TY  - JOUR
AU  - Marković, Maja
AU  - Panić, Vesna
AU  - Šešlija, Sanja
AU  - Milivojević, Ana D.
AU  - Spasojević, Pavle
AU  - Bošković-Vragolović, Nevenka
AU  - Pjanović, Rada
PY  - 2020
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3604
AB  - Carriers for targeted delivery and controlled release of poorly water-soluble active
substances (PWSAS) are facing three challenges: (a) the encapsulation issues, (b)
limitations of PWSAS water solubility, and (c) burst drug release which can be
pharmacologically dangerous and economically inefficient. The present study
brings a novel strategy for encapsulation and controlled release of PWSAS—
caffeine in concentrations which are higher than its maximal water solubility
without the possibility of burst effect. The modification of hydrophilic carrier
based on poly(methacylic acid) was done using casein and liposomes. To further
increase the maximal caffeine loading inside the carrier nicotinamide was used.
The release study of the encapsulated PWSAS was elaborated with respect to morphology
of the carriers and interactions that could be established between its
structural components. The carriers swelling and the release of caffeine and nicotinamide
were also investigated depending on caffeine concentration, the presence
of different liposomal formulations and the volume ratio of liposomal formulation,
in three media with different pH simulating the path of the carrier through the
human gastrointestinal tract. The synthesized carriers are promising candidates
for encapsulation of PWSAS in concentrations which are higher than its maximal
water solubility and for the targeted delivery of those dosages.
PB  - Wiley
T2  - Polymer Engineering & Science
T1  - Novel strategy for encapsulation and targeted delivery of poorly water-soluble active substances
VL  - 60
SP  - 2008
EP  - 2022
DO  - 10.1002/pen.25448
ER  - 

@article{
author = "Marković, Maja and Panić, Vesna and Šešlija, Sanja and Milivojević, Ana D. and Spasojević, Pavle and Bošković-Vragolović, Nevenka and Pjanović, Rada",
year = "2020",
abstract = "Carriers for targeted delivery and controlled release of poorly water-soluble active
substances (PWSAS) are facing three challenges: (a) the encapsulation issues, (b)
limitations of PWSAS water solubility, and (c) burst drug release which can be
pharmacologically dangerous and economically inefficient. The present study
brings a novel strategy for encapsulation and controlled release of PWSAS—
caffeine in concentrations which are higher than its maximal water solubility
without the possibility of burst effect. The modification of hydrophilic carrier
based on poly(methacylic acid) was done using casein and liposomes. To further
increase the maximal caffeine loading inside the carrier nicotinamide was used.
The release study of the encapsulated PWSAS was elaborated with respect to morphology
of the carriers and interactions that could be established between its
structural components. The carriers swelling and the release of caffeine and nicotinamide
were also investigated depending on caffeine concentration, the presence
of different liposomal formulations and the volume ratio of liposomal formulation,
in three media with different pH simulating the path of the carrier through the
human gastrointestinal tract. The synthesized carriers are promising candidates
for encapsulation of PWSAS in concentrations which are higher than its maximal
water solubility and for the targeted delivery of those dosages.",
publisher = "Wiley",
journal = "Polymer Engineering & Science",
title = "Novel strategy for encapsulation and targeted delivery of poorly water-soluble active substances",
volume = "60",
pages = "2008-2022",
doi = "10.1002/pen.25448"
}

Marković, M., Panić, V., Šešlija, S., Milivojević, A. D., Spasojević, P., Bošković-Vragolović, N.,& Pjanović, R.. (2020). Novel strategy for encapsulation and targeted delivery of poorly water-soluble active substances. in Polymer Engineering & Science
Wiley., 60, 2008-2022.
https://doi.org/10.1002/pen.25448

Marković M, Panić V, Šešlija S, Milivojević AD, Spasojević P, Bošković-Vragolović N, Pjanović R. Novel strategy for encapsulation and targeted delivery of poorly water-soluble active substances. in Polymer Engineering & Science. 2020;60:2008-2022.
doi:10.1002/pen.25448 .

Marković, Maja, Panić, Vesna, Šešlija, Sanja, Milivojević, Ana D., Spasojević, Pavle, Bošković-Vragolović, Nevenka, Pjanović, Rada, "Novel strategy for encapsulation and targeted delivery of poorly water-soluble active substances" in Polymer Engineering & Science, 60 (2020):2008-2022,
https://doi.org/10.1002/pen.25448 . .