Prijović, Željko

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  • Prijović, Željko (3)
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Author's Bibliography

Bifunctional (Zn,Fe)3O4 nanoparticles: Tuning their efficiency for potential application in reagentless glucose biosensors and magnetic hyperthermia

Ognjanović, Miloš; Stanković, Dalibor; Ming, Y.; Zhang, H.; Jančar, Boštjan; Dojčinović, Biljana; Prijović, Željko; Antić, Bratislav

(Elsevier, 2019) 

TY  - JOUR
AU  - Ognjanović, Miloš
AU  - Stanković, Dalibor
AU  - Ming, Y.
AU  - Zhang, H.
AU  - Jančar, Boštjan
AU  - Dojčinović, Biljana
AU  - Prijović, Željko
AU  - Antić, Bratislav
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2501
AB  - In a new approach based on a two-step procedure, co-precipitation method followed by hydrothermal treatment in a microwave field, Zn-substituted Fe3O4 nanoparticles (ZnxFe3-xO4) were synthesized. Results of XRD, FT–IR and TEM analysis clearly demonstrate that nanoparticles were single phase, crystallizing in the spinel structure type (S.G. Fd3¯m) with crystallite size in the range of 2–20 nm, which strongly depends on Zn concentration. The produced nanoparticles were used for fabrication of modified carbon paste electrodes as a novel system for electrochemical non-enzymatic glucose detection. It was found that the increase of zinc concentration up to the value of x = 0.56 (Zn0.56Fe2.44O4) of as-prepared nanoparticles was followed with an increase of a performance of the modified carbon paste electrode toward glucose detection. Linear working range from 0.1 to 2 mM was obtained with detection limit of 0.03 mM, and with fast response time (<3 s). Proposed sensor was successfully applied for the determination of glucose level in real samples with satisfactory recovery. The synthesized zinc-ferrite samples were also tested as potential heating agents in magnetic hyperthermia. The heating ability (SAR value) increases with x value, reaching maximum for x = 0.37. This is correlated with changes of particle size and magnetic characteristics which strongly depend on Zn concentration.
PB  - Elsevier
T2  - Journal of Alloys and Compounds
T1  - Bifunctional (Zn,Fe)3O4 nanoparticles: Tuning their efficiency for potential application in reagentless glucose biosensors and magnetic hyperthermia
SP  - 454
EP  - 462
DO  - 10.1016/j.jallcom.2018.10.369
ER  - 
@article{
author = "Ognjanović, Miloš and Stanković, Dalibor and Ming, Y. and Zhang, H. and Jančar, Boštjan and Dojčinović, Biljana and Prijović, Željko and Antić, Bratislav",
year = "2019",
abstract = "In a new approach based on a two-step procedure, co-precipitation method followed by hydrothermal treatment in a microwave field, Zn-substituted Fe3O4 nanoparticles (ZnxFe3-xO4) were synthesized. Results of XRD, FT–IR and TEM analysis clearly demonstrate that nanoparticles were single phase, crystallizing in the spinel structure type (S.G. Fd3¯m) with crystallite size in the range of 2–20 nm, which strongly depends on Zn concentration. The produced nanoparticles were used for fabrication of modified carbon paste electrodes as a novel system for electrochemical non-enzymatic glucose detection. It was found that the increase of zinc concentration up to the value of x = 0.56 (Zn0.56Fe2.44O4) of as-prepared nanoparticles was followed with an increase of a performance of the modified carbon paste electrode toward glucose detection. Linear working range from 0.1 to 2 mM was obtained with detection limit of 0.03 mM, and with fast response time (<3 s). Proposed sensor was successfully applied for the determination of glucose level in real samples with satisfactory recovery. The synthesized zinc-ferrite samples were also tested as potential heating agents in magnetic hyperthermia. The heating ability (SAR value) increases with x value, reaching maximum for x = 0.37. This is correlated with changes of particle size and magnetic characteristics which strongly depend on Zn concentration.",
publisher = "Elsevier",
journal = "Journal of Alloys and Compounds",
title = "Bifunctional (Zn,Fe)3O4 nanoparticles: Tuning their efficiency for potential application in reagentless glucose biosensors and magnetic hyperthermia",
pages = "454-462",
doi = "10.1016/j.jallcom.2018.10.369"
}
Ognjanović, M., Stanković, D., Ming, Y., Zhang, H., Jančar, B., Dojčinović, B., Prijović, Ž.,& Antić, B.. (2019). Bifunctional (Zn,Fe)3O4 nanoparticles: Tuning their efficiency for potential application in reagentless glucose biosensors and magnetic hyperthermia. in Journal of Alloys and Compounds
Elsevier., 454-462.
https://doi.org/10.1016/j.jallcom.2018.10.369
Ognjanović M, Stanković D, Ming Y, Zhang H, Jančar B, Dojčinović B, Prijović Ž, Antić B. Bifunctional (Zn,Fe)3O4 nanoparticles: Tuning their efficiency for potential application in reagentless glucose biosensors and magnetic hyperthermia. in Journal of Alloys and Compounds. 2019;:454-462.
doi:10.1016/j.jallcom.2018.10.369 .
Ognjanović, Miloš, Stanković, Dalibor, Ming, Y., Zhang, H., Jančar, Boštjan, Dojčinović, Biljana, Prijović, Željko, Antić, Bratislav, "Bifunctional (Zn,Fe)3O4 nanoparticles: Tuning their efficiency for potential application in reagentless glucose biosensors and magnetic hyperthermia" in Journal of Alloys and Compounds (2019):454-462,
https://doi.org/10.1016/j.jallcom.2018.10.369 . .
28
15
26

Bifunctional (Zn,Fe)3O4 nanoparticles: Tuning their efficiency for potential application in reagentless glucose biosensors and magnetic hyperthermia

Ognjanović, Miloš; Stanković, Dalibor; Ming, Y.; Zhang, H.; Jančar, Boštjan; Dojčinović, Biljana; Prijović, Željko; Antić, Bratislav

(Elsevier, 2019) 

TY  - JOUR
AU  - Ognjanović, Miloš
AU  - Stanković, Dalibor
AU  - Ming, Y.
AU  - Zhang, H.
AU  - Jančar, Boštjan
AU  - Dojčinović, Biljana
AU  - Prijović, Željko
AU  - Antić, Bratislav
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2501
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2624
AB  - In a new approach based on a two-step procedure, co-precipitation method followed by hydrothermal treatment in a microwave field, Zn-substituted Fe3O4 nanoparticles (ZnxFe3-xO4) were synthesized. Results of XRD, FT–IR and TEM analysis clearly demonstrate that nanoparticles were single phase, crystallizing in the spinel structure type (S.G. Fd3¯m) with crystallite size in the range of 2–20 nm, which strongly depends on Zn concentration. The produced nanoparticles were used for fabrication of modified carbon paste electrodes as a novel system for electrochemical non-enzymatic glucose detection. It was found that the increase of zinc concentration up to the value of x = 0.56 (Zn0.56Fe2.44O4) of as-prepared nanoparticles was followed with an increase of a performance of the modified carbon paste electrode toward glucose detection. Linear working range from 0.1 to 2 mM was obtained with detection limit of 0.03 mM, and with fast response time (<3 s). Proposed sensor was successfully applied for the determination of glucose level in real samples with satisfactory recovery. The synthesized zinc-ferrite samples were also tested as potential heating agents in magnetic hyperthermia. The heating ability (SAR value) increases with x value, reaching maximum for x = 0.37. This is correlated with changes of particle size and magnetic characteristics which strongly depend on Zn concentration.
PB  - Elsevier
T2  - Journal of Alloys and Compounds
T1  - Bifunctional (Zn,Fe)3O4 nanoparticles: Tuning their efficiency for potential application in reagentless glucose biosensors and magnetic hyperthermia
SP  - 454
EP  - 462
DO  - 10.1016/j.jallcom.2018.10.369
ER  - 
@article{
author = "Ognjanović, Miloš and Stanković, Dalibor and Ming, Y. and Zhang, H. and Jančar, Boštjan and Dojčinović, Biljana and Prijović, Željko and Antić, Bratislav",
year = "2019",
abstract = "In a new approach based on a two-step procedure, co-precipitation method followed by hydrothermal treatment in a microwave field, Zn-substituted Fe3O4 nanoparticles (ZnxFe3-xO4) were synthesized. Results of XRD, FT–IR and TEM analysis clearly demonstrate that nanoparticles were single phase, crystallizing in the spinel structure type (S.G. Fd3¯m) with crystallite size in the range of 2–20 nm, which strongly depends on Zn concentration. The produced nanoparticles were used for fabrication of modified carbon paste electrodes as a novel system for electrochemical non-enzymatic glucose detection. It was found that the increase of zinc concentration up to the value of x = 0.56 (Zn0.56Fe2.44O4) of as-prepared nanoparticles was followed with an increase of a performance of the modified carbon paste electrode toward glucose detection. Linear working range from 0.1 to 2 mM was obtained with detection limit of 0.03 mM, and with fast response time (<3 s). Proposed sensor was successfully applied for the determination of glucose level in real samples with satisfactory recovery. The synthesized zinc-ferrite samples were also tested as potential heating agents in magnetic hyperthermia. The heating ability (SAR value) increases with x value, reaching maximum for x = 0.37. This is correlated with changes of particle size and magnetic characteristics which strongly depend on Zn concentration.",
publisher = "Elsevier",
journal = "Journal of Alloys and Compounds",
title = "Bifunctional (Zn,Fe)3O4 nanoparticles: Tuning their efficiency for potential application in reagentless glucose biosensors and magnetic hyperthermia",
pages = "454-462",
doi = "10.1016/j.jallcom.2018.10.369"
}
Ognjanović, M., Stanković, D., Ming, Y., Zhang, H., Jančar, B., Dojčinović, B., Prijović, Ž.,& Antić, B.. (2019). Bifunctional (Zn,Fe)3O4 nanoparticles: Tuning their efficiency for potential application in reagentless glucose biosensors and magnetic hyperthermia. in Journal of Alloys and Compounds
Elsevier., 454-462.
https://doi.org/10.1016/j.jallcom.2018.10.369
Ognjanović M, Stanković D, Ming Y, Zhang H, Jančar B, Dojčinović B, Prijović Ž, Antić B. Bifunctional (Zn,Fe)3O4 nanoparticles: Tuning their efficiency for potential application in reagentless glucose biosensors and magnetic hyperthermia. in Journal of Alloys and Compounds. 2019;:454-462.
doi:10.1016/j.jallcom.2018.10.369 .
Ognjanović, Miloš, Stanković, Dalibor, Ming, Y., Zhang, H., Jančar, Boštjan, Dojčinović, Biljana, Prijović, Željko, Antić, Bratislav, "Bifunctional (Zn,Fe)3O4 nanoparticles: Tuning their efficiency for potential application in reagentless glucose biosensors and magnetic hyperthermia" in Journal of Alloys and Compounds (2019):454-462,
https://doi.org/10.1016/j.jallcom.2018.10.369 . .
28
15
26

Effect of pH and human serum albumin on the cytotoxicity of a glucuronide prodrug of 9-aminocamptothecin

Prijović, Željko; Leu, Yuling; Roffler, Steve R.

(Switzerland : Springer Nature, 2007) 

TY  - JOUR
AU  - Prijović, Željko
AU  - Leu, Yuling
AU  - Roffler, Steve R.
PY  - 2007
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4306
AB  - Purpose: 9-aminocamptothecin glucuronide (9ACG) is a prodrug of 9-aminocamptothecin (9AC) that displays potent antitumor activity against human tumor xenografts in nude mice. Camptothecins exist in a pH dependent equilibrium between active lactone and inactive carboxy forms that can be altered by binding to human serum albumin (HSA). Here we investigated the influence of pH and HSA on the lactone-carboxy equilibrium, HSA binding, and cytotoxicity of 9ACG. Methods: Microfiltration and HPLC were used to measure the influence of pH on lactone to carboxy conversion and HSA binding of 9ACG as compared to other camptothecins. In vitro cytotoxicity of drugs was determined against EJ human bladder carcinoma cells and CL1-5 human lung cancer cells. Results: The rate of lactone to carboxy conversion was similar for 9ACG and 9AC. Decreasing the pH from 7.6 to 6.0 increased the equilibrium levels of the lactone forms of the drugs from 20 to almost 95% of total drug. HSA moderately diminished the amount of free 9ACG lactone but did not change the ratio of 9ACG lactone to 9ACG carboxy. Consistent with the effect of pH on lactone levels, lowering the pH of EJ human bladder carcinoma cells from 7.6 to 6.8 decreased the IC50 of 9ACG from 480 to 98 nM and 9AC from 33 to 12 nM. Activation of 9ACG by human β-glucuronidase anchored on the surface of EJ cells further decreased its IC50 value to 26 nM. Although HSA significantly decreased the cytotoxicity of 9AC and 9ACG, activation of 9ACG at cancer cells with an antibody-β-glucuronidase immunoconjugate produced greater cytotoxicity than 9AC. Conclusions: Acidification and targeted delivery of β-glucuronidase can enhance 9ACG cytotoxicity even in the presence of HSA.
PB  - Switzerland : Springer Nature
T2  - Cancer Chemotherapy and Pharmacology
T1  - Effect of pH and human serum albumin on the cytotoxicity of a glucuronide prodrug of 9-aminocamptothecin
VL  - 60
IS  - 1
SP  - 7
EP  - 17
DO  - 10.1007/s00280-006-0340-4
ER  - 
@article{
author = "Prijović, Željko and Leu, Yuling and Roffler, Steve R.",
year = "2007",
abstract = "Purpose: 9-aminocamptothecin glucuronide (9ACG) is a prodrug of 9-aminocamptothecin (9AC) that displays potent antitumor activity against human tumor xenografts in nude mice. Camptothecins exist in a pH dependent equilibrium between active lactone and inactive carboxy forms that can be altered by binding to human serum albumin (HSA). Here we investigated the influence of pH and HSA on the lactone-carboxy equilibrium, HSA binding, and cytotoxicity of 9ACG. Methods: Microfiltration and HPLC were used to measure the influence of pH on lactone to carboxy conversion and HSA binding of 9ACG as compared to other camptothecins. In vitro cytotoxicity of drugs was determined against EJ human bladder carcinoma cells and CL1-5 human lung cancer cells. Results: The rate of lactone to carboxy conversion was similar for 9ACG and 9AC. Decreasing the pH from 7.6 to 6.0 increased the equilibrium levels of the lactone forms of the drugs from 20 to almost 95% of total drug. HSA moderately diminished the amount of free 9ACG lactone but did not change the ratio of 9ACG lactone to 9ACG carboxy. Consistent with the effect of pH on lactone levels, lowering the pH of EJ human bladder carcinoma cells from 7.6 to 6.8 decreased the IC50 of 9ACG from 480 to 98 nM and 9AC from 33 to 12 nM. Activation of 9ACG by human β-glucuronidase anchored on the surface of EJ cells further decreased its IC50 value to 26 nM. Although HSA significantly decreased the cytotoxicity of 9AC and 9ACG, activation of 9ACG at cancer cells with an antibody-β-glucuronidase immunoconjugate produced greater cytotoxicity than 9AC. Conclusions: Acidification and targeted delivery of β-glucuronidase can enhance 9ACG cytotoxicity even in the presence of HSA.",
publisher = "Switzerland : Springer Nature",
journal = "Cancer Chemotherapy and Pharmacology",
title = "Effect of pH and human serum albumin on the cytotoxicity of a glucuronide prodrug of 9-aminocamptothecin",
volume = "60",
number = "1",
pages = "7-17",
doi = "10.1007/s00280-006-0340-4"
}
Prijović, Ž., Leu, Y.,& Roffler, S. R.. (2007). Effect of pH and human serum albumin on the cytotoxicity of a glucuronide prodrug of 9-aminocamptothecin. in Cancer Chemotherapy and Pharmacology
Switzerland : Springer Nature., 60(1), 7-17.
https://doi.org/10.1007/s00280-006-0340-4
Prijović Ž, Leu Y, Roffler SR. Effect of pH and human serum albumin on the cytotoxicity of a glucuronide prodrug of 9-aminocamptothecin. in Cancer Chemotherapy and Pharmacology. 2007;60(1):7-17.
doi:10.1007/s00280-006-0340-4 .
Prijović, Željko, Leu, Yuling, Roffler, Steve R., "Effect of pH and human serum albumin on the cytotoxicity of a glucuronide prodrug of 9-aminocamptothecin" in Cancer Chemotherapy and Pharmacology, 60, no. 1 (2007):7-17,
https://doi.org/10.1007/s00280-006-0340-4 . .
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