TY  - JOUR
AU  - Stanojevic, A.
AU  - Markovic, V. M.
AU  - Čupić, Željko
AU  - Vukojevic, V.
AU  - Kolar-Anić, Ljiljana
PY  - 2017
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2254
AB  - A model was developed that can be used to study the effect of gradual cholesterol intake by food on the HPA axis dynamics. Namely, well defined oscillatory dynamics of vital neuroendocrine hypothalamic-pituitary-adrenal (HPA) axis has proven to be necessary for maintaining regular basal physiology and formulating appropriate stress response to various types of perturbations. Cholesterol, as a precursor of all steroid HPA axis hormones, can alter the dynamics of HPA axis. To analyse its particular influence on the HPA axis dynamics we used stoichiometric model of HPA axis activity, and simulate cholesterol perturbations in the form of finite duration pulses, with asymmetrically distributed concentration profile. Our numerical simulations showed that there is a complex, nonlinear dependence between the HPA axis responsiveness and different forms of applied cholesterol concentration pulses, indicating the significance of kinetic modelling, and dynamical systems theory for the understanding of large-scale self-regulatory, and homeostatic processes within this neuroendocrine system.
PB  - Maik Nauka/Interperiodica/Springer, New York
T2  - Russian Journal of Physical Chemistry A
T1  - Modelling of the Hypothalamic-Pituitary-Adrenal Axis Perturbations by Externally Induced Cholesterol Pulses of Finite Duration and with Asymmetrically Distributed Concentration Profile
VL  - 91
IS  - 13
SP  - 2600
EP  - 2607
DO  - 10.1134/S0036024417130027
ER  - 

@article{
author = "Stanojevic, A. and Markovic, V. M. and Čupić, Željko and Vukojevic, V. and Kolar-Anić, Ljiljana",
year = "2017",
abstract = "A model was developed that can be used to study the effect of gradual cholesterol intake by food on the HPA axis dynamics. Namely, well defined oscillatory dynamics of vital neuroendocrine hypothalamic-pituitary-adrenal (HPA) axis has proven to be necessary for maintaining regular basal physiology and formulating appropriate stress response to various types of perturbations. Cholesterol, as a precursor of all steroid HPA axis hormones, can alter the dynamics of HPA axis. To analyse its particular influence on the HPA axis dynamics we used stoichiometric model of HPA axis activity, and simulate cholesterol perturbations in the form of finite duration pulses, with asymmetrically distributed concentration profile. Our numerical simulations showed that there is a complex, nonlinear dependence between the HPA axis responsiveness and different forms of applied cholesterol concentration pulses, indicating the significance of kinetic modelling, and dynamical systems theory for the understanding of large-scale self-regulatory, and homeostatic processes within this neuroendocrine system.",
publisher = "Maik Nauka/Interperiodica/Springer, New York",
journal = "Russian Journal of Physical Chemistry A",
title = "Modelling of the Hypothalamic-Pituitary-Adrenal Axis Perturbations by Externally Induced Cholesterol Pulses of Finite Duration and with Asymmetrically Distributed Concentration Profile",
volume = "91",
number = "13",
pages = "2600-2607",
doi = "10.1134/S0036024417130027"
}

Stanojevic, A., Markovic, V. M., Čupić, Ž., Vukojevic, V.,& Kolar-Anić, L.. (2017). Modelling of the Hypothalamic-Pituitary-Adrenal Axis Perturbations by Externally Induced Cholesterol Pulses of Finite Duration and with Asymmetrically Distributed Concentration Profile. in Russian Journal of Physical Chemistry A
Maik Nauka/Interperiodica/Springer, New York., 91(13), 2600-2607.
https://doi.org/10.1134/S0036024417130027

Stanojevic A, Markovic VM, Čupić Ž, Vukojevic V, Kolar-Anić L. Modelling of the Hypothalamic-Pituitary-Adrenal Axis Perturbations by Externally Induced Cholesterol Pulses of Finite Duration and with Asymmetrically Distributed Concentration Profile. in Russian Journal of Physical Chemistry A. 2017;91(13):2600-2607.
doi:10.1134/S0036024417130027 .

Stanojevic, A., Markovic, V. M., Čupić, Željko, Vukojevic, V., Kolar-Anić, Ljiljana, "Modelling of the Hypothalamic-Pituitary-Adrenal Axis Perturbations by Externally Induced Cholesterol Pulses of Finite Duration and with Asymmetrically Distributed Concentration Profile" in Russian Journal of Physical Chemistry A, 91, no. 13 (2017):2600-2607,
https://doi.org/10.1134/S0036024417130027 . .

TY  - JOUR
AU  - Abulseoud, Osama A.
AU  - Ho, Man Choi
AU  - Choi, Doo-Sup
AU  - Stanojevic, Ana
AU  - Čupić, Željko
AU  - Kolar-Anić, Ljiljana
AU  - Vukojevic, Vladana
PY  - 2017
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2269
AB  - Changes in the hypothalamic-pituitary-adrenal (HPA) axis activity constitute a key component of bipolar mania, but the extent and nature of these alterations are not fully understood. We use here the lateral hypothalamic-kindled (LHK) rat model to deliberately induce an acute manic-like episode and measure serum corticosterone concentrations to assess changes in HPA axis activity. A mathematical model is developed to succinctly describe the entwined biochemical transformations that underlay the HPA axis and emulate by numerical simulations the considerable increase in serum corticosterone concentration induced by LHK. Synergistic combination of the LHK rat model and dynamical systems theory allows us to quantitatively characterize changes in HPA axis activity under controlled induction of acute manic-like states and provides a framework to study in silico how the dynamic integration of neurochemical transformations underlying the HPA axis is disrupted in these states.
PB  - Public Library of Science (PLoS)
T2  - Plos One
T1  - Corticosterone oscillations during mania induction in the lateral hypothalamic kindled rat-Experimental observations and mathematical modeling
VL  - 12
IS  - 5
DO  - 10.1371/journal.pone.0177551
ER  - 

@article{
author = "Abulseoud, Osama A. and Ho, Man Choi and Choi, Doo-Sup and Stanojevic, Ana and Čupić, Željko and Kolar-Anić, Ljiljana and Vukojevic, Vladana",
year = "2017",
abstract = "Changes in the hypothalamic-pituitary-adrenal (HPA) axis activity constitute a key component of bipolar mania, but the extent and nature of these alterations are not fully understood. We use here the lateral hypothalamic-kindled (LHK) rat model to deliberately induce an acute manic-like episode and measure serum corticosterone concentrations to assess changes in HPA axis activity. A mathematical model is developed to succinctly describe the entwined biochemical transformations that underlay the HPA axis and emulate by numerical simulations the considerable increase in serum corticosterone concentration induced by LHK. Synergistic combination of the LHK rat model and dynamical systems theory allows us to quantitatively characterize changes in HPA axis activity under controlled induction of acute manic-like states and provides a framework to study in silico how the dynamic integration of neurochemical transformations underlying the HPA axis is disrupted in these states.",
publisher = "Public Library of Science (PLoS)",
journal = "Plos One",
title = "Corticosterone oscillations during mania induction in the lateral hypothalamic kindled rat-Experimental observations and mathematical modeling",
volume = "12",
number = "5",
doi = "10.1371/journal.pone.0177551"
}

Abulseoud, O. A., Ho, M. C., Choi, D., Stanojevic, A., Čupić, Ž., Kolar-Anić, L.,& Vukojevic, V.. (2017). Corticosterone oscillations during mania induction in the lateral hypothalamic kindled rat-Experimental observations and mathematical modeling. in Plos One
Public Library of Science (PLoS)., 12(5).
https://doi.org/10.1371/journal.pone.0177551

Abulseoud OA, Ho MC, Choi D, Stanojevic A, Čupić Ž, Kolar-Anić L, Vukojevic V. Corticosterone oscillations during mania induction in the lateral hypothalamic kindled rat-Experimental observations and mathematical modeling. in Plos One. 2017;12(5).
doi:10.1371/journal.pone.0177551 .

Abulseoud, Osama A., Ho, Man Choi, Choi, Doo-Sup, Stanojevic, Ana, Čupić, Željko, Kolar-Anić, Ljiljana, Vukojevic, Vladana, "Corticosterone oscillations during mania induction in the lateral hypothalamic kindled rat-Experimental observations and mathematical modeling" in Plos One, 12, no. 5 (2017),
https://doi.org/10.1371/journal.pone.0177551 . .