TY  - CONF
AU  - Stanojević, Ana
AU  - Marković, Vladimir
AU  - Čupić, Željko
AU  - Maćešić, Stevan
AU  - Vukojević, Vladana
AU  - Kolar-Anić, Ljiljana
PY  - 2016
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4856
AB  - The hypothalamic-pituitary-adrenal (HPA) axis is a dynamic regulatory network
of biochemical reactions that integrates and synchronizes the nervous and the
endocrine systems functions at the organism level. In order to describe how this
vast network of biochemical interactions operates, we have developed a nonlinear
eleven-dimensional stoichiometric model that concisely describes key biochemical
transformations that comprise the HPA axis in rats. In a stoichiometric
model of a biochemical system, the outcomes of complex biochemical pathways
are succinctly described by stoichiometric relations. In this representation, substances
that initiate, i.e. enter a pathway are regarded to behave as reactants;
substances that are generated in a pathway are regarded to behave as products;
and the rates at which products of a pathway appear are jointly proportional
to the concentrations of the reactants. In order to derive rate constants for specific
biochemical reaction pathways, we have resorted to our recently developed
nonlinear reaction model that concisely describes biochemical transformations
in the HPA axis in humans. In this way, a mathematical framework is developed
to describe in the form of a system of ordinary differential equations (ODEs) the
integration of biochemical pathways that constitute the HPA axis on chemical kinetics
basis. This, in turn, allows us to use numerical simulations to investigate
how the underlying biochemical pathways are intertwined to give an integral
HPA axis response at the organism level to a variety of external or internal perturbators
of the HPA dynamics. Given that the HPA axis is a nonlinear dynamical
network, its response is complex and often cannot be intuitively predicted,
stoichiometric modeling can be harnessed for gaining additional insights into
dynamical functioning of this complex neuroendocrine system.
PB  - Belgrade : The Bioinformatics Research Group, University of Belgrade - Faculty of Mathematics
C3  - Book of Abstracts - Belgrade BioInformatics Conference 2016, BelBI 2016
T1  - Mathematical Modeling of the Hypothalamic-Pituitary-Adrenal Axis Dynamics in Rats
SP  - 98
EP  - 98
UR  - https://hdl.handle.net/21.15107/rcub_cer_4856
ER  - 

@conference{
author = "Stanojević, Ana and Marković, Vladimir and Čupić, Željko and Maćešić, Stevan and Vukojević, Vladana and Kolar-Anić, Ljiljana",
year = "2016",
abstract = "The hypothalamic-pituitary-adrenal (HPA) axis is a dynamic regulatory network
of biochemical reactions that integrates and synchronizes the nervous and the
endocrine systems functions at the organism level. In order to describe how this
vast network of biochemical interactions operates, we have developed a nonlinear
eleven-dimensional stoichiometric model that concisely describes key biochemical
transformations that comprise the HPA axis in rats. In a stoichiometric
model of a biochemical system, the outcomes of complex biochemical pathways
are succinctly described by stoichiometric relations. In this representation, substances
that initiate, i.e. enter a pathway are regarded to behave as reactants;
substances that are generated in a pathway are regarded to behave as products;
and the rates at which products of a pathway appear are jointly proportional
to the concentrations of the reactants. In order to derive rate constants for specific
biochemical reaction pathways, we have resorted to our recently developed
nonlinear reaction model that concisely describes biochemical transformations
in the HPA axis in humans. In this way, a mathematical framework is developed
to describe in the form of a system of ordinary differential equations (ODEs) the
integration of biochemical pathways that constitute the HPA axis on chemical kinetics
basis. This, in turn, allows us to use numerical simulations to investigate
how the underlying biochemical pathways are intertwined to give an integral
HPA axis response at the organism level to a variety of external or internal perturbators
of the HPA dynamics. Given that the HPA axis is a nonlinear dynamical
network, its response is complex and often cannot be intuitively predicted,
stoichiometric modeling can be harnessed for gaining additional insights into
dynamical functioning of this complex neuroendocrine system.",
publisher = "Belgrade : The Bioinformatics Research Group, University of Belgrade - Faculty of Mathematics",
journal = "Book of Abstracts - Belgrade BioInformatics Conference 2016, BelBI 2016",
title = "Mathematical Modeling of the Hypothalamic-Pituitary-Adrenal Axis Dynamics in Rats",
pages = "98-98",
url = "https://hdl.handle.net/21.15107/rcub_cer_4856"
}

Stanojević, A., Marković, V., Čupić, Ž., Maćešić, S., Vukojević, V.,& Kolar-Anić, L.. (2016). Mathematical Modeling of the Hypothalamic-Pituitary-Adrenal Axis Dynamics in Rats. in Book of Abstracts - Belgrade BioInformatics Conference 2016, BelBI 2016
Belgrade : The Bioinformatics Research Group, University of Belgrade - Faculty of Mathematics., 98-98.
https://hdl.handle.net/21.15107/rcub_cer_4856

Stanojević A, Marković V, Čupić Ž, Maćešić S, Vukojević V, Kolar-Anić L. Mathematical Modeling of the Hypothalamic-Pituitary-Adrenal Axis Dynamics in Rats. in Book of Abstracts - Belgrade BioInformatics Conference 2016, BelBI 2016. 2016;:98-98.
https://hdl.handle.net/21.15107/rcub_cer_4856 .

Stanojević, Ana, Marković, Vladimir, Čupić, Željko, Maćešić, Stevan, Vukojević, Vladana, Kolar-Anić, Ljiljana, "Mathematical Modeling of the Hypothalamic-Pituitary-Adrenal Axis Dynamics in Rats" in Book of Abstracts - Belgrade BioInformatics Conference 2016, BelBI 2016 (2016):98-98,
https://hdl.handle.net/21.15107/rcub_cer_4856 .

TY  - JOUR
AU  - Kolar-Anić, Ljiljana
AU  - Čupić, Željko
AU  - Anić, Slobodan
AU  - Adnađević, Borivoj K.
AU  - Vukojević, Vladana
PY  - 2001
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/35
AB  - The model of mechanism of the nitrous oxide (N2O) decomposition over the catalyst Cu-ZSM-5 proposed in 1999 in the article of Ochs and Turek, is adapted for mentioned process in open reactor and analyzed by the stoichiometric network analysis. Under these conditions five reaction pathways that all contribute to same overall process with defined but different contributions are found. Analyzing stoichiometric reactions of all obtained reaction pathways, in only one of them the nitric oxide (NO) as a product of reaction is found. Controlling the contribution of this reaction pathway to overall process, the control of production of NO as pollutant is makes possible.
AB  - Model mehanizma reakcije razlaganja azotsuboksida (N2O) na zeolitnom katalizatoru CuZSM-5 predložen 1999. godine u radu Ochsa i Tureka, podešen je za pomenuti proces u otvorenom reaktoru i analiziran stehiometrijskom mrežnom analizom. Pokazano je da pod tim uslovima model predviđa pet reakcionih puteva. Svi oni doprinose ukupnom procesu sa definisanim, ali različitim udelima. Analizom stehiometrijskih jednačina reakcionih puteva nađeno je da se samo u jednom od njih pojavljuje azotmonoksid (NO) kao proizvod. Kontrolom doprinosa ovog reakcionog puta celokupnom procesu otvara se mogućnost kontrole proizvodnje zagađivača azotmonoksida (NO).
T2  - Nauka, tehnika, bezbednost
T1  - Decomposition of N2O over catalyst cu-ZSM-5: Analysis of reaction model
T1  - Razlaganje N2O na katalizatoru Cu-ZSM-5 - analiza modela reakcije
VL  - 11
IS  - 2
SP  - 39
EP  - 46
UR  - https://hdl.handle.net/21.15107/rcub_cer_35
ER  - 

@article{
author = "Kolar-Anić, Ljiljana and Čupić, Željko and Anić, Slobodan and Adnađević, Borivoj K. and Vukojević, Vladana",
year = "2001",
abstract = "The model of mechanism of the nitrous oxide (N2O) decomposition over the catalyst Cu-ZSM-5 proposed in 1999 in the article of Ochs and Turek, is adapted for mentioned process in open reactor and analyzed by the stoichiometric network analysis. Under these conditions five reaction pathways that all contribute to same overall process with defined but different contributions are found. Analyzing stoichiometric reactions of all obtained reaction pathways, in only one of them the nitric oxide (NO) as a product of reaction is found. Controlling the contribution of this reaction pathway to overall process, the control of production of NO as pollutant is makes possible., Model mehanizma reakcije razlaganja azotsuboksida (N2O) na zeolitnom katalizatoru CuZSM-5 predložen 1999. godine u radu Ochsa i Tureka, podešen je za pomenuti proces u otvorenom reaktoru i analiziran stehiometrijskom mrežnom analizom. Pokazano je da pod tim uslovima model predviđa pet reakcionih puteva. Svi oni doprinose ukupnom procesu sa definisanim, ali različitim udelima. Analizom stehiometrijskih jednačina reakcionih puteva nađeno je da se samo u jednom od njih pojavljuje azotmonoksid (NO) kao proizvod. Kontrolom doprinosa ovog reakcionog puta celokupnom procesu otvara se mogućnost kontrole proizvodnje zagađivača azotmonoksida (NO).",
journal = "Nauka, tehnika, bezbednost",
title = "Decomposition of N2O over catalyst cu-ZSM-5: Analysis of reaction model, Razlaganje N2O na katalizatoru Cu-ZSM-5 - analiza modela reakcije",
volume = "11",
number = "2",
pages = "39-46",
url = "https://hdl.handle.net/21.15107/rcub_cer_35"
}

Kolar-Anić, L., Čupić, Ž., Anić, S., Adnađević, B. K.,& Vukojević, V.. (2001). Decomposition of N2O over catalyst cu-ZSM-5: Analysis of reaction model. in Nauka, tehnika, bezbednost, 11(2), 39-46.
https://hdl.handle.net/21.15107/rcub_cer_35

Kolar-Anić L, Čupić Ž, Anić S, Adnađević BK, Vukojević V. Decomposition of N2O over catalyst cu-ZSM-5: Analysis of reaction model. in Nauka, tehnika, bezbednost. 2001;11(2):39-46.
https://hdl.handle.net/21.15107/rcub_cer_35 .

Kolar-Anić, Ljiljana, Čupić, Željko, Anić, Slobodan, Adnađević, Borivoj K., Vukojević, Vladana, "Decomposition of N2O over catalyst cu-ZSM-5: Analysis of reaction model" in Nauka, tehnika, bezbednost, 11, no. 2 (2001):39-46,
https://hdl.handle.net/21.15107/rcub_cer_35 .

TY  - JOUR
AU  - Anić, Slobodan
AU  - Kolar-Anić, Ljiljana
AU  - Čupić, Željko
AU  - Pejić, Nataša
AU  - Vukojević, Vladana
PY  - 2001
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/41
AB  - The main kinetic characteristics of a catalyst could be obtained by examination of its behavior in some known reaction system, so-called model reaction system. The model reaction system is usually chosen to be as simple as possible. Therefore, for this purpose, the first or second order reaction with relatively simple mechanism and with only one reaction pathway is often selected. However, for the model reaction system one oscillatory chemical reaction, having the complex mechanism with the alternating reaction pathways, could be chosen. It can be expressed over the state far from equilibrium and the variety of kinetic characteristics, resulting from the properties of examined catalyst, can be found. The special attention is paid on Bray-Liebhafsky oscillatory chemical reaction, as well as on the comparative analysis of the iron based catalysts, whereby iron could be used either as peroxydazirene or supported on acidic polyvinylpyridine. .
AB  - Glavne kinetičke karakteristike katalizatora dobijaju se ispitivanjem njegovog ponašanja u nekom poznatom reakcionom sistemu, takozvanom modelnom reakcionom sistemu. Za modelni reakcioni sistem obično se bira što je moguće jednostavniji. Zbog toga se, u tu svrhu, najčešće koristi neka reakcija prvog ili drugog reda sa definisanim i jednostavnim mehanizmom i jasnom stehiometrijom ukupne reakcije, kao i samo jednim reakcionim putem. Međutim, za modelnu reakciju može se izabrati i neka složena hemijska reakcija, na primer, neka od oscilatornih hemijskih reakcija sa nizom alternativnih reakcionih puteva, a koji se ispoljavaju u nekim od njenih stanja daleko od ravnoteže. Kao takva, veoma je osetljiva na uvođenje katalizatora čija svojstva želimo ispitati. Ovom prilikom pažnja je posvećena modelnoj Bray-Liebhafsky (BL) oscilatornoj reakciji i uporednoj analizi katalizatora na bazi gvožda bilo da je u pitanju gvožđe u peroksidazi rena ili ono naneto na kiseli polivinilpiridin. .
PB  - Društvo inženjera plastičara i gumara, Beograd
T2  - Svet polimera
T1  - Oscillatory chemical reaction as model system for the catalysts characterization
T1  - Oscilatorna hemijska reakcija kao modelni sistem za karakterizaciju katalizatora
VL  - 4
IS  - 2
SP  - 55
EP  - 66
UR  - https://hdl.handle.net/21.15107/rcub_cer_41
ER  - 

@article{
author = "Anić, Slobodan and Kolar-Anić, Ljiljana and Čupić, Željko and Pejić, Nataša and Vukojević, Vladana",
year = "2001",
abstract = "The main kinetic characteristics of a catalyst could be obtained by examination of its behavior in some known reaction system, so-called model reaction system. The model reaction system is usually chosen to be as simple as possible. Therefore, for this purpose, the first or second order reaction with relatively simple mechanism and with only one reaction pathway is often selected. However, for the model reaction system one oscillatory chemical reaction, having the complex mechanism with the alternating reaction pathways, could be chosen. It can be expressed over the state far from equilibrium and the variety of kinetic characteristics, resulting from the properties of examined catalyst, can be found. The special attention is paid on Bray-Liebhafsky oscillatory chemical reaction, as well as on the comparative analysis of the iron based catalysts, whereby iron could be used either as peroxydazirene or supported on acidic polyvinylpyridine. ., Glavne kinetičke karakteristike katalizatora dobijaju se ispitivanjem njegovog ponašanja u nekom poznatom reakcionom sistemu, takozvanom modelnom reakcionom sistemu. Za modelni reakcioni sistem obično se bira što je moguće jednostavniji. Zbog toga se, u tu svrhu, najčešće koristi neka reakcija prvog ili drugog reda sa definisanim i jednostavnim mehanizmom i jasnom stehiometrijom ukupne reakcije, kao i samo jednim reakcionim putem. Međutim, za modelnu reakciju može se izabrati i neka složena hemijska reakcija, na primer, neka od oscilatornih hemijskih reakcija sa nizom alternativnih reakcionih puteva, a koji se ispoljavaju u nekim od njenih stanja daleko od ravnoteže. Kao takva, veoma je osetljiva na uvođenje katalizatora čija svojstva želimo ispitati. Ovom prilikom pažnja je posvećena modelnoj Bray-Liebhafsky (BL) oscilatornoj reakciji i uporednoj analizi katalizatora na bazi gvožda bilo da je u pitanju gvožđe u peroksidazi rena ili ono naneto na kiseli polivinilpiridin. .",
publisher = "Društvo inženjera plastičara i gumara, Beograd",
journal = "Svet polimera",
title = "Oscillatory chemical reaction as model system for the catalysts characterization, Oscilatorna hemijska reakcija kao modelni sistem za karakterizaciju katalizatora",
volume = "4",
number = "2",
pages = "55-66",
url = "https://hdl.handle.net/21.15107/rcub_cer_41"
}

Anić, S., Kolar-Anić, L., Čupić, Ž., Pejić, N.,& Vukojević, V.. (2001). Oscillatory chemical reaction as model system for the catalysts characterization. in Svet polimera
Društvo inženjera plastičara i gumara, Beograd., 4(2), 55-66.
https://hdl.handle.net/21.15107/rcub_cer_41

Anić S, Kolar-Anić L, Čupić Ž, Pejić N, Vukojević V. Oscillatory chemical reaction as model system for the catalysts characterization. in Svet polimera. 2001;4(2):55-66.
https://hdl.handle.net/21.15107/rcub_cer_41 .

Anić, Slobodan, Kolar-Anić, Ljiljana, Čupić, Željko, Pejić, Nataša, Vukojević, Vladana, "Oscillatory chemical reaction as model system for the catalysts characterization" in Svet polimera, 4, no. 2 (2001):55-66,
https://hdl.handle.net/21.15107/rcub_cer_41 .