TY  - JOUR
AU  - Aćimović, Milica
AU  - Stanković Jeremić, Jovana
AU  - Miljković, Ana
AU  - Rat, Milica
AU  - Lončar, Biljana
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/7200
AB  - Ironwort (Sideritis montana L.), mountain germander (Teucrium montanum L.), wall germander (Teucrium chamaedrys L.), and horehound (Marrubium peregrinum L.) are species widely distributedacross Europe and are also found in North Africa and West Asia. Because of their wide distributionthey express significant chemical diversity. For generations, these plants have been used as medicalherbs for treating different aliments. The aim of this paper is to analyze volatile compounds of fourselected species that belong to the subfamily Lamioideae, family Lamiaceae, and inspect scientificallyproven biological activities and potential uses in modern phytotherapy in relation to traditionalmedicine. Therefore, in this research, we analyze the volatile compounds from this plants, obtainedin laboratory by a Clevenger-type apparatus, followed by liquid–liquid extraction with hexane as thesolvent. The identification of volatile compounds is conducted by GC-FID and GC-MS. Althoughthese plants are poor in essential oil, the most abundant class of volatile components are mainlysesquiterpenes: germacrene D (22.6%) in ironwort, 7-epi-trans-sesquisabinene hydrate (15.8%) inmountain germander, germacrene D (31.8%) and trans-caryophyllene (19.7%) in wall germander, andtrans-caryophyllene (32.4%) and trans-thujone (25.1%) in horehound. Furthermore, many studiesshow that, in addition to the essential oil, these plants contain phenols, flavonoids, diterpenes andditerpenoids, iridoids and their glycosides, coumarins, terpenes, and sterols, among other activecompounds, which affect biological activities. The other goal of this study is to review the literaturethat describes the traditional use of these plants in folk medicine in regions where they grow spontaneously and compare them with scientifically confirmed activities. Therefore, a bibliographic searchis conducted on Science Direct, PubMed, and Google Scholar to gather information related to thetopic and recommend potential applications in modern phytotherapy. In conclusion, we can say thatselected plants could be used as natural agents for promoting health, as a source of raw materialin the food industry, and as supplements, as well as in the pharmaceutical industry for developingplant-based remedies for prevention and treatment of many diseases, especially cancer.
PB  - Basel : MDPI
T2  - Molecules - Basel
T1  - Screening of Volatile Compounds, Traditional and Modern Phytotherapy Approaches of Selected Non-Aromatic Medicinal Plants (Lamiaceae, Lamioideae) from Rtanj Mountain, Eastern Serbia
VL  - 28
IS  - 12
SP  - 4611
DO  - 10.3390/molecules28124611
ER  - 

@article{
author = "Aćimović, Milica and Stanković Jeremić, Jovana and Miljković, Ana and Rat, Milica and Lončar, Biljana",
year = "2023",
abstract = "Ironwort (Sideritis montana L.), mountain germander (Teucrium montanum L.), wall germander (Teucrium chamaedrys L.), and horehound (Marrubium peregrinum L.) are species widely distributedacross Europe and are also found in North Africa and West Asia. Because of their wide distributionthey express significant chemical diversity. For generations, these plants have been used as medicalherbs for treating different aliments. The aim of this paper is to analyze volatile compounds of fourselected species that belong to the subfamily Lamioideae, family Lamiaceae, and inspect scientificallyproven biological activities and potential uses in modern phytotherapy in relation to traditionalmedicine. Therefore, in this research, we analyze the volatile compounds from this plants, obtainedin laboratory by a Clevenger-type apparatus, followed by liquid–liquid extraction with hexane as thesolvent. The identification of volatile compounds is conducted by GC-FID and GC-MS. Althoughthese plants are poor in essential oil, the most abundant class of volatile components are mainlysesquiterpenes: germacrene D (22.6%) in ironwort, 7-epi-trans-sesquisabinene hydrate (15.8%) inmountain germander, germacrene D (31.8%) and trans-caryophyllene (19.7%) in wall germander, andtrans-caryophyllene (32.4%) and trans-thujone (25.1%) in horehound. Furthermore, many studiesshow that, in addition to the essential oil, these plants contain phenols, flavonoids, diterpenes andditerpenoids, iridoids and their glycosides, coumarins, terpenes, and sterols, among other activecompounds, which affect biological activities. The other goal of this study is to review the literaturethat describes the traditional use of these plants in folk medicine in regions where they grow spontaneously and compare them with scientifically confirmed activities. Therefore, a bibliographic searchis conducted on Science Direct, PubMed, and Google Scholar to gather information related to thetopic and recommend potential applications in modern phytotherapy. In conclusion, we can say thatselected plants could be used as natural agents for promoting health, as a source of raw materialin the food industry, and as supplements, as well as in the pharmaceutical industry for developingplant-based remedies for prevention and treatment of many diseases, especially cancer.",
publisher = "Basel : MDPI",
journal = "Molecules - Basel",
title = "Screening of Volatile Compounds, Traditional and Modern Phytotherapy Approaches of Selected Non-Aromatic Medicinal Plants (Lamiaceae, Lamioideae) from Rtanj Mountain, Eastern Serbia",
volume = "28",
number = "12",
pages = "4611",
doi = "10.3390/molecules28124611"
}

Aćimović, M., Stanković Jeremić, J., Miljković, A., Rat, M.,& Lončar, B.. (2023). Screening of Volatile Compounds, Traditional and Modern Phytotherapy Approaches of Selected Non-Aromatic Medicinal Plants (Lamiaceae, Lamioideae) from Rtanj Mountain, Eastern Serbia. in Molecules - Basel
Basel : MDPI., 28(12), 4611.
https://doi.org/10.3390/molecules28124611

Aćimović M, Stanković Jeremić J, Miljković A, Rat M, Lončar B. Screening of Volatile Compounds, Traditional and Modern Phytotherapy Approaches of Selected Non-Aromatic Medicinal Plants (Lamiaceae, Lamioideae) from Rtanj Mountain, Eastern Serbia. in Molecules - Basel. 2023;28(12):4611.
doi:10.3390/molecules28124611 .

Aćimović, Milica, Stanković Jeremić, Jovana, Miljković, Ana, Rat, Milica, Lončar, Biljana, "Screening of Volatile Compounds, Traditional and Modern Phytotherapy Approaches of Selected Non-Aromatic Medicinal Plants (Lamiaceae, Lamioideae) from Rtanj Mountain, Eastern Serbia" in Molecules - Basel, 28, no. 12 (2023):4611,
https://doi.org/10.3390/molecules28124611 . .