TY  - JOUR
AU  - Mojović, Miloš
AU  - Dakovic, Marko
AU  - Omerasevic, Mia
AU  - Mojović, Zorica
AU  - Banković, Predrag
AU  - Milutinović Nikolić, Aleksandra
AU  - Jovanović, Dušan M.
PY  - 2010
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/648
AB  - The increased use of imaging techniques in diagnostic studies, such as MRI, has contributed to the development of the wide range of new materials which could be successfully used as image improving agents. However, there is a lack of such substances in the area of gastrointestinal tract MRI. Many of the traditionally popular relaxation altering agents show poor results and disadvantages provoking black bowel, side effects of diarrhea and the presence of artifacts arising from clumping. Paramagnetic species seem to be potentially suitable agents for these studies, but contrast opacification has been reported and less than 60% of the gastrointestinal tract magnetic resonance scans showed improved delineation of abdominal pathologies. The new solution has been proposed as zeolites or smectite clays (hectorite and montmorillonite) enclosing of paramagnetic metal ions obtained by ion-exchange methods. However, such materials have problems of leakage of paramagnetic ions causing the appearance of the various side-effects. In this study we show that Co(+2) and Dy(+3) paramagnetic-pillared bentonites could be successfully used as MRI digestive tract non-leaching contrast agents, altering the longitudinal and transverse relaxation times of fluids in contact with the clay minerals.
PB  - World Scientific Publ Co Pte Ltd, Singapore
T2  - International Journal of Modern Physics B
T1  - The paramagnetic pillared bentonites as digestive tract mri contrast agents
VL  - 24
IS  - 6-7
SP  - 780
EP  - 787
DO  - 10.1142/S0217979210064411
ER  - 

@article{
author = "Mojović, Miloš and Dakovic, Marko and Omerasevic, Mia and Mojović, Zorica and Banković, Predrag and Milutinović Nikolić, Aleksandra and Jovanović, Dušan M.",
year = "2010",
abstract = "The increased use of imaging techniques in diagnostic studies, such as MRI, has contributed to the development of the wide range of new materials which could be successfully used as image improving agents. However, there is a lack of such substances in the area of gastrointestinal tract MRI. Many of the traditionally popular relaxation altering agents show poor results and disadvantages provoking black bowel, side effects of diarrhea and the presence of artifacts arising from clumping. Paramagnetic species seem to be potentially suitable agents for these studies, but contrast opacification has been reported and less than 60% of the gastrointestinal tract magnetic resonance scans showed improved delineation of abdominal pathologies. The new solution has been proposed as zeolites or smectite clays (hectorite and montmorillonite) enclosing of paramagnetic metal ions obtained by ion-exchange methods. However, such materials have problems of leakage of paramagnetic ions causing the appearance of the various side-effects. In this study we show that Co(+2) and Dy(+3) paramagnetic-pillared bentonites could be successfully used as MRI digestive tract non-leaching contrast agents, altering the longitudinal and transverse relaxation times of fluids in contact with the clay minerals.",
publisher = "World Scientific Publ Co Pte Ltd, Singapore",
journal = "International Journal of Modern Physics B",
title = "The paramagnetic pillared bentonites as digestive tract mri contrast agents",
volume = "24",
number = "6-7",
pages = "780-787",
doi = "10.1142/S0217979210064411"
}

Mojović, M., Dakovic, M., Omerasevic, M., Mojović, Z., Banković, P., Milutinović Nikolić, A.,& Jovanović, D. M.. (2010). The paramagnetic pillared bentonites as digestive tract mri contrast agents. in International Journal of Modern Physics B
World Scientific Publ Co Pte Ltd, Singapore., 24(6-7), 780-787.
https://doi.org/10.1142/S0217979210064411

Mojović M, Dakovic M, Omerasevic M, Mojović Z, Banković P, Milutinović Nikolić A, Jovanović DM. The paramagnetic pillared bentonites as digestive tract mri contrast agents. in International Journal of Modern Physics B. 2010;24(6-7):780-787.
doi:10.1142/S0217979210064411 .

Mojović, Miloš, Dakovic, Marko, Omerasevic, Mia, Mojović, Zorica, Banković, Predrag, Milutinović Nikolić, Aleksandra, Jovanović, Dušan M., "The paramagnetic pillared bentonites as digestive tract mri contrast agents" in International Journal of Modern Physics B, 24, no. 6-7 (2010):780-787,
https://doi.org/10.1142/S0217979210064411 . .

TY  - JOUR
AU  - Mojović, Miloš
AU  - Dakovic, Marko
AU  - Banković, Predrag
AU  - Mojović, Zorica
PY  - 2010
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/652
AB  - The availability of sophisticated diagnostic methods such as MRI has contributed to the increased use of imaging technologies in therapy and diagnostic studies. However, gastrointestinal tract MRI generally shows poor results because of the lack of suitable contrast agents. The iron oxide is traditionally popular material for MRI gastrointestinal studies because of its well-known superparamagnetic properties. On the other hand, it has many disadvantages which include black bowel, side effects of diarrhea and, from an important analytical standpoint, the presence of artifacts arising from clumping. When paramagnetic iron concentrates, it may become ferromagnetic, drastically altering its imaging properties. Other paramagnetic species, represented by gadolinium, also seem to be potentially suitable agents for these studies. Nevertheless, this metal itself cannot be used in humans because of its toxic properties. Therefore, there is clearly a need for orally effective, well tolerated agents that can be used in humans for digestive imaging studies. This MRI contrast should be useful for visualizing the anatomy of the digestive tract and particularly to differentiate between normal and pathological states, such as tumors. The solution has been proposed as zeolites or smectites (hectorite and montmorillonite) enclosing of paramagnetic metal ions obtained by ion-exchange methods. However, such materials could have problems of leakage of paramagnetic ions causing the appearance of the number side-effects. We propose the usage of the pillaring method for paramagnetic metal encapsulation in bentonites. By that way, paramagnetic cations like Fe(+3), Mn(+2) and Gd(+3) are introduced between clay mineral layers as polyoxo cations. After calcination, these polyoxo cations grow to be pillars (oxides of these metals) which are incorporated into the clay mineral matrix which prevents ion-leaching and dangerous side-effects. In this study we show that paramagnetic-pillared bentonites could be successfully used as MRI digestive tract non-leaching contrast agents, altering the longitudinal relaxation times of fluids in contact with the clay minerals.
PB  - Elsevier
T2  - Applied Clay Science
T1  - Paramagnetic pillared bentonites - The new digestive tract MRI contrast agents
VL  - 48
IS  - 1-2
SP  - 191
EP  - 194
DO  - 10.1016/j.clay.2009.11.041
ER  - 

@article{
author = "Mojović, Miloš and Dakovic, Marko and Banković, Predrag and Mojović, Zorica",
year = "2010",
abstract = "The availability of sophisticated diagnostic methods such as MRI has contributed to the increased use of imaging technologies in therapy and diagnostic studies. However, gastrointestinal tract MRI generally shows poor results because of the lack of suitable contrast agents. The iron oxide is traditionally popular material for MRI gastrointestinal studies because of its well-known superparamagnetic properties. On the other hand, it has many disadvantages which include black bowel, side effects of diarrhea and, from an important analytical standpoint, the presence of artifacts arising from clumping. When paramagnetic iron concentrates, it may become ferromagnetic, drastically altering its imaging properties. Other paramagnetic species, represented by gadolinium, also seem to be potentially suitable agents for these studies. Nevertheless, this metal itself cannot be used in humans because of its toxic properties. Therefore, there is clearly a need for orally effective, well tolerated agents that can be used in humans for digestive imaging studies. This MRI contrast should be useful for visualizing the anatomy of the digestive tract and particularly to differentiate between normal and pathological states, such as tumors. The solution has been proposed as zeolites or smectites (hectorite and montmorillonite) enclosing of paramagnetic metal ions obtained by ion-exchange methods. However, such materials could have problems of leakage of paramagnetic ions causing the appearance of the number side-effects. We propose the usage of the pillaring method for paramagnetic metal encapsulation in bentonites. By that way, paramagnetic cations like Fe(+3), Mn(+2) and Gd(+3) are introduced between clay mineral layers as polyoxo cations. After calcination, these polyoxo cations grow to be pillars (oxides of these metals) which are incorporated into the clay mineral matrix which prevents ion-leaching and dangerous side-effects. In this study we show that paramagnetic-pillared bentonites could be successfully used as MRI digestive tract non-leaching contrast agents, altering the longitudinal relaxation times of fluids in contact with the clay minerals.",
publisher = "Elsevier",
journal = "Applied Clay Science",
title = "Paramagnetic pillared bentonites - The new digestive tract MRI contrast agents",
volume = "48",
number = "1-2",
pages = "191-194",
doi = "10.1016/j.clay.2009.11.041"
}

Mojović, M., Dakovic, M., Banković, P.,& Mojović, Z.. (2010). Paramagnetic pillared bentonites - The new digestive tract MRI contrast agents. in Applied Clay Science
Elsevier., 48(1-2), 191-194.
https://doi.org/10.1016/j.clay.2009.11.041

Mojović M, Dakovic M, Banković P, Mojović Z. Paramagnetic pillared bentonites - The new digestive tract MRI contrast agents. in Applied Clay Science. 2010;48(1-2):191-194.
doi:10.1016/j.clay.2009.11.041 .

Mojović, Miloš, Dakovic, Marko, Banković, Predrag, Mojović, Zorica, "Paramagnetic pillared bentonites - The new digestive tract MRI contrast agents" in Applied Clay Science, 48, no. 1-2 (2010):191-194,
https://doi.org/10.1016/j.clay.2009.11.041 . .