TY  - JOUR
AU  - Mileski, Ksenija S.
AU  - Trifunović, Snežana
AU  - Ciric, Ana D.
AU  - Sakic, Zeljana M.
AU  - Ristic, Mihailo S.
AU  - Todorović, Nina
AU  - Matevski, Vlado S.
AU  - Marin, Petar D.
AU  - Tešević, Vele
AU  - Dzamic, Ana M.
PY  - 2017
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2936
AB  - The essential oil, different extracts, and isolated compounds of Angelica pancicii Vandas (Apiaceae) were investigated for the first time. The GC-FID and GC-MS analyses revealed sesquiterpenoids as the main constituents of A. pancicii essential oil of aerial parts with bornyl acetate (8.08%), n-octanol (5.82%), kessane (4.26%), and beta-selinene (4.26%) as the main constituents. Analysis of methanol extracts, using an HPLC-DAD/ESI-ToF-MS system, showed a total of 52 compounds in the aerial parts and 53 in the roots, indicating coumarins as the main constituents. In addition, new chromone (1) and six known furanocoumarins (2-7) were isolated from the roots and structurally elucidated by combined spectroscopic methods. The aerial part extracts exhibited higher polyphenolic contents and antioxidant activity evaluated by three radical scavenging assays. Using a microwell dilution method, the strongest antibacterial activity profiles were determined for ethanol and methanol root extracts (minimum bactericidal concentrations (MBCs) = 0.25-3.00 mg/mL), which were comparable to the activity of streptomycin (MBCs = 0.34-1.24 mg/mL), while the strongest antibacterial compound of A. pancicii was oxypeucedanin hydrate (MBCs = 0.50-8.00 mg/mL). Antifungal potential was in moderate extent, and the highest activity was obtained for root methanol extract (minimum fungicidal concentrations (MFCs) = 4.00-14.00 mg/mL). Tested sub-minimum inhibitory concentrations (subMICs) of the extracts and isolated compounds inhibited selected Pseudomonasaeruginosa PAO1 virulence determinants. The most reduced growth of P. aeruginosa colony was in the presence of isolated oxypeucedanin. Ethanol (17.36-46.98%) and methanol (34.54-52.43%) root extracts showed higher anti-biofilm activity compared to streptomycin (49.40-88.36%) and ampicillin (56.46-92.16%).
PB  - American Chemical Society (ACS)
T2  - Journal of Agricultural and Food Chemistry
T1  - Research on Chemical Composition and Biological Properties Including Antiquorum Sensing Activity of Angelica pancicii Vandas Aerial Parts and Roots
VL  - 65
IS  - 50
SP  - 10933
EP  - 10949
DO  - 10.1021/acs.jafc.7b04202
ER  - 

@article{
author = "Mileski, Ksenija S. and Trifunović, Snežana and Ciric, Ana D. and Sakic, Zeljana M. and Ristic, Mihailo S. and Todorović, Nina and Matevski, Vlado S. and Marin, Petar D. and Tešević, Vele and Dzamic, Ana M.",
year = "2017",
abstract = "The essential oil, different extracts, and isolated compounds of Angelica pancicii Vandas (Apiaceae) were investigated for the first time. The GC-FID and GC-MS analyses revealed sesquiterpenoids as the main constituents of A. pancicii essential oil of aerial parts with bornyl acetate (8.08%), n-octanol (5.82%), kessane (4.26%), and beta-selinene (4.26%) as the main constituents. Analysis of methanol extracts, using an HPLC-DAD/ESI-ToF-MS system, showed a total of 52 compounds in the aerial parts and 53 in the roots, indicating coumarins as the main constituents. In addition, new chromone (1) and six known furanocoumarins (2-7) were isolated from the roots and structurally elucidated by combined spectroscopic methods. The aerial part extracts exhibited higher polyphenolic contents and antioxidant activity evaluated by three radical scavenging assays. Using a microwell dilution method, the strongest antibacterial activity profiles were determined for ethanol and methanol root extracts (minimum bactericidal concentrations (MBCs) = 0.25-3.00 mg/mL), which were comparable to the activity of streptomycin (MBCs = 0.34-1.24 mg/mL), while the strongest antibacterial compound of A. pancicii was oxypeucedanin hydrate (MBCs = 0.50-8.00 mg/mL). Antifungal potential was in moderate extent, and the highest activity was obtained for root methanol extract (minimum fungicidal concentrations (MFCs) = 4.00-14.00 mg/mL). Tested sub-minimum inhibitory concentrations (subMICs) of the extracts and isolated compounds inhibited selected Pseudomonasaeruginosa PAO1 virulence determinants. The most reduced growth of P. aeruginosa colony was in the presence of isolated oxypeucedanin. Ethanol (17.36-46.98%) and methanol (34.54-52.43%) root extracts showed higher anti-biofilm activity compared to streptomycin (49.40-88.36%) and ampicillin (56.46-92.16%).",
publisher = "American Chemical Society (ACS)",
journal = "Journal of Agricultural and Food Chemistry",
title = "Research on Chemical Composition and Biological Properties Including Antiquorum Sensing Activity of Angelica pancicii Vandas Aerial Parts and Roots",
volume = "65",
number = "50",
pages = "10933-10949",
doi = "10.1021/acs.jafc.7b04202"
}

Mileski, K. S., Trifunović, S., Ciric, A. D., Sakic, Z. M., Ristic, M. S., Todorović, N., Matevski, V. S., Marin, P. D., Tešević, V.,& Dzamic, A. M.. (2017). Research on Chemical Composition and Biological Properties Including Antiquorum Sensing Activity of Angelica pancicii Vandas Aerial Parts and Roots. in Journal of Agricultural and Food Chemistry
American Chemical Society (ACS)., 65(50), 10933-10949.
https://doi.org/10.1021/acs.jafc.7b04202

Mileski KS, Trifunović S, Ciric AD, Sakic ZM, Ristic MS, Todorović N, Matevski VS, Marin PD, Tešević V, Dzamic AM. Research on Chemical Composition and Biological Properties Including Antiquorum Sensing Activity of Angelica pancicii Vandas Aerial Parts and Roots. in Journal of Agricultural and Food Chemistry. 2017;65(50):10933-10949.
doi:10.1021/acs.jafc.7b04202 .

Mileski, Ksenija S., Trifunović, Snežana, Ciric, Ana D., Sakic, Zeljana M., Ristic, Mihailo S., Todorović, Nina, Matevski, Vlado S., Marin, Petar D., Tešević, Vele, Dzamic, Ana M., "Research on Chemical Composition and Biological Properties Including Antiquorum Sensing Activity of Angelica pancicii Vandas Aerial Parts and Roots" in Journal of Agricultural and Food Chemistry, 65, no. 50 (2017):10933-10949,
https://doi.org/10.1021/acs.jafc.7b04202 . .

TY  - JOUR
AU  - Mileski, Ksenija S.
AU  - Trifunović, Snežana
AU  - Ciric, Ana D.
AU  - Sakic, Zeljana M.
AU  - Ristic, Mihailo S.
AU  - Todorović, Nina
AU  - Matevski, Vlado S.
AU  - Marin, Petar D.
AU  - Tešević, Vele
AU  - Dzamic, Ana M.
PY  - 2017
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2110
AB  - The essential oil, different extracts, and isolated compounds of Angelica pancicii Vandas (Apiaceae) were investigated for the first time. The GC-FID and GC-MS analyses revealed sesquiterpenoids as the main constituents of A. pancicii essential oil of aerial parts with bornyl acetate (8.08%), n-octanol (5.82%), kessane (4.26%), and beta-selinene (4.26%) as the main constituents. Analysis of methanol extracts, using an HPLC-DAD/ESI-ToF-MS system, showed a total of 52 compounds in the aerial parts and 53 in the roots, indicating coumarins as the main constituents. In addition, new chromone (1) and six known furanocoumarins (2-7) were isolated from the roots and structurally elucidated by combined spectroscopic methods. The aerial part extracts exhibited higher polyphenolic contents and antioxidant activity evaluated by three radical scavenging assays. Using a microwell dilution method, the strongest antibacterial activity profiles were determined for ethanol and methanol root extracts (minimum bactericidal concentrations (MBCs) = 0.25-3.00 mg/mL), which were comparable to the activity of streptomycin (MBCs = 0.34-1.24 mg/mL), while the strongest antibacterial compound of A. pancicii was oxypeucedanin hydrate (MBCs = 0.50-8.00 mg/mL). Antifungal potential was in moderate extent, and the highest activity was obtained for root methanol extract (minimum fungicidal concentrations (MFCs) = 4.00-14.00 mg/mL). Tested sub-minimum inhibitory concentrations (subMICs) of the extracts and isolated compounds inhibited selected Pseudomonasaeruginosa PAO1 virulence determinants. The most reduced growth of P. aeruginosa colony was in the presence of isolated oxypeucedanin. Ethanol (17.36-46.98%) and methanol (34.54-52.43%) root extracts showed higher anti-biofilm activity compared to streptomycin (49.40-88.36%) and ampicillin (56.46-92.16%).
PB  - American Chemical Society (ACS)
T2  - Journal of Agricultural and Food Chemistry
T1  - Research on Chemical Composition and Biological Properties Including Antiquorum Sensing Activity of Angelica pancicii Vandas Aerial Parts and Roots
VL  - 65
IS  - 50
SP  - 10933
EP  - 10949
DO  - 10.1021/acs.jafc.7b04202
ER  - 

@article{
author = "Mileski, Ksenija S. and Trifunović, Snežana and Ciric, Ana D. and Sakic, Zeljana M. and Ristic, Mihailo S. and Todorović, Nina and Matevski, Vlado S. and Marin, Petar D. and Tešević, Vele and Dzamic, Ana M.",
year = "2017",
abstract = "The essential oil, different extracts, and isolated compounds of Angelica pancicii Vandas (Apiaceae) were investigated for the first time. The GC-FID and GC-MS analyses revealed sesquiterpenoids as the main constituents of A. pancicii essential oil of aerial parts with bornyl acetate (8.08%), n-octanol (5.82%), kessane (4.26%), and beta-selinene (4.26%) as the main constituents. Analysis of methanol extracts, using an HPLC-DAD/ESI-ToF-MS system, showed a total of 52 compounds in the aerial parts and 53 in the roots, indicating coumarins as the main constituents. In addition, new chromone (1) and six known furanocoumarins (2-7) were isolated from the roots and structurally elucidated by combined spectroscopic methods. The aerial part extracts exhibited higher polyphenolic contents and antioxidant activity evaluated by three radical scavenging assays. Using a microwell dilution method, the strongest antibacterial activity profiles were determined for ethanol and methanol root extracts (minimum bactericidal concentrations (MBCs) = 0.25-3.00 mg/mL), which were comparable to the activity of streptomycin (MBCs = 0.34-1.24 mg/mL), while the strongest antibacterial compound of A. pancicii was oxypeucedanin hydrate (MBCs = 0.50-8.00 mg/mL). Antifungal potential was in moderate extent, and the highest activity was obtained for root methanol extract (minimum fungicidal concentrations (MFCs) = 4.00-14.00 mg/mL). Tested sub-minimum inhibitory concentrations (subMICs) of the extracts and isolated compounds inhibited selected Pseudomonasaeruginosa PAO1 virulence determinants. The most reduced growth of P. aeruginosa colony was in the presence of isolated oxypeucedanin. Ethanol (17.36-46.98%) and methanol (34.54-52.43%) root extracts showed higher anti-biofilm activity compared to streptomycin (49.40-88.36%) and ampicillin (56.46-92.16%).",
publisher = "American Chemical Society (ACS)",
journal = "Journal of Agricultural and Food Chemistry",
title = "Research on Chemical Composition and Biological Properties Including Antiquorum Sensing Activity of Angelica pancicii Vandas Aerial Parts and Roots",
volume = "65",
number = "50",
pages = "10933-10949",
doi = "10.1021/acs.jafc.7b04202"
}

Mileski, K. S., Trifunović, S., Ciric, A. D., Sakic, Z. M., Ristic, M. S., Todorović, N., Matevski, V. S., Marin, P. D., Tešević, V.,& Dzamic, A. M.. (2017). Research on Chemical Composition and Biological Properties Including Antiquorum Sensing Activity of Angelica pancicii Vandas Aerial Parts and Roots. in Journal of Agricultural and Food Chemistry
American Chemical Society (ACS)., 65(50), 10933-10949.
https://doi.org/10.1021/acs.jafc.7b04202

Mileski KS, Trifunović S, Ciric AD, Sakic ZM, Ristic MS, Todorović N, Matevski VS, Marin PD, Tešević V, Dzamic AM. Research on Chemical Composition and Biological Properties Including Antiquorum Sensing Activity of Angelica pancicii Vandas Aerial Parts and Roots. in Journal of Agricultural and Food Chemistry. 2017;65(50):10933-10949.
doi:10.1021/acs.jafc.7b04202 .

Mileski, Ksenija S., Trifunović, Snežana, Ciric, Ana D., Sakic, Zeljana M., Ristic, Mihailo S., Todorović, Nina, Matevski, Vlado S., Marin, Petar D., Tešević, Vele, Dzamic, Ana M., "Research on Chemical Composition and Biological Properties Including Antiquorum Sensing Activity of Angelica pancicii Vandas Aerial Parts and Roots" in Journal of Agricultural and Food Chemistry, 65, no. 50 (2017):10933-10949,
https://doi.org/10.1021/acs.jafc.7b04202 . .

TY  - JOUR
AU  - Dzamic, Ana M.
AU  - Soković, Marina
AU  - Novaković, Miroslav
AU  - Jadranin, Milka
AU  - Ristic, Mihailo S.
AU  - Tešević, Vele
AU  - Marin, Petar D.
PY  - 2013
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1242
AB  - The aim of the study was to investigate the chemical composition of Hyssopus officinalis L subsp. pilifer (Pant.) Murb. essential oil (EO) and deodorized extracts (DE) and to evaluate their potential antifungal and antioxidant activities. EO was analyzed by GC-FID and GC-MS. Among the 30 compounds identified in the oil, the main were 1.8-cineole (36.43%), beta-pinene (19.55%), isopinocamphone (15.32%) and trans-pinocamphone (6.39%). Deodorized aqueous extract (DAE) was analyzed by LC-DAD/ESI-TOF MS. The most significant phenolic acids detected in DAE were syringic, caffeoylqunic acids, feruloylquinic and rosmarinic acid. Aspergillus niger, A. ochraceus, A. versicolor, A. fumigatus, Cladosporium cladosporioides, C. fulvum, Penicillium funiculosum, P. ochrochloron, Trichoderma viride and Candida albicans yeast were used for antifungal assay. Minimum inhibitory concentrations (MICs) and minimum fungicidal concentrations (MFCs) of the tested EO and DEs were recorded by the microdilution method. The antioxidant potential of the extracts was evaluated by means of the 2,2-diphenyl-1-picrylhydrazil (DPPH) radical scavenging method. The deodorized aqueous extract (DAE) possessed the highest scavenging activity (EC50=0.54 mg/ml) followed by the deodorized methanol extract (DME) (EC50=0.82 mg/ml) and deodorized ethyl acetate extract (DEE) (EC50 = 2.97 mg/ml). EC/possessed the lowest activities compared to other extracts and control substances. Total phenolic content of DEs was determined by Folin-Ciocalteau (FC) assay and gallic acid was used as the standard. DAE of H. officinalis subsp. pilifer exhibited the highest phenolic content 96.47 GAE.
PB  - Elsevier
T2  - Industrial Crops and Products
T1  - Composition, antifungal and antioxidant properties of Hyssopus officinalis L. subsp pilifer (Pant.) Murb. essential oil and deodorized extracts
VL  - 51
SP  - 401
EP  - 407
DO  - 10.1016/j.indcrop.2013.09.038
ER  - 

@article{
author = "Dzamic, Ana M. and Soković, Marina and Novaković, Miroslav and Jadranin, Milka and Ristic, Mihailo S. and Tešević, Vele and Marin, Petar D.",
year = "2013",
abstract = "The aim of the study was to investigate the chemical composition of Hyssopus officinalis L subsp. pilifer (Pant.) Murb. essential oil (EO) and deodorized extracts (DE) and to evaluate their potential antifungal and antioxidant activities. EO was analyzed by GC-FID and GC-MS. Among the 30 compounds identified in the oil, the main were 1.8-cineole (36.43%), beta-pinene (19.55%), isopinocamphone (15.32%) and trans-pinocamphone (6.39%). Deodorized aqueous extract (DAE) was analyzed by LC-DAD/ESI-TOF MS. The most significant phenolic acids detected in DAE were syringic, caffeoylqunic acids, feruloylquinic and rosmarinic acid. Aspergillus niger, A. ochraceus, A. versicolor, A. fumigatus, Cladosporium cladosporioides, C. fulvum, Penicillium funiculosum, P. ochrochloron, Trichoderma viride and Candida albicans yeast were used for antifungal assay. Minimum inhibitory concentrations (MICs) and minimum fungicidal concentrations (MFCs) of the tested EO and DEs were recorded by the microdilution method. The antioxidant potential of the extracts was evaluated by means of the 2,2-diphenyl-1-picrylhydrazil (DPPH) radical scavenging method. The deodorized aqueous extract (DAE) possessed the highest scavenging activity (EC50=0.54 mg/ml) followed by the deodorized methanol extract (DME) (EC50=0.82 mg/ml) and deodorized ethyl acetate extract (DEE) (EC50 = 2.97 mg/ml). EC/possessed the lowest activities compared to other extracts and control substances. Total phenolic content of DEs was determined by Folin-Ciocalteau (FC) assay and gallic acid was used as the standard. DAE of H. officinalis subsp. pilifer exhibited the highest phenolic content 96.47 GAE.",
publisher = "Elsevier",
journal = "Industrial Crops and Products",
title = "Composition, antifungal and antioxidant properties of Hyssopus officinalis L. subsp pilifer (Pant.) Murb. essential oil and deodorized extracts",
volume = "51",
pages = "401-407",
doi = "10.1016/j.indcrop.2013.09.038"
}

Dzamic, A. M., Soković, M., Novaković, M., Jadranin, M., Ristic, M. S., Tešević, V.,& Marin, P. D.. (2013). Composition, antifungal and antioxidant properties of Hyssopus officinalis L. subsp pilifer (Pant.) Murb. essential oil and deodorized extracts. in Industrial Crops and Products
Elsevier., 51, 401-407.
https://doi.org/10.1016/j.indcrop.2013.09.038

Dzamic AM, Soković M, Novaković M, Jadranin M, Ristic MS, Tešević V, Marin PD. Composition, antifungal and antioxidant properties of Hyssopus officinalis L. subsp pilifer (Pant.) Murb. essential oil and deodorized extracts. in Industrial Crops and Products. 2013;51:401-407.
doi:10.1016/j.indcrop.2013.09.038 .

Dzamic, Ana M., Soković, Marina, Novaković, Miroslav, Jadranin, Milka, Ristic, Mihailo S., Tešević, Vele, Marin, Petar D., "Composition, antifungal and antioxidant properties of Hyssopus officinalis L. subsp pilifer (Pant.) Murb. essential oil and deodorized extracts" in Industrial Crops and Products, 51 (2013):401-407,
https://doi.org/10.1016/j.indcrop.2013.09.038 . .