis Krušić M. Ultrasound assisted extraction of pectin from waste apple pomace using choline chloride based eutectic solvents. in Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, June 9-10, 2022 / Kratki izvodi radova, kjniga radova - 58. Savetovanje Srpskog hemijskog društva, Beograd 9. - 10. jun 2022.. 2022;:170-170.
https://hdl.handle.net/21.15107/rcub_cer_5241 .

Pantić, Olga, Spasojević, Pavle, Panić, Vesna, Marković, Maja D., Savić, Sanja I., Kalagasidis Krušić, Melina, "Ultrasound assisted extraction of pectin from waste apple pomace using choline chloride based eutectic solvents" in Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, June 9-10, 2022 / Kratki izvodi radova, kjniga radova - 58. Savetovanje Srpskog hemijskog društva, Beograd 9. - 10. jun 2022. (2022):170-170,
https://hdl.handle.net/21.15107/rcub_cer_5241 .

TY  - JOUR
AU  - Marković, Maja D.
AU  - Panić, Vesna
AU  - Savić, Sanja I.
AU  - Ugrinović, Vukašin
AU  - Pjanović, Rada
AU  - Spasojević, Milica
AU  - Spasojević, Pavle
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5295
AB  - Materials sensitive to external stimuli are recognized as safe and effective tool able to respond to specific demands in the therapy of various diseases. Thermo sensitive hydrogels based on poly(N-isopropylacrylamide) (P(NIPAAM)) are widely investigated for targeted drug delivery. Still, the abundance of the stimuli in the human body often requires more than one responsive group able to act simultaneously to achieve optimal therapeutic effects. Due to its pH sensitivity and bio-based production, crotonic acid (CA) was a monomer of choice for preparation of eco-friendly copolymer hydrogels based on NIPAAM and CA (P(NIPAAMcoCA)), which turned to be thermo and pH sensitive at the same time. The potential of the P(NIPAAMcoCA) system for encapsulation and controlled release of drugs with different solubility was investigated engaging water-soluble lidocaine hydrochloride and poorly water-soluble ibuprofen as model drugs. The hydrogels were characterized by various technics: FTIR, DSC, SEM and single compressive tests, while swelling behavior and controlled release of the drugs were analyzed with respect to the CA amount in two environments with different pH values at 25 °C and 37 °C. It was demonstrated that due to their dual responsiveness the P(NIPAAMcoCA) hydrogels have potential for controlled release of drugs with different solubility.
PB  - Elsevier
T2  - Microporous and Mesoporous Materials
T1  - Biobased thermo/pH sensitive poly(N-isopropylacrylamide-co-crotonic acid) hydrogels for targeted drug delivery
VL  - 335
SP  - 111817
DO  - 10.1016/j.micromeso.2022.111817
ER  - 

@article{
author = "Marković, Maja D. and Panić, Vesna and Savić, Sanja I. and Ugrinović, Vukašin and Pjanović, Rada and Spasojević, Milica and Spasojević, Pavle",
year = "2022",
abstract = "Materials sensitive to external stimuli are recognized as safe and effective tool able to respond to specific demands in the therapy of various diseases. Thermo sensitive hydrogels based on poly(N-isopropylacrylamide) (P(NIPAAM)) are widely investigated for targeted drug delivery. Still, the abundance of the stimuli in the human body often requires more than one responsive group able to act simultaneously to achieve optimal therapeutic effects. Due to its pH sensitivity and bio-based production, crotonic acid (CA) was a monomer of choice for preparation of eco-friendly copolymer hydrogels based on NIPAAM and CA (P(NIPAAMcoCA)), which turned to be thermo and pH sensitive at the same time. The potential of the P(NIPAAMcoCA) system for encapsulation and controlled release of drugs with different solubility was investigated engaging water-soluble lidocaine hydrochloride and poorly water-soluble ibuprofen as model drugs. The hydrogels were characterized by various technics: FTIR, DSC, SEM and single compressive tests, while swelling behavior and controlled release of the drugs were analyzed with respect to the CA amount in two environments with different pH values at 25 °C and 37 °C. It was demonstrated that due to their dual responsiveness the P(NIPAAMcoCA) hydrogels have potential for controlled release of drugs with different solubility.",
publisher = "Elsevier",
journal = "Microporous and Mesoporous Materials",
title = "Biobased thermo/pH sensitive poly(N-isopropylacrylamide-co-crotonic acid) hydrogels for targeted drug delivery",
volume = "335",
pages = "111817",
doi = "10.1016/j.micromeso.2022.111817"
}

Marković, M. D., Panić, V., Savić, S. I., Ugrinović, V., Pjanović, R., Spasojević, M.,& Spasojević, P.. (2022). Biobased thermo/pH sensitive poly(N-isopropylacrylamide-co-crotonic acid) hydrogels for targeted drug delivery. in Microporous and Mesoporous Materials
Elsevier., 335, 111817.
https://doi.org/10.1016/j.micromeso.2022.111817

Marković MD, Panić V, Savić SI, Ugrinović V, Pjanović R, Spasojević M, Spasojević P. Biobased thermo/pH sensitive poly(N-isopropylacrylamide-co-crotonic acid) hydrogels for targeted drug delivery. in Microporous and Mesoporous Materials. 2022;335:111817.
doi:10.1016/j.micromeso.2022.111817 .

Marković, Maja D., Panić, Vesna, Savić, Sanja I., Ugrinović, Vukašin, Pjanović, Rada, Spasojević, Milica, Spasojević, Pavle, "Biobased thermo/pH sensitive poly(N-isopropylacrylamide-co-crotonic acid) hydrogels for targeted drug delivery" in Microporous and Mesoporous Materials, 335 (2022):111817,
https://doi.org/10.1016/j.micromeso.2022.111817 . .

TY  - JOUR
AU  - Marković, Maja D.
AU  - Tadić, Julijana D.
AU  - Savić, Sanja I.
AU  - Matić, Ivana Z.
AU  - Stanojković, Tatjana
AU  - Mijin, Dušan
AU  - Panić, Vesna
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5429
AB  - Researchers are faced with everyday demands for safer and more efficient therapy for many diseases, especially serious one such as various types of cancer. Numerous anticancer drugs are poorly-water soluble and therefore their encapsulation and controlled release remain quite challenge. In present study, we deepened our research of hydrophilic carrier based on poly(methacrylic acid) and casein (PMAC) by investigating its potential for encapsulation and controlled release of novel poorly water-soluble dihydropyrimidion-azo-pyridon compound (DHPMP). DHPMP is a dye that has been proven to show cytotoxic activity against chronic myeloid leukemia K562 cells. By encapsulating DHPMP into the carrier and delivering it into the intestines, DHPMP absorption could be the fastest and the number of therapeutic doses and side effects can be reduced. Carriers based on PMAC and DHPMP (PMAC-DHPMP) were synthetized and characterized by FTIR, SEM and single compression tests. The swelling behavior of PMAC-DHPMP carriers and cumulative DHPMP release were investigated depending on the amount of crosslinker and encapsulated DHPMP in two media which were simulating pH environments in human stomach and intestines. The prolonged and controlled release of DHPMP was achieved. In vitro cytotoxic activity of PMAC-DHPMP carriers against K562 cells and the cell cycle analysis showed great potential of the carriers for application in leukemia treatment.
PB  - Wiley
T2  - Journal of Biomedical Materials Research - Part A
T1  - Soft 3D hybrid network for delivery and controlled release of poorly soluble dihydropyrimidinone compound: An insight into the novel system for potential application in leukemia treatment
VL  - 110
IS  - 9
SP  - 1564
EP  - 1578
DO  - 10.1002/jbm.a.37396
ER  - 

@article{
author = "Marković, Maja D. and Tadić, Julijana D. and Savić, Sanja I. and Matić, Ivana Z. and Stanojković, Tatjana and Mijin, Dušan and Panić, Vesna",
year = "2022",
abstract = "Researchers are faced with everyday demands for safer and more efficient therapy for many diseases, especially serious one such as various types of cancer. Numerous anticancer drugs are poorly-water soluble and therefore their encapsulation and controlled release remain quite challenge. In present study, we deepened our research of hydrophilic carrier based on poly(methacrylic acid) and casein (PMAC) by investigating its potential for encapsulation and controlled release of novel poorly water-soluble dihydropyrimidion-azo-pyridon compound (DHPMP). DHPMP is a dye that has been proven to show cytotoxic activity against chronic myeloid leukemia K562 cells. By encapsulating DHPMP into the carrier and delivering it into the intestines, DHPMP absorption could be the fastest and the number of therapeutic doses and side effects can be reduced. Carriers based on PMAC and DHPMP (PMAC-DHPMP) were synthetized and characterized by FTIR, SEM and single compression tests. The swelling behavior of PMAC-DHPMP carriers and cumulative DHPMP release were investigated depending on the amount of crosslinker and encapsulated DHPMP in two media which were simulating pH environments in human stomach and intestines. The prolonged and controlled release of DHPMP was achieved. In vitro cytotoxic activity of PMAC-DHPMP carriers against K562 cells and the cell cycle analysis showed great potential of the carriers for application in leukemia treatment.",
publisher = "Wiley",
journal = "Journal of Biomedical Materials Research - Part A",
title = "Soft 3D hybrid network for delivery and controlled release of poorly soluble dihydropyrimidinone compound: An insight into the novel system for potential application in leukemia treatment",
volume = "110",
number = "9",
pages = "1564-1578",
doi = "10.1002/jbm.a.37396"
}

Marković, M. D., Tadić, J. D., Savić, S. I., Matić, I. Z., Stanojković, T., Mijin, D.,& Panić, V.. (2022). Soft 3D hybrid network for delivery and controlled release of poorly soluble dihydropyrimidinone compound: An insight into the novel system for potential application in leukemia treatment. in Journal of Biomedical Materials Research - Part A
Wiley., 110(9), 1564-1578.
https://doi.org/10.1002/jbm.a.37396

Marković MD, Tadić JD, Savić SI, Matić IZ, Stanojković T, Mijin D, Panić V. Soft 3D hybrid network for delivery and controlled release of poorly soluble dihydropyrimidinone compound: An insight into the novel system for potential application in leukemia treatment. in Journal of Biomedical Materials Research - Part A. 2022;110(9):1564-1578.
doi:10.1002/jbm.a.37396 .

Marković, Maja D., Tadić, Julijana D., Savić, Sanja I., Matić, Ivana Z., Stanojković, Tatjana, Mijin, Dušan, Panić, Vesna, "Soft 3D hybrid network for delivery and controlled release of poorly soluble dihydropyrimidinone compound: An insight into the novel system for potential application in leukemia treatment" in Journal of Biomedical Materials Research - Part A, 110, no. 9 (2022):1564-1578,
https://doi.org/10.1002/jbm.a.37396 . .

TY  - JOUR
AU  - Pantić, Olga
AU  - Pjanović, Rada
AU  - Panić, Vesna
AU  - Savić, Sanja
AU  - Spasojević, Pavle
AU  - Marković, Maja D.
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6955
AB  - Drug delivery system is an amazing tool which is widely used for drugprotection and its controlled release in order to enhance drug bioavailability,reduce side effects and therefore to improve overall therapy. Hydrogels havebeen attracted great attention as drug carriers due to their great physicochemicalproperties, similarity to the living tissues and biocompatibility. One group ofpH sensitive hydrogels are based on poly(methacrylic acid) (PMAA). Thesenon-toxic hydrogels are used as drug delivery system because they swell asa response to the change in pH of external environment and drug is beingreleased during the process. In present study, in order to improve the control ofdrug release rate, caffeine was encapsulated in liposomes which were furtherembedded into PMC hydrogel (PMCL). It was investigated how the change inneutralization degree of methacrylic acid affect the swelling degree of PMCLhydrogels and caffeine release in two environments at 37 °C for 24 h: 0.1 Mhydrochloride acid (pH 1) and phosphate buffer with pH value of 6.8 (pH 6.8), asa simulation of pH environment in human stomach and intestines, respectively.Obtained results show that PMCL hydrogels have great potential for controlledrelease of poorly water-soluble drugs in human intestines.
PB  - The Faculty of Technology, University of Banja Luka
T2  - Journal of Chemists, Technologists and Environmentalists
T1  - Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release
VL  - 3
IS  - 1
SP  - 1
EP  - 5
DO  - 10.7251/JCTE2203001P
ER  - 

@article{
author = "Pantić, Olga and Pjanović, Rada and Panić, Vesna and Savić, Sanja and Spasojević, Pavle and Marković, Maja D.",
year = "2022",
abstract = "Drug delivery system is an amazing tool which is widely used for drugprotection and its controlled release in order to enhance drug bioavailability,reduce side effects and therefore to improve overall therapy. Hydrogels havebeen attracted great attention as drug carriers due to their great physicochemicalproperties, similarity to the living tissues and biocompatibility. One group ofpH sensitive hydrogels are based on poly(methacrylic acid) (PMAA). Thesenon-toxic hydrogels are used as drug delivery system because they swell asa response to the change in pH of external environment and drug is beingreleased during the process. In present study, in order to improve the control ofdrug release rate, caffeine was encapsulated in liposomes which were furtherembedded into PMC hydrogel (PMCL). It was investigated how the change inneutralization degree of methacrylic acid affect the swelling degree of PMCLhydrogels and caffeine release in two environments at 37 °C for 24 h: 0.1 Mhydrochloride acid (pH 1) and phosphate buffer with pH value of 6.8 (pH 6.8), asa simulation of pH environment in human stomach and intestines, respectively.Obtained results show that PMCL hydrogels have great potential for controlledrelease of poorly water-soluble drugs in human intestines.",
publisher = "The Faculty of Technology, University of Banja Luka",
journal = "Journal of Chemists, Technologists and Environmentalists",
title = "Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release",
volume = "3",
number = "1",
pages = "1-5",
doi = "10.7251/JCTE2203001P"
}

Pantić, O., Pjanović, R., Panić, V., Savić, S., Spasojević, P.,& Marković, M. D.. (2022). Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release. in Journal of Chemists, Technologists and Environmentalists
The Faculty of Technology, University of Banja Luka., 3(1), 1-5.
https://doi.org/10.7251/JCTE2203001P

Pantić O, Pjanović R, Panić V, Savić S, Spasojević P, Marković MD. Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release. in Journal of Chemists, Technologists and Environmentalists. 2022;3(1):1-5.
doi:10.7251/JCTE2203001P .

Pantić, Olga, Pjanović, Rada, Panić, Vesna, Savić, Sanja, Spasojević, Pavle, Marković, Maja D., "Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release" in Journal of Chemists, Technologists and Environmentalists, 3, no. 1 (2022):1-5,
https://doi.org/10.7251/JCTE2203001P . .

TY  - JOUR
AU  - Pantić, Olga
AU  - Spasojević, Milica
AU  - Džunuzović, Enis S.
AU  - Nikolić, Marija S.
AU  - Savić, Sanja I.
AU  - Marković, Maja
AU  - Spasojević, Pavle
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5240
AB  - The scope of the present study was to prepare fully bio-based unsaturated polyester resins (UPRs) with comparable properties to the commercial formulations. The focus was set on the determination of the optimal prepolymer formulation using the same set of diacids (itaconic and succinic acid) and different diols (propylene glycol, isosorbide and neopentyl glycol) or its equimolar mixtures, keeping the fixed molar ratio of 1:1:2.1 in all feed compositions. Instead of commonly used styrene, bio-based dimethyl itaconate was used as a reactive diluent (RD). The rheology of the obtained resins was studied in detail. The effect of the used diol on structural (FTIR), thermal (DSC), thermomechanical (DMA), and mechanical (tensile) properties was explained. The properties of UPRs were found to be highly dependent on the diol used in the prepolymer formulation. The UPR with an equimolar ratio of propylene glycol and neopentyl glycol was shown to be the most promising candidate to compete with the commercial petroleum-based resins.
PB  - MDPI
T2  - Polymers
T1  - The Effect of Glycol Derivatives on the Properties of Bio-Based Unsaturated Polyesters
VL  - 14
IS  - 15
SP  - 2970
DO  - 10.3390/polym14152970
ER  - 

@article{
author = "Pantić, Olga and Spasojević, Milica and Džunuzović, Enis S. and Nikolić, Marija S. and Savić, Sanja I. and Marković, Maja and Spasojević, Pavle",
year = "2022",
abstract = "The scope of the present study was to prepare fully bio-based unsaturated polyester resins (UPRs) with comparable properties to the commercial formulations. The focus was set on the determination of the optimal prepolymer formulation using the same set of diacids (itaconic and succinic acid) and different diols (propylene glycol, isosorbide and neopentyl glycol) or its equimolar mixtures, keeping the fixed molar ratio of 1:1:2.1 in all feed compositions. Instead of commonly used styrene, bio-based dimethyl itaconate was used as a reactive diluent (RD). The rheology of the obtained resins was studied in detail. The effect of the used diol on structural (FTIR), thermal (DSC), thermomechanical (DMA), and mechanical (tensile) properties was explained. The properties of UPRs were found to be highly dependent on the diol used in the prepolymer formulation. The UPR with an equimolar ratio of propylene glycol and neopentyl glycol was shown to be the most promising candidate to compete with the commercial petroleum-based resins.",
publisher = "MDPI",
journal = "Polymers",
title = "The Effect of Glycol Derivatives on the Properties of Bio-Based Unsaturated Polyesters",
volume = "14",
number = "15",
pages = "2970",
doi = "10.3390/polym14152970"
}

Pantić, O., Spasojević, M., Džunuzović, E. S., Nikolić, M. S., Savić, S. I., Marković, M.,& Spasojević, P.. (2022). The Effect of Glycol Derivatives on the Properties of Bio-Based Unsaturated Polyesters. in Polymers
MDPI., 14(15), 2970.
https://doi.org/10.3390/polym14152970

Pantić O, Spasojević M, Džunuzović ES, Nikolić MS, Savić SI, Marković M, Spasojević P. The Effect of Glycol Derivatives on the Properties of Bio-Based Unsaturated Polyesters. in Polymers. 2022;14(15):2970.
doi:10.3390/polym14152970 .

Pantić, Olga, Spasojević, Milica, Džunuzović, Enis S., Nikolić, Marija S., Savić, Sanja I., Marković, Maja, Spasojević, Pavle, "The Effect of Glycol Derivatives on the Properties of Bio-Based Unsaturated Polyesters" in Polymers, 14, no. 15 (2022):2970,
https://doi.org/10.3390/polym14152970 . .

TY  - CONF
AU  - Pantić, Olga
AU  - Panić, Vesna
AU  - Savić, Sanja
AU  - Marković, Maja
AU  - Kalagasidis Krušić, Melina
AU  - Spasojević, Pavle
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6952
AB  - Replacing styrene with biobased monomers to produce fully biobased unsaturated polyester
resins (UPRs) turned out to be quite a challenging task. Styrene has been recognized as a hazardous and a potentially carcinogenic substance for human health. Using dimethyl itaconate as an alternative reactive diluent to styrene, which can be obtained from renewable resources, enables low viscosity for easy manipulation of mentioned UPRs. Fully biobased UPRs in question were based on itaconic acid, succinic acid, and propylene glycol, which were then diluted with dimethyl itaconate. Having in mind that UPRs can be used as a matrix for composite materials, this paper examines the effect of different weight ratios of spent coffee grounds as a filler. To determine the application of thus obtained composite materials, characterization consisted of examining mechanical properties based on viscosity measurements, uniaxial stretching experiments, FTIR spectroscopy and gel content analysis.
AB  - Upotreba bioobnovljivih monomera umesto stirena u proizvodnji nezasićenih poliestarskih (NZPE) smola, koje se u potpunosti dobijaju iz bioobnovljivih izvora predstavlja veliki izazov. Savremena istraživanja su ukazala da je stiren vrlo toksičan po ljudsko zdravlje i kategorizovan je kao potencijalno kancerogena supstanca. Upotrebom dimetil itakonata kao alternativnog rastvarača, koji se može dobiti iz obnovljivih izvora, obezbeđuje se niska viskoznost koja je neophodna  za industrijsku primenu NZPE smola. U ovom radu je sintetisana NZPE smola na bazi ćilibarne kiseline, itakonske kiseline i propilen glikola, koja je zatim razblažena dimetil itakonatom. S obzirom da NZPE smole imaju značajnu primenu u izradi kompozitnih materijala, u ovom radu su dalje ispitivana svojstva materijala pri različitim udelima otpadne kafe kao punioca (10, 20, 30 mas.%). Nakon sinteze određena je viskozimetrija, mehaničke karakteristike kompozitinih materijala, kao i sadržaj gel faze. Strukturna  svojstva ispitana su  primenom  FTIR spektrokopije .
PB  - Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS)
PB  - Društvo za procesnu tehniku
C3  - Zbornik radova - 35. Međunarodni kongres o procesnoj industriji, PROCESING ‘22, 1-3. jun 2022, Beograd
T1  - Biobased composite materials obtained from unsaturated polyester resins and waste coffee
T1  - Kompozitni materijali na bazi nezasićenih poliestarskih smola dobijenih iz bioobnovljivih izvora i otpadne kafe
SP  - 41
EP  - 48
DO  - 10.24094/ptk.022.041
ER  - 

@conference{
author = "Pantić, Olga and Panić, Vesna and Savić, Sanja and Marković, Maja and Kalagasidis Krušić, Melina and Spasojević, Pavle",
year = "2022",
abstract = "Replacing styrene with biobased monomers to produce fully biobased unsaturated polyester
resins (UPRs) turned out to be quite a challenging task. Styrene has been recognized as a hazardous and a potentially carcinogenic substance for human health. Using dimethyl itaconate as an alternative reactive diluent to styrene, which can be obtained from renewable resources, enables low viscosity for easy manipulation of mentioned UPRs. Fully biobased UPRs in question were based on itaconic acid, succinic acid, and propylene glycol, which were then diluted with dimethyl itaconate. Having in mind that UPRs can be used as a matrix for composite materials, this paper examines the effect of different weight ratios of spent coffee grounds as a filler. To determine the application of thus obtained composite materials, characterization consisted of examining mechanical properties based on viscosity measurements, uniaxial stretching experiments, FTIR spectroscopy and gel content analysis., Upotreba bioobnovljivih monomera umesto stirena u proizvodnji nezasićenih poliestarskih (NZPE) smola, koje se u potpunosti dobijaju iz bioobnovljivih izvora predstavlja veliki izazov. Savremena istraživanja su ukazala da je stiren vrlo toksičan po ljudsko zdravlje i kategorizovan je kao potencijalno kancerogena supstanca. Upotrebom dimetil itakonata kao alternativnog rastvarača, koji se može dobiti iz obnovljivih izvora, obezbeđuje se niska viskoznost koja je neophodna  za industrijsku primenu NZPE smola. U ovom radu je sintetisana NZPE smola na bazi ćilibarne kiseline, itakonske kiseline i propilen glikola, koja je zatim razblažena dimetil itakonatom. S obzirom da NZPE smole imaju značajnu primenu u izradi kompozitnih materijala, u ovom radu su dalje ispitivana svojstva materijala pri različitim udelima otpadne kafe kao punioca (10, 20, 30 mas.%). Nakon sinteze određena je viskozimetrija, mehaničke karakteristike kompozitinih materijala, kao i sadržaj gel faze. Strukturna  svojstva ispitana su  primenom  FTIR spektrokopije .",
publisher = "Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS), Društvo za procesnu tehniku",
journal = "Zbornik radova - 35. Međunarodni kongres o procesnoj industriji, PROCESING ‘22, 1-3. jun 2022, Beograd",
title = "Biobased composite materials obtained from unsaturated polyester resins and waste coffee, Kompozitni materijali na bazi nezasićenih poliestarskih smola dobijenih iz bioobnovljivih izvora i otpadne kafe",
pages = "41-48",
doi = "10.24094/ptk.022.041"
}

Pantić, O., Panić, V., Savić, S., Marković, M., Kalagasidis Krušić, M.,& Spasojević, P.. (2022). Biobased composite materials obtained from unsaturated polyester resins and waste coffee. in Zbornik radova - 35. Međunarodni kongres o procesnoj industriji, PROCESING ‘22, 1-3. jun 2022, Beograd
Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS)., 41-48.
https://doi.org/10.24094/ptk.022.041

Pantić O, Panić V, Savić S, Marković M, Kalagasidis Krušić M, Spasojević P. Biobased composite materials obtained from unsaturated polyester resins and waste coffee. in Zbornik radova - 35. Međunarodni kongres o procesnoj industriji, PROCESING ‘22, 1-3. jun 2022, Beograd. 2022;:41-48.
doi:10.24094/ptk.022.041 .

Pantić, Olga, Panić, Vesna, Savić, Sanja, Marković, Maja, Kalagasidis Krušić, Melina, Spasojević, Pavle, "Biobased composite materials obtained from unsaturated polyester resins and waste coffee" in Zbornik radova - 35. Međunarodni kongres o procesnoj industriji, PROCESING ‘22, 1-3. jun 2022, Beograd (2022):41-48,
https://doi.org/10.24094/ptk.022.041 . .

TY  - CONF
AU  - Pantić, Olga
AU  - Savić, Sanja
AU  - Panić, Vesna
AU  - Marković, Maja
AU  - Kalagasidis Krušić, Melina
AU  - Spasojević, Pavle
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6953
AB  - Most used raw materials for production of unsaturated polyester resins are obtained from 
petroleum. Transitioning to biobased unsaturated polyester resins is a complex, costly and time consuming process, but it is necessary to lower the dependence of petroleum. Unsaturated polyester 
resins are the most used type of resin as a matrix for composite materials. Natural fillers in these 
materials can provide several benefits as they are abundant, recyclable, and non-toxic. Synthesized 
unsaturated polyester consisted of itaconic acid, succinic acid, propylene glycol and neopentyl 
glycol, while dimethyl itaconate was used as a reactive diluent. In this paper we examined two 
different natural fillers, rosehip flour and hemp fibres, both of which were varied in weight ratios. 
Characterization of obtained composite materials consisted of examining mechanical properties by 
uniaxial tensile test, FTIR spectroscopy and gel content analysis.
PB  - Banja Luka : University in Banjaluka, Faculty of Technology
C3  - Book of proceedings - XIV Conference of  Chemists, Technologists and Environmentalists of Republic of Srpska,  Banja Luka, October 21-22, 2022
T1  - Biobased unsaturated polyester resins reinforced with natural fillers
SP  - 42
EP  - 42
UR  - https://hdl.handle.net/21.15107/rcub_cer_6953
ER  - 

@conference{
author = "Pantić, Olga and Savić, Sanja and Panić, Vesna and Marković, Maja and Kalagasidis Krušić, Melina and Spasojević, Pavle",
year = "2022",
abstract = "Most used raw materials for production of unsaturated polyester resins are obtained from 
petroleum. Transitioning to biobased unsaturated polyester resins is a complex, costly and time consuming process, but it is necessary to lower the dependence of petroleum. Unsaturated polyester 
resins are the most used type of resin as a matrix for composite materials. Natural fillers in these 
materials can provide several benefits as they are abundant, recyclable, and non-toxic. Synthesized 
unsaturated polyester consisted of itaconic acid, succinic acid, propylene glycol and neopentyl 
glycol, while dimethyl itaconate was used as a reactive diluent. In this paper we examined two 
different natural fillers, rosehip flour and hemp fibres, both of which were varied in weight ratios. 
Characterization of obtained composite materials consisted of examining mechanical properties by 
uniaxial tensile test, FTIR spectroscopy and gel content analysis.",
publisher = "Banja Luka : University in Banjaluka, Faculty of Technology",
journal = "Book of proceedings - XIV Conference of  Chemists, Technologists and Environmentalists of Republic of Srpska,  Banja Luka, October 21-22, 2022",
title = "Biobased unsaturated polyester resins reinforced with natural fillers",
pages = "42-42",
url = "https://hdl.handle.net/21.15107/rcub_cer_6953"
}

Pantić, O., Savić, S., Panić, V., Marković, M., Kalagasidis Krušić, M.,& Spasojević, P.. (2022). Biobased unsaturated polyester resins reinforced with natural fillers. in Book of proceedings - XIV Conference of  Chemists, Technologists and Environmentalists of Republic of Srpska,  Banja Luka, October 21-22, 2022
Banja Luka : University in Banjaluka, Faculty of Technology., 42-42.
https://hdl.handle.net/21.15107/rcub_cer_6953

Pantić O, Savić S, Panić V, Marković M, Kalagasidis Krušić M, Spasojević P. Biobased unsaturated polyester resins reinforced with natural fillers. in Book of proceedings - XIV Conference of  Chemists, Technologists and Environmentalists of Republic of Srpska,  Banja Luka, October 21-22, 2022. 2022;:42-42.
https://hdl.handle.net/21.15107/rcub_cer_6953 .

Pantić, Olga, Savić, Sanja, Panić, Vesna, Marković, Maja, Kalagasidis Krušić, Melina, Spasojević, Pavle, "Biobased unsaturated polyester resins reinforced with natural fillers" in Book of proceedings - XIV Conference of  Chemists, Technologists and Environmentalists of Republic of Srpska,  Banja Luka, October 21-22, 2022 (2022):42-42,
https://hdl.handle.net/21.15107/rcub_cer_6953 .

TY  - CONF
AU  - Pantić, Olga
AU  - Pjanović, Rada
AU  - Panić, Vesna
AU  - Savić, Sanja
AU  - Spasojević, Pavle
AU  - Marković, Maja
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6954
AB  - Drug delivery system is an amazing tool which is widely used for drug protection and its controlled 
release in order to enhance drug bioavailability, reduce side effects and therefore to improve overall 
therapy. Hydrogels have been attracted great attention as drug carriers due to their great 
physicochemical properties, similarity to the living tissues and biocompatibility. One group of pH 
sensitive hydrogels are based on poly(methacrylic acid) (PMAA). These non-toxic hydrogels are 
used as drug delivery system because they swell as a response to the change in pH of external 
environment and drug is being released during the process. In our previous research we modified 
hydrophilic PMAA with amphiphilic casein (PMC) and enabled in that manner the encapsulation of 
poorly water-soluble caffein and its controlled release. Casein is non-toxic, pH sensitive and 
biocompatible natural polymer which improved mechanical properties of PMAA, as well. In 
present study, in order to improve the control of drug release rate, caffeine was encapsulated in 
liposomes which were further embedded into PMC hydrogel (PMCL). It was investigated how the 
change in neutralization degree of methacrylic acid affect the swelling degree of PMCL hydrogels 
and caffeine release in two environments at 37 ℃ for 24 h: 0.1 M hydrochloride acid (PH 1) and 
phosphate buffer with pH value of 6.8 (PH 6.8), as a simulation of pH environment in human 
stomach and intestines, respectively. Obtained results show that PMCL hydrogels have great 
potential for controlled release of poorly water-soluble drugs in human intestines.
PB  - Banja Luka : University in Banjaluka, Faculty of Technology
C3  - Book of proceedings - XIV Conference of Chemists, Technologists and Environmentalists of Republic of Srpska, Banja Luka, October 21-22, 2022
T1  - Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release
SP  - 43
EP  - 43
UR  - https://hdl.handle.net/21.15107/rcub_cer_6954
ER  - 

@conference{
author = "Pantić, Olga and Pjanović, Rada and Panić, Vesna and Savić, Sanja and Spasojević, Pavle and Marković, Maja",
year = "2022",
abstract = "Drug delivery system is an amazing tool which is widely used for drug protection and its controlled 
release in order to enhance drug bioavailability, reduce side effects and therefore to improve overall 
therapy. Hydrogels have been attracted great attention as drug carriers due to their great 
physicochemical properties, similarity to the living tissues and biocompatibility. One group of pH 
sensitive hydrogels are based on poly(methacrylic acid) (PMAA). These non-toxic hydrogels are 
used as drug delivery system because they swell as a response to the change in pH of external 
environment and drug is being released during the process. In our previous research we modified 
hydrophilic PMAA with amphiphilic casein (PMC) and enabled in that manner the encapsulation of 
poorly water-soluble caffein and its controlled release. Casein is non-toxic, pH sensitive and 
biocompatible natural polymer which improved mechanical properties of PMAA, as well. In 
present study, in order to improve the control of drug release rate, caffeine was encapsulated in 
liposomes which were further embedded into PMC hydrogel (PMCL). It was investigated how the 
change in neutralization degree of methacrylic acid affect the swelling degree of PMCL hydrogels 
and caffeine release in two environments at 37 ℃ for 24 h: 0.1 M hydrochloride acid (PH 1) and 
phosphate buffer with pH value of 6.8 (PH 6.8), as a simulation of pH environment in human 
stomach and intestines, respectively. Obtained results show that PMCL hydrogels have great 
potential for controlled release of poorly water-soluble drugs in human intestines.",
publisher = "Banja Luka : University in Banjaluka, Faculty of Technology",
journal = "Book of proceedings - XIV Conference of Chemists, Technologists and Environmentalists of Republic of Srpska, Banja Luka, October 21-22, 2022",
title = "Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release",
pages = "43-43",
url = "https://hdl.handle.net/21.15107/rcub_cer_6954"
}

Pantić, O., Pjanović, R., Panić, V., Savić, S., Spasojević, P.,& Marković, M.. (2022). Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release. in Book of proceedings - XIV Conference of Chemists, Technologists and Environmentalists of Republic of Srpska, Banja Luka, October 21-22, 2022
Banja Luka : University in Banjaluka, Faculty of Technology., 43-43.
https://hdl.handle.net/21.15107/rcub_cer_6954

Pantić O, Pjanović R, Panić V, Savić S, Spasojević P, Marković M. Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release. in Book of proceedings - XIV Conference of Chemists, Technologists and Environmentalists of Republic of Srpska, Banja Luka, October 21-22, 2022. 2022;:43-43.
https://hdl.handle.net/21.15107/rcub_cer_6954 .

Pantić, Olga, Pjanović, Rada, Panić, Vesna, Savić, Sanja, Spasojević, Pavle, Marković, Maja, "Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release" in Book of proceedings - XIV Conference of Chemists, Technologists and Environmentalists of Republic of Srpska, Banja Luka, October 21-22, 2022 (2022):43-43,
https://hdl.handle.net/21.15107/rcub_cer_6954 .

TY  - CONF
AU  - Pantić, Olga
AU  - Spasojević, Pavle
AU  - Marković, Maja
AU  - Savić, Sanja
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6956
AB  - Processing of waste by-products of agricultural origin generated by different kinds of 
industries can entail environmental problems. Waste apple pomace (biomass) could play 
an important role in pectin production, offering economic advantages and decreasing the 
environmental impact. Pectin and pectin derived oligosaccharides have many 
applications in food and pharmaceutical products as gelling agents and stabilizers. 
Traditional method for pectin extraction involved the use of diluted mineral acids at 
elevated temperatures, with yields of about 10 to 15%. Because of the relatively long 
period of exposure to direct heating, thermal degradation of pectin often occurs in this 
process. The use of deep eutectic solvents could be the solution to this problem. Deep 
eutectic solvents have shown superior properties when it comes to targeted extraction of 
certain components from biomass, while providing mild conditions when compared to 
conventional methods. The aim of this paper is thermal extraction of pectin from waste 
apple pomace using choline chloride based deep eutectic solvents combined with 
different acids (oxalic acid, lactic acid and malic acid). Properties of extracted products 
were examined using FTIR spectroscopy and differential scanning calorimetry.
PB  - Belgrade : Serbian Chemical Society
PB  - Belgrade : Serbian Young Chemists’ Club
C3  - 8th Conference of Young Chemists of Serbia Book of Abstracts, Belgrade, 29th October 2022
T1  - Thermal extraction of pectin from waste apple pomace using choline chloride based eutectic solvents
SP  - 66
EP  - 66
UR  - https://hdl.handle.net/21.15107/rcub_cer_6956
ER  - 

@conference{
author = "Pantić, Olga and Spasojević, Pavle and Marković, Maja and Savić, Sanja",
year = "2022",
abstract = "Processing of waste by-products of agricultural origin generated by different kinds of 
industries can entail environmental problems. Waste apple pomace (biomass) could play 
an important role in pectin production, offering economic advantages and decreasing the 
environmental impact. Pectin and pectin derived oligosaccharides have many 
applications in food and pharmaceutical products as gelling agents and stabilizers. 
Traditional method for pectin extraction involved the use of diluted mineral acids at 
elevated temperatures, with yields of about 10 to 15%. Because of the relatively long 
period of exposure to direct heating, thermal degradation of pectin often occurs in this 
process. The use of deep eutectic solvents could be the solution to this problem. Deep 
eutectic solvents have shown superior properties when it comes to targeted extraction of 
certain components from biomass, while providing mild conditions when compared to 
conventional methods. The aim of this paper is thermal extraction of pectin from waste 
apple pomace using choline chloride based deep eutectic solvents combined with 
different acids (oxalic acid, lactic acid and malic acid). Properties of extracted products 
were examined using FTIR spectroscopy and differential scanning calorimetry.",
publisher = "Belgrade : Serbian Chemical Society, Belgrade : Serbian Young Chemists’ Club",
journal = "8th Conference of Young Chemists of Serbia Book of Abstracts, Belgrade, 29th October 2022",
title = "Thermal extraction of pectin from waste apple pomace using choline chloride based eutectic solvents",
pages = "66-66",
url = "https://hdl.handle.net/21.15107/rcub_cer_6956"
}

Pantić, O., Spasojević, P., Marković, M.,& Savić, S.. (2022). Thermal extraction of pectin from waste apple pomace using choline chloride based eutectic solvents. in 8th Conference of Young Chemists of Serbia Book of Abstracts, Belgrade, 29th October 2022
Belgrade : Serbian Chemical Society., 66-66.
https://hdl.handle.net/21.15107/rcub_cer_6956

Pantić O, Spasojević P, Marković M, Savić S. Thermal extraction of pectin from waste apple pomace using choline chloride based eutectic solvents. in 8th Conference of Young Chemists of Serbia Book of Abstracts, Belgrade, 29th October 2022. 2022;:66-66.
https://hdl.handle.net/21.15107/rcub_cer_6956 .

Pantić, Olga, Spasojević, Pavle, Marković, Maja, Savić, Sanja, "Thermal extraction of pectin from waste apple pomace using choline chloride based eutectic solvents" in 8th Conference of Young Chemists of Serbia Book of Abstracts, Belgrade, 29th October 2022 (2022):66-66,
https://hdl.handle.net/21.15107/rcub_cer_6956 .

TY  - JOUR
AU  - Ugrinović, Vukašin
AU  - Panić, Vesna
AU  - Spasojević, Pavle
AU  - Šešlija, Sanja
AU  - Božić, Bojan
AU  - Petrović, Rada
AU  - Janaćković, Đorđe
AU  - Veljović, Đorđe
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5243
AB  - Hydrogels are promising materials for biomedical applications due to highly hydrated, porous, permeable structure with possibility to accommodate living cells, drugs, or bioactive factors. In this paper, we reported poly(methacrylic acid) (PMAA)/gelatin IPN hydrogels, synthesized by free-radical polymerization, with adjustable mechanical, structural, physicochemical, and biological characteristics. The influence of methacrylic acid (MAA), gelatin, and cross-linker in the precursor solution on hydrogels properties was investigated. The increasing concentration of MAA, gelatin, and cross-linker led to better mechanical properties, lower porosity, and water content. The compressive mechanical properties of hydrogels were significantly better in comparison to a single-network PMAA hydrogel, while the obtained compressive strength values up to 16 MPa were comparable with tough hydrogels. The increasing concentration of MAA and cross-linker reduced fatigue resistance and degradability, while the increase in gelatin content acted in the opposite way. Swelling tests in different pH conditions demonstrated strong pH-sensibility of the hydrogels, which was more pronounced as MAA concentration was higher, and gelatin and cross-linker concentrations were lower. In addition, the hydrogels strongly promoted the proliferation of human periodontal ligament stem cells and MRC-5 cells as assayed by MTT assay.
PB  - Wiley
T2  - Polymer Engineering and Science
T1  - Strong and tough, pH sensible, interpenetrating network hydrogels based on gelatin and poly(methacrylic acid)
VL  - 62
SP  - 622
EP  - 636
DO  - 10.1002/pen.25870
ER  - 

@article{
author = "Ugrinović, Vukašin and Panić, Vesna and Spasojević, Pavle and Šešlija, Sanja and Božić, Bojan and Petrović, Rada and Janaćković, Đorđe and Veljović, Đorđe",
year = "2022",
abstract = "Hydrogels are promising materials for biomedical applications due to highly hydrated, porous, permeable structure with possibility to accommodate living cells, drugs, or bioactive factors. In this paper, we reported poly(methacrylic acid) (PMAA)/gelatin IPN hydrogels, synthesized by free-radical polymerization, with adjustable mechanical, structural, physicochemical, and biological characteristics. The influence of methacrylic acid (MAA), gelatin, and cross-linker in the precursor solution on hydrogels properties was investigated. The increasing concentration of MAA, gelatin, and cross-linker led to better mechanical properties, lower porosity, and water content. The compressive mechanical properties of hydrogels were significantly better in comparison to a single-network PMAA hydrogel, while the obtained compressive strength values up to 16 MPa were comparable with tough hydrogels. The increasing concentration of MAA and cross-linker reduced fatigue resistance and degradability, while the increase in gelatin content acted in the opposite way. Swelling tests in different pH conditions demonstrated strong pH-sensibility of the hydrogels, which was more pronounced as MAA concentration was higher, and gelatin and cross-linker concentrations were lower. In addition, the hydrogels strongly promoted the proliferation of human periodontal ligament stem cells and MRC-5 cells as assayed by MTT assay.",
publisher = "Wiley",
journal = "Polymer Engineering and Science",
title = "Strong and tough, pH sensible, interpenetrating network hydrogels based on gelatin and poly(methacrylic acid)",
volume = "62",
pages = "622-636",
doi = "10.1002/pen.25870"
}

Ugrinović, V., Panić, V., Spasojević, P., Šešlija, S., Božić, B., Petrović, R., Janaćković, Đ.,& Veljović, Đ.. (2022). Strong and tough, pH sensible, interpenetrating network hydrogels based on gelatin and poly(methacrylic acid). in Polymer Engineering and Science
Wiley., 62, 622-636.
https://doi.org/10.1002/pen.25870

Ugrinović V, Panić V, Spasojević P, Šešlija S, Božić B, Petrović R, Janaćković Đ, Veljović Đ. Strong and tough, pH sensible, interpenetrating network hydrogels based on gelatin and poly(methacrylic acid). in Polymer Engineering and Science. 2022;62:622-636.
doi:10.1002/pen.25870 .

Ugrinović, Vukašin, Panić, Vesna, Spasojević, Pavle, Šešlija, Sanja, Božić, Bojan, Petrović, Rada, Janaćković, Đorđe, Veljović, Đorđe, "Strong and tough, pH sensible, interpenetrating network hydrogels based on gelatin and poly(methacrylic acid)" in Polymer Engineering and Science, 62 (2022):622-636,
https://doi.org/10.1002/pen.25870 . .

TY  - JOUR
AU  - Marković, Maja D.
AU  - Šešlija, Sanja
AU  - Ugrinović, Vukašin
AU  - Kunaver, Matjaz
AU  - Panić, Vesna
AU  - Pjanović, Rada
AU  - Spasojević, Pavle
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4807
AB  - pH- and magnetic-sensitive hybrid hydrogels based on poly(methacrylic acid) (PMAA), nanocellulose (NC), carboxymethyl cellulose (CMC) and magnetite particles (MN) were prepared as ibuprofen delivery system. NC was isolated from wood waste material and added to highly hydrophilic PMAA in order to improve the mechanical properties of PMAA and enable the encapsulation of poorly water-soluble ibuprofen. CMC was added in order to stabilize magnetite particles. The pH- and magnetic-sensitivity of the obtained hybrid hydrogels (originated from PMAA and MN, respectively) provided targeted delivery and controlled release of ibuprofen. Hybrid hydrogels were characterized by various technics: FTIR, SEM, XRD, VSM, the modified Faraday method, photon correlation spectroscopy and by using single compression tests. The swelling behavior of hybrid hydrogels and cumulative ibuprofen release were investigated depending on wt% of NC and MN in two media which were simulating pH environments in human stomach and intestines. The swelling degree of hybrid hydrogels and the percent of cumulative ibuprofen release decreased with the increase in wt% of NC. The same was found for increasing wt% of MN. Ibuprofen release kinetics was investigated with Korsmeyer–Peppas model. The obtained results showed that the prepared green dual responsive hybrid hydrogels were excellent candidates for the controlled release of ibuprofen, showing that the release kinetic can be easily tuned by changing only one hydrogel component.
PB  - Springer
T2  - Cellulose
T1  - Green pH- and magnetic-responsive hybrid hydrogels based on poly(methacrylic acid) and Eucalyptus wood nanocellulose for controlled release of ibuprofen
DO  - 10.1007/s10570-021-04222-w
ER  - 

@article{
author = "Marković, Maja D. and Šešlija, Sanja and Ugrinović, Vukašin and Kunaver, Matjaz and Panić, Vesna and Pjanović, Rada and Spasojević, Pavle",
year = "2021",
abstract = "pH- and magnetic-sensitive hybrid hydrogels based on poly(methacrylic acid) (PMAA), nanocellulose (NC), carboxymethyl cellulose (CMC) and magnetite particles (MN) were prepared as ibuprofen delivery system. NC was isolated from wood waste material and added to highly hydrophilic PMAA in order to improve the mechanical properties of PMAA and enable the encapsulation of poorly water-soluble ibuprofen. CMC was added in order to stabilize magnetite particles. The pH- and magnetic-sensitivity of the obtained hybrid hydrogels (originated from PMAA and MN, respectively) provided targeted delivery and controlled release of ibuprofen. Hybrid hydrogels were characterized by various technics: FTIR, SEM, XRD, VSM, the modified Faraday method, photon correlation spectroscopy and by using single compression tests. The swelling behavior of hybrid hydrogels and cumulative ibuprofen release were investigated depending on wt% of NC and MN in two media which were simulating pH environments in human stomach and intestines. The swelling degree of hybrid hydrogels and the percent of cumulative ibuprofen release decreased with the increase in wt% of NC. The same was found for increasing wt% of MN. Ibuprofen release kinetics was investigated with Korsmeyer–Peppas model. The obtained results showed that the prepared green dual responsive hybrid hydrogels were excellent candidates for the controlled release of ibuprofen, showing that the release kinetic can be easily tuned by changing only one hydrogel component.",
publisher = "Springer",
journal = "Cellulose",
title = "Green pH- and magnetic-responsive hybrid hydrogels based on poly(methacrylic acid) and Eucalyptus wood nanocellulose for controlled release of ibuprofen",
doi = "10.1007/s10570-021-04222-w"
}

Marković, M. D., Šešlija, S., Ugrinović, V., Kunaver, M., Panić, V., Pjanović, R.,& Spasojević, P.. (2021). Green pH- and magnetic-responsive hybrid hydrogels based on poly(methacrylic acid) and Eucalyptus wood nanocellulose for controlled release of ibuprofen. in Cellulose
Springer..
https://doi.org/10.1007/s10570-021-04222-w

Marković MD, Šešlija S, Ugrinović V, Kunaver M, Panić V, Pjanović R, Spasojević P. Green pH- and magnetic-responsive hybrid hydrogels based on poly(methacrylic acid) and Eucalyptus wood nanocellulose for controlled release of ibuprofen. in Cellulose. 2021;.
doi:10.1007/s10570-021-04222-w .

Marković, Maja D., Šešlija, Sanja, Ugrinović, Vukašin, Kunaver, Matjaz, Panić, Vesna, Pjanović, Rada, Spasojević, Pavle, "Green pH- and magnetic-responsive hybrid hydrogels based on poly(methacrylic acid) and Eucalyptus wood nanocellulose for controlled release of ibuprofen" in Cellulose (2021),
https://doi.org/10.1007/s10570-021-04222-w . .