TY  - CONF
AU  - Lović, Jelena
AU  - Mijin, Dušan
AU  - Bogdanović, Aleksandra
AU  - Vuković, Dragan
AU  - Petrović, Slobodan
AU  - Avramov -  Ivić, Milka
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6186
AB  - Duloxetine hydrochloride ( D U L ) , a naphth) I ether amine, inhibits the
uptake of serotonin and norepinephrine. The electrochemical behavior of D U L
was determined by cyclic voltammetry ( C V ) in phosphate buffer solution at gold
electrode by varying pH and scan rate. The electroanalytical application was
studied with the aid of differential pulse voltammetry (DPV) in sodium
bicarbonate solution. A linear response ranged from 5x10'^ M to 10'" M. The
validation of the DPV method was carried out by determine of the limit of
detection (LOD) and limit of quantitation (LOQ) and the calculate values were
4.6 X 10"'' and 2 x 10'^' M, respective!). The proposed DPV method has been
successfully applied to assessment DUL as standard and in Taita® tablets and
standard spiked with human serum.
PB  - Sarajevo : Faculty of Science University of Sarajevo
C3  - Bulletin of the Chemists and Technologists of Bosnia and Herzegovina
T1  - Electrochemical determination of duloxetine hydrochloride at gold electrode
SP  - 42
EP  - 42
UR  - https://hdl.handle.net/21.15107/rcub_cer_6186
ER  - 

@conference{
author = "Lović, Jelena and Mijin, Dušan and Bogdanović, Aleksandra and Vuković, Dragan and Petrović, Slobodan and Avramov -  Ivić, Milka",
year = "2022",
abstract = "Duloxetine hydrochloride ( D U L ) , a naphth) I ether amine, inhibits the
uptake of serotonin and norepinephrine. The electrochemical behavior of D U L
was determined by cyclic voltammetry ( C V ) in phosphate buffer solution at gold
electrode by varying pH and scan rate. The electroanalytical application was
studied with the aid of differential pulse voltammetry (DPV) in sodium
bicarbonate solution. A linear response ranged from 5x10'^ M to 10'" M. The
validation of the DPV method was carried out by determine of the limit of
detection (LOD) and limit of quantitation (LOQ) and the calculate values were
4.6 X 10"'' and 2 x 10'^' M, respective!). The proposed DPV method has been
successfully applied to assessment DUL as standard and in Taita® tablets and
standard spiked with human serum.",
publisher = "Sarajevo : Faculty of Science University of Sarajevo",
journal = "Bulletin of the Chemists and Technologists of Bosnia and Herzegovina",
title = "Electrochemical determination of duloxetine hydrochloride at gold electrode",
pages = "42-42",
url = "https://hdl.handle.net/21.15107/rcub_cer_6186"
}

Lović, J., Mijin, D., Bogdanović, A., Vuković, D., Petrović, S.,& Avramov -  Ivić, M.. (2022). Electrochemical determination of duloxetine hydrochloride at gold electrode. in Bulletin of the Chemists and Technologists of Bosnia and Herzegovina
Sarajevo : Faculty of Science University of Sarajevo., 42-42.
https://hdl.handle.net/21.15107/rcub_cer_6186

Lović J, Mijin D, Bogdanović A, Vuković D, Petrović S, Avramov -  Ivić M. Electrochemical determination of duloxetine hydrochloride at gold electrode. in Bulletin of the Chemists and Technologists of Bosnia and Herzegovina. 2022;:42-42.
https://hdl.handle.net/21.15107/rcub_cer_6186 .

Lović, Jelena, Mijin, Dušan, Bogdanović, Aleksandra, Vuković, Dragan, Petrović, Slobodan, Avramov -  Ivić, Milka, "Electrochemical determination of duloxetine hydrochloride at gold electrode" in Bulletin of the Chemists and Technologists of Bosnia and Herzegovina (2022):42-42,
https://hdl.handle.net/21.15107/rcub_cer_6186 .

TY  - JOUR
AU  - Lović, Jelena
AU  - Bogdanović, Aleksandra
AU  - Tadić, Vanja
AU  - Mijin, Dušan
AU  - Vuković, Dragan
AU  - Petrović, Slobodan D.
AU  - Avramov -  Ivić, Milka
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5171
AB  - Duloxetine hydrochloride (DUL) is effective in treating depression, and was examined for electroanalytical purposes. The DUL
standard was investigated by cyclic voltammetry (CV) and determined using differential pulse voltammetry (DPV) via its electrooxidation
at the Au electrode in 0.05 M NaHCO3. DPV showed a linear dependency of the anodic peak currents vs DUL standard
concentrations in the range from 0.1 to 3.33 μg ml−1 with the values of the limit of detection (LOD) and the limit of quantification
(LOQ): 0.133 and 0.667 μg ml−1, respectively. Using the constructed and validated calibration curve, the values of unknown DUL
concentrations in both Taita® tablets and in human serum spiked with the standard were determined. The number of protons and
electrons transferred was calculated and possible reaction mechanisms taking place on the surface of both electrodes were
proposed. The Au electrode exhibited a better sensitivity and a wider range of current vs concentration linear dependency for DUL
quantitative determination than the GC electrode. The study of DUL degradation showed that at the Au and GC electrodes, after
4.5 h of potential cycling, degradation occurs, giving formaldehyde as a product, which was confirmed by high performance liquid
chromatography (HPLC)
PB  - The Electrochemical Society
T2  - Journal of The Electrochemical Society
T1  - Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation
DO  - 10.1149/1945-7111/ac7e74
ER  - 

@article{
author = "Lović, Jelena and Bogdanović, Aleksandra and Tadić, Vanja and Mijin, Dušan and Vuković, Dragan and Petrović, Slobodan D. and Avramov -  Ivić, Milka",
year = "2022",
abstract = "Duloxetine hydrochloride (DUL) is effective in treating depression, and was examined for electroanalytical purposes. The DUL
standard was investigated by cyclic voltammetry (CV) and determined using differential pulse voltammetry (DPV) via its electrooxidation
at the Au electrode in 0.05 M NaHCO3. DPV showed a linear dependency of the anodic peak currents vs DUL standard
concentrations in the range from 0.1 to 3.33 μg ml−1 with the values of the limit of detection (LOD) and the limit of quantification
(LOQ): 0.133 and 0.667 μg ml−1, respectively. Using the constructed and validated calibration curve, the values of unknown DUL
concentrations in both Taita® tablets and in human serum spiked with the standard were determined. The number of protons and
electrons transferred was calculated and possible reaction mechanisms taking place on the surface of both electrodes were
proposed. The Au electrode exhibited a better sensitivity and a wider range of current vs concentration linear dependency for DUL
quantitative determination than the GC electrode. The study of DUL degradation showed that at the Au and GC electrodes, after
4.5 h of potential cycling, degradation occurs, giving formaldehyde as a product, which was confirmed by high performance liquid
chromatography (HPLC)",
publisher = "The Electrochemical Society",
journal = "Journal of The Electrochemical Society",
title = "Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation",
doi = "10.1149/1945-7111/ac7e74"
}

Lović, J., Bogdanović, A., Tadić, V., Mijin, D., Vuković, D., Petrović, S. D.,& Avramov -  Ivić, M.. (2022). Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation. in Journal of The Electrochemical Society
The Electrochemical Society..
https://doi.org/10.1149/1945-7111/ac7e74

Lović J, Bogdanović A, Tadić V, Mijin D, Vuković D, Petrović SD, Avramov -  Ivić M. Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation. in Journal of The Electrochemical Society. 2022;.
doi:10.1149/1945-7111/ac7e74 .

Lović, Jelena, Bogdanović, Aleksandra, Tadić, Vanja, Mijin, Dušan, Vuković, Dragan, Petrović, Slobodan D., Avramov -  Ivić, Milka, "Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation" in Journal of The Electrochemical Society (2022),
https://doi.org/10.1149/1945-7111/ac7e74 . .

TY  - JOUR
AU  - Lović, Jelena
AU  - Bogdanović, Aleksandra
AU  - Mijin, Dušan
AU  - Vuković, Dragan
AU  - Petrović, Slobodan
AU  - Avramov Ivić, Milka
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5221
AB  - Ticagrelor hydrochloride (TCG) is effective in platelet inhibition and useful for preventing cardiovascular death, myocardial infarction, or ischaemic stroke. The drug standard was investigated by cyclic voltammetry (CV) and quantitatively determined using differential pulse voltammetry (DPV) via its electrooxidation at Au electrode in 0.05 M NaHCO3. DPV showed a linear dependency of the anodic peak currents vs. TCG standard concentrations in the range from 3 x 10-7 mol l-1 to 10-5 mol l-1 with the values of the limit of detection (LOD) and the limit of quantification: 0.288 μmol l-1 and 0.96 μmol l-1, respectively. Using the constructed and validated calibration curve, the values of unknown ticagrelor concentrations in Ticagrex® tablets and in human serum spiked with the standard were determined. Mechanistic study suggests that the oxidation proceeds at sulfur atom by removal of one electron as the rate determining step. In the next, fast step, formed radical cation loose another electron and sulfoxide is formed (with water molecule as nucleophile). The study of TCG degradation showed that at the Au, after 4.5 h of potential cycling, degradation occurs, which was confirmed by UV spectroscopy.
PB  - ESG
T2  - International Journal of Electrochemical Science
T1  - Ticagrelor Determination via Its Electrooxidation as the Standard, in Tablets and the Spiked Human Serum at Au Solid Electrode
VL  - 17
SP  - 220928
DO  - 10.20964/2022.09.36
ER  - 

@article{
author = "Lović, Jelena and Bogdanović, Aleksandra and Mijin, Dušan and Vuković, Dragan and Petrović, Slobodan and Avramov Ivić, Milka",
year = "2022",
abstract = "Ticagrelor hydrochloride (TCG) is effective in platelet inhibition and useful for preventing cardiovascular death, myocardial infarction, or ischaemic stroke. The drug standard was investigated by cyclic voltammetry (CV) and quantitatively determined using differential pulse voltammetry (DPV) via its electrooxidation at Au electrode in 0.05 M NaHCO3. DPV showed a linear dependency of the anodic peak currents vs. TCG standard concentrations in the range from 3 x 10-7 mol l-1 to 10-5 mol l-1 with the values of the limit of detection (LOD) and the limit of quantification: 0.288 μmol l-1 and 0.96 μmol l-1, respectively. Using the constructed and validated calibration curve, the values of unknown ticagrelor concentrations in Ticagrex® tablets and in human serum spiked with the standard were determined. Mechanistic study suggests that the oxidation proceeds at sulfur atom by removal of one electron as the rate determining step. In the next, fast step, formed radical cation loose another electron and sulfoxide is formed (with water molecule as nucleophile). The study of TCG degradation showed that at the Au, after 4.5 h of potential cycling, degradation occurs, which was confirmed by UV spectroscopy.",
publisher = "ESG",
journal = "International Journal of Electrochemical Science",
title = "Ticagrelor Determination via Its Electrooxidation as the Standard, in Tablets and the Spiked Human Serum at Au Solid Electrode",
volume = "17",
pages = "220928",
doi = "10.20964/2022.09.36"
}

Lović, J., Bogdanović, A., Mijin, D., Vuković, D., Petrović, S.,& Avramov Ivić, M.. (2022). Ticagrelor Determination via Its Electrooxidation as the Standard, in Tablets and the Spiked Human Serum at Au Solid Electrode. in International Journal of Electrochemical Science
ESG., 17, 220928.
https://doi.org/10.20964/2022.09.36

Lović J, Bogdanović A, Mijin D, Vuković D, Petrović S, Avramov Ivić M. Ticagrelor Determination via Its Electrooxidation as the Standard, in Tablets and the Spiked Human Serum at Au Solid Electrode. in International Journal of Electrochemical Science. 2022;17:220928.
doi:10.20964/2022.09.36 .

Lović, Jelena, Bogdanović, Aleksandra, Mijin, Dušan, Vuković, Dragan, Petrović, Slobodan, Avramov Ivić, Milka, "Ticagrelor Determination via Its Electrooxidation as the Standard, in Tablets and the Spiked Human Serum at Au Solid Electrode" in International Journal of Electrochemical Science, 17 (2022):220928,
https://doi.org/10.20964/2022.09.36 . .