TY  - CONF
AU  - Mrđan, Gorana
AU  - Verbić, Tatjana
AU  - Marković, Olivera
AU  - Vaštag, Đenđi
AU  - Apostolov, Suzana
AU  - Matijević, Borko
PY  - 2021
UR  - http://savremenimaterijali.info/
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4361
AB  - Carbohydrazone derivatives represent a very significant
class of compounds due to their wide biological activity. Ionization states of
functional groups present in the molecule are of vital importance for understanding
of the pharmacokinetic and pharmacodynamic properties of the
newly synthesized compounds. One of the physicochemical parameters, the
ionization constant (pKa), can be used as a molecular descriptor in order to relate
structure and activity of a compound, which may indicate further potential
application of newly synthesized derivatives. In this work, ionization
constants of thirteen monocarbohydrazone derivatives were determined using
potentiometric method, in order to obtain information about their ionization
states under certain conditions.
AB  - Деривати карбохидразона представљају веома значај-
на једињења за проучавање с обзиром да многа од њих показују веома
изражену биолошку активност. Познавање јонизационог стања функци-
оналних група присутних у молекулу је од виталног значаја за разумева-
ње фармакокинетичких и фармакодинамичких особина новосинтетиса-
них једињења. Један од важнијих физичко-хемијских параметара, кисе-
линска константа (pKa), може да послужи као молекулски дескриптор за
повезивање односа стуктуре и активности једињења, што може укази-
вати на даљу потенцијалну примену новосинтетисаних деривата. У
овом раду, применом потенциометријске методе, одређене су киселин-
ске константе за тринаест синтетисаних једињења из серије монокарбо-
хидразона у циљу добијања информација о њиховим јонизационим ста-
њима при одређеним условима.
PB  - Academy of Sciences and Arts of the Republic of Srpska / Академија наука и умјетности Републике Српске
C3  - 13th International Scientific Conference Contemporary Materials 2020, Proccedings,  Banja Luka, 11.09.2020.
T1  - Determination of ionization constants of selected monocarbohydrazone derivatives
T1  - Одређивање јонизационих константи одабраних деривата монокарбохидразона
SP  - 415
EP  - 422
UR  - https://hdl.handle.net/21.15107/rcub_cer_4361
ER  - 

@conference{
author = "Mrđan, Gorana and Verbić, Tatjana and Marković, Olivera and Vaštag, Đenđi and Apostolov, Suzana and Matijević, Borko",
year = "2021",
abstract = "Carbohydrazone derivatives represent a very significant
class of compounds due to their wide biological activity. Ionization states of
functional groups present in the molecule are of vital importance for understanding
of the pharmacokinetic and pharmacodynamic properties of the
newly synthesized compounds. One of the physicochemical parameters, the
ionization constant (pKa), can be used as a molecular descriptor in order to relate
structure and activity of a compound, which may indicate further potential
application of newly synthesized derivatives. In this work, ionization
constants of thirteen monocarbohydrazone derivatives were determined using
potentiometric method, in order to obtain information about their ionization
states under certain conditions., Деривати карбохидразона представљају веома значај-
на једињења за проучавање с обзиром да многа од њих показују веома
изражену биолошку активност. Познавање јонизационог стања функци-
оналних група присутних у молекулу је од виталног значаја за разумева-
ње фармакокинетичких и фармакодинамичких особина новосинтетиса-
них једињења. Један од важнијих физичко-хемијских параметара, кисе-
линска константа (pKa), може да послужи као молекулски дескриптор за
повезивање односа стуктуре и активности једињења, што може укази-
вати на даљу потенцијалну примену новосинтетисаних деривата. У
овом раду, применом потенциометријске методе, одређене су киселин-
ске константе за тринаест синтетисаних једињења из серије монокарбо-
хидразона у циљу добијања информација о њиховим јонизационим ста-
њима при одређеним условима.",
publisher = "Academy of Sciences and Arts of the Republic of Srpska / Академија наука и умјетности Републике Српске",
journal = "13th International Scientific Conference Contemporary Materials 2020, Proccedings,  Banja Luka, 11.09.2020.",
title = "Determination of ionization constants of selected monocarbohydrazone derivatives, Одређивање јонизационих константи одабраних деривата монокарбохидразона",
pages = "415-422",
url = "https://hdl.handle.net/21.15107/rcub_cer_4361"
}

Mrđan, G., Verbić, T., Marković, O., Vaštag, Đ., Apostolov, S.,& Matijević, B.. (2021). Determination of ionization constants of selected monocarbohydrazone derivatives. in 13th International Scientific Conference Contemporary Materials 2020, Proccedings,  Banja Luka, 11.09.2020.
Academy of Sciences and Arts of the Republic of Srpska / Академија наука и умјетности Републике Српске., 415-422.
https://hdl.handle.net/21.15107/rcub_cer_4361

Mrđan G, Verbić T, Marković O, Vaštag Đ, Apostolov S, Matijević B. Determination of ionization constants of selected monocarbohydrazone derivatives. in 13th International Scientific Conference Contemporary Materials 2020, Proccedings,  Banja Luka, 11.09.2020.. 2021;:415-422.
https://hdl.handle.net/21.15107/rcub_cer_4361 .

Mrđan, Gorana, Verbić, Tatjana, Marković, Olivera, Vaštag, Đenđi, Apostolov, Suzana, Matijević, Borko, "Determination of ionization constants of selected monocarbohydrazone derivatives" in 13th International Scientific Conference Contemporary Materials 2020, Proccedings,  Banja Luka, 11.09.2020. (2021):415-422,
https://hdl.handle.net/21.15107/rcub_cer_4361 .

TY  - CONF
AU  - Mrđan, Gorana
AU  - Vaštag, Đenđi
AU  - Apostolov, Suzana
AU  - Rašeta, Milena
AU  - Verbić, Tatjana
AU  - Marković, Olivera
AU  - Matijević, Borko
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4760
AB  - Carbohydrazones and their thio analogs represent compounds obtained by condensation of carbohydrazide and thiocarbohydrazide with carbonyl compounds. Due to their structure, relatively simple synthesis, and high reactivity, mentioned derivatives have a wide range of applications in all fields. In this study, ionization constants of four newly synthesized mono(thio)carbohydrazones were determined by applying the potentiometric method. Also, the influence of specific 
and nonspecific intermolecular interactions on maxima shifting in UV-Vis absorption spectra was investigated and quantified using the linear solvation energy relationships method and Catalan’s model. Finally, by applying the DPPH assay, the antioxidant potential of the newly synthesized compounds was determined, and thiocarbohydrazone derivatives proved to be significantly more active when compared to carbohydrazones.
C3  - Programme and the book of abstracts, 14th International Scientific Conference Contemporary Materials 2021
T1  - Investigation of physicochemical properties and potential biological activity of 2-pyridine-(thio)carbohydrazone derivatives
SP  - 40
EP  - 40
UR  - https://hdl.handle.net/21.15107/rcub_cer_4760
ER  - 

@conference{
author = "Mrđan, Gorana and Vaštag, Đenđi and Apostolov, Suzana and Rašeta, Milena and Verbić, Tatjana and Marković, Olivera and Matijević, Borko",
year = "2021",
abstract = "Carbohydrazones and their thio analogs represent compounds obtained by condensation of carbohydrazide and thiocarbohydrazide with carbonyl compounds. Due to their structure, relatively simple synthesis, and high reactivity, mentioned derivatives have a wide range of applications in all fields. In this study, ionization constants of four newly synthesized mono(thio)carbohydrazones were determined by applying the potentiometric method. Also, the influence of specific 
and nonspecific intermolecular interactions on maxima shifting in UV-Vis absorption spectra was investigated and quantified using the linear solvation energy relationships method and Catalan’s model. Finally, by applying the DPPH assay, the antioxidant potential of the newly synthesized compounds was determined, and thiocarbohydrazone derivatives proved to be significantly more active when compared to carbohydrazones.",
journal = "Programme and the book of abstracts, 14th International Scientific Conference Contemporary Materials 2021",
title = "Investigation of physicochemical properties and potential biological activity of 2-pyridine-(thio)carbohydrazone derivatives",
pages = "40-40",
url = "https://hdl.handle.net/21.15107/rcub_cer_4760"
}

Mrđan, G., Vaštag, Đ., Apostolov, S., Rašeta, M., Verbić, T., Marković, O.,& Matijević, B.. (2021). Investigation of physicochemical properties and potential biological activity of 2-pyridine-(thio)carbohydrazone derivatives. in Programme and the book of abstracts, 14th International Scientific Conference Contemporary Materials 2021, 40-40.
https://hdl.handle.net/21.15107/rcub_cer_4760

Mrđan G, Vaštag Đ, Apostolov S, Rašeta M, Verbić T, Marković O, Matijević B. Investigation of physicochemical properties and potential biological activity of 2-pyridine-(thio)carbohydrazone derivatives. in Programme and the book of abstracts, 14th International Scientific Conference Contemporary Materials 2021. 2021;:40-40.
https://hdl.handle.net/21.15107/rcub_cer_4760 .

Mrđan, Gorana, Vaštag, Đenđi, Apostolov, Suzana, Rašeta, Milena, Verbić, Tatjana, Marković, Olivera, Matijević, Borko, "Investigation of physicochemical properties and potential biological activity of 2-pyridine-(thio)carbohydrazone derivatives" in Programme and the book of abstracts, 14th International Scientific Conference Contemporary Materials 2021 (2021):40-40,
https://hdl.handle.net/21.15107/rcub_cer_4760 .

TY  - CONF
AU  - Mrđan, Gorana
AU  - Verbić, Tatjana
AU  - Marković, Olivera
AU  - Matijević, Borko
AU  - Vaštag, Đenđi
AU  - Apostolov, Suzana
PY  - 2020
UR  - http://savremenimaterijali.info/
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3688
AB  - Carbohydrazone derivatives represent a very significant class of compounds due to their wide biological activity. Ionization states of functional groups present in the molecule are of vital importance for understanding of the pharmacokinetic and pharmacodynamic properties of the newly synthesized compounds. One of the physicochemical parameters, the ionization constant (pKa), can be used as a molecular descriptor in order to relate structure and activity of a compound, which may indicate further potential application of newly synthesized derivatives. In this work, ionization constants of twenty monocarbohydrazone derivatives were determined using potentiometric method, in order to obtain information about their ionization states under certain conditions.
PB  - Academy of Sciences and Arts of the Republic of Srpska
C3  - 13th International Scientific Conference Contemporary Materials 2020, Programme and the Book of Abstracts, 11.09.2020.
T1  - Determination of ionization constants of selected monocarbohydrazone derivatives
SP  - 50
EP  - 50
UR  - https://hdl.handle.net/21.15107/rcub_cer_3688
ER  - 

@conference{
author = "Mrđan, Gorana and Verbić, Tatjana and Marković, Olivera and Matijević, Borko and Vaštag, Đenđi and Apostolov, Suzana",
year = "2020",
abstract = "Carbohydrazone derivatives represent a very significant class of compounds due to their wide biological activity. Ionization states of functional groups present in the molecule are of vital importance for understanding of the pharmacokinetic and pharmacodynamic properties of the newly synthesized compounds. One of the physicochemical parameters, the ionization constant (pKa), can be used as a molecular descriptor in order to relate structure and activity of a compound, which may indicate further potential application of newly synthesized derivatives. In this work, ionization constants of twenty monocarbohydrazone derivatives were determined using potentiometric method, in order to obtain information about their ionization states under certain conditions.",
publisher = "Academy of Sciences and Arts of the Republic of Srpska",
journal = "13th International Scientific Conference Contemporary Materials 2020, Programme and the Book of Abstracts, 11.09.2020.",
title = "Determination of ionization constants of selected monocarbohydrazone derivatives",
pages = "50-50",
url = "https://hdl.handle.net/21.15107/rcub_cer_3688"
}

Mrđan, G., Verbić, T., Marković, O., Matijević, B., Vaštag, Đ.,& Apostolov, S.. (2020). Determination of ionization constants of selected monocarbohydrazone derivatives. in 13th International Scientific Conference Contemporary Materials 2020, Programme and the Book of Abstracts, 11.09.2020.
Academy of Sciences and Arts of the Republic of Srpska., 50-50.
https://hdl.handle.net/21.15107/rcub_cer_3688

Mrđan G, Verbić T, Marković O, Matijević B, Vaštag Đ, Apostolov S. Determination of ionization constants of selected monocarbohydrazone derivatives. in 13th International Scientific Conference Contemporary Materials 2020, Programme and the Book of Abstracts, 11.09.2020.. 2020;:50-50.
https://hdl.handle.net/21.15107/rcub_cer_3688 .

Mrđan, Gorana, Verbić, Tatjana, Marković, Olivera, Matijević, Borko, Vaštag, Đenđi, Apostolov, Suzana, "Determination of ionization constants of selected monocarbohydrazone derivatives" in 13th International Scientific Conference Contemporary Materials 2020, Programme and the Book of Abstracts, 11.09.2020. (2020):50-50,
https://hdl.handle.net/21.15107/rcub_cer_3688 .

TY  - CONF
AU  - Mrđan, Gorana
AU  - Verbić, Tatjana
AU  - Marković, Olivera
AU  - Matijević, Borko
AU  - Vaštag, Đenđi
AU  - Apostolov, Suzana
PY  - 2020
UR  - http://savremenimaterijali.info/
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3689
AB  - Poster presented at: 13th International Scientific Conference Contemporary Materials 2020, Banja Luka, 11th September, 2020
T1  - Determination of ionization constants of selected monocarbohydrazone derivatites
UR  - https://hdl.handle.net/21.15107/rcub_cer_3689
ER  - 

@conference{
author = "Mrđan, Gorana and Verbić, Tatjana and Marković, Olivera and Matijević, Borko and Vaštag, Đenđi and Apostolov, Suzana",
year = "2020",
abstract = "Poster presented at: 13th International Scientific Conference Contemporary Materials 2020, Banja Luka, 11th September, 2020",
title = "Determination of ionization constants of selected monocarbohydrazone derivatites",
url = "https://hdl.handle.net/21.15107/rcub_cer_3689"
}

Mrđan, G., Verbić, T., Marković, O., Matijević, B., Vaštag, Đ.,& Apostolov, S.. (2020). Determination of ionization constants of selected monocarbohydrazone derivatites. .
https://hdl.handle.net/21.15107/rcub_cer_3689

Mrđan G, Verbić T, Marković O, Matijević B, Vaštag Đ, Apostolov S. Determination of ionization constants of selected monocarbohydrazone derivatites. 2020;.
https://hdl.handle.net/21.15107/rcub_cer_3689 .

Mrđan, Gorana, Verbić, Tatjana, Marković, Olivera, Matijević, Borko, Vaštag, Đenđi, Apostolov, Suzana, "Determination of ionization constants of selected monocarbohydrazone derivatites" (2020),
https://hdl.handle.net/21.15107/rcub_cer_3689 .

TY  - JOUR
AU  - Matijević, Borko
AU  - Mrđan, Gorana S.
AU  - Vaštag, Đenđi Đ.
AU  - Apostolov, Suzana
AU  - Nikolić, Jovana
AU  - Marinković, Aleksandar D.
PY  - 2016
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1870
AB  - Amide derivates are biologically active compounds and they are widely used in all spheres of life. Therefore, it is very important to know their physical-chemical properties. In this work the influence of characteristics and nature of the solvent on the absorption spectra of N-aryl-phenylacetamide was investigated, in order to obtain information about their solvatochromic properties. The spectra of the compounds were recorded in 15 solvents, with different properties, in the wavelength range from 200 to 400 nm. The effect of the solvents on the absorption spectra of N-aryl-phenylacetamide was analyzed by using Kamlet-Taft's solvatochromic model. Also, in order to obtain detailed information on the type and dominance of the interactions that occur between the compound and the surrounding medium, correlations were made with absorption maxima and Hansen's solvent parameters. In addition to the effect of solvent, the impact of the chemical structure on the spectral behavior of tested amide derivatives was analyzed.
AB  - Derivati amida su biološki aktivna jedinjenja i imaju široku primenu u svim sferama života. Zbog toga je veoma važno poznavati njihova fizičko-hemijska svojstva. U ovom radu ispitivan je uticaj osobina i prirode rastvarača na apsorpcione spektre N-aril-fenilacetamida radi dobijanja informacija o njihovim solvatohromnim svojstvima. Spektri ispitivanih jedinjenja su snimljeni u 15 rastvarača različitih osobina, u opsegu talasnih dužina od 200 do 400 nm. Uticaj rastvarača na apsorpcione spektre N-aril-fenilacetamida analiziran je pomoću Kamlet-Taft-ovog solvatohromnog modela. Takođe, radi dobijanja detaljnijih informacija o vrsti i dominantnosti interakcija koje se javljaju između jedinjenja i okolnog medijuma, urađene su korelacije apsorpcionih maksimuma sa Hansen-ovim parametrima rastvarača. Pored uticaja rastvarača analiziran je i uticaj hemijske strukture na spektralno ponašanje ispitivanih derivata amida.
PB  - Belgrade, Serbia : Engineering Society for Corrosion
T2  - Zaštita materijala
T1  - Solvatochromism of N-aryl-phenylacetamides
T1  - Solvatohromizam N-aril-fenilacetamida
VL  - 57
IS  - 2
SP  - 253
EP  - 264
DO  - 10.5937/ZasMat1602253M
ER  - 

@article{
author = "Matijević, Borko and Mrđan, Gorana S. and Vaštag, Đenđi Đ. and Apostolov, Suzana and Nikolić, Jovana and Marinković, Aleksandar D.",
year = "2016",
abstract = "Amide derivates are biologically active compounds and they are widely used in all spheres of life. Therefore, it is very important to know their physical-chemical properties. In this work the influence of characteristics and nature of the solvent on the absorption spectra of N-aryl-phenylacetamide was investigated, in order to obtain information about their solvatochromic properties. The spectra of the compounds were recorded in 15 solvents, with different properties, in the wavelength range from 200 to 400 nm. The effect of the solvents on the absorption spectra of N-aryl-phenylacetamide was analyzed by using Kamlet-Taft's solvatochromic model. Also, in order to obtain detailed information on the type and dominance of the interactions that occur between the compound and the surrounding medium, correlations were made with absorption maxima and Hansen's solvent parameters. In addition to the effect of solvent, the impact of the chemical structure on the spectral behavior of tested amide derivatives was analyzed., Derivati amida su biološki aktivna jedinjenja i imaju široku primenu u svim sferama života. Zbog toga je veoma važno poznavati njihova fizičko-hemijska svojstva. U ovom radu ispitivan je uticaj osobina i prirode rastvarača na apsorpcione spektre N-aril-fenilacetamida radi dobijanja informacija o njihovim solvatohromnim svojstvima. Spektri ispitivanih jedinjenja su snimljeni u 15 rastvarača različitih osobina, u opsegu talasnih dužina od 200 do 400 nm. Uticaj rastvarača na apsorpcione spektre N-aril-fenilacetamida analiziran je pomoću Kamlet-Taft-ovog solvatohromnog modela. Takođe, radi dobijanja detaljnijih informacija o vrsti i dominantnosti interakcija koje se javljaju između jedinjenja i okolnog medijuma, urađene su korelacije apsorpcionih maksimuma sa Hansen-ovim parametrima rastvarača. Pored uticaja rastvarača analiziran je i uticaj hemijske strukture na spektralno ponašanje ispitivanih derivata amida.",
publisher = "Belgrade, Serbia : Engineering Society for Corrosion",
journal = "Zaštita materijala",
title = "Solvatochromism of N-aryl-phenylacetamides, Solvatohromizam N-aril-fenilacetamida",
volume = "57",
number = "2",
pages = "253-264",
doi = "10.5937/ZasMat1602253M"
}

Matijević, B., Mrđan, G. S., Vaštag, Đ. Đ., Apostolov, S., Nikolić, J.,& Marinković, A. D.. (2016). Solvatochromism of N-aryl-phenylacetamides. in Zaštita materijala
Belgrade, Serbia : Engineering Society for Corrosion., 57(2), 253-264.
https://doi.org/10.5937/ZasMat1602253M

Matijević B, Mrđan GS, Vaštag ĐĐ, Apostolov S, Nikolić J, Marinković AD. Solvatochromism of N-aryl-phenylacetamides. in Zaštita materijala. 2016;57(2):253-264.
doi:10.5937/ZasMat1602253M .

Matijević, Borko, Mrđan, Gorana S., Vaštag, Đenđi Đ., Apostolov, Suzana, Nikolić, Jovana, Marinković, Aleksandar D., "Solvatochromism of N-aryl-phenylacetamides" in Zaštita materijala, 57, no. 2 (2016):253-264,
https://doi.org/10.5937/ZasMat1602253M . .