TY  - JOUR
AU  - Tsoukatou, M.
AU  - Maréchal, J.P.
AU  - Hellio, C.
AU  - Novaković, Irena
AU  - Tufegdžić, Srđan
AU  - Sladić, Dušan
AU  - Gašić, Miroslav J.
AU  - Clare, A.S.
AU  - Vagias, C.
AU  - Roussis, V.
PY  - 2007
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/359
AB  - The sesquiterpene hydroquinone avarol (1) was isolated from the marine sponge Dysidea avara, whereas the corresponding quinone, avarone (2), was obtained by oxidation of avarol, and the significantly more lipophilic compounds [3′-(p-chlorophenyl) avarone (3), 3′,4′-ethylenedithioavarone (4), 4′-isopropylthioavarone (5), 4′-tert-butylthioavarone (6), 4′-propylthioavarone (7), 4′-octylthioavarone (8)] were obtained by nucleophilic addition of thiols or p-chloroaniline to avarone. All these compounds were tested, at concentrations ranging from 0.5 to 50 μg/mL, for their effect on the settlement of the cyprid stage of Balanus amphitrite, for toxicity to both nauplii and cyprids and for their growth inhibitory activity on marine bacteria (Cobetia marina, Marinobacterium stanieri, Vibrio fischeri and Pseudoalteromonas haloplanktis) and marine fungi (Halosphaeriopsis mediosetigera, Asteromyces cruciatus, Lulworthia uniseptata and Monodictys pelagica).
PB  - MDPI
T2  - Molecules
T1  - Evaluation of the activity of the sponge metabolites avarol and avarone and their synthetic derivatives against fouling micro- and macroorganisms
VL  - 12
IS  - 5
SP  - 1022
EP  - 1034
DO  - 10.3390/12051022
ER  - 

@article{
author = "Tsoukatou, M. and Maréchal, J.P. and Hellio, C. and Novaković, Irena and Tufegdžić, Srđan and Sladić, Dušan and Gašić, Miroslav J. and Clare, A.S. and Vagias, C. and Roussis, V.",
year = "2007",
abstract = "The sesquiterpene hydroquinone avarol (1) was isolated from the marine sponge Dysidea avara, whereas the corresponding quinone, avarone (2), was obtained by oxidation of avarol, and the significantly more lipophilic compounds [3′-(p-chlorophenyl) avarone (3), 3′,4′-ethylenedithioavarone (4), 4′-isopropylthioavarone (5), 4′-tert-butylthioavarone (6), 4′-propylthioavarone (7), 4′-octylthioavarone (8)] were obtained by nucleophilic addition of thiols or p-chloroaniline to avarone. All these compounds were tested, at concentrations ranging from 0.5 to 50 μg/mL, for their effect on the settlement of the cyprid stage of Balanus amphitrite, for toxicity to both nauplii and cyprids and for their growth inhibitory activity on marine bacteria (Cobetia marina, Marinobacterium stanieri, Vibrio fischeri and Pseudoalteromonas haloplanktis) and marine fungi (Halosphaeriopsis mediosetigera, Asteromyces cruciatus, Lulworthia uniseptata and Monodictys pelagica).",
publisher = "MDPI",
journal = "Molecules",
title = "Evaluation of the activity of the sponge metabolites avarol and avarone and their synthetic derivatives against fouling micro- and macroorganisms",
volume = "12",
number = "5",
pages = "1022-1034",
doi = "10.3390/12051022"
}

Tsoukatou, M., Maréchal, J.P., Hellio, C., Novaković, I., Tufegdžić, S., Sladić, D., Gašić, M. J., Clare, A.S., Vagias, C.,& Roussis, V.. (2007). Evaluation of the activity of the sponge metabolites avarol and avarone and their synthetic derivatives against fouling micro- and macroorganisms. in Molecules
MDPI., 12(5), 1022-1034.
https://doi.org/10.3390/12051022

Tsoukatou M, Maréchal J, Hellio C, Novaković I, Tufegdžić S, Sladić D, Gašić MJ, Clare A, Vagias C, Roussis V. Evaluation of the activity of the sponge metabolites avarol and avarone and their synthetic derivatives against fouling micro- and macroorganisms. in Molecules. 2007;12(5):1022-1034.
doi:10.3390/12051022 .

Tsoukatou, M., Maréchal, J.P., Hellio, C., Novaković, Irena, Tufegdžić, Srđan, Sladić, Dušan, Gašić, Miroslav J., Clare, A.S., Vagias, C., Roussis, V., "Evaluation of the activity of the sponge metabolites avarol and avarone and their synthetic derivatives against fouling micro- and macroorganisms" in Molecules, 12, no. 5 (2007):1022-1034,
https://doi.org/10.3390/12051022 . .